Published in Br J Pharmacol on March 10, 2008
American Gastroenterological Association technical review on constipation. Gastroenterology (2013) 3.27
Lubiprostone targets prostanoid signaling and promotes ion transporter trafficking, mucus exocytosis, and contractility. Dig Dis Sci (2012) 1.61
E-type prostanoid receptor 4 (EP4) in disease and therapy. Pharmacol Ther (2013) 1.28
Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon. Am J Physiol Gastrointest Liver Physiol (2009) 1.12
Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects. Am J Physiol Gastrointest Liver Physiol (2008) 1.09
Lubiprostone reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther (2010) 1.08
Review article: new receptor targets for medical therapy in irritable bowel syndrome. Aliment Pharmacol Ther (2010) 1.06
Lubiprostone stimulates duodenal bicarbonate secretion in rats. Dig Dis Sci (2009) 1.03
Lubiprostone stimulates secretion from tracheal submucosal glands of sheep, pigs, and humans. Am J Physiol Lung Cell Mol Physiol (2009) 1.02
Behavioural and new pharmacological treatments for constipation: getting the balance right. Gut (2010) 1.01
Lubiprostone activates Cl- secretion via cAMP signaling and increases membrane CFTR in the human colon carcinoma cell line, T84. Dig Dis Sci (2010) 1.00
Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Dig Dis Sci (2010) 1.00
Lubiprostone ameliorates the cystic fibrosis mouse intestinal phenotype. BMC Gastroenterol (2010) 0.93
Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway. J Neurogastroenterol Motil (2013) 0.89
Emerging Pharmacologic Therapies for Constipation-predominant Irritable Bowel Syndrome and Chronic Constipation. J Neurogastroenterol Motil (2014) 0.88
Severe defects in absorptive ion transport in distal colons of mice that lack ClC-2 channels. Gastroenterology (2011) 0.87
Lubiprostone activates CFTR, but not ClC-2, via the prostaglandin receptor (EP(4)). Biochem Biophys Res Commun (2012) 0.86
Prophylactic and therapeutic benefits of COX-2 inhibitor on motility dysfunction in bowel obstruction: roles of PGE₂ and EP receptors. Am J Physiol Gastrointest Liver Physiol (2011) 0.85
Lubiprostone: evaluation of the newest medication for the treatment of adult women with constipation-predominant irritable bowel syndrome. Int J Womens Health (2010) 0.85
Prostaglandin E2 EP3 receptor regulates cyclooxygenase-2 expression in the kidney. Am J Physiol Renal Physiol (2012) 0.84
Effects of lubiprostone on pacemaker activity of interstitial cells of cajal from the mouse colon. Korean J Physiol Pharmacol (2014) 0.79
Challenges and prospects for pharmacotherapy in functional gastrointestinal disorders. Therap Adv Gastroenterol (2010) 0.78
Prokinetic effects of large-dose lubiprostone on gastrointestinal transit in dogs and its mechanisms. Am J Transl Res (2015) 0.78
Lubiprostone induced ischemic colitis. World J Gastroenterol (2013) 0.78
Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice. PLoS One (2016) 0.77
New treatment options for chronic constipation: mechanisms, efficacy and safety. Can J Gastroenterol (2011) 0.77
Role of lubiprostone on gastrointestinal motility. J Neurogastroenterol Motil (2013) 0.76
A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa. Pharmacol Res Perspect (2015) 0.76
Lubiprostone: clinical applications beyond constipation. World J Gastroenterol (2009) 0.76
May the truth be with you: lubiprostone as EP receptor agonist/ClC-2 internalizing "inhibitor". Dig Dis Sci (2012) 0.76
ClC-2 regulation of intestinal barrier function: Translation of basic science to therapeutic target. Tissue Barriers (2015) 0.75
Treatment of Chronic Constipation: Prescription Medications and Surgical Therapies. Gastroenterol Hepatol (N Y) (2015) 0.75
Adenosine A(1) and prostaglandin E receptor 3 receptors mediate global airway contraction after local epithelial injury. Am J Respir Cell Mol Biol (2012) 0.75
Lubiprostone improves intestinal permeability in humans, a novel therapy for the leaky gut: A prospective randomized pilot study in healthy volunteers. PLoS One (2017) 0.75
SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol (2004) 2.33
