Published in Nature on December 04, 1997
The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits. Int J Biol Sci (2005) 2.76
G-protein signaling: back to the future. Cell Mol Life Sci (2005) 2.38
TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc Natl Acad Sci U S A (2009) 2.20
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol (2005) 1.68
R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther (2007) 1.63
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal (2015) 1.61
Rapid GTP binding and hydrolysis by G(q) promoted by receptor and GTPase-activating proteins. Proc Natl Acad Sci U S A (1999) 1.61
Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers. Biochim Biophys Acta (2006) 1.53
Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels. Proc Natl Acad Sci U S A (1998) 1.46
C. elegans G protein regulator RGS-3 controls sensitivity to sensory stimuli. Neuron (2007) 1.36
Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun (2011) 1.34
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity. Proc Natl Acad Sci U S A (2010) 1.30
Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis lines. Proc Natl Acad Sci U S A (2008) 1.17
Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation. J Physiol (2002) 1.11
Abundance and stability of complexes containing inactive G protein-coupled receptors and G proteins. FASEB J (2008) 1.09
Interaction between RGS7 and polycystin. Proc Natl Acad Sci U S A (1999) 1.09
New roles for RGS2, 5 and 8 on the ratio-dependent modulation of recombinant GIRK channels expressed in Xenopus oocytes. J Physiol (1999) 1.08
Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction. Proc Natl Acad Sci U S A (2004) 1.06
Voltage- and [ATP]-dependent gating of the P2X(2) ATP receptor channel. J Gen Physiol (2009) 1.03
A regulator of G protein signalling (RGS) protein confers agonist-dependent relaxation gating to a G protein-gated K+ channel. J Physiol (2000) 1.01
G protein modulation of recombinant P/Q-type calcium channels by regulators of G protein signalling proteins. J Physiol (2000) 1.00
Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits. Mol Cell Biol (2009) 0.99
Muscarinic K+ channel in the heart. Modal regulation by G protein beta gamma subunits. J Gen Physiol (1998) 0.98
Kinetic diversity in G-protein-coupled receptor signalling. Biochem J (2007) 0.96
Differential regulation of G protein-gated inwardly rectifying K(+) channel kinetics by distinct domains of RGS8. J Physiol (2001) 0.94
Regulators of G protein signaling attenuate the G protein-mediated inhibition of N-type Ca channels. J Gen Physiol (1999) 0.93
Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling. J Biol Chem (2009) 0.93
Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel. J Physiol (2001) 0.93
Cell signal control of the G protein-gated potassium channel and its subcellular localization. J Physiol (2003) 0.92
Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. Pflugers Arch (2004) 0.91
Endogenous regulators of G protein signaling proteins regulate presynaptic inhibition at rat hippocampal synapses. Proc Natl Acad Sci U S A (2000) 0.91
Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Galpha subtype dependent. J Neurochem (2009) 0.89
Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. Proc Natl Acad Sci U S A (2003) 0.89
RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons. Proc Natl Acad Sci U S A (2003) 0.88
A role for RGS10 in beta-adrenergic modulation of G-protein-activated K+ (GIRK) channel current in rat atrial myocytes. J Physiol (2008) 0.87
Single channel analysis of the regulation of GIRK1/GIRK4 channels by protein phosphorylation. Biophys J (2003) 0.86
Alternative splicing of RGS8 gene determines inhibitory function of receptor type-specific Gq signaling. Proc Natl Acad Sci U S A (2002) 0.85
Graded contribution of the Gbeta gamma binding domains to GIRK channel activation. Proc Natl Acad Sci U S A (2002) 0.85
The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels. Channels (Austin) (2010) 0.84
R4 Regulator of G Protein Signaling (RGS) Proteins in Inflammation and Immunity. AAPS J (2015) 0.84
Acute desensitization of GIRK current in rat atrial myocytes is related to K+ current flow. J Physiol (2004) 0.84
RNA interference screen for RGS protein specificity at muscarinic and protease-activated receptors reveals bidirectional modulation of signaling. Am J Physiol Cell Physiol (2010) 0.83
Roles for Regulator of G Protein Signaling Proteins in Synaptic Signaling and Plasticity. Mol Pharmacol (2015) 0.81
Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. PLoS Genet (2015) 0.80
Expression of regulator of G protein signalling proteins in natural killer cells, and their modulation by Ly49A and Ly49D. Immunology (2005) 0.80
And the winner is ... RGS4! Circ Res (2008) 0.79
Functional characterization of a small conductance GIRK channel in rat atrial cells. Biophys J (2004) 0.78
The Ras-binding domain region of RGS14 regulates its functional interactions with heterotrimeric G proteins. J Cell Biochem (2013) 0.78
