A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae.

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Published in Proc Natl Acad Sci U S A on December 09, 1997

Authors

J Verna1, A Lodder, K Lee, A Vagts, R Ballester

Author Affiliations

1: Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA.

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Association of standardized estimated glomerular filtration rate with the prevalence of hypertension among adults in the United States. J Hum Hypertens (2011) 1.40

Infection of a Chlorella-like alga with the virus, PBCV-1: ultrastructural studies. Virology (1984) 1.39

Greater beneficial effects of visceral fat reduction compared with subcutaneous fat reduction on parameters of the metabolic syndrome: a study of weight reduction programmes in subjects with visceral and subcutaneous obesity. Diabet Med (2005) 1.39

Endoscopic sphincterotomy in young patients with choledochal dilatation and a long common channel: a preliminary report. Br J Surg (1992) 1.39

The role of the primate extrastriate area V4 in vision. Science (1991) 1.38

Attractiveness of facial averageness and symmetry in non-western cultures: in search of biologically based standards of beauty. Perception (2001) 1.37

Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol Life Sci (2003) 1.37

Two types of RAS mutants that dominantly interfere with activators of RAS. Mol Cell Biol (1994) 1.36

The binding site for ribosomal protein L11 within 23 S ribosomal RNA of Escherichia coli. J Biol Chem (1981) 1.36

Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Mol Cell Biol (2000) 1.36

Impact of residential nitrogen dioxide exposure on personal exposure: an international study. J Air Waste Manag Assoc (1998) 1.36

Globalisation and public health. J Epidemiol Community Health (2002) 1.34

Contrast-enhanced ultrasound using SonoVue® (sulphur hexafluoride microbubbles) compared with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterisation of focal liver lesions and detection of liver metastases: a systematic review and cost-effectiveness analysis. Health Technol Assess (2013) 1.33

Symbiotic Role of the Viable but Nonculturable State of Vibrio fischeri in Hawaiian Coastal Seawater. Appl Environ Microbiol (1995) 1.33

The mode selection trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients. Am Heart J (2000) 1.33

Korean Nationwide Surveillance of Antimicrobial Resistance of bacteria in 1997. Yonsei Med J (1998) 1.31

Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics (1999) 1.31

An RNA species involved in Escherichia coli ribonuclease P activity. Gene cloning and effect on transfer RnA synthesis in vivo. J Mol Biol (1982) 1.31

Particulate exposure and size distribution from wood burning stoves in Costa Rica. Indoor Air (2003) 1.30

Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem (2001) 1.30