DNA mismatch repair gene mutations in human cancer.

Genetic susceptibility to non-polyposis colorectal cancer. J Med Genet (1999) 4.16

Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary. World J Gastroenterol (2008) 0.87

12th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals: susceptibility to environmental hazards. Environ Health Perspect (1997) 0.84

Assay validation for identification of hereditary nonpolyposis colon cancer-causing mutations in mismatch repair genes MLH1, MSH2, and MSH6. J Mol Diagn (2005) 0.82

Missense mutations in MLH1, MSH2, KRAS, and APC genes in colorectal cancer patients in Malaysia. Dig Dis Sci (2012) 0.79

Immunohistochemical analysis of expression and allelotype of mismatch repair genes (hMLH1 and hMSH2) in bladder cancer. Br J Cancer (2001) 0.77

Rheumatoid Arthritis as a Therapeutic Challenge in a Patient with Lynch Syndrome. Am J Case Rep (2015) 0.75

Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet (1989) 62.23

Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52

Microsatellite instability in cancer of the proximal colon. Science (1993) 14.51

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell (1993) 13.54

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (1993) 12.74

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (1993) 10.95

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell (1993) 9.93

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (1994) 8.04

Mechanisms and biological effects of mismatch repair. Annu Rev Genet (1991) 7.86

Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (1994) 6.21

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet (1996) 6.06

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer. Cell (1995) 5.54

Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res (1993) 4.93

Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells. Science (1995) 4.48

Genetic mapping of a locus predisposing to human colorectal cancer. Science (1993) 4.12

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet (1995) 4.01

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology (1993) 3.76

Mismatch repair deficiency in phenotypically normal human cells. Science (1995) 3.55

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. Nucleic Acids Res (1987) 3.52

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells. Science (1995) 3.34

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell (1995) 3.34

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients. Cancer Res (1994) 3.25

Mutations of GTBP in genetically unstable cells. Science (1995) 3.23

MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast. Science (1994) 3.19

Heteroduplex repair in extracts of human HeLa cells. J Biol Chem (1991) 3.13

Mutator phenotypes in human colorectal carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 3.10

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation. Nat Genet (1994) 2.95

Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res (1994) 2.89

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability. J Biol Chem (1994) 2.82

A simple p53 functional assay for screening cell lines, blood, and tumors. Proc Natl Acad Sci U S A (1995) 2.70

Mechanisms of DNA excision repair. Science (1994) 2.69

Mismatch repair, genetic stability, and cancer. Science (1994) 2.65

ERCC2: cDNA cloning and molecular characterization of a human nucleotide excision repair gene with high homology to yeast RAD3. EMBO J (1990) 2.53

MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet (1995) 2.49

Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res (1993) 2.48

Instability of short tandem repeats (microsatellites) in human cancers. Nat Genet (1994) 2.45

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1995) 2.29

Genetic instability of microsatellites in endometrial carcinoma. Cancer Res (1993) 2.20

DNA loop repair by human cell extracts. Science (1994) 2.19

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer. Nat Genet (1994) 2.08

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res (1993) 2.06

Microsatellite instability in colorectal cancer: improved assessment using fluorescent polymerase chain reaction. Gastroenterology (1995) 1.92

A transforming growth factor beta receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res (1995) 1.86

Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene. J Biol Chem (1989) 1.83

Microsatellite alterations as clonal markers for the detection of human cancer. Proc Natl Acad Sci U S A (1994) 1.81

How many mutations are required for tumorigenesis? Implications from human cancer data. Mol Carcinog (1993) 1.73

Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia. Blood (1994) 1.72

Monoallelic mutation analysis (MAMA) for identifying germline mutations. Nat Genet (1995) 1.68

DNA mismatch repair gene mutations in 55 kindreds with verified or putative hereditary non-polyposis colorectal cancer. Hum Mol Genet (1996) 1.64

Genomic organization of the human PMS2 gene family. Genomics (1995) 1.50

Microsatellite instability occurs frequently and in both diploid and aneuploid cell populations of Barrett's-associated esophageal adenocarcinomas. Cancer Res (1994) 1.49

Frequent microsatellite instability in primary small cell lung cancer. Cancer Res (1994) 1.44

Binding of mismatched microsatellite DNA sequences by the human MSH2 protein. Science (1994) 1.41

Microsatellite instability and loss of heterozygosity in breast cancer. Cancer Res (1994) 1.38

Genetics of hereditary colon cancer. Annu Rev Genet (1995) 1.36

Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis. Am J Hum Genet (1995) 1.30

Microsatellite instability in bladder cancer. Cancer Res (1993) 1.29

Microsatellite instability and other molecular abnormalities in non-small cell lung cancer. Cancer Res (1995) 1.22

Microsatellite instability occurs frequently in human gastric carcinoma. Oncogene (1994) 1.21

In vitro transcription/translation assay for the screening of hMLH1 and hMSH2 mutations in familial colon cancer. Gastroenterology (1995) 1.21

Microsatellite instability in sporadic endometrial carcinoma. J Natl Cancer Inst (1994) 1.20

Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes. Biochem Biophys Res Commun (1994) 1.11

Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res (1994) 1.09

Mismatch repair, somatic mutations, and the origins of cancer. Cancer Res (1995) 1.07

Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients. Hum Mol Genet (1994) 1.02

Chromosome 9 allelic losses and microsatellite alterations in human bladder tumors. Cancer Res (1994) 0.96

Sporadic gastric carcinomas with microsatellite instability display a particular clinicopathologic profile. Int J Cancer (1995) 0.96

A hereditary genetic marker closely associated with microsatellite instability in lung cancer. Cancer Res (1995) 0.89

High frequency of mutator phenotype in human prostatic adenocarcinoma. Oncogene (1994) 0.89

Replication error-type genetic instability at 1q42-43 in human male germ cell tumors. Cancer Res (1994) 0.85

Genomic instability of microsatellite repeats and mutations of H-, K-, and N-ras, and p53 genes in renal cell carcinoma. Cancer Res (1994) 0.85

Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes. Nucleic Acids Res (1994) 0.84

Instability of microsatellites in rat colon tumors induced by heterocyclic amines. Cancer Res (1994) 0.83

Genetic consequences of tolerance to methylation DNA damage in mammalian cells. Carcinogenesis (1993) 0.80