Normal Thymocyte Egress, T Cell Trafficking, and CD4(+) T Cell Homeostasis Require Interactions between RGS Proteins and Gαi2. J Immunol (2017) 0.75
A ciliary opsin in the brain of a marine annelid zooplankton is UV-sensitive and the sensitivity is tuned by a single amino acid residue. J Biol Chem (2017) 0.75
Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc (1987) 12.04
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature (1999) 3.93
Choice in the repeated-gambles experiment. J Exp Anal Behav (1988) 3.57
Propensity of ectopic liver to hepatocarcinogenesis: case reports and a review of the literature. Hepatology (1999) 3.29
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res (1990) 2.76
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet (1992) 2.71
A prolactin-releasing peptide in the brain. Nature (1998) 2.43
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem (1998) 2.42
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. J Nucl Med (1992) 2.30
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat Genet (1995) 2.25
Cyclic nucleotide-gated channels colocalize with adenylyl cyclase in regions of restricted cAMP diffusion. J Gen Physiol (2000) 2.25
Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation (1987) 2.15
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene (1990) 2.12
Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia (1993) 2.11
Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery (1999) 2.09
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol (2000) 2.04
Effects of combination treatment with FK506 and cyclosporine on survival time and vascular changes in renal-allograft-recipient dogs. Transplantation (1989) 2.03
Formation of the male-specific muscle in female Drosophila by ectopic fruitless expression. Nat Cell Biol (2000) 1.99
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol (1995) 1.97
Differential expression and internal feedback regulation of 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase, and ethylene receptor genes in tomato fruit during development and ripening. Plant Physiol (1998) 1.96
Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese. Gut (1997) 1.89
Reconstitution of catecholamine-stimulated guanosinetriphosphatase activity. Biochemistry (1983) 1.87
Role of infrainguinal bypass in Buerger's disease: an eighteen-year experience. Eur J Vasc Endovasc Surg (1997) 1.83
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation (1997) 1.83
Peripheral lung adenocarcinoma: correlation of thin-section CT findings with histologic prognostic factors and survival. Radiology (2001) 1.82
Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group. Stroke (1998) 1.79
The Colletotrichum lagenarium MAP kinase gene CMK1 regulates diverse aspects of fungal pathogenesis. Mol Plant Microbe Interact (2000) 1.69
Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem (1996) 1.59
Studies with antipeptide antibody suggest the presence of at least two types of glucose transporter in rat brain and adipocyte. J Biol Chem (1988) 1.59
Evolution of peripheral lung adenocarcinomas: CT findings correlated with histology and tumor doubling time. AJR Am J Roentgenol (2000) 1.57
Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma. J Invest Dermatol (1995) 1.55
Human neurolymphomatosis by adult T-cell leukemia. Neurology (1989) 1.54
Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins (1977) 1.53
Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model. Jpn J Cancer Res (1997) 1.52
Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J Biol Chem (1997) 1.51
Cloning and expression of an A1 adenosine receptor from rat brain. Mol Pharmacol (1991) 1.51
Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria. Bioorg Med Chem (2000) 1.50
Cloning and characterization of a melanin biosynthetic THR1 reductase gene essential for appressorial penetration of Colletotrichum lagenarium. Mol Plant Microbe Interact (1996) 1.50
Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: a study of 57 autopsy-proven cases. Cancer (1977) 1.49
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res (1999) 1.48
Multiple PIP2 binding sites in Kir2.1 inwardly rectifying potassium channels. FEBS Lett (2001) 1.47
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J Biol Chem (1996) 1.47
Heteromeric association creates a P2Y-like adenosine receptor. Proc Natl Acad Sci U S A (2001) 1.46
Screening of patients with maternally transmitted diabetes for mitochondrial gene mutations in the tRNA[Leu(UUR)] region. Diabet Med (1997) 1.46
Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium. Mol Gen Genet (1995) 1.46
Effects of staphylococcal enterotoxin B on intestinal transport in the rat. Am J Physiol (1971) 1.45
Irreversible data compression in chest imaging using computed radiography: an evaluation. J Thorac Imaging (1994) 1.45
Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after carotid endarterectomy: a 3T proton MR spectroscopy study. AJNR Am J Neuroradiol (2012) 1.44
