Published in J Cereb Blood Flow Metab on August 01, 1997
Bidirectional control of CNS capillary diameter by pericytes. Nature (2006) 5.27
Capillary pericytes regulate cerebral blood flow in health and disease. Nature (2014) 2.82
Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex (2008) 1.76
Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery. Ther Deliv (2011) 1.57
Norepinephrine: a neuromodulator that boosts the function of multiple cell types to optimize CNS performance. Neurochem Res (2012) 1.38
The effects of hypertension on the cerebral circulation. Am J Physiol Heart Circ Physiol (2013) 1.25
Recent advances in blood-brain barrier disruption as a CNS delivery strategy. AAPS J (2008) 1.24
A guide to delineate the logic of neurovascular signaling in the brain. Front Neuroenergetics (2011) 1.20
How do astrocytes participate in neural plasticity? Cold Spring Harb Perspect Biol (2014) 1.17
Regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology (2008) 1.12
Control of brain capillary blood flow. J Cereb Blood Flow Metab (2012) 1.12
The locus coeruleus-norepinephrine network optimizes coupling of cerebral blood volume with oxygen demand. J Cereb Blood Flow Metab (2012) 1.03
Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr Pharm Des (2012) 1.03
Monocyte chemoattractant protein-1 and the blood-brain barrier. Cell Mol Life Sci (2013) 1.02
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev (2015) 0.99
Role of the blood-brain barrier in the formation of brain metastases. Int J Mol Sci (2013) 0.96
Imaging pericytes and capillary diameter in brain slices and isolated retinae. Nat Protoc (2014) 0.95
Effects of the α₂-adrenergic receptor agonist dexmedetomidine on neural, vascular and BOLD fMRI responses in the somatosensory cortex. Eur J Neurosci (2012) 0.93
"You Shall Not Pass"-tight junctions of the blood brain barrier. Front Neurosci (2014) 0.92
Binaural blood flow control by astrocytes: listening to synapses and the vasculature. J Physiol (2016) 0.91
G protein-coupled receptors as therapeutic targets for multiple sclerosis. Cell Res (2012) 0.90
Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells. J Physiol (2003) 0.89
Uptake of inorganic mercury by human locus ceruleus and corticomotor neurons: implications for amyotrophic lateral sclerosis. Acta Neuropathol Commun (2013) 0.88
Transporters at CNS barrier sites: obstacles or opportunities for drug delivery? Curr Pharm Des (2014) 0.88
The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project. BMC Med Genet (2010) 0.88
Striatal vessels receive phosphorylated tyrosine hydroxylase-rich innervation from midbrain dopaminergic neurons. Front Neuroanat (2014) 0.86
Brain-Computer Interface-Based Communication in the Completely Locked-In State. PLoS Biol (2017) 0.86
Cell-culture models of the blood-brain barrier. Stroke (2014) 0.85
Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab (2014) 0.85
Volume transmission signalling via astrocytes. Philos Trans R Soc Lond B Biol Sci (2014) 0.84
Heavy metals in locus ceruleus and motor neurons in motor neuron disease. Acta Neuropathol Commun (2013) 0.81
Regulation of myogenic tone and structure of parenchymal arterioles by hypertension and the mineralocorticoid receptor. Am J Physiol Heart Circ Physiol (2015) 0.80
Age-associated physiological and pathological changes at the blood-brain barrier: A review. J Cereb Blood Flow Metab (2016) 0.80
Blood-brain barrier regulation: Environmental cues controlling the onset of barrier properties. Tissue Barriers (2013) 0.79
Vascular biology: Brain vessels squeezed to death. Nature (2014) 0.78
Amphetamine- and methamphetamine-induced hyperthermia: Implications of the effects produced in brain vasculature and peripheral organs to forebrain neurotoxicity. Temperature (Austin) (2014) 0.78
Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity. Curr Vasc Pharmacol (2013) 0.77
Monoaminergic Control of Cellular Glucose Utilization by Glycogenolysis in Neocortex and Hippocampus. Neurochem Res (2015) 0.77
Central α-adrenoceptors contribute to mustard oil-induced central sensitization in the rat medullary dorsal horn. Neuroscience (2013) 0.76
Functional impact of glycogen degradation on astrocytic signalling. Biochem Soc Trans (2014) 0.76
Distinct functional states of astrocytes during sleep and wakefulness: Is norepinephrine the master regulator? Curr Sleep Med Rep (2015) 0.76
Is there a persistent dysfunction of neurovascular coupling in migraine? Biomed Res Int (2015) 0.75
Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice. PLoS One (2016) 0.75
Stress does not increase blood-brain barrier permeability in mice. J Cereb Blood Flow Metab (2016) 0.75
Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience. Philos Trans R Soc Lond B Biol Sci (2016) 0.75
Vascular Dynamics Aid a Coupled Neurovascular Network Learn Sparse Independent Features: A Computational Model. Front Neural Circuits (2016) 0.75
Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states. Philos Trans R Soc Lond B Biol Sci (2016) 0.75
Requirement of an Escherichia coli 50 S ribosomal protein component for effective interaction of the ribosome with T and G factors and with guanosine triphosphate. J Biol Chem (1972) 14.68
