A natural polymorphism in beta-lactamase is a global suppressor.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMC 23137)

Published in Proc Natl Acad Sci U S A on August 05, 1997

Authors

W Huang1, T Palzkill

Author Affiliations

1: Department of Microbiology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.

Articles citing this

Exploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysis. J Biol Chem (2012) 1.93

Ceftazidime-resistant Klebsiella pneumoniae and Escherichia coli isolates producing TEM-10 and TEM-43 beta-lactamases from St. Louis, Missouri. Antimicrob Agents Chemother (1998) 1.77

A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A (2001) 1.58

TEM-72, a new extended-spectrum beta-lactamase detected in Proteus mirabilis and Morganella morganii in Italy. Antimicrob Agents Chemother (2000) 1.41

Genetic constraints on protein evolution. Crit Rev Biochem Mol Biol (2007) 1.41

Potential role of phenotypic mutations in the evolution of protein expression and stability. Proc Natl Acad Sci U S A (2009) 1.35

Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding. BMC Evol Biol (2003) 1.34

Selection of naturally occurring extended-spectrum TEM beta-lactamase variants by fluctuating beta-lactam pressure. Antimicrob Agents Chemother (2000) 1.27

Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop. J Antimicrob Chemother (2015) 1.18

Structural bases for stability-function tradeoffs in antibiotic resistance. J Mol Biol (2009) 1.16

Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases. J Mol Biol (2010) 1.14

Chemical chaperone rescue of mutant human cystathionine beta-synthase. Mol Genet Metab (2007) 1.14

Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase. J Mol Biol (2008) 1.05

Evolution of TEM-type extended-spectrum beta-lactamases in clinical Enterobacteriaceae strains in Poland. Antimicrob Agents Chemother (2005) 0.99

Deep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution. J Mol Biol (2012) 0.96

Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world. Front Microbiol (2013) 0.93

A new TEM-derived extended-spectrum beta-lactamase (TEM-91) with an R164C substitution at the omega-loop confers ceftazidime resistance. Antimicrob Agents Chemother (2003) 0.92

E240V substitution increases catalytic efficiency toward ceftazidime in a new natural TEM-type extended-spectrum beta-lactamase, TEM-149, from Enterobacter aerogenes and Serratia marcescens clinical isolates. Antimicrob Agents Chemother (2007) 0.92

Fisher's geometric model of adaptation meets the functional synthesis: data on pairwise epistasis for fitness yields insights into the shape and size of phenotype space. Evolution (2013) 0.92

An analysis of why highly similar enzymes evolve differently. Genetics (2003) 0.91

Dissecting protein structure and function using directed evolution. Nat Methods (2007) 0.91

Network Analysis of Sequence-Function Relationships and Exploration of Sequence Space of TEM β-Lactamases. Antimicrob Agents Chemother (2016) 0.91

Characterisation of blaTEM genes and types of β-lactamase plasmids in Neisseria gonorrhoeae - the prevalent and conserved blaTEM-135 has not recently evolved and existed in the Toronto plasmid from the origin. BMC Infect Dis (2014) 0.89

Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories. PLoS Comput Biol (2011) 0.89

Mutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history. Mol Biol Evol (2014) 0.89

Epistasis in protein evolution. Protein Sci (2016) 0.88

Quantitative Description of a Protein Fitness Landscape Based on Molecular Features. Mol Biol Evol (2015) 0.86

Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel (2010) 0.85

A triple mutant in the Ω-loop of TEM-1 β-lactamase changes the substrate profile via a large conformational change and an altered general base for catalysis. J Biol Chem (2015) 0.82

Mistranslation drives the evolution of robustness in TEM-1 β-lactamase. Proc Natl Acad Sci U S A (2015) 0.82

Novel TEM-type extended-spectrum beta-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother (2005) 0.81

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability. PLoS Pathog (2015) 0.80

