Published in Stroke on January 01, 1998
Redox regulation of cell survival. Antioxid Redox Signal (2008) 4.33
Neuroprotection for ischemic stroke: past, present and future. Neuropharmacology (2008) 3.04
Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch (2010) 2.83
Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke (2006) 2.54
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal (2011) 1.57
A safe lithium mimetic for bipolar disorder. Nat Commun (2013) 1.51
Oxidative stress in early diabetic nephropathy: fueling the fire. Nat Rev Endocrinol (2010) 1.51
Thioredoxins, glutaredoxins, and peroxiredoxins--molecular mechanisms and health significance: from cofactors to antioxidants to redox signaling. Antioxid Redox Signal (2013) 1.48
Selective impairment of hippocampal neurogenesis by chronic alcoholism: protective effects of an antioxidant. Proc Natl Acad Sci U S A (2003) 1.36
Selenium: its role as antioxidant in human health. Environ Health Prev Med (2008) 1.28
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx (2006) 1.21
Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons. Proc Natl Acad Sci U S A (2009) 1.20
Catalase and glutathione peroxidase mimics. Biochem Pharmacol (2008) 1.19
Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies. Life Sci (2011) 1.16
Ebselen: a substrate for human thioredoxin reductase strongly stimulating its hydroperoxide reductase activity and a superfast thioredoxin oxidant. Proc Natl Acad Sci U S A (2002) 1.15
Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis. Crit Care (2012) 1.12
Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans. Neuropsychopharmacology (2015) 1.11
A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis (2010) 1.10
Clinical trials for cytoprotection in stroke. NeuroRx (2004) 1.08
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
Central nervous system agents for ischemic stroke: neuroprotection mechanisms. Cent Nerv Syst Agents Med Chem (2011) 1.06
Brief exposure to hyperoxia depletes the glial progenitor pool and impairs functional recovery after hypoxic-ischemic brain injury. J Cereb Blood Flow Metab (2008) 1.04
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action. J Biol Chem (2010) 1.01
Autologous intravenous bone marrow mononuclear cell therapy for patients with subacute ischaemic stroke: a pilot study. Indian J Med Res (2012) 1.00
Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake. Chem Biol (2006) 0.98
Methylmercury-induced alterations in astrocyte functions are attenuated by ebselen. Neurotoxicology (2011) 0.98
Antioxidants: The new frontier for translational research in cerebroprotection. J Anaesthesiol Clin Pharmacol (2014) 0.92
Xyloketal B exhibits its antioxidant activity through induction of HO-1 in vascular endothelial cells and zebrafish. Mar Drugs (2013) 0.91
Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi. Mol Biochem Parasitol (2009) 0.90
Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors. Biochem Biophys Res Commun (2013) 0.89
Noninvasive MRI monitoring of the effect of interventions on endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent. J Am Heart Assoc (2013) 0.89
High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S). Mol Cancer Ther (2011) 0.89
NADPH oxidase in stroke and cerebrovascular disease. Neurol Res (2012) 0.88
Lipoxygenase: an emerging target for stroke therapy. CNS Neurol Disord Drug Targets (2013) 0.88
AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils. Br J Pharmacol (2007) 0.88
Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress. Free Radic Biol Med (2012) 0.87
Why have neuro-protectants failed?: lessons learned from stroke trials. J Neurol (2005) 0.87
Ebselen induced C6 glioma cell death in oxygen and glucose deprivation. Chem Res Toxicol (2006) 0.87
Ebselen attenuates oxidative stress-induced apoptosis via the inhibition of the c-Jun N-terminal kinase and activator protein-1 signalling pathway in PC12 cells. Br J Pharmacol (2002) 0.87
Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes (2013) 0.86
Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila. Hum Mol Genet (2014) 0.86
Screening for dimethylarginine dimethylaminohydrolase inhibitors reveals ebselen as a bioavailable inactivator. ACS Med Chem Lett (2011) 0.84
Induction of apoptosis in human multiple myeloma cell lines by ebselen via enhancing the endogenous reactive oxygen species production. Biomed Res Int (2014) 0.84
