Published in EMBO J on October 15, 1997
Nine hydrophobic side chains are key determinants of the thermodynamic stability and oligomerization status of tumour suppressor p53 tetramerization domain. EMBO J (1998) 1.39
Structural evolution of C-terminal domains in the p53 family. EMBO J (2007) 1.32
Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions. Protein Sci (1999) 0.95
Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils. Protein Sci (2005) 0.86
NAD+ modulates p53 DNA binding specificity and function. Mol Cell Biol (2004) 0.85
Soft-shell clam (Mya arenaria) p53: a structural and functional comparison to human p53. Gene (2008) 0.82
DisPredict: A Predictor of Disordered Protein Using Optimized RBF Kernel. PLoS One (2015) 0.77
Utilizing NMR to study the structure of growth-inhibitory proteins. Methods Mol Biol (2003) 0.75
One-Dimensional Search Dynamics of Tumor Suppressor p53 Regulated by a Disordered C-Terminal Domain. Biophys J (2017) 0.75
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01
Some factors in the interpretation of protein denaturation. Adv Protein Chem (1959) 24.89
Principles that govern the folding of protein chains. Science (1973) 23.40
Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr D Biol Crystallogr (1994) 17.44
A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science (1993) 10.16
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
Theory for the folding and stability of globular proteins. Biochemistry (1985) 5.92
3D domain swapping: a mechanism for oligomer assembly. Protein Sci (1995) 4.96
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature (1990) 4.87
Deciphering the message in protein sequences: tolerance to amino acid substitutions. Science (1990) 3.89
Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms. Science (1995) 3.69
Mutations in lambda repressor's amino-terminal domain: implications for protein stability and DNA binding. Proc Natl Acad Sci U S A (1983) 3.67
Sequence-specific transcriptional activation is essential for growth suppression by p53. Proc Natl Acad Sci U S A (1994) 3.36
Combinatorial cassette mutagenesis as a probe of the informational content of protein sequences. Science (1988) 3.13
High-resolution structure of the oligomerization domain of p53 by multidimensional NMR. Science (1994) 2.98
Alternative packing arrangements in the hydrophobic core of lambda repressor. Nature (1989) 2.89
Contribution to the thermodynamics of protein folding from the reduction in water-accessible nonpolar surface area. Biochemistry (1991) 2.83
The role of internal packing interactions in determining the structure and stability of a protein. J Mol Biol (1991) 2.83
Refined solution structure of the oligomerization domain of the tumour suppressor p53. Nat Struct Biol (1995) 2.75
p53: at the crossroads of molecular carcinogenesis and risk assessment. Science (1993) 2.54
Extracting hydrophobic free energies from experimental data: relationship to protein folding and theoretical models. Biochemistry (1991) 2.46
Solution structure of the tetrameric minimum transforming domain of p53. Nat Struct Biol (1994) 2.44
Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science (1993) 2.09
Genetic and structural analysis of the protein stability problem. Biochemistry (1987) 2.07
Synthetic model for two-stranded alpha-helical coiled-coils. Design, synthesis, and characterization of an 86-residue analog of tropomyosin. J Biol Chem (1981) 1.95
Structural and energetic consequences of disruptive mutations in a protein core. Biochemistry (1992) 1.85
A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes. FEBS Lett (1994) 1.84
Contribution of the hydrophobic effect to globular protein stability. J Mol Biol (1992) 1.72
p53 domains: structure, oligomerization, and transformation. Mol Cell Biol (1994) 1.68
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J (1995) 1.58