Effect of 5 days linaclotide on transit and bowel function in females with constipation-predominant irritable bowel syndrome. Gastroenterology (2007) 2.30
Effect of a selective chloride channel activator, lubiprostone, on gastrointestinal transit, gastric sensory, and motor functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol (2006) 1.94
GW627368X ((N-{2-[4-(4,9-diethoxy-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl)phenyl]acetyl} benzene sulphonamide): a novel, potent and selective prostanoid EP4 receptor antagonist. Br J Pharmacol (2006) 1.17
Structure-activity relationship of cinnamic acylsulfonamide analogues on the human EP3 prostanoid receptor. Bioorg Med Chem (2001) 1.16
Efferent-like roles of afferent neurons in the gut: Blood flow regulation and tissue protection. Auton Neurosci (2006) 1.13
Cellular distribution of prostanoid EP receptors mRNA in the rat gastrointestinal tract. Prostaglandins Other Lipid Mediat (2000) 1.04
Lubiprostone: a chloride channel activator for treatment of chronic constipation. Ann Pharmacother (2007) 1.01
Characterization of [3H]-prostaglandin E2 binding to prostaglandin EP4 receptors expressed with Semliki Forest virus. Br J Pharmacol (1997) 0.98
Characterization of prostanoid receptors mediating actions of the isoprostanes, 8-iso-PGE(2) and 8-iso-PGF(2alpha), in some isolated smooth muscle preparations. Br J Pharmacol (2000) 0.96
Actions of prostanoids to induce emesis and defecation in the ferret. Eur J Pharmacol (2002) 0.88
New drugs 07, part I. Nursing (2007) 0.86
Excitatory action of prostanoids on the ferret isolated vagus nerve preparation. Eur J Pharmacol (2004) 0.85
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein. Science (1996) 8.14
Complete genome sequence and comparative analysis of the metabolically versatile Pseudomonas putida KT2440. Environ Microbiol (2002) 8.11
The CONSTANS gene of Arabidopsis promotes flowering and encodes a protein showing similarities to zinc finger transcription factors. Cell (1995) 7.76
Coverage by the news media of the benefits and risks of medications. N Engl J Med (2000) 7.50
Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector. Genes Dev (1989) 6.81
PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth. Science (1996) 6.33
GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic flowering in Arabidopsis and encodes a protein with several possible membrane-spanning domains. EMBO J (1999) 5.60
Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell (2001) 5.39
Advancing the science of symptom management. J Adv Nurs (2001) 3.14
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth. Dev Biol (2001) 3.13
Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure (1998) 3.10
Inhibition of cisplatin-induced vomiting by selective 5-hydroxytryptamine M-receptor antagonism. Br J Pharmacol (1986) 2.93
CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes. J Immunol (1990) 2.84
The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev (2000) 2.72
A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1997) 2.69
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking. Science (1991) 2.65
Complicity in contraband: British American Tobacco and cigarette smuggling in Asia. Tob Control (2004) 2.64
Strengthening governance for global health research. BMJ (2000) 2.57
Surgical site infection after groin hernia repair. Br J Surg (2004) 2.54
Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide. Proc Natl Acad Sci U S A (1997) 2.52
A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells. Nat Genet (1999) 2.51
Electrical control of antiferromagnetic domains in multiferroic BiFeO3 films at room temperature. Nat Mater (2006) 2.49
The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol (2013) 2.48
Mortality of gasworkers - final report of a prospective study. Br J Ind Med (1972) 2.31
sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development. Development (2000) 2.28
The face-inversion effect as a deficit in the encoding of configural information: direct evidence. Perception (2000) 2.24
Targeted disruption of the LAMA3 gene in mice reveals abnormalities in survival and late stage differentiation of epithelial cells. J Cell Biol (1999) 2.14
