Published in J Neurosci on December 01, 1997
Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci U S A (1998) 4.82
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A (1999) 3.82
BDNF regulates eating behavior and locomotor activity in mice. EMBO J (2000) 3.52
Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci (2001) 2.16
Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo. Neuron (1998) 1.60
Stem cell therapy for the inner ear: recent advances and future directions. Trends Amplif (2012) 1.58
Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. J Neurosci (2009) 1.46
Brn3a is a transcriptional regulator of soma size, target field innervation and axon pathfinding of inner ear sensory neurons. Development (2001) 1.41
Fate mapping of mammalian embryonic taste bud progenitors. Development (2009) 1.20
Alterations in size, number, and morphology of gustatory papillae and taste buds in BDNF null mutant mice demonstrate neural dependence of developing taste organs. J Comp Neurol (1999) 1.19
Regulation of neuronal survival and death by extracellular signals during development. EMBO J (2003) 1.16
Mutant mice reveal the molecular and cellular basis for specific sensory connections to inner ear epithelia and primary nuclei of the brain. Hear Res (2005) 1.15
Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A (2000) 1.10
Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development. Neural Dev (2011) 1.07
The zinc finger transcription factor Klf7 is required for TrkA gene expression and development of nociceptive sensory neurons. Genes Dev (2005) 1.06
Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle. Proc Natl Acad Sci U S A (2004) 1.06
A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol (2004) 1.03
Lack of the endosomal SNAREs vti1a and vti1b led to significant impairments in neuronal development. Proc Natl Acad Sci U S A (2011) 0.95
The number of herpes simplex virus-infected neurons and the number of viral genome copies per neuron correlate with the latent viral load in ganglia. Virology (2007) 0.95
TrkC kinase expression in distinct subsets of cutaneous trigeminal innervation and nonneuronal cells. J Comp Neurol (2004) 0.95
Amphetamine-induced locomotion and gene expression are altered in BDNF heterozygous mice. Genes Brain Behav (2008) 0.94
Factors that regulate embryonic gustatory development. BMC Neurosci (2007) 0.93
Developmental expression of Bdnf, Ntf4/5, and TrkB in the mouse peripheral taste system. Dev Dyn (2010) 0.92
Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging. Genes Brain Behav (2010) 0.90
TSLIM imaging and a morphometric analysis of the mouse spiral ganglion. Hear Res (2011) 0.89
Peripheral somatosensation: a touch of genetics. Curr Opin Genet Dev (2011) 0.87
Molecular conservation and novelties in vertebrate ear development. Curr Top Dev Biol (2003) 0.86
Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn (2011) 0.86
Taste cell formation does not require gustatory and somatosensory innervation. Neurosci Lett (2010) 0.86
Differential Trk expression in explant and dissociated trigeminal ganglion cell cultures. J Neurobiol (2005) 0.85
Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number. J Comp Neurol (2006) 0.84
BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol (2013) 0.83
Embryonic origin of gustatory cranial sensory neurons. Dev Biol (2007) 0.83
Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Invest Ophthalmol Vis Sci (2007) 0.82
The efficiency of design-based stereology in estimating spiral ganglion populations in mice. Hear Res (2013) 0.82
Midbrain-derived neurotrophins support survival of immature striatal projection neurons. J Neurosci (2013) 0.82
Genetics of peripheral vestibular dysfunction: lessons from mutant mouse strains. J Am Acad Audiol (2014) 0.81
Directing traffic in neural cells: determinants of receptor tyrosine kinase localization and cellular responses. J Neurochem (2008) 0.81
Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. PLoS One (2013) 0.81
A novel phenotype for the dynein heavy chain mutation Loa: altered dendritic morphology, organelle density, and reduced numbers of trigeminal motoneurons. J Comp Neurol (2012) 0.80
Brain-derived neurotrophic factor mediates non-cell-autonomous regulation of sensory neuron position and identity. J Neurosci (2010) 0.80
Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract. Cell Tissue Res (2010) 0.79
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes. J Neurosci (2016) 0.79
Development of gustatory papillae in the absence of Six1 and Six4. J Anat (2011) 0.79