Oxidative Stress and the Use of Antioxidants in Stroke. Antioxidants (Basel) (2014) 0.84
Inactivation of the Mycobacterium tuberculosis antigen 85 complex by covalent, allosteric inhibitors. J Biol Chem (2014) 0.83
Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. Diabetes (2010) 0.83
Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. J Biol Inorg Chem (2012) 0.82
Strategies for Pharmacological Organoprotection during Extracorporeal Circulation Targeting Ischemia-Reperfusion Injury. Front Pharmacol (2015) 0.82
Cytotoxicity and genotoxicity evaluation of organochalcogens in human leucocytes: a comparative study between ebselen, diphenyl diselenide, and diphenyl ditelluride. Biomed Res Int (2013) 0.81
Oxidative Stress in Diabetic Nephropathy with Early Chronic Kidney Disease. J Diabetes Res (2016) 0.81
Selenite stimulates mitochondrial biogenesis signaling and enhances mitochondrial functional performance in murine hippocampal neuronal cells. PLoS One (2012) 0.80
Pharmacology of iron transport. Annu Rev Pharmacol Toxicol (2012) 0.79
Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia-ischemia in neonatal rats. Exp Neurol (2013) 0.79
Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines. Oncotarget (2015) 0.78
Molecular Dissection of Cyclosporin A's Neuroprotective Effect Reveals Potential Therapeutics for Ischemic Brain Injury. Brain Sci (2013) 0.78
Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity. ChemMedChem (2016) 0.78
Cell Death-Autophagy Loop and Glutamate-Glutamine Cycle in Amyotrophic Lateral Sclerosis. Front Mol Neurosci (2017) 0.77
Identification of small molecules that inhibit the interaction of TEM8 with anthrax protective antigen using a FRET assay. J Biomol Screen (2013) 0.77
Apocynin and ebselen reduce influenza A virus-induced lung inflammation in cigarette smoke-exposed mice. Sci Rep (2016) 0.77
Development of ebsulfur analogues as potent antibacterials against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem (2016) 0.77
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. Antioxid Redox Signal (2014) 0.77
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice. J Neurochem (2012) 0.77
Cerebral Small Vessel Disease: Targeting Oxidative Stress as a Novel Therapeutic Strategy? Front Pharmacol (2016) 0.76
Glutathione peroxidase mimic ebselen improves glucose-stimulated insulin secretion in murine islets. Antioxid Redox Signal (2013) 0.76
Neuroprotection by Polynitrogen Manganese Complexes: Regulation of Reactive Oxygen Species-Related Pathways. Sci Rep (2016) 0.75
Advances in the Microbiome: Applications to Clostridium difficile Infection. J Clin Med (2016) 0.75
Targeting antioxidant enzyme expression as a therapeutic strategy for ischemic stroke. Neurochem Int (2016) 0.75
Selenium in the Therapy of Neurological Diseases. Where is it Going? Curr Neuropharmacol (2016) 0.75
XAS studies of Se speciation in selenite-fed rats. Metallomics (2014) 0.75
Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial. Am J Physiol Heart Circ Physiol (2016) 0.75
High-dose intravenous selenium does not improve clinical outcomes in the critically ill: a systematic review and meta-analysis. Crit Care (2016) 0.75
Some nontoxic metal-based drugs for selected prevalent tropical pathogenic diseases. J Biol Inorg Chem (2016) 0.75
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem (1982) 16.71
Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc (1987) 12.04
Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology (1990) 6.34
HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Nucleic Acids Res (1989) 4.29
Human immunodeficiency virus type 1 infection in homosexual men who remain seronegative for prolonged periods. N Engl J Med (1989) 4.20
Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature (1999) 3.93
Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome. Proc Natl Acad Sci U S A (1996) 3.85
Choice in the repeated-gambles experiment. J Exp Anal Behav (1988) 3.57
Role of nucleotide sequences of loxP spacer region in Cre-mediated recombination. Gene (1998) 3.31
Development of an MRI-compatible needle insertion manipulator for stereotactic neurosurgery. J Image Guid Surg (1995) 3.07
The genetic structure of natural populations of Drosophila melanogaster. IV. Heterozygous effects of radiation-induced mutations on viability in various genetic backgrounds. Genetics (1966) 2.95
