PubRank

M Esteller

Author PubWeight™ 100.61‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gene-expression profiles in hereditary breast cancer. N Engl J Med 2001 29.80
2 Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001 4.99
3 Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 1997 4.73
4 Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001 3.96
5 Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 2006 2.69
6 Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 2011 2.42
7 Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer. J Natl Cancer Inst 1999 2.34
8 Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res 2001 2.10
9 Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res 1999 2.09
10 Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 2000 1.91
11 Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene 2008 1.78
12 DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene 2011 1.76
13 Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation. Cancer Res 1999 1.69
14 CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene 2010 1.65
15 Molecular detection of prostate cancer in urine by GSTP1 hypermethylation. Clin Cancer Res 2001 1.63
16 Late Crohn's disease patients present an increase in peripheral Th17 cells and cytokine production compared with early patients. Aliment Pharmacol Ther 2009 1.62
17 The PDGFRβ-AKT pathway contributes to CDDP-acquired resistance in testicular germ cell tumors. Clin Cancer Res 2013 1.47
18 Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene 1998 1.36
19 Epigenetic regulation of telomeres in human cancer. Oncogene 2008 1.33
20 Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer. Oncogene 2011 1.31
21 Proteins that bind methylated DNA and human cancer: reading the wrong words. Br J Cancer 2008 1.27
22 The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding. Carcinogenesis 2006 1.25
23 NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva. Cancer Prev Res (Phila) 2011 1.21
24 Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia. Oncogene 2001 1.17
25 The chromatin remodeling factor CHD8 interacts with elongating RNA polymerase II and controls expression of the cyclin E2 gene. Nucleic Acids Res 2009 1.16
26 Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 2011 1.13
27 Identification of DNA hypermethylation of SOX9 in association with bladder cancer progression using CpG microarrays. Br J Cancer 2007 1.12
28 Specific hypermethylation of LINE-1 elements during abnormal overgrowth and differentiation of human placenta. Oncogene 2006 1.11
29 Novel epigenetically deregulated genes in testicular cancer include homeobox genes and SCGB3A1 (HIN-1). J Pathol 2006 1.10
30 Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res 2000 1.10
31 Unmasking of epigenetically silenced candidate tumor suppressor genes by removal of methyl-CpG-binding domain proteins. Oncogene 2008 1.07
32 Viral epigenomes in human tumorigenesis. Oncogene 2010 1.06
33 5'-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut 2000 1.04
34 Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. Cancer Res 2001 0.98
35 Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence. Clin Cancer Res 1999 0.97
36 Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. Oncogene 2009 0.97
37 Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene 2008 0.93
38 Genetic and epigenetic profile of sporadic pheochromocytomas. J Med Genet 2004 0.90
39 Epigenetic control of nuclear architecture. Cell Mol Life Sci 2007 0.90
40 Multiple binding of methyl-CpG and polycomb proteins in long-term gene silencing events. J Cell Physiol 2007 0.89
41 Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas. Oncogene 2008 0.88
42 Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents. P R Health Sci J 2009 0.87
43 DNA methylation determines nucleosome occupancy in the 5'-CpG islands of tumor suppressor genes. Oncogene 2013 0.86
44 Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasms. Leukemia 2005 0.85
45 Merkel cell carcinoma of the vulva. Gynecol Oncol 1997 0.83
46 Aberrant epigenetic landscape in intellectual disability. Prog Brain Res 2012 0.81
47 Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity. Oncogene 2009 0.78
48 Towards defining the lymphoma methylome. Leukemia 2006 0.78
49 Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. Oncogene 2016 0.78
50 Epigenetic silencing of E- and N-cadherins in the stroma of mouse thymic lymphomas. Carcinogenesis 2005 0.76
51 Loss of chromosome arms 3p and 9p and inactivation of P16 (INK4a) in normal epithelium of patients with primary lung cancer. Genes Chromosomes Cancer 2001 0.76
52 [Introduction to molecular biology of endometrial cancer]. Med Clin (Barc) 1996 0.75
53 DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene 2017 0.75