Association between BDNF gene polymorphisms and serotonergic activity using loudness dependence of auditory evoked potentials in healthy subjects. PLoS One (2013) 0.78
Neurotrophin-4 is more potent than brain-derived neurotrophic factor in promoting, attracting and suppressing geniculate ganglion neurite outgrowth. Dev Neurosci (2012) 0.78
Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood. Anat Rec A Discov Mol Cell Evol Biol (2006) 0.78
Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation. Am J Physiol Regul Integr Comp Physiol (2013) 0.78
An intrastriatal brain-derived neurotrophic factor infusion restores striatal gene expression in Bdnf heterozygous mice. Brain Struct Funct (2010) 0.77
Expression of Trk A receptors in the mammalian inner ear. Hear Res (2004) 0.77
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature (1983) 19.76
A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics (2001) 15.03
Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature (1985) 7.07
Cellular oncogenes and multistep carcinogenesis. Science (1983) 6.52
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature (1982) 6.09
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev (2001) 4.68
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature (1991) 4.44
Smad3 mutant mice develop metastatic colorectal cancer. Cell (1998) 3.92
The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science (1991) 3.86
Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci U S A (1999) 3.82
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med (2001) 3.64
BDNF regulates eating behavior and locomotor activity in mice. EMBO J (2000) 3.52
Analysis of Hox gene expression in the chick limb bud. Development (1996) 3.47
Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev (1994) 3.40
Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature (1991) 3.37
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell (1990) 3.21
The HL-60 transforming sequence: a ras oncogene coexisting with altered myc genes in hematopoietic tumors. Cell (1983) 3.00
An essential role for C/EBPbeta in female reproduction. Genes Dev (1997) 2.96
Mouse tumor model for neurofibromatosis type 1. Science (1999) 2.89
Behavior of myc and ras oncogenes in transformation of rat embryo fibroblasts. Mol Cell Biol (1986) 2.86
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. Proc Natl Acad Sci U S A (2000) 2.80
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr Biol (2001) 2.72
Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev (1992) 2.54
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell (1991) 2.46
Spatial shaping of cochlear innervation by temporally regulated neurotrophin expression. J Neurosci (2001) 2.16
Specific growth response of ras-transformed embryo fibroblasts to tumour promoters. Nature (1986) 2.15
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J (1989) 2.14
K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J Biol Chem (1992) 2.01
Cryptorchidism in mice mutant for Insl3. Nat Genet (1999) 1.99
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene (2007) 1.97
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron (1992) 1.96
Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development (1990) 1.75
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci U S A (2000) 1.70
Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev (1990) 1.67
Forward signaling mediated by ephrin-B3 prevents contralateral corticospinal axons from recrossing the spinal cord midline. Neuron (2001) 1.64
The status of voltage-dependent calcium channels in alpha 1E knock-out mice. J Neurosci (2000) 1.63
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proc Natl Acad Sci U S A (1997) 1.62
The rat trkC locus encodes multiple neurogenic receptors that exhibit differential response to neurotrophin-3 in PC12 cells. Neuron (1993) 1.61
Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl Acad Sci U S A (2000) 1.60
Selectively enhanced contextual fear conditioning in mice lacking the transcriptional regulator CCAAT/enhancer binding protein delta. Proc Natl Acad Sci U S A (1998) 1.59
Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor. Mol Cell Biol (2001) 1.58
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons. Proc Natl Acad Sci U S A (1994) 1.54
Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice. J Neurosci Res (2001) 1.53
Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene. Proc Natl Acad Sci U S A (1991) 1.53
Neurofibromin, a tumor suppressor in the nervous system. Exp Cell Res (2001) 1.53