Folding and function of a T4 lysozyme containing 10 consecutive alanines illustrate the redundancy of information in an amino acid sequence. Proc Natl Acad Sci U S A (1992) 1.49
The role of backbone flexibility in the accommodation of variants that repack the core of T4 lysozyme. Science (1993) 1.39
Rapid screening for structural integrity of expressed proteins by heteronuclear NMR spectroscopy. Protein Sci (1996) 1.33
Specific sequences from the carboxyl terminus of human p53 gene product form anti-parallel tetramers in solution. Proc Natl Acad Sci U S A (1994) 1.25
Protein folding: predicting predicting. Proteins (1994) 0.99
(H)NCAHA and (H)CANNH experiments for the determination of the vicinal coupling constants related to the phi-torsion angle. J Biomol NMR (1995) 0.93
p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks. J Cell Biol (2000) 7.26
Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73
A solid-state NMR index of helical membrane protein structure and topology. J Magn Reson (2000) 3.67
Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature (2000) 3.34
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci U S A (1999) 3.13
ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins. Nat Genet (1998) 3.01
Protein structure by solid-state NMR spectroscopy. Q Rev Biophys (1987) 2.27
Complete resolution of the solid-state NMR spectrum of a uniformly 15N-labeled membrane protein in phospholipid bilayers. Proc Natl Acad Sci U S A (1997) 2.27
Structure and orientation of the antibiotic peptide magainin in membranes by solid-state nuclear magnetic resonance spectroscopy. Protein Sci (1993) 2.16
Sensitivity-enhanced NMR of biological solids: dynamic nuclear polarization of Y21M fd bacteriophage and purple membrane. J Am Chem Soc (2001) 1.88
Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1. Proc Natl Acad Sci U S A (1999) 1.87
Orientations of amphipathic helical peptides in membrane bilayers determined by solid-state NMR spectroscopy. J Biomol NMR (1991) 1.82
Evolutionarily conserved regions of the human c-myc protein can be uncoupled from transforming activity. Proc Natl Acad Sci U S A (1987) 1.82
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene (1997) 1.70
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res (1997) 1.70
Two-dimensional 1H NMR experiments show that the 23-residue magainin antibiotic peptide is an alpha-helix in dodecylphosphocholine micelles, sodium dodecylsulfate micelles, and trifluoroethanol/water solution. J Biomol NMR (1997) 1.66
Three-dimensional solid-state NMR experiment that correlates the chemical shift and dipolar coupling frequencies of two heteronuclei. J Magn Reson B (1995) 1.66
Genomic instability in induced stem cells. Cell Death Differ (2011) 1.63
NMR structural studies of membrane proteins. Curr Opin Struct Biol (1998) 1.61
fd coat protein structure in membrane environments. J Mol Biol (1993) 1.59
Protein structure by solid state nuclear magnetic resonance. Residues 40 to 45 of bacteriophage fd coat protein. J Mol Biol (1985) 1.58
The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding. EMBO J (1995) 1.58
fd coat protein structure in membrane environments: structural dynamics of the loop between the hydrophobic trans-membrane helix and the amphipathic in-plane helix. J Mol Biol (1997) 1.49
High-resolution solid-state NMR spectra of integral membrane proteins reconstituted into magnetically oriented phospholipid bilayers. J Magn Reson B (1996) 1.49
Comparison of protein and deoxyribonucleic acid backbone structures in fd and Pf1 bacteriophages. Biochemistry (1983) 1.46
Protein dynamics by solid-state NMR: aromatic rings of the coat protein in fd bacteriophage. Proc Natl Acad Sci U S A (1982) 1.40
Experimental aspects of multidimensional solid-state NMR correlation spectroscopy. J Magn Reson (1999) 1.40
Identification of an additional negative regulatory region for p53 sequence-specific DNA binding. Proc Natl Acad Sci U S A (1998) 1.39
Three-dimensional solid-state NMR spectroscopy of a peptide oriented in membrane bilayers. J Biomol NMR (1995) 1.37
