Published in J Neurosci on August 01, 1997
Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization. Eur J Neurosci (2010) 1.50
Diminished neurokinin-1 receptor availability in patients with two forms of chronic visceral pain. Pain (2013) 1.45
Responsiveness of rat substantia gelatinosa neurones to mechanical but not thermal stimuli revealed by in vivo patch-clamp recording. J Physiol (1999) 1.38
Substance P in the medial amygdala: emotional stress-sensitive release and modulation of anxiety-related behavior in rats. Proc Natl Acad Sci U S A (2004) 1.30
Mode of action of cytokines on nociceptive neurons. Exp Brain Res (2009) 1.26
Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice. Diabetes (2011) 1.10
Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation. Mol Pain (2007) 1.02
Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids. J Neurosci (2003) 0.97
Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce micro-opioid receptor internalization in the rat spinal cord. J Neurosci (2003) 0.96
Spinal N-methyl-D-aspartate receptors and nociception-evoked release of primary afferent substance P. Neuroscience (2008) 0.94
Tachykinin NK₁ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. Eur J Pharmacol (2012) 0.91
NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord. Neuroscience (2010) 0.89
Biomechanics of stretch-induced beading. Biophys J (1999) 0.88
Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis. Exp Neurol (2012) 0.88
Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers. Neuroscience (2009) 0.88
Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord. Br J Pharmacol (2003) 0.84
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci (2014) 0.83
Spinal μ and δ opioids inhibit both thermal and mechanical pain in rats. J Neurosci (2013) 0.82
Acute colitis induces neurokinin 1 receptor internalization in the rat lumbosacral spinal cord. PLoS One (2013) 0.82
Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce mu-opioid receptor internalization in the presence of peptidase inhibitors. Brain Res (2008) 0.82
Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. Elife (2015) 0.81
Inflammation in acute CNS injury: a focus on the role of substance P. Br J Pharmacol (2015) 0.81
μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain. Neuroscience (2014) 0.80
Kainate receptors are primarily postsynaptic to SP-containing axon terminals in the trigeminal dorsal horn. Brain Res (2007) 0.79
Increased neuronal expression of neurokinin-1 receptor and stimulus-evoked internalization of the receptor in the rostral ventromedial medulla of the rat after peripheral inflammatory injury. J Comp Neurol (2014) 0.79
Src family kinases mediate the inhibition of substance P release in the rat spinal cord by μ-opioid receptors and GABA(B) receptors, but not α2 adrenergic receptors. Eur J Neurosci (2010) 0.79
Substance P induces the reversible formation of varicosities in the dendrites of rat brainstem neurons. Brain Res (2010) 0.78
Inflammation enhances Y1 receptor signaling, neuropeptide Y-mediated inhibition of hyperalgesia, and substance P release from primary afferent neurons. Neuroscience (2013) 0.78
TRP Channels Involved in Spontaneous L-Glutamate Release Enhancement in the Adult Rat Spinal Substantia Gelatinosa. Cells (2014) 0.76
Targeting inflammation as a treatment modality for neuropathic pain in spinal cord injury: a randomized clinical trial. J Neuroinflammation (2016) 0.75
Endomorphin-2 Inhibition of Substance P Signaling within Lamina I of the Spinal Cord Is Impaired in Diabetic Neuropathic Pain Rats. Front Mol Neurosci (2017) 0.75
Mechanisms of μ-opioid receptor inhibition of NMDA receptor-induced substance P release in the rat spinal cord. Neuropharmacology (2017) 0.75
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron (1998) 13.03
Molecular mechanisms of nociception. Nature (2001) 7.75
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature (2001) 6.26
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu Rev Neurosci (1984) 4.87
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor. Science (1997) 4.03
Intradendritic recordings from hippocampal neurons. Proc Natl Acad Sci U S A (1979) 3.18
Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway. Nat Med (2001) 3.17
Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science (1997) 2.98
Primary afferent tachykinins are required to experience moderate to intense pain. Nature (1998) 2.97
Endogenous pain control mechanisms: review and hypothesis. Ann Neurol (1978) 2.63
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience (2002) 2.57
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med (2000) 2.54
Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol (1991) 2.54
Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science (1999) 2.43
Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism. Biochemistry (2000) 2.37
Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia. J Neurophysiol (1991) 2.33
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience (2000) 2.28
The molecular dynamics of pain control. Nat Rev Neurosci (2001) 2.21
Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci (1999) 2.19
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science (1995) 2.12
The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron (2001) 1.97
Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC gamma mutant mice. Pain (2001) 1.97
Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation. Pain (1999) 1.90
Partial sciatic nerve injury in the mouse as a model of neuropathic pain: behavioral and neuroanatomical correlates. Pain (1998) 1.90
Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Proc Natl Acad Sci U S A (1988) 1.87
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci (1986) 1.84
Intraneuronal substance P contributes to the severity of experimental arthritis. Science (1984) 1.77
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. J Neurosci (1990) 1.77
Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial. J Wound Care (2009) 1.76
Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J Neurosci (1998) 1.68
NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature (1997) 1.65
Response properties of mechanoreceptors and nociceptors in mouse glabrous skin: an in vivo study. J Neurophysiol (2001) 1.62
A new device to quantify tactile sensation in neuropathy. Neurology (2011) 1.62
Leukotriene and prostaglandin sensitization of cutaneous high-threshold C- and A-delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience (1987) 1.62
Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci U S A (1995) 1.60
Peptides and the primary afferent nociceptor. J Neurosci (1993) 1.58
Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence. Biochemistry (1996) 1.58
Wound infection after infrainguinal bypass operations: multivariate analysis of putative risk factors. Surg Infect (Larchmt) (2000) 1.53
Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms. FASEB J (1990) 1.51
Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats. Pain (1996) 1.49
1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence. Biochemistry (1995) 1.48
Brainstem control of spinal pain-transmission neurons. Annu Rev Physiol (1978) 1.45
Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci (2000) 1.44
Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway. Proc Natl Acad Sci U S A (1976) 1.43
The differences in toxicity and release of bone-resorbing mediators induced by titanium and cobalt-chromium-alloy wear particles. J Bone Joint Surg Am (1993) 1.43
Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J Rheumatol (1985) 1.42
Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci U S A (1992) 1.41
The development of opioid tolerance in the formalin test in the rat. Pain (1995) 1.40
Dementia in Parkinson disease: a neuropsychological analysis. Brain Cogn (1982) 1.38
Expression of c-fos protein in interneurons and projection neurons of the rat spinal cord in response to noxious somatic, articular, and visceral stimulation. J Comp Neurol (1989) 1.38
A beta deposition inhibitor screen using synthetic amyloid. Nat Biotechnol (1997) 1.37
Spinal and trigeminal projections to the nucleus of the solitary tract: a possible substrate for somatovisceral and viscerovisceral reflex activation. J Comp Neurol (1987) 1.36
Spinal cannabinoids are anti-allodynic in rats with persistent inflammation. Pain (1999) 1.36
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J Neurosci (1997) 1.33
Immunohistochemical localization of GABA(B) receptors in the rat central nervous system. J Comp Neurol (1999) 1.32
Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology (1996) 1.32
Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. J Neurosci (1999) 1.32
Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience (2010) 1.31
Windup leads to characteristics of central sensitization. Pain (1999) 1.29
Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception. J Neurosci (2001) 1.28
Brain amyloid--a physicochemical perspective. Brain Pathol (1996) 1.27
Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations. Biochemistry (1999) 1.27
Neural control of vascular permeability: interactions between primary afferents, mast cells, and sympathetic efferents. J Neurophysiol (1989) 1.26
Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc Natl Acad Sci U S A (1994) 1.25
Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems. J Comp Neurol (1978) 1.24