Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects.

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Published in Nat Med on October 01, 1997

Authors

L Vígh1, P N Literáti, I Horváth, Z Török, G Balogh, A Glatz, E Kovács, I Boros, P Ferdinándy, B Farkas, L Jaszlits, A Jednákovits, L Korányi, B Maresca

Author Affiliations

1: Institute of Biochemistry, Hungarian Academy of Sciences, Szeged, Hungary.

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Interaction of plasmin with endothelial cells. Biochem J (1984) 0.91

[Influences of fluorine on plants during ontogenesis]. Biologia (Bratisl) (1970) 0.90

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Production of glucagon antibodies by thyroglobulin-zinc glucagon conjugate. Horm Metab Res (1977) 0.90

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