Lanthanide ions bind specifically to an added "EF-hand" and orient a membrane protein in micelles for solution NMR spectroscopy. J Magn Reson (2000) 1.37
NMR experiments on aligned samples of membrane proteins. Methods Enzymol (2005) 1.34
Detection of new temperature-dependent conformational transition in lysozyme by carbon-13 nuclear magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1975) 1.34
Solid-state NMR studies of the membrane-bound closed state of the colicin E1 channel domain in lipid bilayers. Protein Sci (1998) 1.33
Structure-based rescue of common tumor-derived p53 mutants. Nat Med (1996) 1.32
Three-dimensional solid-state NMR spectroscopy is essential for resolution of resonances from in-plane residues in uniformly (15)N-labeled helical membrane proteins in oriented lipid bilayers. J Magn Reson (2000) 1.31
Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J (1998) 1.30
NMR studies of the structure and dynamics of membrane-bound bacteriophage Pf1 coat protein. Science (1991) 1.30
Dilute spin-exchange assignment of solid-state NMR spectra of oriented proteins: acetylcholine M2 in bilayers. J Biomol NMR (1999) 1.29
Solid-state nuclear magnetic resonance structural studies of proteins. Methods Enzymol (1989) 1.29
Orientation of cecropin A helices in phospholipid bilayers determined by solid-state NMR spectroscopy. Biophys J (1999) 1.27
High resolution solid state C NMR spectroscopy of sporopollenins from different plant taxa. Plant Physiol (1988) 1.27
Aberrant regulation and function of wild-type p53 in radioresistant melanoma cells. Cell Growth Differ (2000) 1.25
Structure and interactions of magainin antibiotic peptides in lipid bilayers: a solid-state nuclear magnetic resonance investigation. Biophys J (1992) 1.22
Solid-state NMR triple-resonance backbone assignments in a protein. J Biomol NMR (1999) 1.21
An engineered four-stranded coiled coil substitutes for the tetramerization domain of wild-type p53 and alleviates transdominant inhibition by tumor-derived p53 mutants. Cancer Res (1996) 1.19
Four-dimensional solid-state NMR experiment that correlates the chemical-shift and dipolar-coupling frequencies of two heteronuclei with the exchange of dilute-spin magnetization. J Magn Reson B (1995) 1.18
Orientations of helical peptides in membrane bilayers by solid state NMR spectroscopy. Solid State Nucl Magn Reson (1996) 1.13
Selectively deuterated amino acid analogues. Synthesis, incorporation into proteins and NMR properties. Biochim Biophys Acta (1977) 1.12
Structural properties of fd coat protein in sodium dodecyl sulfate micelles. Biochem Biophys Res Commun (1980) 1.11
Three-dimensional solid-state NMR correlation experiment with 1H homonuclear spin exchange. J Magn Reson B (1996) 1.08
Two-dimensional chemical shift/heteronuclear dipolar coupling spectra obtained with polarization inversion spin exchange at the magic angle and magic-angle sample spinning (PISEMAMAS). Solid State Nucl Magn Reson (1995) 1.07
Dynamics of fd coat protein in lipid bilayers. Biochemistry (1987) 1.06
Protein dynamics by solid state nuclear magnetic resonance. Methods Enzymol (1986) 1.05
Alterations of the p16-pRb pathway and the chromosome locus 9p21-22 in non-small-cell lung carcinomas: relationship with p53 and MDM2 protein expression. Am J Pathol (1998) 1.04
Structures of the reduced and mercury-bound forms of MerP, the periplasmic protein from the bacterial mercury detoxification system. Biochemistry (1997) 1.04
Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max. Oncogene (1993) 1.03
Dynamics of fd coat protein in the bacteriophage. Biochemistry (1987) 1.03
31P nuclear magnetic resonance of the RNA in tobacco mosaic virus. J Mol Biol (1983) 1.02
Substitutions that compromise the ionizing radiation-induced association of p53 with 14-3-3 proteins also compromise the ability of p53 to induce cell cycle arrest. Cancer Res (2001) 1.02