Neuropharmacology of emesis induced by anti-cancer therapy. Trends Pharmacol Sci (1988) 2.13
Implications of early systemic therapy on the incidence of endogenous fungal endophthalmitis. Ophthalmology (1997) 2.12
Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol Cell Biol (1997) 2.11
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1. Pain (2000) 2.11
A cysteine-rich adipose tissue-specific secretory factor inhibits adipocyte differentiation. J Biol Chem (2001) 2.09
Endoscopic ultrasound-guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: a multicenter experience. Endoscopy (2007) 2.08
Subunit positional effects revealed by novel heteromeric inwardly rectifying K+ channels. EMBO J (1996) 2.03
British American Tobacco and the "insidious impact of illicit trade" in cigarettes across Africa. Tob Control (2008) 2.02
Factors affecting the forward shift of posterior corneal surface after laser in situ keratomileusis. Ophthalmology (2001) 2.00
Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. Am J Pathol (1993) 1.94
The parathyroid hormone/parathyroid hormone-related peptide receptor coordinates endochondral bone development by directly controlling chondrocyte differentiation. Proc Natl Acad Sci U S A (1998) 1.94
CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production. J Immunol (1992) 1.91
beta 3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci U S A (2000) 1.89
A short sequence upstream of the 5' major splice site is important for encapsidation of HIV-1 genomic RNA. Virology (1994) 1.89
Plasmid-encoded AmpC beta-lactamases: how far have we gone 10 years after the discovery? Yonsei Med J (1998) 1.88
Multiple organ dysfunction: baseline and serial component scores. Crit Care Med (2001) 1.88
Differential gene expression profiling in human brain tumors. Physiol Genomics (2001) 1.88
Potentially lethal bacterial infection associated with varicella zoster virus. BMJ (1996) 1.88
Desaturation, dioxygenation, and monooxygenation reactions catalyzed by naphthalene dioxygenase from Pseudomonas sp. strain 9816-4. J Bacteriol (1995) 1.84
Alcohol-induced brain damage and liver damage in young males. Lancet (1979) 1.82
Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects. J Periodontol (1992) 1.80
Vibrio alginolyticus infections in Hawaii. J Clin Microbiol (1977) 1.79
Place your BETs: the therapeutic potential of bromodomains. Trends Pharmacol Sci (2012) 1.71
Viruses of symbiotic Chlorella-like algae isolated from Paramecium bursaria and Hydra viridis. Proc Natl Acad Sci U S A (1982) 1.70
Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine. J Biol Chem (2001) 1.68
Isolation and characterization of toluene-sensitive mutants from the toluene-resistant bacterium Pseudomonas putida GM73. J Bacteriol (1998) 1.68
Deep-vein thrombosis rates after major orthopedic surgery in Asia. An epidemiological study based on postoperative screening with centrally adjudicated bilateral venography. J Thromb Haemost (2005) 1.66
Release of lactate by the lung in acute lung injury. Chest (1997) 1.66
Substrate binding site of naphthalene 1,2-dioxygenase: functional implications of indole binding. J Mol Biol (2000) 1.62
Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. Br J Pharmacol (2002) 1.60
Spread of the serotype 23F multidrug-resistant Streptococcus pneumoniae clone to South Korea. Microb Drug Resist (1997) 1.59
Regiospecific and stereoselective hydroxylation of 1-indanone and 2-indanone by naphthalene dioxygenase and toluene dioxygenase. Appl Environ Microbiol (1994) 1.57
Imaging superficial tissues with polarized light. Lasers Surg Med (2000) 1.55
Smuggling as the "key to a combined market": British American Tobacco in Lebanon. Tob Control (2008) 1.55
Effects of short-term recombinant human insulin-like growth factor I administration on bone turnover in osteopenic women with anorexia nervosa. J Clin Endocrinol Metab (1996) 1.54
Substrate specificity of naphthalene dioxygenase: effect of specific amino acids at the active site of the enzyme. J Bacteriol (2000) 1.54
Identification of ecdysone response elements by analysis of the Drosophila Eip28/29 gene. Genes Dev (1991) 1.53