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res (1995) 2.79
Treatment of dry eye by autologous serum application in Sjögren's syndrome. Br J Ophthalmol (1999) 2.77
Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res (1990) 2.76
Recurrent subarachnoid hemorrhage from untreated ruptured vertebrobasilar dissecting aneurysms. Neurosurgery (1995) 2.71
Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet (1992) 2.71
Pituitary apoplexy: its incidence and clinical significance. J Neurosurg (1981) 2.65
Primary structure of poliovirus defective-interfering particle genomes and possible generation mechanisms of the particles. J Mol Biol (1986) 2.63
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases. J Neurosurg (1997) 2.60
DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrob Agents Chemother (1995) 2.57
PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification. Am J Pathol (2001) 2.52
A prolactin-releasing peptide in the brain. Nature (1998) 2.43
Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery (1999) 2.43
Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. J Biol Chem (1998) 2.42
Charomids: cosmid vectors for efficient cloning and mapping of large or small restriction fragments. Proc Natl Acad Sci U S A (1986) 2.42
Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrob Agents Chemother (1996) 2.42
Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul (1991) 2.38
High-affinity receptor-mediated internalization and degradation of interleukin 2 in human T cells. J Exp Med (1986) 2.37
Angiotensin II antagonists for hypertension: are there differences in efficacy? Am J Hypertens (2000) 2.35
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. J Nucl Med (1992) 2.30
Glia-synapse interaction through Ca2+-permeable AMPA receptors in Bergmann glia. Science (2001) 2.29
Selective vulnerability in the gerbil hippocampus following transient ischemia. Acta Neuropathol (1984) 2.27
Randomized comparison of ultrasonic vs clamp transection of the liver. Arch Surg (2001) 2.25
Treatment of severe intraventricular hemorrhage by intraventricular infusion of urokinase. J Neurosurg (1991) 2.24
Structure and gene organization in the transformed Hind III-G fragment of Ad12. Cell (1980) 2.22
Spontaneous intracranial hemorrhage caused by brain tumor: its incidence and clinical significance. Neurosurgery (1982) 2.16
Studies of the induction and maintenance of long-term graft acceptance by treatment with FK506 in heterotopic cardiac allotransplantation in rats. Transplantation (1987) 2.15
Detection of antibody against antigen expressed by molecularly cloned hepatitis C virus cDNA: application to diagnosis and blood screening for posttransfusion hepatitis. Proc Natl Acad Sci U S A (1990) 2.12
Hepatitis C viral cDNA clones isolated from a healthy carrier donor implicated in post-transfusion non-A, non-B hepatitis. Gene (1990) 2.12
Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia (1993) 2.11
Risk of bile duct carcinogenesis after excision of extrahepatic bile ducts in pancreaticobiliary maljunction. Surgery (1999) 2.09
Identification of alpha-fodrin as a candidate autoantigen in primary Sjögren's syndrome. Science (1997) 2.06
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts. J Cell Biol (2000) 2.04
Synergistic functions of phorbol ester and calcium in serotonin release from human platelets. Biochem Biophys Res Commun (1983) 2.03
Effects of combination treatment with FK506 and cyclosporine on survival time and vascular changes in renal-allograft-recipient dogs. Transplantation (1989) 2.03
Transgenesis by adenovirus-mediated gene transfer into mouse zona-free eggs. Nat Biotechnol (1996) 2.03
A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions. J Biol Chem (1983) 2.02
A universal subarachnoid hemorrhage scale: report of a committee of the World Federation of Neurosurgical Societies. J Neurol Neurosurg Psychiatry (1988) 1.99
Scanning of guanine-guanine mismatches in DNA by synthetic ligands using surface plasmon resonance. Nat Biotechnol (2001) 1.98
A simple and efficient method for purification of infectious recombinant adenovirus. Jpn J Med Sci Biol (1994) 1.97
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol (1995) 1.97
Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation. Antimicrob Agents Chemother (2001) 1.96