Hydrogen-1 and carbon-13 nuclear magnetic resonance of the aromatic residues of fd coat protein. Biochemistry (1981) 1.02
Two- and three-dimensional 1H/13C PISEMA experiments and their application to backbone and side chain sites of amino acids and peptides. J Magn Reson (1999) 1.01
Structural studies of the HIV-1 accessory protein Vpu in langmuir monolayers: synchrotron X-ray reflectivity. Biophys J (2001) 0.98
Nuclear magnetic resonance description of molecular motion and phase separations of cholesterol in lecithin dispersions. Proc Natl Acad Sci U S A (1976) 0.97
Three-dimensional 13C shift/1H-15N coupling/15N shift solid-state NMR correlation spectroscopy. J Magn Reson (1999) 0.96
One- and two- dimensional 15N/1H NMR of filamentous phage coat proteins in solution. Biochem Biophys Res Commun (1985) 0.96
Evaluation of claspin as a proliferation marker in human cancer and normal tissues. J Pathol (2007) 0.95
Change in oligomerization specificity of the p53 tetramerization domain by hydrophobic amino acid substitutions. Protein Sci (1999) 0.95
Familial holoprosencephaly associated with a translocation breakpoint at chromosomal position 7q36. Am J Med Genet (1991) 0.95
NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein. J Mol Biol (1997) 0.94
Application of Maximum Entropy reconstruction to PISEMA spectra. J Magn Reson (2005) 0.94
Involvement of a p53-dependent pathway in rubella virus-induced apoptosis. Virology (1999) 0.91
Phosphorus-31 nuclear magnetic resonance of fd virus. Biochemistry (1981) 0.91
13C nuclear magnetic resonance study of molecular motions and conformational transitions in muscle calcium binding parvalbumins. Biochemistry (1976) 0.91
Structure and dynamics of the Pf1 filamentous bacteriophage coat protein in micelles. Biochemistry (1987) 0.90
Sugar pucker and phosphodiester conformations in viral genomes of filamentous bacteriophages: fd, If1, IKe, Pf1, Xf, and Pf3. Biochemistry (1988) 0.89
Proximal regulatory domains of rat atrial natriuretic factor gene. Circulation (1991) 0.89
Evidence from 13C NMR for protonation of carbamyl-P and N-(phosphonacetyl)-L-aspartate in the active site of aspartate transcarbamylase. J Biol Chem (1976) 0.89
Peptides and the development of double- and triple-resonance solid-state NMR of aligned samples. J Pept Res (2005) 0.89
Nuclear magnetic resonance of the filamentous bacteriophage fd. Biophys J (1980) 0.88
Membrane-mediated assembly of filamentous bacteriophage Pf1 coat protein. Science (1991) 0.88
Structure and topology of a peptide segment of the 6th transmembrane domain of the Saccharomyces cerevisae alpha-factor receptor in phospholipid bilayers. Biopolymers (2001) 0.87
Pf1 virus particle dynamics. Biopolymers (1986) 0.87
Letter: Carbon magnetic resonance study of the conformational changes in carp muscle calcium binding parvalbumin. J Am Chem Soc (1974) 0.87
Effects of glycosylation on the structure and dynamics of eel calcitonin in micelles and lipid bilayers determined by nuclear magnetic resonance spectroscopy. Biochemistry (1999) 0.86
The structure of the M2 channel-lining segment from the nicotinic acetylcholine receptor. Biochim Biophys Acta (2002) 0.86
The DNA damage checkpoint and human cancer. Cold Spring Harb Symp Quant Biol (2000) 0.86
Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells. Proc Natl Acad Sci U S A (1990) 0.86
Comparison of the dynamics of the membrane-bound form of fd coat protein in micelles and in bilayers by solution and solid-state nitrogen-15 nuclear magnetic resonance spectroscopy. Proteins (1988) 0.86
A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. Oncogene (2012) 0.86
Hemoglobin Raleigh (beta1 valine replaced by acetylalanine). Structural and functional characterization. Biochemistry (1977) 0.86
A serine 37 mutation associated with two missense mutations at highly conserved regions of p53 affect pro-apoptotic genes expression in a T-lymphoblastoid drug resistant cell line. Oncogene (2000) 0.85