MHCPEP, a database of MHC-binding peptides: update 1997.

Prediction of MHC class I binding peptides, using SVMHC. BMC Bioinformatics (2002) 2.66

Peptide binding predictions for HLA DR, DP and DQ molecules. BMC Bioinformatics (2010) 2.53

Enhancement to the RANKPEP resource for the prediction of peptide binding to MHC molecules using profiles. Immunogenetics (2004) 2.49

AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data. Immunome Res (2005) 2.40

Definition of supertypes for HLA molecules using clustering of specificity matrices. Immunogenetics (2004) 2.39

Bcipep: a database of B-cell epitopes. BMC Genomics (2005) 2.27

The sentinel within: exploiting the immune system for cancer biomarkers. J Proteome Res (2005) 2.22

Predicting Class II MHC-Peptide binding: a kernel based approach using similarity scores. BMC Bioinformatics (2006) 1.41

MHCBN 4.0: A database of MHC/TAP binding peptides and T-cell epitopes. BMC Res Notes (2009) 1.41

CED: a conformational epitope database. BMC Immunol (2006) 1.39

Protection against P. aeruginosa with an adenovirus vector containing an OprF epitope in the capsid. J Clin Invest (2005) 1.35

Immunoinformatics comes of age. PLoS Comput Biol (2006) 1.35

Integrated modeling of the major events in the MHC class I antigen processing pathway. Protein Sci (2005) 1.23

Phase-dependent immune evasion of herpesviruses. J Virol (2007) 1.20

An ontology for immune epitopes: application to the design of a broad scope database of immune reactivities. Immunome Res (2005) 1.15

PepDist: a new framework for protein-peptide binding prediction based on learning peptide distance functions. BMC Bioinformatics (2006) 1.10

FIMM, a database of functional molecular immunology: update 2002. Nucleic Acids Res (2002) 1.06

FIMM, a database of functional molecular immunology. Nucleic Acids Res (2000) 1.06

Strength in numbers: achieving greater accuracy in MHC-I binding prediction by combining the results from multiple prediction tools. Immunome Res (2007) 1.06

Predicting peptides binding to MHC class II molecules using multi-objective evolutionary algorithms. BMC Bioinformatics (2007) 1.05

Adoptive transfer of CD4+ T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling. Infect Immun (2001) 1.04

On evaluating MHC-II binding peptide prediction methods. PLoS One (2008) 1.04

POPISK: T-cell reactivity prediction using support vector machines and string kernels. BMC Bioinformatics (2011) 1.03

Viruses selectively mutate their CD8+ T-cell epitopes--a large-scale immunomic analysis. Bioinformatics (2009) 1.03

Signal peptides and trans-membrane regions are broadly immunogenic and have high CD8+ T cell epitope densities: Implications for vaccine development. Mol Immunol (2011) 0.99

NERVE: new enhanced reverse vaccinology environment. BMC Biotechnol (2006) 0.97

Dana-Farber repository for machine learning in immunology. J Immunol Methods (2011) 0.93

Predicting MHC class I epitopes in large datasets. BMC Bioinformatics (2010) 0.90

Amino acid biophysical properties in the statistical prediction of peptide-MHC class I binding. Immunome Res (2007) 0.88

Designing of interferon-gamma inducing MHC class-II binders. Biol Direct (2013) 0.86

Dataset size and composition impact the reliability of performance benchmarks for peptide-MHC binding predictions. BMC Bioinformatics (2014) 0.85

Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells. Int Immunol (2009) 0.85

Human self-protein CD8+ T-cell epitopes are both positively and negatively selected. Eur J Immunol (2009) 0.83

A geometric and algebraic view of MHC-peptide complexes and their binding properties. BMC Struct Biol (2001) 0.82

EpicCapo: epitope prediction using combined information of amino acid pairwise contact potentials and HLA-peptide contact site information. BMC Bioinformatics (2012) 0.81

Predicting sequences and structures of MHC-binding peptides: a computational combinatorial approach. J Comput Aided Mol Des (2001) 0.81

Proteomics in Vaccinology and Immunobiology: An Informatics Perspective of the Immunone. J Biomed Biotechnol (2003) 0.79

