Published in J Pharmacol Exp Ther on July 01, 1997
Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol (2009) 4.16
Guidelines on nicotine dose selection for in vivo research. Psychopharmacology (Berl) (2006) 3.68
Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors. Arch Gen Psychiatry (2006) 2.53
A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. Am J Hum Genet (2004) 2.47
Prenatal nicotine increases pulmonary alpha7 nicotinic receptor expression and alters fetal lung development in monkeys. J Clin Invest (1999) 1.77
Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. Biochem Pharmacol (2009) 1.76
Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. AAPS J (2009) 1.68
Methodological considerations for gene expression profiling of human brain. J Neurosci Methods (2007) 1.59
Nicotinic receptor mechanisms and cognition in normal states and neuropsychiatric disorders. J Psychopharmacol (2004) 1.58
beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. Arch Gen Psychiatry (2009) 1.53
Functional brain imaging of tobacco use and dependence. J Psychiatr Res (2005) 1.52
Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380. J Nucl Med (2008) 1.51
Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction. Biochem Pharmacol (2007) 1.49
Nicotine up-regulates alpha4beta2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning. J Gen Physiol (2011) 1.46
Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia. Neuropsychopharmacology (2011) 1.42
Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res (2009) 1.32
α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease. Pharmacol Rev (2011) 1.29
In vivo brain imaging of human exposure to nicotine and tobacco. Handb Exp Pharmacol (2009) 1.26
Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. Behav Pharmacol (2008) 1.23
Sex differences in availability of β2*-nicotinic acetylcholine receptors in recently abstinent tobacco smokers. Arch Gen Psychiatry (2012) 1.17
Recent advances in understanding nicotinic receptor signaling mechanisms that regulate drug self-administration behavior. Biochem Pharmacol (2011) 1.17
Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain. J Pharmacol Exp Ther (2011) 1.15
Deletion of the beta 2 nicotinic acetylcholine receptor subunit alters development of tolerance to nicotine and eliminates receptor upregulation. Psychopharmacology (Berl) (2005) 1.14
Merging old and new perspectives on nicotinic acetylcholine receptors. Biochem Pharmacol (2014) 1.14
Nicotine-induced upregulation of native neuronal nicotinic receptors is caused by multiple mechanisms. J Neurosci (2012) 1.12
Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. J Gen Physiol (2014) 1.07
Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. Int J Neuropsychopharmacol (2012) 1.06
Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. JAMA Psychiatry (2014) 1.06
Tobacco dependence and withdrawal: science base, challenges and opportunities for pharmacotherapy. Pharmacol Ther (2009) 1.04
Quantification of nicotinic acetylcholine receptors in the human brain with PET: bolus plus infusion administration of 2-[18F]F-A85380. Neuroimage (2007) 1.04
Smoking, Genetics and Schizophrenia: Evidence for Self Medication. J Dual Diagn (2007) 1.04
The effects of chronic cigarette smoking on gray matter volume: influence of sex. PLoS One (2014) 1.02
Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology (Berl) (2010) 1.02
Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine. Pharmacol Biochem Behav (2009) 1.00
Chronic sazetidine-A at behaviorally active doses does not increase nicotinic cholinergic receptors in rodent brain. J Pharmacol Exp Ther (2012) 0.99
Cognitive deficits in schizophrenia: focus on neuronal nicotinic acetylcholine receptors and smoking. Cell Mol Neurobiol (2007) 0.99
Cognitive function during nicotine withdrawal: Implications for nicotine dependence treatment. Neuropharmacology (2013) 0.98
Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward. J Neurosci (2016) 0.97
Lower ß2*-nicotinic acetylcholine receptor availability in smokers with schizophrenia. Am J Psychiatry (2012) 0.97
Association of CHRNA4 polymorphisms with smoking behavior in two populations. Am J Med Genet B Neuropsychiatr Genet (2011) 0.96
86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization. Biochem Pharmacol (2010) 0.95
Functional brain imaging of nicotinic effects on higher cognitive processes. Biochem Pharmacol (2011) 0.95
Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. Neuropharmacology (2013) 0.95
Accentuated behavioral sensitization to nicotine in the neonatal ventral hippocampal lesion model of schizophrenia. Neuropharmacology (2008) 0.94
Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. Arch Gen Psychiatry (2011) 0.93
Cocainomics: new insights into the molecular basis of cocaine addiction. J Neuroimmune Pharmacol (2010) 0.92
Historical and current perspective on tobacco use and nicotine addiction. Trends Neurosci (2011) 0.91
Nicotinic receptors in neurodegeneration. Curr Neuropharmacol (2013) 0.91
The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology (2015) 0.90
Assessment of genome and proteome profiles in cocaine abuse. Prog Brain Res (2006) 0.90
Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. Psychiatry Res (2010) 0.90
Receptor-associated proteins and synaptic plasticity. FASEB J (2008) 0.90
Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology (2015) 0.89
Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatr Genet (2012) 0.89
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats. J Med Chem (2013) 0.88
Effects of chronic nicotine on heteromeric neuronal nicotinic receptors in rat primary cultured neurons. J Neurochem (2011) 0.88
Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. Neuropsychopharmacology (2013) 0.88
Long-term upregulation of protein kinase A and adenylate cyclase levels in human smokers. J Neurosci (2007) 0.88
Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history. Neuropharmacology (2012) 0.86
Stimulation of the alpha4beta2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice. Brain Res (2008) 0.86
Changes in the cholinergic system between bipolar depression and euthymia as measured with [123I]5IA single photon emission computed tomography. Biol Psychiatry (2013) 0.86
Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia. Curr Pharm Des (2014) 0.86
Impact of sustained exposure to β-amyloid on calcium homeostasis and neuronal integrity in model nerve cell system expressing α4β2 nicotinic acetylcholine receptors. J Biol Chem (2013) 0.85
Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers. Synapse (2009) 0.84
Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. Genes Brain Behav (2015) 0.84
Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells. Br J Pharmacol (2001) 0.84
Neurocognitive endophenotypes in schizophrenia: modulation by nicotinic receptor systems. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.83
In vivo evidence for β2 nicotinic acetylcholine receptor subunit upregulation in smokers as compared with nonsmokers with schizophrenia. Biol Psychiatry (2013) 0.83
Cellular events in nicotine addiction. Semin Cell Dev Biol (2009) 0.83
Activation of α4β2*/α6β2* nicotinic receptors alleviates anxiety during nicotine withdrawal without upregulating nicotinic receptors. J Pharmacol Exp Ther (2014) 0.82
Regulation of the distribution and function of [(125)I]epibatidine binding sites by chronic nicotine in mouse embryonic neuronal cultures. J Pharmacol Exp Ther (2012) 0.81
Placebo-controlled pilot trial of mecamylamine for treatment of autism spectrum disorders. J Child Adolesc Psychopharmacol (2012) 0.81
High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. Psychopharmacology (Berl) (2013) 0.80
Chronic sazetidine-A maintains anxiolytic effects and slower weight gain following chronic nicotine without maintaining increased density of nicotinic receptors in rodent brain. J Neurochem (2014) 0.80
Airway-related vagal preganglionic neurons express multiple nicotinic acetylcholine receptor subunits. Auton Neurosci (2006) 0.80
Mechanisms of Inhibition and Potentiation of α4β2 Nicotinic Acetylcholine Receptors by Members of the Ly6 Protein Family. J Biol Chem (2015) 0.80
Anxiolytic-like and anxiogenic-like effects of nicotine are regulated via diverse action at β2*nicotinic acetylcholine receptors. Br J Pharmacol (2015) 0.79
Medications Development for the Treatment of Nicotine Dependence in Individuals with Schizophrenia. J Dual Diagn (2007) 0.79
Baseline impulsive choice predicts the effects of nicotine and nicotine withdrawal on impulsivity in rats. Prog Neuropsychopharmacol Biol Psychiatry (2013) 0.79
Α4β2 and α7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision-making tasks. Neuroscience (2012) 0.78
Functional genomics approaches to a primate model of autistic symptomology. J Autism Dev Disord (2001) 0.78
Regional brain [(11)C]carfentanil binding following tobacco smoking. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.78
Nicotinic receptor contributions to smoking: insights from human studies and animal models. Curr Addict Rep (2015) 0.78
Density of α4β2* nAChR on the surface of neurons is modulated by chronic antagonist exposure. Pharmacol Res Perspect (2015) 0.78
Functional genomics and psychiatric illness. Prog Brain Res (2002) 0.78
