Published in J Biol Chem on July 25, 1997
The sphingolipid salvage pathway in ceramide metabolism and signaling. Cell Signal (2007) 2.16
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem Rev (2011) 1.93
Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc Natl Acad Sci U S A (1998) 1.72
Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med (2010) 1.30
Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ Health Perspect (2001) 1.29
Ceramide and ceramide 1-phosphate in health and disease. Lipids Health Dis (2010) 1.24
Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med (2000) 1.19
Plant sphingolipids: decoding the enigma of the Sphinx. New Phytol (2009) 1.17
Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation. J Lipid Res (2007) 1.14
Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. Proc Natl Acad Sci U S A (2004) 1.08
Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. Biochim Biophys Acta (2009) 0.93
Identification of a novel amidase motif in neutral ceramidase. Biochem J (2006) 0.88
Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/- mice fed on a high-fat diet. Biosci Rep (2012) 0.85
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. Adv Biol Regul (2014) 0.85
Diaphragm dysfunction in heart failure is accompanied by increases in neutral sphingomyelinase activity and ceramide content. Eur J Heart Fail (2014) 0.84
AP-1 binding transcriptionally regulates human neutral ceramidase. Arch Biochem Biophys (2011) 0.84
Interleukin 1β regulation of FoxO1 protein content and localization: evidence for a novel ceramide-dependent mechanism. J Biol Chem (2012) 0.83
Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta. J Biol Chem (2011) 0.81
Neutral sphingomyelinase-3 mediates TNF-stimulated oxidant activity in skeletal muscle. Redox Biol (2014) 0.78
Transcriptional regulation of the human neutral ceramidase gene. Arch Biochem Biophys (2011) 0.78
Effect of procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3. J Lipid Res (2014) 0.77
Novel functional association of serine palmitoyltransferase subunit 1-A peptide in sphingolipid metabolism with cytochrome P4501A1 transactivation and proliferative capacity of the human Glioma LN18 brain tumor cell line. Int J Environ Res Public Health (2006) 0.76
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols. J Lipid Res (2015) 0.75
Direct regulation of IGF-binding protein 1 promoter by interleukin-1β via an insulin- and FoxO-1-independent mechanism. Am J Physiol Endocrinol Metab (2016) 0.75
ORMDL proteins regulate ceramide levels during sterile inflammation. J Lipid Res (2016) 0.75
Ceramidases, roles in sphingolipid metabolism and in health and disease. Adv Biol Regul (2016) 0.75
Purification and biochemical characterization of membrane-bound neutral ceramidase from camel brain (Camelus dromedarius). Int J Biochem Mol Biol (2013) 0.75
Outcomes of Spatially Fractionated Radiotherapy (GRID) for Bulky Soft Tissue Sarcomas in a Large Animal Model. Technol Cancer Res Treat (2017) 0.75
Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides. Antimicrob Agents Chemother (1993) 5.08
Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues. Proc Natl Acad Sci U S A (1991) 3.82
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem (1991) 3.20
Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem (1986) 3.05
Sphingolipid metabolism and cell growth regulation. FASEB J (1996) 2.53
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother (1992) 2.38
The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila) (2014) 2.31
Breast-feeding and infant illness: a dose-response relationship? Am J Public Health (1999) 2.16
The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron (1992) 2.11
Bridging the research-practice gap: exploring the research cultures of practitioners and managers. J Adv Nurs (1998) 2.10
Diaphragm movements and the diagnosis of diaphragmatic paralysis. Clin Radiol (1966) 2.04
Breakthrough adverse reactions to low-osmolar contrast media after steroid premedication. AJR Am J Roentgenol (2001) 1.92
Baseline HIV drug resistance profile predicts response to ritonavir-saquinavir protease inhibitor therapy in a community setting. AIDS (1999) 1.85
Inhibition of the oxidative burst in human neutrophils by sphingoid long-chain bases. Role of protein kinase C in activation of the burst. J Biol Chem (1986) 1.77
Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem (1982) 1.71
Enzymology of long-chain base synthesis by liver: characterization of serine palmitoyltransferase in rat liver microsomes. Arch Biochem Biophys (1984) 1.62
Spina bifida occulta in the parents of offspring with neural tube defects. J Genet Hum (1974) 1.61
Prediction criteria for successful weaning from respiratory support: statistical and connectionist analyses. Crit Care Med (1992) 1.57
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2'-deoxycytidine kinase. Biochem Pharmacol (1993) 1.56
OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance. Hum Mol Genet (2001) 1.54
Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Sci STKE (2001) 1.53
Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal Biochem (1988) 1.51
Influence of right ventricular stimulation site on left ventricular function in atrial synchronous ventricular pacing. J Am Coll Cardiol (1999) 1.50
Development of donor yield models. Am J Transplant (2011) 1.45
Bacterial adhesion at synthetic surfaces. Appl Environ Microbiol (1999) 1.45
Sphingolipids in food and the emerging importance of sphingolipids to nutrition. J Nutr (1999) 1.44
Donor screening for human T-cell lymphotrophic virus 1/2: changing paradigms for changing testing capacity. Am J Transplant (2009) 1.44
Environmental risk factors in Parkinson's disease. Neurology (1990) 1.39
Characterization of ceramide synthesis. A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J Biol Chem (1997) 1.37
Inhibition of phorbol ester-dependent differentiation of human promyelocytic leukemic (HL-60) cells by sphinganine and other long-chain bases. J Biol Chem (1986) 1.35
Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. J Biol Chem (1995) 1.31
Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ Health Perspect (2001) 1.31
Genetic control of variable and constant regions of immunoglobulin heavy chains. Nat New Biol (1971) 1.28
A high-performance liquid chromatographic method to measure sphingosine 1-phosphate and related compounds from sphingosine kinase assays and other biological samples. Anal Biochem (2000) 1.28
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. Br J Surg (1993) 1.26
U.S. Geological Survey Radiocarbon Dates IV. Science (1958) 1.24
Membrane phospholipid synthesis in Escherichia coli. Purification, reconstitution, and characterization of sn-glycerol-3-phosphate acyltransferase. J Biol Chem (1981) 1.23
Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim Biophys Acta (1983) 1.23
Pure nucleoside enantiomers of beta-2',3'-dideoxycytidine analogs are selective inhibitors of hepatitis B virus in vitro. Antimicrob Agents Chemother (1994) 1.23
Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J Nutr (1994) 1.20
Regulation of phosphatidate phosphatase activity from the yeast Saccharomyces cerevisiae by sphingoid bases. J Biol Chem (1993) 1.20
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys. Antimicrob Agents Chemother (1992) 1.20
Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J Biol Chem (1999) 1.13
Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). J Biol Chem (1986) 1.13
Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res (2001) 1.13
A frameshift mutation in exon 28 of the OPA1 gene explains the high prevalence of dominant optic atrophy in the Danish population: evidence for a founder effect. Hum Genet (2001) 1.12
Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues. J Lipid Res (1985) 1.12
Fumonisins: fungal toxins that shed light on sphingolipid function. Trends Cell Biol (1996) 1.12
Stress, stress reduction, and hypertension in African Americans: an updated review. J Natl Med Assoc (1997) 1.11
Caring for survivors of breast cancer: perspective of the primary care physician. Curr Oncol (2011) 1.11
Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. Toxicol Appl Pharmacol (1992) 1.10
Hepatic cytochrome P450 regulation in disease states. Curr Drug Metab (2001) 1.10
Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. Biochim Biophys Acta (2002) 1.08
Alteration in sphingolipid metabolism: bioassays for fumonisin- and ISP-I-like activity in tissues, cells and other matrices. Nat Toxins (1999) 1.08
Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol Appl Pharmacol (1998) 1.07
Social environment and vulnerability of low birth weight children: a social-epidemiological perspective. Pediatrics (1991) 1.07
Hormonal and developmental regulation of expression of the hepatic microsomal steroid 16 alpha-hydroxylase cytochrome P-450 apoprotein in the rat. J Biol Chem (1985) 1.07
Structure determination of soybean and wheat glucosylceramides by tandem mass spectrometry. J Mass Spectrom (2000) 1.05
Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols. J Biol Chem (1982) 1.03
Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition. J Am Chem Soc (2001) 1.03
Quantitative digitography (QDG): a sensitive measure of digital motor control in idiopathic Parkinson's disease. Mov Disord (2000) 1.02
Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. Biochem Soc Trans (2001) 1.02
Antiplatelet drugs in femoropopliteal vein bypasses: a multicenter trial. J Vasc Surg (1991) 1.01
Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5. Drug Metab Dispos (1984) 1.01
Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. J Biol Chem (1994) 1.01
Effects of early maternal separation on ethanol intake, GABA receptors and metabolizing enzymes in adult rats. Psychopharmacology (Berl) (2005) 1.01
Identification and genetic control of two rabbit immunoglobulin allotypes at a second light chain locus, the c locus. J Immunol (1969) 1.00
Viral nucleic acid testing (NAT) and OPO-level disposition of high-risk donor organs. Am J Transplant (2009) 1.00
Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J Nutr (1994) 1.00
Polymorphism and utilization of human VH Genes. Ann N Y Acad Sci (1995) 1.00
The 5'-triphosphates of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolane-5-yl]cytosine equally inhibit human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother (1993) 0.99
Free sphingosine formation from endogenous substrates by a liver plasma membrane system with a divalent cation dependence and a neutral pH optimum. J Biol Chem (1989) 0.99
Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. J Pharmacol Exp Ther (1999) 0.99
Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. Biochem Biophys Res Commun (1983) 0.98
Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china. Cancer Causes Control (2001) 0.97
Ceramidases. Methods Enzymol (2000) 0.97
Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: evidence for an involvement of protein kinase C. Biochim Biophys Acta (1990) 0.97
Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450. Drug Metab Dispos (1996) 0.96
Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J Biol Chem (1997) 0.96
Formation and mode of action of flavoproteins. Annu Rev Nutr (1981) 0.96
Regulation of cytochrome P450 2C11 (CYP2C11) gene expression by interleukin-1, sphingomyelin hydrolysis, and ceramides in rat hepatocytes. J Biol Chem (1995) 0.95
Affinity chromatographic purification and properties of flavokinase (ATP:riboflavin 5'-phosphotransferase) from rat liver. J Biol Chem (1980) 0.95
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone. Org Lett (1999) 0.94
Utilization of different fatty acyl-CoA thioesters by serine palmitoyltransferase from rat brain. J Lipid Res (1984) 0.94
Allotype-specific probes. A molecular approach to the study of serologically defined determinants. J Immunol Methods (1986) 0.94
Riboflavin-binding proteins. Annu Rev Nutr (1988) 0.94
Probable reaction mechanisms of flavokinase and FAD synthetase from rat liver. Arch Biochem Biophys (1990) 0.94
The Unpleasant Events Schedule: a scale for the measurement of aversive events. J Clin Psychol (1985) 0.93
Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. J Nutr (1994) 0.93