Unexpected enzyme TEM-126: role of mutation Asp179Glu. Antimicrob Agents Chemother (2005) 0.80

Negative feedback in genetic circuits confers evolutionary resilience and capacitance. Cell Rep (2014) 0.79

Exploring the potential impact of an expanded genetic code on protein function. Proc Natl Acad Sci U S A (2015) 0.78

TEM-80, a novel inhibitor-resistant beta-lactamase in a clinical isolate of Enterobacter cloacae. Antimicrob Agents Chemother (2002) 0.78

Characterization of the Global Stabilizing Substitution A77V and Its Role in the Evolution of CTX-M β-Lactamases. Antimicrob Agents Chemother (2015) 0.76

SHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family? Mol Biol Evol (2015) 0.75

Enzyme efficiency but not thermostability drives cefotaxime resistance evolution in TEM-1 β-lactamase. Mol Biol Evol (2017) 0.75

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem. Antimicrob Agents Chemother (2016) 0.75

Removal of the Side Chain at the Active-Site Serine by a Glycine Substitution Increases the Stability of a Wide Range of Serine β-Lactamases by Relieving Steric Strain. Biochemistry (2016) 0.75

The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M β-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry (2017) 0.75

Articles cited by this

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81

Rapid and efficient site-specific mutagenesis without phenotypic selection. Methods Enzymol (1987) 66.52

The release of enzymes from Escherichia coli by osmotic shock and during the formation of spheroplasts. J Biol Chem (1965) 22.76

More extended-spectrum beta-lactamases. Antimicrob Agents Chemother (1991) 11.28

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature (1995) 10.13

Classification of beta-lactamases: groups 1, 2a, 2b, and 2b'. Antimicrob Agents Chemother (1989) 4.21

Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science (1990) 3.89

Crystal structure of Escherichia coli TEM1 beta-lactamase at 1.8 A resolution. Proteins (1993) 3.70

Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug. J Gen Virol (1996) 2.95

Molecular characterization of nine different types of mutants among 107 inhibitor-resistant TEM beta-lactamases from clinical isolates of Escherichia coli. Antimicrob Agents Chemother (1995) 2.56

The structural stability of a protein is an important determinant of its proteolytic susceptibility in Escherichia coli. J Biol Chem (1989) 2.54

Characterization of a new TEM-type beta-lactamase resistant to clavulanate, sulbactam, and tazobactam in a clinical isolate of Escherichia coli. Antimicrob Agents Chemother (1993) 2.34

Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol (1996) 2.24

Genetic analysis of staphylococcal nuclease: identification of three intragenic "global" suppressors of nuclease-minus mutations. Genetics (1985) 2.08

Evolution of antibiotic resistance: several different amino acid substitutions in an active site loop alter the substrate profile of beta-lactamase. Mol Microbiol (1994) 2.03

Direct DNA sequencing of PCR-amplified vector inserts following enzymatic degradation of primer and dNTPs. Biotechniques (1994) 1.70

Mutator mutations in Escherichia coli induced by the insertion of phage mu and the transposable resistance elements Tn5 and Tn10. Mutat Res (1982) 1.61

Selection and neutrality in lactose operons of Escherichia coli. Genetics (1989) 1.55

The epidemiology of beta-lactamases. J Antimicrob Chemother (1989) 1.47

Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins (1992) 1.31

Implication of Ile-69 and Thr-182 residues in kinetic characteristics of IRT-3 (TEM-32) beta-lactamase. Antimicrob Agents Chemother (1996) 1.30

Phage lambda repressor revertants. Amino acid substitutions that restore activity to mutant proteins. J Mol Biol (1985) 1.12

Guanidine hydrochloride denaturation studies of mutant forms of staphylococcal nuclease. J Cell Biochem (1986) 0.95

Recovery of active beta-lactamases from Proteus vulgaris and RTEM-1 hybrid by random mutagenesis by using a dnaQ strain of Escherichia coli. Antimicrob Agents Chemother (1996) 0.84