Genetic matters: thirty years of progress using mouse models in nicotinic research. Biochem Pharmacol (2013) 0.78
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. Neuropharmacology (2015) 0.77
Smoking restores impaired LTD-like plasticity in schizophrenia: a transcranial direct current stimulation study. Neuropsychopharmacology (2014) 0.77
Contribution of position alpha4S336 on functional expression and up-regulation of alpha4beta2 neuronal nicotinic receptors. Cell Mol Neurobiol (2008) 0.77
Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed α4β2 nicotinic receptors. J Biol Chem (2011) 0.77
A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability. Psychiatry Res (2013) 0.77
Impact of short access nicotine self-administration on expression of α4β2* nicotinic acetylcholine receptors in non-human primates. Psychopharmacology (Berl) (2016) 0.76
Involvement of neuronal β2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. J Clin Pharm Ther (2014) 0.76
Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats. Pharmacol Biochem Behav (2008) 0.76
Nicotinic receptors in non-human primates: Analysis of genetic and functional conservation with humans. Neuropharmacology (2015) 0.76
Evaluation of the Nicotinic Acetylcholine Receptor-Associated Proteome at Baseline and Following Nicotine Exposure in Human and Mouse Cortex. eNeuro (2016) 0.76
Nicotinic acetylcholine receptor expression on B-lymphoblasts of healthy versus schizophrenic subjects stratified for smoking: [3H]-nicotine binding is decreased in schizophrenia and correlates with negative symptoms. J Neural Transm (Vienna) (2011) 0.76
Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. J Nucl Med (2015) 0.76
Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet (2016) 0.75
Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature (2001) 16.89
LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell (2001) 11.99
A method for fine mapping quantitative trait loci in outbred animal stocks. Proc Natl Acad Sci U S A (2000) 5.46
Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A (1997) 4.89
Aripiprazole for schizophrenia. Systematic review. Br J Psychiatry (2006) 2.88
International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev (1999) 2.76
Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry (1995) 2.72
High-resolution mapping of quantitative trait loci in outbred mice. Nat Genet (1999) 2.69
Nicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment. J Neurosci (1992) 2.29
Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Nature (2000) 2.16
Aspartame, behavior, and cognitive function in children with attention deficit disorder. Pediatrics (1994) 2.08
A simple genetic basis for a complex psychological trait in laboratory mice. Science (1995) 2.06
Effects of chronic nicotine infusion on tolerance development and nicotinic receptors. J Pharmacol Exp Ther (1983) 2.03
Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J Neurosci (1998) 1.99
Psychological therapies for people with borderline personality disorder. Cochrane Database Syst Rev (2006) 1.93
Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull (1998) 1.92
Why some people smoke and others do not: new perspectives. J Consult Clin Psychol (1993) 1.88
Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology (2000) 1.77
Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol (1997) 1.72
Smoking and mental illness. Pharmacol Biochem Behav (2001) 1.63
Two pharmacologically distinct components of nicotinic receptor-mediated rubidium efflux in mouse brain require the beta2 subunit. J Pharmacol Exp Ther (1999) 1.61
Does an encouraging letter encourage attendance at psychiatric out-patient clinics? The Leeds PROMPTS randomized study. Psychol Med (2007) 1.58
Delayed implantation in the spayed, progesterone treated adult mouse. J Reprod Fertil (1966) 1.57
Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice. J Pharmacol Exp Ther (2010) 1.57
Nosocomial sepsis associated with interleukin-2. Ann Intern Med (1990) 1.56
Systematic does not necessarily mean comprehensive. Br J Psychiatry (1998) 1.54
Evidence against the involvement of chemotaxis in swarming of Proteus mirabilis. J Bacteriol (1976) 1.53
Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet (2001) 1.47
125I-alpha-conotoxin MII identifies a novel nicotinic acetylcholine receptor population in mouse brain. Mol Pharmacol (2000) 1.46
Characterization of nicotinic receptor-mediated [3H]dopamine release from synaptosomes prepared from mouse striatum. J Neurochem (1992) 1.45
Two-dimensional and Doppler echocardiography alone can adequately define preoperative anatomy and hemodynamic status before repair of complete atrioventricular septal defect in infants < 1 year old. J Am Coll Cardiol (1994) 1.44