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4. Experientia (1989) 2.90
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. Mol Pharmacol (1998) 2.81
Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem (1997) 2.41
Synthesis of epothilones A and B in solid and solution phase. Nature (1997) 2.35
Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry (1989) 2.34
Indanocine, a microtubule-binding indanone and a selective inducer of apoptosis in multidrug-resistant cancer cells. J Natl Cancer Inst (2000) 2.33
Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. Biochemistry (1984) 2.04
Antineoplastic agents. 291. Isolation and synthesis of combretastatins A-4, A-5, and A-6(1a) J Med Chem (1995) 1.98
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem (1991) 1.97
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer Res (1997) 1.97
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J Med Chem (1991) 1.84
Antitumor agents. 181. Synthesis and biological evaluation of 6,7,2',3',4'-substituted-1,2,3,4-tetrahydro-2-phenyl-4-quinolones as a new class of antimitotic antitumor agents. J Med Chem (1998) 1.71
Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum. J Nat Prod (1987) 1.64
Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study. Mol Pharmacol (1988) 1.54
Discodermolide, a cytotoxic marine agent that stabilizes microtubules more potently than taxol. Biochemistry (1996) 1.52
Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data. Cancer Res (1992) 1.49
Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones. Bioorg Med Chem Lett (2001) 1.48
Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. J Biol Chem (1990) 1.47
2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site. Proc Natl Acad Sci U S A (1994) 1.43
6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem (2000) 1.37
Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain. Biochem Pharmacol (1990) 1.34
Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. J Med Chem (1992) 1.32
Serotonin in the regulation of brain microcirculation. Prog Neurobiol (1996) 1.30
Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat. Neurosci Lett (1985) 1.29
The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain. Biochemistry (1995) 1.29
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin. Mol Pharmacol (1993) 1.28
The neurovascular unit in brain function and disease. Acta Physiol (Oxf) (2011) 1.27
Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin. J Med Chem (1993) 1.25
Glutamate-induced polymerization of tubulin: characteristics of the reaction and application to the large-scale purification of tubulin. Arch Biochem Biophys (1981) 1.25
Antineoplastic agents. 379. Synthesis of phenstatin phosphate. J Med Chem (1998) 1.23
Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cereb Cortex (2002) 1.19
Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain. Cephalalgia (2004) 1.16
Antitumor agents. 150. 2',3',4',5',5,6,7-substituted 2-phenyl-4-quinolones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem (1994) 1.11
GABA neurons provide a rich input to microvessels but not nitric oxide neurons in the rat cerebral cortex: a means for direct regulation of local cerebral blood flow. J Comp Neurol (2000) 1.09
Identification of cysteine 354 of beta-tubulin as part of the binding site for the A ring of colchicine. J Biol Chem (1996) 1.08
BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y(2) receptor antagonist. Br J Pharmacol (2000) 1.08
Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. Mol Pharmacol (1996) 1.07
Antineoplastic agents 365. Dolastatin 10 SAR probes. Anticancer Drug Des (1998) 1.04
Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease. Neuroscience (1999) 1.04
Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain. Proc Natl Acad Sci U S A (1986) 1.04
Stabilization of the colchicine-binding activity of tubulin by organic acids. Biochim Biophys Acta (1981) 1.04
Functional acetylcholine muscarinic receptor subtypes in human brain microcirculation: identification and cellular localization. J Cereb Blood Flow Metab (1999) 1.04
Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. Phytochemistry (1998) 1.04
Antitumor agents. 155. Synthesis and biological evaluation of 3',6,7-substituted 2-phenyl-4-quinolones as antimicrotubule agents. J Med Chem (1994) 1.04
Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin. Mol Pharmacol (2001) 1.03
Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1. Biochemistry (1999) 1.01
Sumatriptan normalizes the migraine attack-related increase in brain serotonin synthesis. Neurology (2008) 1.01
Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules. Biochem Pharmacol (1992) 1.01
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis. J Med Chem (2000) 1.01
Intracranial intradural epidermoids and dermoids. Surgical results of 38 cases. Neurosurg Rev (1980) 1.01
Mapping the binding site of colchicinoids on beta -tubulin. 2-Chloroacetyl-2-demethylthiocolchicine covalently reacts predominantly with cysteine 239 and secondarily with cysteine 354. J Biol Chem (2000) 1.01
Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography. Biochemistry (1989) 0.99
A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents. Org Lett (2001) 0.99