Beta-lactamase inhibitors: another approach to overcoming antimicrobial resistance. Infect Control (1987) 0.83

Articles by these authors

Outbreak of ceftazidime resistance due to a novel extended-spectrum beta-lactamase in isolates from cancer patients. Antimicrob Agents Chemother (1992) 3.31

Amino acid sequence determinants of beta-lactamase structure and activity. J Mol Biol (1996) 2.24

Characterization of TEM-1 beta-lactamase mutants from positions 238 to 241 with increased catalytic efficiency for ceftazidime. J Biol Chem (1994) 1.72

Systematic mutagenesis of the active site omega loop of TEM-1 beta-lactamase. J Bacteriol (1996) 1.65

Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime. J Biol Chem (1996) 1.63

A secondary drug resistance mutation of TEM-1 beta-lactamase that suppresses misfolding and aggregation. Proc Natl Acad Sci U S A (2001) 1.58

beta-Lactamases: protein evolution in real time. Trends Microbiol (1998) 1.44

Cephalosporin substrate specificity determinants of TEM-1 beta-lactamase. J Biol Chem (1997) 1.25

Identification of residues critical for metallo-beta-lactamase function by codon randomization and selection. Protein Sci (2001) 1.23

Contributions of aspartate 49 and phenylalanine 142 residues of a tight binding inhibitory protein of beta-lactamases. J Biol Chem (1999) 1.20

Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics. J Infect Dis (2000) 1.17

Effect of threonine-to-methionine substitution at position 265 on structure and function of TEM-1 beta-lactamase. Antimicrob Agents Chemother (1994) 1.16

Systematic mutagenesis of the yeast mating pheromone receptor third intracellular loop. J Biol Chem (1994) 1.11

The role of residue 238 of TEM-1 beta-lactamase in the hydrolysis of extended-spectrum antibiotics. J Biol Chem (1998) 1.08

The rate-limiting step in the folding of the cis-Pro167Thr mutant of TEM-1 beta-lactamase is the trans to cis isomerization of a non-proline peptide bond. Proteins (1996) 0.97

Design of potent beta-lactamase inhibitors by phage display of beta-lactamase inhibitory protein. J Biol Chem (2000) 0.93

Roles of amino acids 161 to 179 in the PSE-4 omega loop in substrate specificity and in resistance to ceftazidime. Antimicrob Agents Chemother (1998) 0.92

Amino acid sequence determinants of extended spectrum cephalosporin hydrolysis by the class C P99 beta-lactamase. J Biol Chem (2001) 0.92

Identification of residues in beta-lactamase critical for binding beta-lactamase inhibitory protein. J Biol Chem (1999) 0.89

Binding properties of a peptide derived from beta-lactamase inhibitory protein. Antimicrob Agents Chemother (2001) 0.85

Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display. Protein Eng Des Sel (2010) 0.85

Structure-function analysis of alpha-helix H4 using PSE-4 as a model enzyme representative of class A beta-lactamases. Protein Eng (2000) 0.84

Alanine-scanning mutagenesis reveals residues involved in binding of pap-3-encoded pili. J Bacteriol (1994) 0.84

Use of the arabinose p(bad) promoter for tightly regulated display of proteins on bacteriophage. Gene (2000) 0.81

Characterization of a PSE-4 mutant with different properties in relation to penicillanic acid sulfones: importance of residues 216 to 218 in class A beta-lactamases. Antimicrob Agents Chemother (1998) 0.81

Enzymes involved in oxygen detoxification during development of Drosophila melanogaster. Experientia (1983) 0.81

Protein minimization by random fragmentation and selection. Protein Eng (2001) 0.78

Susceptibility of beta-lactamase to core amino acid substitutions. Protein Eng (1999) 0.77

Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage. Antimicrob Agents Chemother (1998) 0.76