The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development (1998) 1.52
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. Am J Pathol (1995) 1.49
The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines. Cell (1991) 1.47
Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice. Proc Natl Acad Sci U S A (1999) 1.46
trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development (1993) 1.46
Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene (1999) 1.41
Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development (1993) 1.38
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron (1992) 1.38
Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J (1991) 1.37
Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice. Genomics (2001) 1.37
p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J Neurosci (1998) 1.34
BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain. J Neurosci (2000) 1.32
Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nat Genet (1996) 1.30
The Mos/mitogen-activated protein kinase (MAPK) pathway regulates the size and degradation of the first polar body in maturing mouse oocytes. Proc Natl Acad Sci U S A (1996) 1.25
Lsh, a SNF2 family member, is required for normal murine development. Biochim Biophys Acta (2001) 1.25
Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. FASEB J (2001) 1.21
In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. Neuroscience (2003) 1.20
Loss of neurofibromin results in neurotrophin-independent survival of embryonic sensory and sympathetic neurons. Cell (1995) 1.20
Isolation, microinjection, and transfer of mouse blastocysts. Methods Mol Biol (2001) 1.19
Presence of a Kirsten murine sarcoma virus ras oncogene in cells transformed by 3-methylcholanthrene. Mol Cell Biol (1983) 1.18
Hormones in male sexual development. Genes Dev (2000) 1.18
An improved method for the detection of DNA fragmentation. J Immunol Methods (1991) 1.17
Dissection of NT3 functions in vivo by gene replacement strategy. Development (2001) 1.17
Trks: signal transduction and intracellular pathways. Microsc Res Tech (1999) 1.14
An immunoglobulin-like domain determines the specificity of neurotrophin receptors. EMBO J (1995) 1.13
Regulation of neurotrophin receptor expression during embryonic and postnatal development. J Neurosci (1994) 1.12
Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product. Science (1991) 1.11
The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin. EMBO J (1994) 1.11
A molecular basis for estrogen-induced cryptorchidism. Dev Biol (2000) 1.11
Loss of brain-derived neurotrophic factor-dependent neural crest-derived sensory neurons in neurotrophin-4 mutant mice. Proc Natl Acad Sci U S A (2000) 1.10
NT4/5 mutant mice have deficiency in gustatory papillae and taste bud formation. Dev Biol (1999) 1.09
Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development. Mol Cell Biol (2000) 1.07
Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis (2001) 1.05
Role of N-myc in the developing mouse kidney. Dev Biol (2000) 1.05
Germ line transmission of an inactive N-myc allele generated by homologous recombination in mouse embryonic stem cells. Mol Cell Biol (1990) 1.04
Notch1 signaling promotes survival of glioblastoma cells via EGFR-mediated induction of anti-apoptotic Mcl-1. Oncogene (2012) 1.03
Potential role of glial cell line-derived neurotrophic factor receptors in Müller glial cells during light-induced retinal degeneration. Neuroscience (2003) 1.01
TrkC isoforms with inserts in the kinase domain show impaired signaling responses. J Biol Chem (1996) 0.98
Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells. Glia (1999) 0.97
Regulation of Trk receptors following contusion of the rat spinal cord. Exp Neurol (2001) 0.97
Molecular characterization of the TrkA/NGF receptor minimal enhancer reveals regulation by multiple cis elements to drive embryonic neuron expression. Development (2000) 0.97
Two CDC25 homologues are differentially expressed during mouse development. Development (1995) 0.95
Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J Neurosci (2001) 0.95
Insulin receptor-related receptor expression in non-A intercalated cells in the kidney. Kidney Int (1997) 0.95
Neurotrophins are not required for normal embryonic development of olfactory neurons. Dev Biol (2001) 0.95
The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells. J Neurochem (2001) 0.95
Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes Purkinje cell differentiation. J Cell Biol (1993) 0.95