HLA class I molecular variation and peptide-binding properties suggest a model of joint divergent asymmetric selection. Immunogenetics (2016) 0.79

PAComplex: a web server to infer peptide antigen families and binding models from TCR-pMHC complexes. Nucleic Acids Res (2011) 0.78

Integrating peptides' sequence and energy of contact residues information improves prediction of peptide and HLA-I binding with unknown alleles. BMC Bioinformatics (2013) 0.75

Prediction of HLA-A2 binding peptides using Bayesian network. Bioinformation (2005) 0.75

Genome-wide structural modelling of TCR-pMHC interactions. BMC Genomics (2013) 0.75

A potent multivalent vaccine for modulation of immune system in atherosclerosis: an in silico approach. Clin Exp Vaccine Res (2016) 0.75

SRS--an indexing and retrieval tool for flat file data libraries. Comput Appl Biosci (1993) 24.73

The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998. Nucleic Acids Res (1998) 10.20

MHC ligands and peptide motifs: first listing. Immunogenetics (1995) 7.78

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles. J Exp Med (1993) 4.99

Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics (1990) 3.53

Promiscuous and allele-specific anchors in HLA-DR-binding peptides. Cell (1993) 3.41

The PIR-International Protein Sequence Database. Nucleic Acids Res (1998) 2.45

MHCPEP: a database of MHC-binding peptides. Nucleic Acids Res (1994) 1.41

Nomenclature for factors of the HLA system, 1995. Hum Immunol (1995) 1.16

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med (1997) 1.09

MHCPEP, a database of MHC-binding peptides: update 1996. Nucleic Acids Res (1997) 1.07

Generation and phenotypic characterization of new human ovarian cancer cell lines with the identification of antigens potentially recognizable by HLA-restricted cytotoxic T cells. Int J Cancer (1997) 1.02

Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus. Ann Med (1997) 0.89

Latent autoimmune diabetes in adults (LADA) should be less latent. Diabetologia (2005) 4.87

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet (2001) 2.54

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature (1988) 2.46

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis. Neurology (2011) 2.39

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes (1997) 2.19

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice. J Clin Invest (1991) 2.07

IFN-gamma and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans. J Immunol (1988) 1.83

Prediction of MHC class II-binding peptides using an evolutionary algorithm and artificial neural network. Bioinformatics (1998) 1.77

Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci U S A (1981) 1.72

Insulin receptors, receptor antibodies, and the mechanism of insulin action. Recent Prog Horm Res (1981) 1.68

INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells. Diabetologia (2011) 1.68

Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes (2000) 1.67

Insulin resistance is a risk factor for progression to type 1 diabetes. Diabetologia (2004) 1.64

Diurnal rhythms of pro-inflammatory cytokines: regulation by plasma cortisol and therapeutic implications. Cytokine (1998) 1.63

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. Oncogene (2000) 1.59

Purification of the insulin receptor from human placenta by chromatography on immobilized wheat germ lectin and receptor antibody. J Biol Chem (1980) 1.54

Immune characterization of an individual with an exceptionally high natural killer T cell frequency and her immediate family. Clin Exp Immunol (2009) 1.52

Neural network-based prediction of candidate T-cell epitopes. Nat Biotechnol (1998) 1.49

Autoantibodies to beta 2-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Science (1980) 1.48

The chronobiology of human cytokine production. Int Rev Immunol (1998) 1.47

Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochemistry (1981) 1.45

MHCPEP: a database of MHC-binding peptides. Nucleic Acids Res (1994) 1.41

Correlation between insulin receptor binding in isolated fat cells and insulin sensitivity in obese human subjects. J Clin Invest (1976) 1.40

Immunotherapy in pre-type 1 diabetes mellitus. Diabetologia (1990) 1.39

Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors. N Engl J Med (1978) 1.37

Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection. Proc Natl Acad Sci U S A (1989) 1.32

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med (1995) 1.28

Subunit structure of the insulin receptor of the human lymphocyte. Biochemistry (1980) 1.25

Evidence that a peptide spanning the B-C junction of proinsulin is an early Autoantigen epitope in the pathogenesis of type 1 diabetes. J Immunol (2001) 1.23

