Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms.

PubWeight™: 1.98‹?› | Rank: Top 2%

🔗 View Article (PMID 9384384)

Published in Nature on November 20, 1997

Authors

A P Naren1, D J Nelson, W Xie, B Jovov, J Pevsner, M K Bennett, D J Benos, M W Quick, K L Kirk

Author Affiliations

1: Department of Physiology and Biophysics, Gregory Fleming James Cystic Fibrosis Research Center, Birmingham, Alabama 35294, USA.

Articles citing this

Lung infections associated with cystic fibrosis. Clin Microbiol Rev (2002) 9.20

A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proc Natl Acad Sci U S A (1998) 2.68

Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (2008) 2.44

Failure of cAMP agonists to activate rescued deltaF508 CFTR in CFBE41o- airway epithelial monolayers. J Physiol (2005) 1.97

Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest (2000) 1.86

A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proc Natl Acad Sci U S A (2002) 1.78

Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction. Proc Natl Acad Sci U S A (2001) 1.78

Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions. Mol Biol Cell (2006) 1.69

The abscisic acid-related SNARE homolog NtSyr1 contributes to secretion and growth: evidence from competition with its cytosolic domain. Plant Cell (2002) 1.44

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol (2008) 1.38

Mouse VAP33 is associated with the endoplasmic reticulum and microtubules. Proc Natl Acad Sci U S A (2000) 1.38

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions. Proc Natl Acad Sci U S A (1998) 1.35

Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina. BMC Neurosci (2006) 1.30

Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest (2007) 1.29

Syntaxin 5 regulates the endoplasmic reticulum channel-release properties of polycystin-2. Proc Natl Acad Sci U S A (2008) 1.26

Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa. PLoS One (2011) 1.24

Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission. Proc Natl Acad Sci U S A (2008) 1.21

PDZ domains: More than just a glue. Proc Natl Acad Sci U S A (2001) 1.17

DeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers. Pulm Pharmacol Ther (2010) 1.16

Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents. J Clin Invest (2000) 1.16

Localization studies of rare missense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) facilitate interpretation of genotype-phenotype relationships. Hum Mutat (2008) 1.15

Molecular determinants of the functional interaction between syntaxin and N-type Ca2+ channel gating. Proc Natl Acad Sci U S A (2000) 1.10

A novel motif essential for SNARE interaction with the K(+) channel KC1 and channel gating in Arabidopsis. Plant Cell (2010) 1.05

Selective regulation of maize plasma membrane aquaporin trafficking and activity by the SNARE SYP121. Plant Cell (2012) 1.05

Syntaxin 16 binds to cystic fibrosis transmembrane conductance regulator and regulates its membrane trafficking in epithelial cells. J Biol Chem (2010) 1.01

CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex. Proc Natl Acad Sci U S A (2002) 1.01

Epimorphin expression in intestinal myofibroblasts induces epithelial morphogenesis. J Clin Invest (2002) 0.99

The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein. Proc Natl Acad Sci U S A (1999) 0.97

Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production. Biochem J (2004) 0.97

Syntaxin-3 and syntaxin-1A inhibit L-type calcium channel activity, insulin biosynthesis and exocytosis in beta-cell lines. Diabetologia (2002) 0.97

Regulation of CFTR trafficking by its R domain. J Biol Chem (2008) 0.95

The formation of the cAMP/protein kinase A-dependent annexin 2-S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function. Mol Biol Cell (2007) 0.95

Regulation of gap junctional communication by a pro-inflammatory cytokine in cystic fibrosis transmembrane conductance regulator-expressing but not cystic fibrosis airway cells. Am J Pathol (2001) 0.94

The EF-hand Ca(2+)-binding protein p22 associates with microtubules in an N-myristoylation-dependent manner. Mol Biol Cell (1999) 0.92

A dibasic motif involved in parathyroid hormone-induced down-regulation of the type IIa NaPi cotransporter. Proc Natl Acad Sci U S A (2000) 0.91

