Published in Nucleic Acids Res on August 15, 1997
Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside. Nucleic Acids Res (2003) 0.82
Direct chemical method for sequencing RNA. Proc Natl Acad Sci U S A (1979) 25.15
Efficient methods for attaching non-radioactive labels to the 5' ends of synthetic oligodeoxyribonucleotides. Nucleic Acids Res (1986) 4.12
Organization of restriction-modification systems. Nucleic Acids Res (1991) 3.12
Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site. Proc Natl Acad Sci U S A (1987) 3.00
Structure and function of restriction endonucleases. Curr Opin Struct Biol (1995) 2.07
A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA. Nature (1988) 1.70
The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding. Nucleic Acids Res (1993) 1.20
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability. Nucleic Acids Res (1992) 1.16
Cross-linking of bromodeoxyuridine-substituted oligonucleotides to the EcoRI and EcoRV restriction endonucleases. Eur J Biochem (1986) 1.16
Oligodeoxynucleotides containing 4-thiothymidine and 6-thiodeoxyguanosine as affinity labels for the Eco RV restriction endonuclease and modification methylase. Nucleic Acids Res (1992) 1.14
DNA modification by methyltransferases. Curr Opin Struct Biol (1995) 1.04
A new affinity reagent for the site-specific, covalent attachment of DNA to active-site nucleophiles: application to the EcoRI and RsrI restriction and modification enzymes. Nucleic Acids Res (1992) 1.00
Interactions between the mitochondrial adenosinetriphosphatase and periodate-oxidized adenosine 5'-triphosphate, an affinity label for adenosine 5'-triphosphate binding sites. Biochemistry (1982) 0.98
Peculiarities of recognition of CCA/TGG sequences in DNA by restriction endonucleases MvaI and EcoRII. J Mol Recognit (1992) 0.95
[Differing molecular structures of EcoRII and Eco MRE600 dcmII DNA methylases]. Dokl Akad Nauk SSSR (1981) 0.91
Cross-linking of SsoII restriction endonuclease to cognate and non-cognate DNAs. FEBS Lett (1996) 0.90
[Synthesis and properties of DNA-duplexes, containing 9-(1'-hydroxy-2'-(hydroxymethyl)ethoxy)methylguanine]. Bioorg Khim (1991) 0.83
Affinity labeling of nicotinamide adenine dinucleotide dependent isocitrate dehydrogenase by the 2',3'-dialdehyde derivative of adenosine 5'-diphosphate. Evidence for the formation of an unusual reaction product. Biochemistry (1983) 0.83
Chemical cross-linking of MvaI and EcoRII enzymes to DNA duplexes containing monosubstituted pyrophosphate internucleotide bond. Gene (1995) 0.80
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds. J Virol Methods (1988) 7.74
Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro. Antimicrob Agents Chemother (1987) 2.24
Sensitive and rapid assay on MT-4 cells for detection of antiviral compounds against the AIDS virus. J Virol Methods (1987) 2.10
Differential patterns of intracellular metabolism of 2',3'-didehydro-2',3'-dideoxythymidine and 3'-azido-2',3'-dideoxythymidine, two potent anti-human immunodeficiency virus compounds. J Biol Chem (1989) 1.89
Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands. J Med Chem (2000) 1.85
Molecular dipstick test for diagnosis of sleeping sickness. J Clin Microbiol (2006) 1.84
Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent. Proc Natl Acad Sci U S A (1989) 1.74
Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound. Proc Natl Acad Sci U S A (1991) 1.67
Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro. Biochem Biophys Res Commun (1987) 1.67
Modifications in lignin and accumulation of phenolic glucosides in poplar xylem upon down-regulation of caffeoyl-coenzyme A O-methyltransferase, an enzyme involved in lignin biosynthesis. J Biol Chem (2000) 1.58
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. J Med Chem (1987) 1.53
The in vitro and in vivo anti-retrovirus activity, and intracellular metabolism of 3'-azido-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly dependent on the cell species. Biochem Pharmacol (1988) 1.45
Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. VI. The binding and cleavage of substrates containing nucleotide analogs. Nucleic Acids Res (1985) 1.40