Muscarinic--but not nicotinic--acetylcholine receptors mediate a nitric oxide-dependent dilation in brain cortical arterioles: a possible role for the M5 receptor subtype. J Cereb Blood Flow Metab (2000) 0.98
Role of guanine nucleotides in protein synthesis. Elongation factor G and guanosine 5'-triphosphate,3'-diphosphate. Proc Natl Acad Sci U S A (1973) 0.98
A new anti-tubulin agent containing the benzo[b]thiophene ring system. Bioorg Med Chem Lett (1999) 0.98
Electron microscopic autoradiographic localization of opioid receptors in rat neostriatum. Nature (1984) 0.98
Effects of inhibitors of tubulin polymerization on GTP hydrolysis. J Biol Chem (1981) 0.97
Synthesis and biological evaluation of 2-styrylquinazolin-4(3H)-ones, a new class of antimitotic anticancer agents which inhibit tubulin polymerization. J Med Chem (1990) 0.97
Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin. Bioorg Med Chem (2000) 0.97
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4. Bioorg Med Chem Lett (2001) 0.96
Characterization of the interaction of the marine cyanobacterial natural product curacin A with the colchicine site of tubulin and initial structure-activity studies with analogues. Mol Pharmacol (1995) 0.96
Interactions of taxol, microtubule-associated proteins, and guanine nucleotides in tubulin polymerization. J Biol Chem (1981) 0.96
Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization. J Cereb Blood Flow Metab (1999) 0.96
A steroid derivative with paclitaxel-like effects on tubulin polymerization. Mol Pharmacol (2000) 0.96
Guanosine 5'-O-(3-thiotriphosphate), a potent nucleotide inhibitor of microtubule assembly. J Biol Chem (1984) 0.95
Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent. Cancer Res (1997) 0.95
Antineoplastic agents 337. Synthesis of dolastatin 10 structural modifications. Anticancer Drug Des (1995) 0.95
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina spp. sponges. Bioorg Med Chem (1999) 0.95
Characterization of the interaction of cryptophycin 1 with tubulin: binding in the Vinca domain, competitive inhibition of dolastatin 10 binding, and an unusual aggregation reaction. Cancer Res (1996) 0.95
Antitumor agents. 178. Synthesis and biological evaluation of substituted 2-aryl-1,8-naphthyridin-4(1H)-ones as antitumor agents that inhibit tubulin polymerization. J Med Chem (1997) 0.94
Structure-activity requirements for flavone cytotoxicity and binding to tubulin. J Med Chem (1998) 0.94
Antitumor agents. 196. Substituted 2-thienyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem (1999) 0.94
Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization. J Med Chem (1997) 0.93
Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity. Mol Pharmacol (2000) 0.93
Characterization of neuropeptide Y (NPY) receptors in human cerebral arteries with selective agonists and the new Y1 antagonist BIBP 3226. Br J Pharmacol (1995) 0.93
N-acetylcolchinol O-methyl ether and thiocolchicine, potent analogs of colchicine modified in the C ring. Evaluation of the mechanistic basis for their enhanced biological properties. J Biol Chem (1990) 0.92
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. J Med Chem (2000) 0.92
Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug. Anticancer Drug Des (1998) 0.91
Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease. Neuroscience (2005) 0.91
Efficacy of the non-peptide CGRP receptor antagonist BIBN4096BS in blocking CGRP-induced dilations in human and bovine cerebral arteries: potential implications in acute migraine treatment. Neuropharmacology (2002) 0.90
Derivatives of 5,6-diphenylpyridazin-3-one: synthetic antimitotic agents which interact with plant and mammalian tubulin at a new drug-binding site. Cancer Res (1986) 0.90
Effect of oral morphine and naloxone on pituitary-adrenal response in man induced by human corticotropin-releasing hormone. Acta Endocrinol (Copenh) (1987) 0.90
Direct incorporation of guanosine 5'-diphosphate into microtubules without guanosine 5'-triphosphate hydrolysis. Biochemistry (1986) 0.89
Effects of organic acids on tubulin polymerization and associated guanosine 5'-triphosphate hydrolysis. Biochemistry (1982) 0.89
Interaction of dolastatin 10 with tubulin: induction of aggregation and binding and dissociation reactions. Mol Pharmacol (1995) 0.88
The magnesium-GTP interaction in microtubule assembly. Eur J Biochem (1994) 0.88
Muscarinic receptor subtype mediating vasodilation feline middle cerebral artery exhibits M3 pharmacology. Eur J Pharmacol (1990) 0.88
Effect of methanol on the partial reactions of polypeptide chain elongation. Biochemistry (1972) 0.88
Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization. J Med Chem (1999) 0.87
Studies on the role of an Escherichia coli 50 S ribosomal component in polypeptide chain elongation. J Biol Chem (1972) 0.87
The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer. Br J Cancer (2009) 0.87
Antitumor agents, 154. Cytotoxic and antimitotic flavonols from Polanisia dodecandra. J Nat Prod (1995) 0.87
No contractile effect for 5-HT1D and 5-HT1F receptor agonists in human and bovine cerebral arteries: similarity with human coronary artery. Br J Pharmacol (2000) 0.87
Some metabolic and hormonal effects of salbutamol in man. Acta Diabetol Lat (1977) 0.87