Expression of processed core protein of hepatitis C virus in mammalian cells. J Virol (1991) 1.91
Clinical course and surgical prognosis of 33 cases of intracranial epidermoid tumors. Neurosurgery (1989) 1.90
Intrafamilial transmission of hepatitis C virus. Lancet (1989) 1.90
Surgical techniques and innovations in living related liver transplantation. Ann Surg (1993) 1.88
Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome. J Virol (1985) 1.88
Reconstitution of catecholamine-stimulated guanosinetriphosphatase activity. Biochemistry (1983) 1.87
Nitric oxide production and inducible nitric oxide synthase expression in inflammatory arthritides. J Clin Invest (1995) 1.85
Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta. Circulation (1997) 1.83
Efficient gene transfer into various mammalian cells, including non-hepatic cells, by baculovirus vectors. J Gen Virol (1997) 1.82
Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg (1992) 1.77
RGS8 accelerates G-protein-mediated modulation of K+ currents. Nature (1997) 1.73
Persistent and secondary adenovirus-mediated hepatic gene expression using adenovirus vector containing CTLA4IgG. Hum Gene Ther (1998) 1.72
Arteriovenous malformations in the basal ganglia and thalamus: management and results in 101 cases. J Neurosurg (1998) 1.72
Predictive value of gross classification of hepatocellular carcinoma on recurrence and survival after hepatectomy. J Hepatol (2000) 1.71
Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells. J Virol (1992) 1.68
An objective assessment of intermittent claudication by near-infrared spectroscopy. Eur J Vasc Surg (1994) 1.64
Risk of developing ovarian cancer among women with ovarian endometrioma: a cohort study in Shizuoka, Japan. Int J Gynecol Cancer (2007) 1.64
Phosphatidylinositol turnover in platelet activation; calcium mobilization and protein phosphorylation. Cell Calcium (1982) 1.59
Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem (1996) 1.59
Studies with antipeptide antibody suggest the presence of at least two types of glucose transporter in rat brain and adipocyte. J Biol Chem (1988) 1.59
Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J Cell Biol (2001) 1.57
Delayed neuronal death in the rat hippocampus following transient forebrain ischemia. Acta Neuropathol (1984) 1.57
Fine structural nature of delayed neuronal death following ischemia in the gerbil hippocampus. Acta Neuropathol (1984) 1.55
Frequent p53 accumulation in the chronically sun-exposed epidermis and clonal expansion of p53 mutant cells in the epidermis adjacent to basal cell carcinoma. J Invest Dermatol (1995) 1.55
Resistance of germfree rats to indomethacin-induced intestinal lesions. Prostaglandins (1977) 1.53
Increased androgen receptor activity and altered c-myc expression in prostate cancer cells after long-term androgen deprivation. Cancer Res (1994) 1.52
Nuclear localization of the truncated hepatitis C virus core protein with its hydrophobic C terminus deleted. J Gen Virol (1995) 1.52
Proteome analysis of Bacillus subtilis extracellular proteins: a two-dimensional protein electrophoretic study. Microbiology (2000) 1.52
Massive actin polymerization induced by phosphatidylinositol-4-phosphate 5-kinase in vivo. J Biol Chem (1997) 1.51
Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. J Biomed Mater Res (1997) 1.51
Postero-medial hypothalamotomy in the treatment of aggressive behaviors. Confin Neurol (1966) 1.51
Effective control of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis with immunochemotherapy. Histiocyte Society. Blood (1999) 1.51
Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1. Am J Physiol Regul Integr Comp Physiol (2000) 1.50
Prevalence of Mycoplasma genitalium in men with gonococcal urethritis. Int J STD AIDS (1996) 1.50
A carcinoid tumor of the rectum removed by strip biopsy. Endoscopy (1993) 1.50
New indices of ischemic heart disease and aging: studies on the serum levels of soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular cell adhesion molecule-1 (VCAM-1) in patients with hypercholesterolemia and ischemic heart disease. Atherosclerosis (1997) 1.49
Ulcerative colitis with skip lesions at the mouth of the appendix: a clinical study. Am J Gastroenterol (1998) 1.49
Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res (1999) 1.48
A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. J Biol Chem (1996) 1.47