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells. BMC Med (2014) 0.90

Calcium/calmodulin-dependent kinase II regulates the interaction between the serotonin transporter and syntaxin 1A. Neuropharmacology (2008) 0.89

A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gating. J Physiol (2001) 0.89

Analysis of CFTR interactome in the macromolecular complexes. Methods Mol Biol (2011) 0.87

Substrates regulate gamma-aminobutyric acid transporters in a syntaxin 1A-dependent manner. Proc Natl Acad Sci U S A (2002) 0.87

Human amnion epithelial cells induced to express functional cystic fibrosis transmembrane conductance regulator. PLoS One (2012) 0.86

CFTR surface expression and chloride currents are decreased by inhibitors of N-WASP and actin polymerization. Biochim Biophys Acta (2006) 0.85

Morphological docking of secretory vesicles. Histochem Cell Biol (2010) 0.83

Proteomic identification of calumenin as a G551D-CFTR associated protein. PLoS One (2012) 0.80

Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells. Int J Biol Sci (2006) 0.80

Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). J Proteomics (2013) 0.79

Clinical and molecular characterization of the potential CF disease modifier syntaxin 1A. Eur J Hum Genet (2013) 0.78

Botulinum toxins inhibit the antidiuretic hormone (ADH)-stimulated increase in rabbit cortical collecting-tubule water Permeability. J Membr Biol (2005) 0.78

In vitro analysis of PDZ-dependent CFTR macromolecular signaling complexes. J Vis Exp (2012) 0.77

Personalized medicine in cystic fibrosis: genistein supplementation as a treatment option for patients with a rare S1045Y-CFTR mutation. Am J Physiol Lung Cell Mol Physiol (2016) 0.75

Porosome in Cystic Fibrosis. Discoveries (Craiova) (2015) 0.75

Role of Interaction and Nucleoside Diphosphate Kinase B in Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Function by cAMP-Dependent Protein Kinase A. PLoS One (2016) 0.75

Articles by these authors

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66

Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell (1999) 5.23

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (2000) 4.75

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (2000) 4.61

Specificity and regulation of a synaptic vesicle docking complex. Neuron (1994) 4.02

The synaptic SNARE complex is a parallel four-stranded helical bundle. Nat Struct Biol (1998) 3.74

The natural history of nonalcoholic fatty liver: a follow-up study. Hepatology (1995) 3.73

Amiloride: a molecular probe of sodium transport in tissues and cells. Am J Physiol (1982) 3.49

The biology of the mammalian Krüppel-like family of transcription factors. Int J Biochem Cell Biol (2001) 3.31

Mutations in the gene encoding gap junction protein beta-3 associated with autosomal dominant hearing impairment. Nat Genet (1998) 3.24

Protein-protein interactions contributing to the specificity of intracellular vesicular trafficking. Science (1994) 3.08

Distinct transport vesicles mediate the delivery of plasma membrane proteins to the apical and basolateral domains of MDCK cells. J Cell Biol (1990) 3.05

A previously unrecognized H-2D(b)-restricted peptide prominent in the primary influenza A virus-specific CD8(+) T-cell response is much less apparent following secondary challenge. J Virol (2000) 2.79

Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet (1985) 2.76

Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev (2001) 2.68

Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells. J Biol Chem (1999) 2.67

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase. Proc Natl Acad Sci U S A (1983) 2.66

Determinants of progression to cirrhosis or fibrosis in pure alcoholic fatty liver. Lancet (1995) 2.64

Single ionic channels observed in tissue-cultured muscle. Nature (1980) 2.63

Functionalized congeners of 1,3-dialkylxanthines: preparation of analogues with high affinity for adenosine receptors. J Med Chem (1985) 2.52

Regulation of plasma membrane recycling by CFTR. Science (1992) 2.50

Postmortem brain abnormalities of the glutamate neurotransmitter system in autism. Neurology (2001) 2.49

Regulated secretion in platelets: identification of elements of the platelet exocytosis machinery. Blood (1997) 2.44

Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A (1997) 2.43

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain. J Biol Chem (1983) 2.39

The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob Agents Chemother (1992) 2.38

Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways. J Immunol (1994) 2.29

Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line. Nat Med (1997) 2.24

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli. J Exp Med (1996) 2.19

Diversity of epitope and cytokine profiles for primary and secondary influenza a virus-specific CD8+ T cell responses. J Immunol (2001) 2.14

Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors. J Med Chem (1985) 2.12

Control of fusion pore dynamics during exocytosis by Munc18. Science (2001) 2.11

Unique forms of human and mouse nuclear receptor corepressor SMRT. Proc Natl Acad Sci U S A (1999) 2.10

CFTR chloride channel regulation by an interdomain interaction. Science (1999) 2.09

Botulinum neurotoxin type C cleaves a single Lys-Ala bond within the carboxyl-terminal region of syntaxins. J Biol Chem (1995) 2.06

Quality control procedure for 6-[18F]fluoro-L-DOPA: a presynaptic PET imaging ligand for brain dopamine neurons. J Nucl Med (1989) 2.04

Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus. Proc Natl Acad Sci U S A (1985) 2.02

Characteristics and regulatory mechanisms of the amiloride-blockable Na+ channel. Physiol Rev (1988) 2.00

Differential localization of syntaxin isoforms in polarized Madin-Darby canine kidney cells. Mol Biol Cell (1996) 1.99

Microscopic image analysis for quantitative measurement and feature identification of normal and cancerous colonic mucosa. IEEE Trans Inf Technol Biomed (1998) 1.95

In-hospital cardiopulmonary resuscitation: a 30-year review. J Am Board Fam Pract (1993) 1.95

CFTR is a conductance regulator as well as a chloride channel. Physiol Rev (1999) 1.90

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid. Proc Natl Acad Sci U S A (1996) 1.89

Differential gene expression profiling in human brain tumors. Physiol Genomics (2001) 1.88

[3H]xanthine amine congener of 1,3-dipropyl-8-phenylxanthine: an antagonist radioligand for adenosine receptors. Proc Natl Acad Sci U S A (1986) 1.85

Xanthogranulomatous appendicitis. Histopathology (1993) 1.82

Nosocomial pneumonia caused by carbapenem-resistant Raoultella planticola: a case report and literature review. Infection (2015) 1.82

Conserved and variable regions in the subunits of brain type II Ca2+/calmodulin-dependent protein kinase. Neuron (1988) 1.80

Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine. J Neurosci (1997) 1.79

Distinct cellular locations of the syntaxin family of proteins in rat pancreatic acinar cells. Mol Biol Cell (1996) 1.77

Cloning of an epithelial chloride channel from bovine trachea. J Biol Chem (1995) 1.77

Functional interaction of syntaxin and SNAP-25 with voltage-sensitive L- and N-type Ca2+ channels. EMBO J (1996) 1.75

Human model of duodenogastro-oesophageal reflux in the development of Barrett's metaplasia. Br J Surg (2003) 1.74

Functionalized congeners of 1,3-dipropyl-8-phenylxanthine: potent antagonists for adenosine receptors that modulate membrane adenylate cyclase in pheochromocytoma cells, platelets and fat cells. Life Sci (1986) 1.69

Analysis of the phosphorylation, DNA-binding and dimerization properties of the RNA polymerase I transcription factors UBF1 and UBF2. Nucleic Acids Res (1992) 1.69

Rapamycin protects against rotenone-induced apoptosis through autophagy induction. Neuroscience (2009) 1.67

Potassium-coupled chloride cotransport controls intracellular chloride in rat neocortical pyramidal neurons. J Neurosci (2000) 1.67

Deduced primary structure of the beta subunit of brain type II Ca2+/calmodulin-dependent protein kinase determined by molecular cloning. Proc Natl Acad Sci U S A (1987) 1.63

Role of the faecal stream in the maintenance of Crohn's colitis. Gut (1985) 1.63

Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase. J Biol Chem (2001) 1.62

