Published in Development on September 01, 1997
The Berkeley Drosophila Genome Project gene disruption project: Single P-element insertions mutating 25% of vital Drosophila genes. Genetics (1999) 7.56
Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol (2011) 2.96
The Wnts. Genome Biol (2001) 2.90
Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. Proc Natl Acad Sci U S A (1999) 2.73
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase. Genes Dev (1998) 2.51
Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity. EMBO J (2000) 2.15
Shaping morphogen gradients by proteoglycans. Cold Spring Harb Perspect Biol (2009) 1.96
The elusive functions of proteoglycans: in vivo veritas. J Cell Biol (2000) 1.84
Differential gene expression of the honey bee Apis mellifera associated with Varroa destructor infection. BMC Genomics (2008) 1.78
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Protruding vulva mutants identify novel loci and Wnt signaling factors that function during Caenorhabditis elegans vulva development. Genetics (2000) 1.48
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins. Dev Dyn (2010) 1.33
sqv-3, -7, and -8, a set of genes affecting morphogenesis in Caenorhabditis elegans, encode enzymes required for glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A (2000) 1.31
Sulfation of chondroitin sulfate proteoglycans is necessary for proper Indian hedgehog signaling in the developing growth plate. Development (2009) 1.27
The SQV-1 UDP-glucuronic acid decarboxylase and the SQV-7 nucleotide-sugar transporter may act in the Golgi apparatus to affect Caenorhabditis elegans vulval morphogenesis and embryonic development. Proc Natl Acad Sci U S A (2002) 1.19
The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development. Development (2010) 1.18
SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose. Proc Natl Acad Sci U S A (2001) 1.17
Extracellular movement of signaling molecules. Dev Cell (2011) 1.13
Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics (2003) 1.11
Many P-element insertions affect wing shape in Drosophila melanogaster. Genetics (2004) 1.08
Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis. Dev Biol (2007) 1.06
Developmental roles of heparan sulfate proteoglycans in Drosophila. Glycoconj J (2003) 1.03
Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans. J Biol Chem (2011) 1.03
A translational block to HSPG synthesis permits BMP signaling in the early Drosophila embryo. Development (2008) 1.01
Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila. EMBO J (2003) 1.00
Biosynthesis of UDP-GlcA, a key metabolite for capsular polysaccharide synthesis in the pathogenic fungus Cryptococcus neoformans. Biochem J (2004) 0.96
Glycosylated synaptomatrix regulation of trans-synaptic signaling. Dev Neurobiol (2012) 0.95
Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels. Cancer Res (2009) 0.90
Seven Wnt homologues in Drosophila: a case study of the developing tracheae. Proc Natl Acad Sci U S A (2001) 0.89
Loss of β-catenin induces multifocal periosteal chondroma-like masses in mice. Am J Pathol (2012) 0.87
D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol (2005) 0.86
Overgrowth syndromes and the regulation of signaling complexes by proteoglycans. Am J Hum Genet (1999) 0.86
The human D-glucuronyl C5-epimerase gene is transcriptionally activated through the beta-catenin-TCF4 pathway. Biochem J (2005) 0.85
Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model. Dis Model Mech (2014) 0.85
Effect of genetic variation in a Drosophila model of diabetes-associated misfolded human proinsulin. Genetics (2013) 0.85
Defining boundaries during joint cavity formation: going out on a limb. Int J Exp Pathol (2003) 0.85
UDP-glucose dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. J Biol Chem (2012) 0.84
Whole transcriptome analysis of a reversible neurodegenerative process in Drosophila reveals potential neuroprotective genes. BMC Genomics (2012) 0.83
Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development. Dev Biol (2013) 0.82
Wingless/Wnt signaling in Drosophila: the pattern and the pathway. Mol Reprod Dev (2013) 0.81
Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans. G3 (Bethesda) (2014) 0.81
Distinct heparan sulfate compositions in wild-type and pipe-mutant eggshell matrix. Fly (Austin) (2008) 0.81
A starting place for the road to function. Glycoconj J (2003) 0.80
Functions and Mechanisms of Fibroblast Growth Factor (FGF) Signalling in Drosophila melanogaster. Int J Mol Sci (2013) 0.78
UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces. J Biol Chem (2013) 0.78
