Published in Proc Natl Acad Sci U S A on May 01, 1988
CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci U S A (1994) 2.22
Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats. Proc Natl Acad Sci U S A (1997) 1.70
Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis. J Clin Invest (1998) 1.57
Modulation of lymphatic muscle contractility by the neuropeptide substance P. Am J Physiol Heart Circ Physiol (2008) 1.39
Substance P (neurokinin-1) and neurokinin A (neurokinin-2) receptor gene and protein expression in the healthy and inflamed human intestine. Am J Pathol (2000) 1.26
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P. Proc Natl Acad Sci U S A (1999) 1.22
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci U S A (2006) 1.22
Stimulation of angiogenesis by substance P and interleukin-1 in the rat and its inhibition by NK1 or interleukin-1 receptor antagonists. Br J Pharmacol (1993) 1.20
Neurotensin is a proinflammatory neuropeptide in colonic inflammation. J Clin Invest (1999) 1.20
Substance P receptor binding sites are expressed by glia in vivo after neuronal injury. Proc Natl Acad Sci U S A (1989) 1.15
Neurokinin-1 receptor expression in inflammatory bowel disease: molecular quantitation and localisation. Gut (2000) 1.15
Regulation of the NK-1 receptor gene expression in human macrophage cells via an NF-kappa B site on its promoter. Proc Natl Acad Sci U S A (2003) 1.15
Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor. Br J Pharmacol (2002) 1.14
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol (2012) 1.14
Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology (1990) 1.12
A substance P antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proc Natl Acad Sci U S A (1997) 1.10
Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann N Y Acad Sci (2010) 1.09
Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J (2002) 1.07
Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis. Gut (2000) 1.05
Chronic pancreatitis: the perspective of pain generation by neuroimmune interaction. Gut (2003) 1.04
NF-kappaB activation precedes increases in mRNA encoding neurokinin-1 receptor, proinflammatory cytokines, and adhesion molecules in dextran sulfate sodium-induced colitis in rats. Dig Dis Sci (2005) 1.04
Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci U S A (2007) 1.02
Neuroendocrine disorders of the gut. West J Med (1995) 1.01
Interleukin-1beta upregulates functional expression of neurokinin-1 receptor (NK-1R) via NF-kappaB in astrocytes. Glia (2004) 0.97
Role of substance P in inflammatory arthritis. Ann Rheum Dis (1992) 0.95
Characterization of substance P binding to human monocytes/macrophages. Clin Diagn Lab Immunol (1994) 0.94
Enhanced immunoglobulin A response and protection against Salmonella enterica serovar typhimurium in the absence of the substance P receptor. Infect Immun (2005) 0.93
Contractile properties of the pig bladder mucosa in response to neurokinin A: a role for myofibroblasts? Br J Pharmacol (2008) 0.92
Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis. PLoS One (2008) 0.91
Delayed-type hypersensitivity-induced increase in vascular permeability in the mouse small intestine: inhibition by depletion of sensory neuropeptides and NK1 receptor blockade. Br J Pharmacol (1995) 0.90
Substance P up-regulates macrophage inflammatory protein-1beta expression in human T lymphocytes. J Neuroimmunol (2002) 0.90
Octreotide effectively decreases mucosal damage in experimental colitis. Gut (1993) 0.89
Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. J Cell Mol Med (2008) 0.89
Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats. World J Gastroenterol (2008) 0.89
Differential expression of neurokinin-1 receptor by human mucosal and peripheral lymphoid cells. Clin Diagn Lab Immunol (2000) 0.88
Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse. Gut (2003) 0.86
Relevance of Somatostatin Receptors and Other Peptide Receptors in Pathology. Endocr Pathol (1997) 0.84
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease. Br J Pharmacol (2001) 0.83
Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol Gastrointest Liver Physiol (2001) 0.83
Neuropeptides, mesenteric fat, and intestinal inflammation. Ann N Y Acad Sci (2008) 0.82
Inflammatory intermediaries in inflammatory bowel disease. Int J Colorectal Dis (1989) 0.82
Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs. Am J Physiol Lung Cell Mol Physiol (2010) 0.81
Novel method for determination of substance P levels in unextracted human plasma by using acidification. Clin Vaccine Immunol (2009) 0.81
Substance P, obesity, and gut inflammation. Curr Opin Endocrinol Diabetes Obes (2009) 0.80
Increased fecal levels of chromogranin A, chromogranin B, and secretoneurin in collagenous colitis. Inflammation (2013) 0.79
Measurement of plasma-derived substance P: biological, methodological, and statistical considerations. Clin Vaccine Immunol (2006) 0.78
Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease. Mediators Inflamm (2016) 0.77
Characterization of the [125I]-neurokinin A binding site in the circular muscle of human colon. Br J Pharmacol (1999) 0.77
Substance P regulates migration in rat intestinal epithelial cells. Ann Surg (2007) 0.77
Gastrin releasing peptide receptor expression is decreased in patients with Crohn's disease but not in ulcerative colitis. J Clin Pathol (2004) 0.77
A lay doctor's guide to the inflammatory process in the gastrointestinal tract. Postgrad Med J (2000) 0.76
Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans. Gut (2003) 0.75
The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut. Immunity (2017) 0.75
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br J Pharmacol Chemother (1967) 4.33
Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch Pharmacol (1979) 3.80
Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature (1977) 2.74
Capsaicin-induced desensitization of airway mucosa to cigarette smoke, mechanical and chemical irritants. Nature (1983) 2.57
A new method for receptor autoradiography: [3H]opioid receptors in rat brain. Brain Res (1979) 2.44
Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci (1986) 1.84
The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br J Pharmacol Chemother (1968) 1.84
Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice. Brain Res (1981) 1.61
Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin. Neuroscience (1981) 1.50
Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality. J Neurosci (1982) 1.50
Hypothesis: the nervous system may contribute to the pathophysiology of rheumatoid arthritis. J Rheumatol (1985) 1.42
Vascular permeability changes and smooth muscle contraction in relation to capsaicin-sensitive substance P afferents in the guinea-pig. Acta Physiol Scand (1984) 1.38
Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs. Neuroscience (1982) 1.30
Local oedema and general excitation of cutaneous sensory receptors produced by electrical stimulation of the saphenous nerve in the rat. Pain (1976) 1.05
Axonal transport of substance P in the vagus and sciatic nerves of the guinea pig. Brain Res (1980) 1.00
Release of substance P from the spinal dorsal horn is enhanced in polyarthritic rats. Neurosci Lett (1987) 0.92
Regional distribution of kassinin-like immunoreactivity in rat central and peripheral tissues and the effect of capsaicin. Brain Res (1984) 0.91
Quantitative receptor autoradiography with tritium-labeled ligands: comparison of biochemical and densitometric measurements. J Neurosci Methods (1984) 0.85
Primary afferent tachykinins are required to experience moderate to intense pain. Nature (1998) 2.97
Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur. Neuroscience (2002) 2.57
Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med (2000) 2.54
Postoperative ileus. Dig Dis Sci (1990) 2.48
Transmission of chronic nociception by spinal neurons expressing the substance P receptor. Science (1999) 2.43
Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism. Biochemistry (2000) 2.37
The clinical effectiveness and cost-effectiveness of screening for anal squamous intraepithelial lesions in homosexual and bisexual HIV-positive men. JAMA (1999) 2.35
Murine models of inflammatory, neuropathic and cancer pain each generates a unique set of neurochemical changes in the spinal cord and sensory neurons. Neuroscience (2000) 2.28
The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J Struct Biol (2000) 2.26
The molecular dynamics of pain control. Nat Rev Neurosci (2001) 2.21
Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. J Neurosci (1999) 2.19
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation. Science (1995) 2.12
Purification and characterization of chlorotoxin, a chloride channel ligand from the venom of the scorpion. Am J Physiol (1993) 1.77
Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation. Proc Natl Acad Sci U S A (1994) 1.72
Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J Neurosci (1998) 1.68
NMDA-receptor regulation of substance P release from primary afferent nociceptors. Nature (1997) 1.65
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. J Biol Chem (1996) 1.61
A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. Gut (2008) 1.61
Rapid endocytosis of a G protein-coupled receptor: substance P evoked internalization of its receptor in the rat striatum in vivo. Proc Natl Acad Sci U S A (1995) 1.60
Point substitution in the central hydrophobic cluster of a human beta-amyloid congener disrupts peptide folding and abolishes plaque competence. Biochemistry (1996) 1.58
Electron microscopy of oligodendrocytes in normal rat cerebrum. Am J Anat (1966) 1.57
Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry (1998) 1.54
Selective neuronal glycoconjugate expression in sensory and autonomic ganglia: relation of lectin reactivity to peptide and enzyme markers. J Neurocytol (1990) 1.53
Diversity in mammalian tachykinin peptidergic neurons: multiple peptides, receptors, and regulatory mechanisms. FASEB J (1990) 1.51
1H NMR of A beta amyloid peptide congeners in water solution. Conformational changes correlate with plaque competence. Biochemistry (1995) 1.48
Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci U S A (1992) 1.41
The non-sensory basis of autotomy in rats: a reply to the editorial by Devor and the article by Blumenkopf and Lipman. Pain (1992) 1.40
A beta deposition inhibitor screen using synthetic amyloid. Nat Biotechnol (1997) 1.37
Inflammation increases the distribution of dorsal horn neurons that internalize the neurokinin-1 receptor in response to noxious and non-noxious stimulation. J Neurosci (1997) 1.33
Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states. J Neurosci (1999) 1.32
Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. Gastroenterology (1996) 1.32
Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain. Neuroscience (2010) 1.31
Novel peptide fragments originating from PGLa and the caerulein and xenopsin precursors from Xenopus laevis. J Biol Chem (1986) 1.30
Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception. J Neurosci (2001) 1.28
Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. J Neurosci (1989) 1.27
Brain amyloid--a physicochemical perspective. Brain Pathol (1996) 1.27
Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations. Biochemistry (1999) 1.27
Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors. Mol Pharmacol (1996) 1.26
THE FINE STRUCTURE OF ASTROCYTES IN THE CEREBRAL CORTEX AND THEIR RESPONSE TO FOCAL INJURY PRODUCED BY HEAVY IONIZING PARTICLES. J Cell Biol (1965) 1.25
Localization of cholecystokinin A and cholecystokinin B/gastrin receptors in the canine upper gastrointestinal tract. Gastroenterology (1994) 1.24
Spinal cord substance P receptor immunoreactivity increases in both inflammatory and nerve injury models of persistent pain. Neuroscience (1996) 1.22
Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. Biochem J (1994) 1.22
Activation barriers to structural transition determine deposition rates of Alzheimer's disease a beta amyloid. J Struct Biol (2000) 1.20
In vitro growth of Alzheimer's disease beta-amyloid plaques displays first-order kinetics. Biochemistry (1996) 1.19
Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of beta-amyloid peptide. J Neurochem (1993) 1.19
Osteoprotegerin diminishes advanced bone cancer pain. Cancer Res (2001) 1.19
Synaptic relationship between substance P and the substance P receptor: light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc Natl Acad Sci U S A (1994) 1.19
Morphological characterization of substance P receptor-immunoreactive neurons in the rat spinal cord and trigeminal nucleus caudalis. J Comp Neurol (1995) 1.19
Noxious cutaneous thermal stimuli induce a graded release of endogenous substance P in the spinal cord: imaging peptide action in vivo. J Neurosci (1997) 1.18
Electron microscopy of non-neuronal cellular changes accompanying neural degeneration in thalamic nuclei of the rabbit. I. Reactive hematogenous and perivascular elements within the basal lamina. J Comp Neurol (1973) 1.17
Selective arterial embolization for the control of lower gastrointestinal bleeding. Am J Surg (1997) 1.17
The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A. Neuroscience (2011) 1.16
Electron microscopy of non-neuronal cellular changes accompanying neural degeneration in thalamic nuclei of the rabbit. II. Reactive elements within the neuropil. J Comp Neurol (1973) 1.16
Substance P receptor binding sites are expressed by glia in vivo after neuronal injury. Proc Natl Acad Sci U S A (1989) 1.15
Photoaffinity cross-linking of Alzheimer's disease amyloid fibrils reveals interstrand contact regions between assembled beta-amyloid peptide subunits. Biochemistry (2001) 1.14
Endothelin and the tumorigenic component of bone cancer pain. Neuroscience (2004) 1.14
Calcitonin-gene-related-peptide-immunoreactive innervation of the rat head with emphasis on specialized sensory structures. J Comp Neurol (1989) 1.13
The trigeminal nerve root with special reference to the central-peripheral transition zone: an electron microscopic study in the macaque. Anat Rec (1969) 1.13
Spinal opioid analgesia: how critical is the regulation of substance P signaling? J Neurosci (1999) 1.10
Localisation of NK1 receptor immunoreactivity to neurons and interstitial cells of the guinea-pig gastrointestinal tract. J Comp Neurol (1996) 1.10
Correlation between inositol phospholipid hydrolysis and substance P receptors in rat CNS. Nature (1984) 1.09
Intestinal absorption and excretion of octapeptides composed of D amino acids. Proc Natl Acad Sci U S A (1994) 1.08
Relationship between visual and tactile representations in cat superior colliculus. J Neurophysiol (1976) 1.08
The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. Int J Radiat Oncol Biol Phys (1999) 1.07
Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol (2001) 1.06
Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis. Gastroenterology (1995) 1.06
Peripheral patterns of calcitonin-gene-related peptide general somatic sensory innervation: cutaneous and deep terminations. J Comp Neurol (1989) 1.06
Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo. Brain Res (2000) 1.05
Bone cancer pain: from mechanism to model to therapy. Pain Med (2000) 1.05
Sequence of changes in properties of neurons of superior colliculus of the kitten during maturation. J Neurophysiol (1973) 1.05
Forebrain projections to the periaqueductal gray in the monkey, with observations in the cat and rat. J Comp Neurol (1982) 1.04
CFTR: development of high- affinity antibodies and localization in sweat gland. Biochem Biophys Res Commun (1991) 1.04
Local excision of rectal carcinoma. Arch Surg (1999) 1.03
Pharmacological analysis of [3H]-senktide binding to NK3 tachykinin receptors in guinea-pig ileum longitudinal muscle-myenteric plexus and cerebral cortex membranes. Br J Pharmacol (1990) 1.02
The fine structure of neurons and satellite cells in the trigeminal ganglion of cat and monkey. Am J Anat (1967) 1.02
Diencephalic mechanisms of pain sensation. Brain Res (1985) 1.02
Intra-arterial infusion of [125I]A beta 1-40 labels amyloid deposits in the aged primate brain in vivo. Neuroreport (1996) 1.01
Natural and induced cytotoxicity of oligodendrocytes by microglia is inhibitable by TGF beta. Glia (1991) 1.00
Capsaicin-sensitive sensory nerve fibers contribute to the generation and maintenance of skeletal fracture pain. Neuroscience (2009) 1.00
Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides (1989) 0.99