Alpha-bungarotoxin binding to hippocampal interneurons: immunocytochemical characterization and effects on growth factor expression. J Neurosci (1993) 1.42
Recombination in a schizophrenic proband fails to exclude CHRNA7 at chromosome 15q14. Mol Psychiatry (2003) 1.41
Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychopharmacology (1996) 1.41
Time course study of the effects of chronic nicotine infusion on drug response and brain receptors. J Pharmacol Exp Ther (1985) 1.39
A simple bedside test to identify ulnar collateral flow. Ann Intern Med (1995) 1.38
Differential inhibitory effects of lovastatin on protein isoprenylation and sterol synthesis. J Biol Chem (1990) 1.36
Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics (1998) 1.36
Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev (2006) 1.35
Electroconvulsive therapy for schizophrenia. Cochrane Database Syst Rev (2002) 1.34
Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients. Schizophr Res (2000) 1.34
Regulation of microautophagy and basal protein turnover in rat liver. Effects of short-term starvation. J Biol Chem (1988) 1.34
Describing the phenotype in Rett syndrome using a population database. Arch Dis Child (2003) 1.33
Differential agonist inhibition identifies multiple epibatidine binding sites in mouse brain. J Pharmacol Exp Ther (1998) 1.32
Schistosoma mansoni in IL-4-deficient mice. Int Immunol (1996) 1.32
Clinical and bacteriological responses to three antibiotic regimens for acute exacerbations of cystic fibrosis: ticarcillin-tobramycin, azlocillin-tobramycin, and azlocillin-placebo. J Infect Dis (1983) 1.32
Identification of a novel nicotinic binding site in mouse brain using [(125)I]-epibatidine. Br J Pharmacol (2000) 1.31
Brain pH has a significant impact on human postmortem hippocampal gene expression profiles. Brain Res (2006) 1.31
Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry (1999) 1.31
Non-commercial clinical trials of a medicinal product: can they survive the current process of research approvals in the UK? J Med Ethics (2006) 1.30
Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate. Proc Natl Acad Sci U S A (1985) 1.30
Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals. Am J Respir Crit Care Med (1995) 1.29
The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron (2001) 1.28
Rifampin chemoprophylaxis for household contacts of patients with invasive infections due to Haemophilus influenzae type b. J Pediatr (1981) 1.26
Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos? Toxicol Appl Pharmacol (2011) 1.25
Downregulation of nicotinic receptor function after chronic nicotine infusion. J Pharmacol Exp Ther (1993) 1.24
Inbred mouse strains vary in oral self-selection of nicotine. Psychopharmacology (Berl) (1996) 1.23
Electroconvulsive therapy for schizophrenia. Cochrane Database Syst Rev (2005) 1.22
Schizophrenia and nicotinic receptors. Harv Rev Psychiatry (1998) 1.22
Genetic influences on nicotine responses. Pharmacol Biochem Behav (1989) 1.22
Pharmacological interventions for people with borderline personality disorder. Cochrane Database Syst Rev (2006) 1.21
Abundance, diversity, and patterns of distribution of primates on the Tapiche River in Amazonian Peru. Am J Primatol (2001) 1.21
Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum. J Neurochem (2001) 1.21
Long sleep and short sleep mice differ in nicotine-stimulated 86Rb+ efflux and alpha4 nicotinic receptor subunit cDNA sequence. Pharmacogenetics (2001) 1.19
Nicotine-induced tolerance and receptor changes in four mouse strains. J Pharmacol Exp Ther (1986) 1.19
An autoradiographic analysis of cholinergic receptors in mouse brain after chronic nicotine treatment. J Pharmacol Exp Ther (1991) 1.19
Evidence for the multigenic inheritance of schizophrenia. Am J Med Genet (2001) 1.18
Noncompliance with arthritis drugs: magnitude, correlates, and clinical implications. J Rheumatol (1982) 1.18
Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers. Brain Res Mol Brain Res (2005) 1.17
Surgical anatomy of the infratemporal fossa: the styloid diaphragm revisited. Neurosurgery (1998) 1.16
NURR1 mutations in cases of schizophrenia and manic-depressive disorder. Am J Med Genet (2000) 1.16
Characterization of nicotine binding in mouse brain and comparison with the binding of alpha-bungarotoxin and quinuclidinyl benzilate. Mol Pharmacol (1982) 1.15
The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. J Chem Neuroanat (2000) 1.14
Biological stability of mRNA isolated from human postmortem brain collections. Biol Psychiatry (1993) 1.14