Drosophila embryos as model to assess cellular and developmental toxicity of multi-walled carbon nanotubes (MWCNT) in living organisms. PLoS One (2014) 0.78
Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling. BMC Dev Biol (2011) 0.78
Molecular cloning of a novel glucuronokinase/putative pyrophosphorylase from zebrafish acting in an UDP-glucuronic acid salvage pathway. PLoS One (2014) 0.77
Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Hum Mol Genet (2016) 0.77
Wnt Signaling: Role in Regulation of Haematopoiesis. Indian J Hematol Blood Transfus (2015) 0.75
The role of heparan sulphate in development: the ectodermal story. Int J Exp Pathol (2016) 0.75
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell (1999) 7.99
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science (2000) 6.44
A functional genomic analysis of cell morphology using RNA interference. J Biol (2003) 5.99
The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster. Genetics (1996) 5.72
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature (2000) 4.80
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev (1998) 4.51
Genetic definition and sequence analysis of Arabidopsis centromeres. Science (1999) 4.20
Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila. Genetics (1992) 4.18
GeneSplicer: a new computational method for splice site prediction. Nucleic Acids Res (2001) 3.71
Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups. Am J Hum Genet (2001) 3.51
Ectopic expression in Drosophila. Methods Cell Biol (1994) 3.50
Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects. EMBO J (1995) 3.40
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature (1998) 3.34
Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras. Development (1993) 3.19
Diuretic therapy for hypertension and the risk of primary cardiac arrest. N Engl J Med (1994) 3.04
X-linked female-sterile loci in Drosophila melanogaster. Genetics (1986) 2.94
Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. Dev Biol (1983) 2.91
wingless signaling acts through zeste-white 3, the Drosophila homolog of glycogen synthase kinase-3, to regulate engrailed and establish cell fate. Cell (1992) 2.85
Components of wingless signalling in Drosophila. Nature (1994) 2.84
The effects of zygotic lethal mutations on female germ-line functions in Drosophila. Dev Biol (1984) 2.70
corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso. Cell (1992) 2.69
Marelle acts downstream of the Drosophila HOP/JAK kinase and encodes a protein similar to the mammalian STATs. Cell (1996) 2.69
The ovo locus is required for sex-specific germ line maintenance in Drosophila. Genes Dev (1987) 2.63
Complete genome sequence of the shrimp white spot bacilliform virus. J Virol (2001) 2.58
Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling. Nature (1999) 2.53
The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev (1994) 2.50
Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev (1998) 2.47
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J (2000) 2.41
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science (1996) 2.31
Activation of posterior gap gene expression in the Drosophila blastoderm. Nature (1995) 2.30
dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature (1994) 2.29
A functional promoter polymorphism in the macrophage migration inhibitory factor (MIF) gene associated with disease severity in rheumatoid arthritis. Genes Immun (2002) 2.21
Towards automated cellular image segmentation for RNAi genome-wide screening. Med Image Comput Comput Assist Interv (2005) 2.19
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Stripe-specific regulation of pair-rule genes by hopscotch, a putative Jak family tyrosine kinase in Drosophila. Genes Dev (1994) 2.14
DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila. Genes Dev (1998) 2.14
Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein. EMBO J (1993) 2.12
Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature (2001) 2.11
DQ (rather than DR) gene marks susceptibility to narcolepsy. Lancet (1992) 2.08
The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development. Nature (1990) 2.05
Latent variable models for longitudinal data with multiple continuous outcomes. Biometrics (2000) 2.02
Putative protein kinase product of the Drosophila segment-polarity gene zeste-white3. Nature (1990) 2.01
Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science (2000) 2.01
Simple and efficient generation of marked clones in Drosophila. Curr Biol (1993) 2.00
Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless. Development (2001) 1.96