Anti-retrovirus activity of 3'-fluoro- and 3'-azido-substituted pyrimidine 2',3'-dideoxynucleoside analogues. Biochem Pharmacol (1988) 1.37
Selective inhibition of human immunodeficiency virus (HIV) by 3'-azido-2', 3'-dideoxyguanosine in vitro. Biochem Biophys Res Commun (1987) 1.27
RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA). Nucleic Acids Res (2001) 1.25
Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists. J Med Chem (1999) 1.25
The anti-HTLV-III (anti-HIV) and cytotoxic activity of 2',3'-didehydro-2',3'-dideoxyribonucleosides: a comparison with their parental 2',3'-dideoxyribonucleosides. Mol Pharmacol (1987) 1.21
The cysteine conserved among DNA cytosine methylases is required for methyl transfer, but not for specific DNA binding. Nucleic Acids Res (1993) 1.20
Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine. Biochem Biophys Res Commun (1986) 1.19
Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability. Nucleic Acids Res (1992) 1.16
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties. Biochemistry (1997) 1.13
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. J Med Chem (1988) 1.12
Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands. Proteins (1998) 1.11
Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain. J Med Chem (1992) 1.10
Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem (1994) 1.10
9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo. Proc Natl Acad Sci U S A (1991) 1.09
Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides. Nucleic Acids Res (1993) 1.06
Influence of the incorporation of (S)-9-(3,4-dihydroxybutyl)adenine on the enzymatic stability and base-pairing properties of oligodeoxynucleotides. Nucleic Acids Res (1991) 1.05
Eicar (5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide). A novel potent inhibitor of inosinate dehydrogenase activity and guanylate biosynthesis. J Biol Chem (1993) 1.04
DNA-like duplexes with repetitions. I. Properties of concatemer duplexes formed by d(T-G-C-A-C-A-T-G). Nucleic Acids Res (1980) 1.03
Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. FEBS Lett (1996) 1.01
Synthesis and antiviral activity of (E)-5-(2-bromovinyl)uracil and (E)-5-(2-bromovinyl)uridine. J Med Chem (1986) 1.01
The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro. Biochem Biophys Res Commun (1987) 1.00
Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus. J Biol Chem (1991) 0.99
Incorporation of 2'-amido-nucleosides in oligodeoxynucleotides and oligoribonucleotides as a model for 2'-linked conjugates. Nucleic Acids Res (1995) 0.99
Base pairing of anhydrohexitol nucleosides with 2,6-diaminopurine, 5-methylcytosine and uracil asbase moiety. Nucleic Acids Res (1999) 0.98
Enzymatic incorporation in DNA of 1,5-anhydrohexitol nucleotides. Biochemistry (2000) 0.98
Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. EcoRII endonuclease cleavage of substrates with repeated natural and modified recognition sites. FEBS Lett (1984) 0.98
Antisense PNA tridecamers targeted to the coding region of Ha-ras mRNA arrest polypeptide chain elongation. J Mol Biol (1999) 0.97
Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo. Nucleic Acids Res (1984) 0.96
Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure. J Am Chem Soc (1999) 0.94
Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice. Cancer Res (1986) 0.94
(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity. Nucleosides Nucleotides Nucleic Acids (2001) 0.94
Differential inhibitory effects of several pyrimidine 2',3'-dideoxynucleoside 5'-triphosphates on the activities of reverse transcriptase and various cellular DNA polymerases. Mol Pharmacol (1989) 0.92
An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside. Nucleic Acids Res (1995) 0.92
Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. J Med Chem (1995) 0.91
Cross-linking of SsoII restriction endonuclease to cognate and non-cognate DNAs. FEBS Lett (1996) 0.90
Cloning and sequences of the genes encoding the CfrBI restriction-modification system from Citrobacter freundii. Gene (1993) 0.90
Solution structure of a HNA-RNA hybrid. Chem Biol (2000) 0.90
Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides. Nucleic Acids Res (2001) 0.90
Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1. J Med Chem (1996) 0.89
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication. J Med Chem (1991) 0.89
The Ecl18kI restriction-modification system: cloning, expression, properties of the purified enzymes. FEBS Lett (1998) 0.89
Investigations on the anti-HIV activity of 2',3'-dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HIV activity of 2,6-diaminopurine 2',3'-dideoxyriboside. Biochem Pharmacol (1988) 0.89
Polyethylenimine but not cationic lipid improves antisense activity of 3'-capped phosphodiester oligonucleotides. Antisense Nucleic Acid Drug Dev (1999) 0.88
[Characteristics of a plasmid bearing a gene of a restriction modification type II system--the SsoII isoschizomer]. Mol Biol (Mosk) (1998) 0.87
Processive cleavage of concatemer DNA duplexes by Eco RII restriction endonuclease. Mol Biol Rep (1985) 0.87
Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. V. Study of single-strand cleavages. Nucleic Acids Res (1985) 0.87
Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30. Eur J Biochem (1997) 0.86
Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides. Chemistry (2000) 0.86
Resolution of aristeromycin enantiomers. J Med Chem (1985) 0.86
RNA as a target for drug design, the example of Tat-TAR interaction. Curr Top Med Chem (2002) 0.86
Antimalarial antisense activity of hexitol nucleic acids. Parasitol Res (1999) 0.85
The role of modifications in oligonucleotides in sequence recognition by MvaI restriction endonuclease. Eur J Biochem (1988) 0.85
Modified substrates as probes for studying uracil-DNA glycosylase. Gene (1995) 0.85
Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA. Biochem Pharmacol (2000) 0.85
[Restriction endonuclease SsoII: interaction with modified substrates]. Dokl Akad Nauk SSSR (1987) 0.84
Selective inhibition of arthropod-borne and arenaviruses in vitro by 3'-fluoro-3'-deoxyadenosine. Antiviral Res (1992) 0.84
[Type IIE and IIF restriction endonucleases interacting with two recognition sites in DNA]. Mol Biol (Mosk) (2004) 0.83
The interaction of DNA duplexes containing 2-aminopurine with restriction endonucleases EcoRII and SsoII. Nucleic Acids Res (1995) 0.83
3'-Fluoro-2',3'-dideoxy-5-chlorouridine: most selective anti-HIV-1 agent among a series of new 2'- and 3'-fluorinated 2',3'-dideoxynucleoside analogues. J Med Chem (1989) 0.83
Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine. Antiviral Res (1989) 0.83
[Interaction of EcoRII restriction and modification enzyme with synthetic DNA fragments. IV. DNA duplexes with phosphoamide and pyrophosphate internucleotide bonds--the substrates for the study of single-strand breaks]. Mol Biol (Mosk) (1986) 0.83
[Synthesis and properties of DNA-duplexes, containing 9-(1'-hydroxy-2'-(hydroxymethyl)ethoxy)methylguanine]. Bioorg Khim (1991) 0.83
[The secondary structure of nucleotidyl-(5' bound to N)-amino acids containing different heterocyclic bases and amino acids]. Mol Biol (Mosk) (1976) 0.82
The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. J Med Chem (2000) 0.82
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. Bioorg Med Chem Lett (1999) 0.82
Nucleic acid related compounds. 57. Synthesis, x-ray crystal structure, lipophilic partition properties, and antiretroviral activities of anomeric 3'-azido-2',3'-dideoxy-2,6-diaminopurine ribosides. J Med Chem (1989) 0.82
Catalytic activity and stability of hammerhead ribozymes containing 2'-acetamido-2'-deoxyribonucleosides. Biochem Biophys Res Commun (1995) 0.81
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides. J Med Chem (1993) 0.81
Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids. Nucleic Acids Res (2007) 0.81
Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues. J Med Chem (1993) 0.81
Thermodynamic characterization of the partially unfolded state of Ca(2+)-loaded bovine alpha-lactalbumin: evidence that partial unfolding can precede Ca2+ release. Biochemistry (1996) 0.81
Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines. J Med Chem (1990) 0.81