Purine metabolism in Leishmania donovani and Leishmania braziliensis. Biochim Biophys Acta (1978) 1.60

Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification. Neurobiol Dis (2001) 1.59

Osmotic pressure regulates alpha beta gamma-rENaC expressed in Xenopus oocytes. Am J Physiol (1998) 1.58

A targeting signal in VAMP regulating transport to synaptic vesicles. Cell (1995) 1.57

A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dipropylxanthine. Mol Pharmacol (1986) 1.55

CFTR! Am J Physiol (1992) 1.52

Probing the adenosine receptor with adenosine and xanthine biotin conjugates. FEBS Lett (1985) 1.52

Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease. J Neurosci (2001) 1.52

Point mutations in the post-M2 region of human alpha-ENaC regulate cation selectivity. Am J Physiol Cell Physiol (2001) 1.50

Upregulation of surface alpha4beta2 nicotinic receptors is initiated by receptor desensitization after chronic exposure to nicotine. J Neurosci (1999) 1.49

Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1. Am J Med (1982) 1.49

Allopurinol ribonucleoside as an antileishmanial agent. Biological effects, metabolism, and enzymatic phosphorylation. J Biol Chem (1979) 1.49

Molecular probes for extracellular adenosine receptors. Biochem Pharmacol (1987) 1.47

Spontaneous autoinflation of saline mammary implants. Ann Plast Surg (1997) 1.47

Syntaxin 4 in 3T3-L1 adipocytes: regulation by insulin and participation in insulin-dependent glucose transport. Mol Biol Cell (1996) 1.45

Characterization of SNARE protein expression in beta cell lines and pancreatic islets. Endocrinology (1996) 1.45

On the ability of prostaglandin E1, and arachidonic acid to modulate experimentally induced oedema in the rat paw. Br J Pharmacol (1975) 1.45

Nucleoside analogue therapy in fibrosing cholestatic hepatitis--a case report in an HBsAg positive renal transplant recipient. Liver (1998) 1.45

Mucin gene expression in human urothelium and in intestinal segments transposed into the urinary tract. J Urol (2000) 1.45

Ethics, revisited. J Appl Physiol (1985) (2001) 1.45

Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse. J Neurochem (2000) 1.44

Syntaxin 7 and VAMP-7 are soluble N-ethylmaleimide-sensitive factor attachment protein receptors required for late endosome-lysosome and homotypic lysosome fusion in alveolar macrophages. Mol Biol Cell (2000) 1.43

Roles of phospholipase C beta2 in chemoattractant-elicited responses. Proc Natl Acad Sci U S A (1997) 1.43

Species differences in structure-activity relationships of adenosine agonists and xanthine antagonists at brain A1 adenosine receptors. FEBS Lett (1986) 1.42

The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition. Nat Struct Biol (1996) 1.41

Now what? Am J Physiol (1993) 1.41

Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells. Mol Cell Biol (1996) 1.41

Cystic fibrosis transmembrane conductance regulator facilitates ATP release by stimulating a separate ATP release channel for autocrine control of cell volume regulation. J Biol Chem (2000) 1.40

Inflammatory obstruction of oesophageal tubes. Gut (1983) 1.39

Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase II-activated chloride conductance in T84 colonic epithelial cells. J Biol Chem (1996) 1.38

Epithelial Na+ channels. Annu Rev Physiol (1991) 1.38

Observation of an antimatter hypernucleus. Science (2010) 1.38

Dieulafoy's vascular malformation as a cause of large intestinal bleeding. J Clin Pathol (1992) 1.37

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification. J Cell Sci (2001) 1.37

Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings. J Biol Chem (1998) 1.36

A cloned renal epithelial Na+ channel protein displays stretch activation in planar lipid bilayers. Am J Physiol (1995) 1.36

Syntaxin 1A inhibits CFTR chloride channels by means of domain-specific protein-protein interactions. Proc Natl Acad Sci U S A (1998) 1.35