Prospective comparison treatment of 595-nm pulsed-dye lasers for virgin port-wine stain. Br J Dermatol (2015) 1.96
Prevalence of Staphylococcus aureus carrying Panton-Valentine leukocidin genes among isolates from hospitalised patients in China. Clin Microbiol Infect (2008) 1.95
Multiple functions of segment polarity genes in Drosophila. Dev Biol (1987) 1.94
Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled. Dev Biol (1994) 1.89
The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. Genes Dev (1996) 1.87
Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development (1999) 1.86
Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Nature (2000) 1.85
Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan. Mol Cell (1999) 1.84
Differential effects of BMI on diabetes risk among black and white Americans. Diabetes Care (1998) 1.84
The nuclear hormone receptor Ftz-F1 is a cofactor for the Drosophila homeodomain protein Ftz. Nature (1997) 1.82
Identifying loci required for follicular patterning using directed mosaics. Development (1998) 1.81
Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol Cell Biol (1998) 1.79
The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes Dev (1992) 1.68
Crystal structure of the catalytic domain of human plasmin complexed with streptokinase. Science (1998) 1.68
Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol (2001) 1.67
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis. Cancer Res (1999) 1.65
Collective nomenclature for LAP proteins. Nat Cell Biol (2000) 1.64
Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement. Genes Dev (1997) 1.64
Raf acts downstream of the EGF receptor to determine dorsoventral polarity during Drosophila oogenesis. Genes Dev (1994) 1.62
Genetic evidence that the sans fille locus is involved in Drosophila sex determination. Genetics (1988) 1.62
Acetylcholine, outer hair cell electromotility, and the cochlear amplifier. J Neurosci (1997) 1.61
The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures. Genes Dev (1990) 1.61
Requirement of the Drosophila raf homologue for torso function. Nature (1989) 1.60
Frizzled signaling and the developmental control of cell polarity. Trends Genet (1998) 1.60
A genetic screen for mutations that disrupt an auditory response in Drosophila melanogaster. Proc Natl Acad Sci U S A (1997) 1.59
Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines. Genome Res (2001) 1.59
CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev (1998) 1.59
Familial hypobetalipoproteinemia: genetics and metabolism. Cell Mol Life Sci (2005) 1.58
Stress signaling in Drosophila. Oncogene (1999) 1.56
Effect of point mutations on the kinetics and the inhibition of human immunodeficiency virus type 1 protease: relationship to drug resistance. Biochemistry (1995) 1.56
Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations. Clin Pharmacol Ther (2008) 1.53
The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem (1997) 1.53
The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell (1999) 1.50
The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway. Cell (1995) 1.49
I-SceI endonuclease, a new tool for studying DNA double-strand break repair mechanisms in Drosophila. Genetics (1999) 1.49
Dual role of the fringe connection gene in both heparan sulphate and fringe-dependent signalling events. Nat Cell Biol (2001) 1.46
Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol (2000) 1.46
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. Development (1995) 1.43
Altering the insertional specificity of a Drosophila transposable element. Proc Natl Acad Sci U S A (1992) 1.43
Multivariate linear mixed models for multiple outcomes. Stat Med (1999) 1.43
Relation of weight gain and weight loss on subsequent diabetes risk in overweight adults. J Epidemiol Community Health (2000) 1.43
Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project. Am J Trop Med Hyg (1999) 1.41
Changes in methadone treatment practices: results from a panel study, 1988-1995. Am J Drug Alcohol Abuse (1999) 1.41
Multiple roles for four-jointed in planar polarity and limb patterning. Dev Biol (2000) 1.41
The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification. Curr Biol (1999) 1.40
Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol. Mol Psychiatry (2007) 1.40
Sleep disordered breathing in patients with cluster headache. Neurology (2000) 1.40
The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family. Eur J Biochem (2000) 1.40
Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling. Bioessays (1994) 1.39