Risk models for mortality following elective open and endovascular abdominal aortic aneurysm repair: a single institution experience. Eur J Vasc Endovasc Surg (2012) 1.53
Location of the mouse complement factor H gene (cfh) by FISH analysis and replication R-banding. Cytogenet Cell Genet (1992) 1.53
Surface damage to cobalt-chrome femoral head prostheses. J Bone Joint Surg Br (1994) 1.50
Stage-specific accumulation of the terminal differentiation factor LIN-29 during Caenorhabditis elegans development. Development (1996) 1.50
The anti-emetic potential of the 5-hydroxytryptamine3 receptor antagonist BRL 43694. Br J Cancer (1988) 1.48
Proficient manipulation of fibreoptic bronchoscope to carina by novices on first clinical attempt after specialized bench practice. Br J Anaesth (2010) 1.43
Previously undetected human hematopoietic cell populations with short-term repopulating activity selectively engraft NOD/SCID-beta2 microglobulin-null mice. J Clin Invest (2001) 1.43
The sodium channel beta-subunit SCN3b modulates the kinetics of SCN5a and is expressed heterogeneously in sheep heart. J Physiol (2001) 1.43
Increased gut cholinergic activity and antagonism of 5-hydroxytryptamine M-receptors by BRL 24924: potential clinical importance of BRL 24924. Br J Pharmacol (1987) 1.41
What are the barriers faced by general practitioners in treating depression and anxiety in Hong Kong? Int J Clin Pract (2006) 1.41
Determinants of the neonatal mortality. Am J Dis Child (1976) 1.41
Association of standardized estimated glomerular filtration rate with the prevalence of hypertension among adults in the United States. J Hum Hypertens (2011) 1.40
The Doa locus encodes a member of a new protein kinase family and is essential for eye and embryonic development in Drosophila melanogaster. Genes Dev (1994) 1.40
Infection of a Chlorella-like alga with the virus, PBCV-1: ultrastructural studies. Virology (1984) 1.39
Endoscopic sphincterotomy in young patients with choledochal dilatation and a long common channel: a preliminary report. Br J Surg (1992) 1.39
The role of the primate extrastriate area V4 in vision. Science (1991) 1.38
Attractiveness of facial averageness and symmetry in non-western cultures: in search of biologically based standards of beauty. Perception (2001) 1.37
Cellular and molecular action of the putative GABA-mimetic, gabapentin. Cell Mol Life Sci (2003) 1.37
Characterization and targeted disruption of murine Nup50, a p27(Kip1)-interacting component of the nuclear pore complex. Mol Cell Biol (2000) 1.36
The binding site for ribosomal protein L11 within 23 S ribosomal RNA of Escherichia coli. J Biol Chem (1981) 1.36
Impact of residential nitrogen dioxide exposure on personal exposure: an international study. J Air Waste Manag Assoc (1998) 1.36
Globalisation and public health. J Epidemiol Community Health (2002) 1.34
Symbiotic Role of the Viable but Nonculturable State of Vibrio fischeri in Hawaiian Coastal Seawater. Appl Environ Microbiol (1995) 1.33
The mode selection trial (MOST) in sinus node dysfunction: design, rationale, and baseline characteristics of the first 1000 patients. Am Heart J (2000) 1.33
Korean Nationwide Surveillance of Antimicrobial Resistance of bacteria in 1997. Yonsei Med J (1998) 1.31
Impaired innate immunity in the newborn: newborn neutrophils are deficient in bactericidal/permeability-increasing protein. Pediatrics (1999) 1.31
An RNA species involved in Escherichia coli ribonuclease P activity. Gene cloning and effect on transfer RnA synthesis in vivo. J Mol Biol (1982) 1.31
Particulate exposure and size distribution from wood burning stoves in Costa Rica. Indoor Air (2003) 1.30
Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J Biol Chem (2001) 1.30
Randomized controlled trial comparing the McGrath videolaryngoscope with the C-MAC videolaryngoscope in intubating adult patients with potential difficult airways. Br J Anaesth (2012) 1.30
Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar. Dev Dyn (2004) 1.30
Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol (1997) 1.29
Acute pancreatitis and bacterial translocation. Dig Dis Sci (2001) 1.29