Naftopidil, a novel alpha1-adrenoceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human alpha1-adrenoceptors. Jpn J Pharmacol (1999) 1.41
Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes. J Biol Chem (1996) 1.39
Radiation exposure to anaesthetists during endovascular procedures. Anaesthesia (2014) 1.38
Prolongation of canine renal allograft survival by treatment with FK-506. Transplant Proc (1987) 1.38
Copurification of small heat shock protein with alpha B crystallin from human skeletal muscle. J Biol Chem (1992) 1.37
p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem (1997) 1.37
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes (1998) 1.37
Treatment of pyogenic granuloma with a sclerosing agent. Dermatol Surg (2001) 1.37
Maximizing present value: A model to explain why moderate response rates obtain on variable-interval schedules. J Exp Anal Behav (1988) 1.33
Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity. Mol Cell Biol (2001) 1.32
14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain. J Biol Chem (1997) 1.32
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes. Diabetes (1999) 1.32
Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1. Biochemistry (2000) 1.28
Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles. J Biol Chem (1986) 1.27
C-terminal truncated glucose transporter is locked into an inward-facing form without transport activity. Nature (1990) 1.27
Human blood platelet 3': 5'-cyclic nucleotide phosphodiesterase. Isolation of low-Km and high-Km phosphodiesterase. Biochim Biophys Acta (1976) 1.26
Spectroscopic and kinetic evidence for the thiolate anion of glutathione at the active site of glutathione S-transferase. Biochemistry (1989) 1.26
Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. J Biol Chem (1994) 1.25
STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma. Br J Cancer (2010) 1.25
Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. Life Sci (2001) 1.25
Successful combined operation for mitral stenosis and atrial fibrillation. Ann Thorac Surg (1993) 1.24
Reconstitution of catecholamine-stimulated binding of guanosine 5'-O-(3-thiotriphosphate) to the stimulatory GTP-binding protein of adenylate cyclase. Biochemistry (1984) 1.24
The radiological findings in chronic expanding hematoma. Skeletal Radiol (1999) 1.23
Intraductal papillary mucinous tumors of the pancreas. Am J Surg (1999) 1.23
Intrapancreatic accessory spleen diagnosed by technetium-99m heat-damaged red blood cell SPECT. J Nucl Med (1997) 1.23
Gelation of Limulus amoebocyte lysate by an antitumor (1 leads to 3)-beta-D-glucan. Biochem Biophys Res Commun (1981) 1.23
Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction. Diabetes (2000) 1.22
Metabolism of vitamin D in animals. V. Isolation of vitamin D sulfate from mammalian milk. J Vitaminol (Kyoto) (1967) 1.21
Purification and characterization of recombinant human interleukin-2 produced in Escherichia coli. Biochem Biophys Res Commun (1985) 1.21
Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem Biophys Res Commun (1995) 1.19
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem (1996) 1.18
Effects of rabeprazole, lansoprazole and omeprazole on intragastric pH in CYP2C19 extensive metabolizers. Aliment Pharmacol Ther (2002) 1.18
Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Int J Radiat Biol (2003) 1.17
Protective immune responses induced by secretion of a chimeric soluble protein from a recombinant Mycobacterium bovis bacillus Calmette-Guérin vector candidate vaccine for human immunodeficiency virus type 1 in small animals. Proc Natl Acad Sci U S A (1995) 1.17
Defect in negative selection in lpr donor-derived T cells differentiating in non-lpr host thymus. J Exp Med (1991) 1.16
Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo. Cardiovasc Res (2001) 1.15
Clinicopathologic features of encapsulated hepatocellular carcinoma: a study of 26 cases. Cancer (1977) 1.15
Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma--a comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Cancer Chemother Pharmacol (1992) 1.15
CT simulator: a new 3-D planning and simulating system for radiotherapy: Part 1. Description of system. Int J Radiat Oncol Biol Phys (1990) 1.14
Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of PI3 kinase/Akt. Circulation (2000) 1.14
Vasodilatory action of HA1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide], a novel calcium antagonist with no effect on cardiac function. J Pharmacol Exp Ther (1984) 1.14
Two glucose transporter isoforms are sorted differentially and are expressed in distinct cellular compartments. Biochem J (1992) 1.13
Identification of inosine and hypoxanthine as endogenous ligands for the brain benzodiazepine-binding sites. Proc Natl Acad Sci U S A (1979) 1.13
Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet (1999) 1.12
Activation of the inhibitory GTP-binding protein of adenylate cyclase, Gi, by beta-adrenergic receptors in reconstituted phospholipid vesicles. J Biol Chem (1984) 1.12