Diurnal rhythmicity of human cytokine production: a dynamic disequilibrium in T helper cell type 1/T helper cell type 2 balance? J Immunol (1997) 1.23

Immunoprecipitation of the insulin receptor: a sensitive assay for receptor antibodies and a specific technique for receptor purification. J Clin Endocrinol Metab (1979) 1.20

Evidence for IL-6 production by and effects on the pancreatic beta-cell. J Immunol (1989) 1.20

Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia (2000) 1.20

Thyrotrophin (TSH) binding sites on Yersinia enterocolitica recognized by immunoglobulins from humans with Graves' disease. Clin Exp Immunol (1986) 1.18

Autoantibodies against the insulin receptor recognize the insulin binding subunits of an oligomeric receptor. Diabetes (1981) 1.18

T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents. Mol Med (1998) 1.17

The effect of solubilization on the properties of the insulin receptor of human placental membranes. Endocrinology (1978) 1.15

Double-blind controlled trial of azathioprine in children with newly diagnosed type I diabetes. Diabetes (1989) 1.14

Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. J Exp Med (1993) 1.13

Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes. J Immunol (1998) 1.13

Increase in remission rate in newly diagnosed type I diabetic subjects treated with azathioprine. Diabetes (1985) 1.13

Overview: the major histocompatibility complex and insulin dependent diabetes mellitus. Baillieres Clin Endocrinol Metab (1991) 1.11

Regulation of insulin receptors in normal and abnormal physiology in humans. Adv Intern Med (1979) 1.10

Analysis of families at risk for insulin-dependent diabetes mellitus reveals that HLA antigens influence progression to clinical disease. Mol Med (1995) 1.10

Direct evidence for the expression of multiple endogenous retroviruses in the synovial compartment in rheumatoid arthritis. Arthritis Rheum (1997) 1.08

MHCPEP, a database of MHC-binding peptides: update 1996. Nucleic Acids Res (1997) 1.07

HLA antigens and age at diagnosis of insulin-dependent diabetes mellitus. Hum Immunol (1995) 1.07

Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity. Diabetes (1999) 1.06

Interferon-gamma enhances the expression of the major histocompatibility class I antigens on mouse pancreatic beta cells. Diabetes (1985) 1.06

The human placenta contains two distinct binding and immunoreactive species of insulin-like growth factor-I receptors. J Biol Chem (1985) 1.06

Markers on distal chromosome 2q linked to insulin-dependent diabetes mellitus. Science (1996) 1.06

Insulin binding leads to the formation of covalent (-S-S-) hormone receptor complexes. J Biol Chem (1982) 1.04

Laminin-1 promotes differentiation of fetal mouse pancreatic beta-cells. Diabetes (1999) 1.04

IFN-gamma induces islet cell MHC antigens and enhances autoimmune, streptozotocin-induced diabetes in the mouse. J Immunol (1988) 1.04

The potential roles of endogenous retroviruses in autoimmunity. Immunol Rev (1996) 1.04

Cloning and partial nucleotide sequence of human glutamic acid decarboxylase cDNA from brain and pancreatic islets. Biochem Biophys Res Commun (1991) 1.03

High level of concordance between assays for glutamic acid decarboxylase antibodies. The First International Glutamic Acid Decarboxylase Antibody Workshop. Diabetes (1994) 1.03

Molecular pathology of type 1 diabetes. Mol Biol Med (1990) 1.00

Regulation of MHC protein expression in pancreatic beta-cells by interferon-gamma and tumor necrosis factor-alpha. Mol Endocrinol (1988) 0.99

Cytokine-based human whole blood assay for the detection of antigen-reactive T cells. J Immunol Methods (1995) 0.98

Heterogeneity of the insulin-receptor interaction in lipoatropic diabetes. J Clin Endocrinol Metab (1981) 0.97

Reduction in insulitis following administration of IFN-gamma and TNF-alpha in the NOD mouse. J Autoimmun (1991) 0.97

Cytotoxic T cells to an epitope in the islet autoantigen IA-2 are not disease-specific. Clin Immunol (2001) 0.97

Retroviral superantigens and type 1 diabetes mellitus. Cell (1998) 0.96

Glutamic acid decarboxylase autoantibodies in preclinical insulin-dependent diabetes. Proc Natl Acad Sci U S A (1992) 0.96

Structural differences between insulin and somatomedin-C/insulin-like growth factor-1 receptors revealed by autoantibodies to the insulin receptor. Biochem Biophys Res Commun (1982) 0.96

Reovirus infection enhances expression of class I MHC proteins on human beta-cell and rat RINm5F cell. Diabetes (1988) 0.96

T-cell antigen receptor transmembrane peptides modulate T-cell function and T cell-mediated disease. Nat Med (1997) 0.96

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat. Endocrinology (1993) 0.95

Mucosal antigen primes diabetogenic cytotoxic T-lymphocytes regardless of dose or delivery route. Diabetes (2001) 0.94

The beta cell in autoimmune diabetes: many mechanisms and pathways of loss. Trends Endocrinol Metab (2001) 0.94

Identification of pancreatic beta cell-related genes by representational difference analysis. Endocrinology (1997) 0.94

Report from the 1st International NOD Mouse T-Cell Workshop and the follow-up mini-workshop. Diabetes (2001) 0.94

Fuzzy neural network-based prediction of the motif for MHC class II binding peptides. J Biosci Bioeng (2001) 0.94

IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes. Hum Immunol (1998) 0.93

The A-chain of insulin is a hot-spot for CD4+ T cell epitopes in human type 1 diabetes. Clin Exp Immunol (2009) 0.93

Evidence that macrophages are required for T-cell infiltration and rejection of fetal pig pancreas xenografts in nonobese diabetic mice. Transplantation (1998) 0.93

An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors. Proc Natl Acad Sci U S A (1986) 0.93

Precipitation of the thyrotropin receptor and identification of thyroid autoantigens using Graves' disease immunoglobulins. J Clin Invest (1984) 0.93

Antitopoisomerase I monoclonal autoantibodies from scleroderma patients and tight skin mouse interact with similar epitopes. J Exp Med (1992) 0.92

The Melbourne Pre-Diabetes Study: prediction of type 1 diabetes mellitus using antibody and metabolic testing. Med J Aust (1998) 0.92

Overexpression of class I major histocompatibility complex accompanies insulitis in the non-obese diabetic mouse and is prevented by anti-interferon-gamma antibody. Diabetologia (1991) 0.92

Innate and adaptive immune responses to nonvascular xenografts: evidence that macrophages are direct effectors of xenograft rejection. J Immunol (2001) 0.92

MHCPEP--a database of MHC-binding peptides: update 1995. Nucleic Acids Res (1996) 0.92

Gamma delta T cells as mediators of mucosal tolerance: the autoimmune diabetes model. Immunol Rev (2000) 0.91

Disulfide exchange between insulin and its receptor. A possible post-binding step in insulin action. J Biol Chem (1983) 0.90

Stabilization of glucose transporter mRNA by insulin/IGF-1 and glucose deprivation. Biochem Biophys Res Commun (1990) 0.90

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens (2003) 0.90

Mapping of multiple B cell epitopes on the 70-kilodalton autoantigen of the U1 ribonucleoprotein complex. J Immunol (1990) 0.90

Changes in insulin-receptor structure associated with trypsin-induced activation of the receptor tyrosine kinase. Biochem J (1991) 0.90

Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control. FASEB J (2006) 0.89

Factors predicting residual beta-cell function in the first year after diagnosis of childhood type 1 diabetes. Diabetes Res Clin Pract (1991) 0.89

Strategies for identifying and predicting islet autoantigen T-cell epitopes in insulin-dependent diabetes mellitus. Ann Med (1997) 0.89

Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients. Diabetes (1988) 0.89

Calcium-dependence of insulin receptor phosphorylation. Biochem J (1983) 0.89

Nonimmune thyroid destruction results from transgenic overexpression of an allogeneic major histocompatibility complex class I protein. Mol Cell Biol (1993) 0.89

HLA-DRB1*0401 is associated with susceptibility to insulin-dependent diabetes mellitus independently of the DQB1 locus. Eur J Immunogenet (1995) 0.88