Published in EMBO J on March 01, 1993
Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice. J Virol (1994) 2.73
Epidermal stem cell diversity and quiescence. EMBO Mol Med (2009) 2.14
Soluble dominant-negative receptor uncovers essential roles for fibroblast growth factors in multi-organ induction and patterning. EMBO J (1998) 2.07
Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. J Clin Invest (1995) 1.68
Psoriasis: what we have learned from mouse models. Nat Rev Rheumatol (2010) 1.61
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation. J Cell Biol (1996) 1.55
Alternative splicing in fibroblast growth factor receptor 2 is associated with induced epithelial-mesenchymal transition in rat bladder carcinoma cells. Mol Biol Cell (1994) 1.46
The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development. EMBO J (2007) 1.45
Emerging interactions between skin stem cells and their niches. Nat Med (2014) 1.45
Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development. Proc Natl Acad Sci U S A (1994) 1.42
Myofibroblast differentiation is induced in keratinocyte-fibroblast co-cultures and is antagonistically regulated by endogenous transforming growth factor-beta and interleukin-1. Am J Pathol (2004) 1.39
Psoriasis genetics: breaking the barrier. Trends Genet (2010) 1.38
Expression of the chemokine N51/KC in the thymus and epidermis of transgenic mice results in marked infiltration of a single class of inflammatory cells. J Exp Med (1994) 1.33
Stimulation of all epithelial elements during skin regeneration by keratinocyte growth factor. J Exp Med (1994) 1.32
Plakoglobin suppresses epithelial proliferation and hair growth in vivo. J Cell Biol (2000) 1.30
Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J Exp Med (1995) 1.29
Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest (1997) 1.28
Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Mol Cell Biol (2002) 1.25
Constitutive expression of aryl hydrocarbon receptor in keratinocytes causes inflammatory skin lesions. Mol Cell Biol (2005) 1.23
Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22
Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. J Clin Invest (1998) 1.19
Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med (2001) 1.17
Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc Natl Acad Sci U S A (2003) 1.15
An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc Natl Acad Sci U S A (1996) 1.10
FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma. J Clin Invest (2013) 1.07
Biomimetic delivery of keratinocyte growth factor upon cellular demand for accelerated wound healing in vitro and in vivo. Am J Pathol (2005) 1.05
Differential binding of fibroblast growth factor-2 and -7 to basement membrane heparan sulfate: comparison of normal and abnormal human tissues. Am J Pathol (1997) 1.05
Altered expression of keratinocyte growth factor and its receptor in psoriasis. Am J Pathol (1997) 1.03
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. Development (2009) 1.03
Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice. Am J Pathol (2008) 1.01
Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells. Am J Pathol (1999) 0.99
Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling. J Invest Dermatol (2010) 0.97
β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol (2012) 0.92
Antigen presentation by keratinocytes directs autoimmune skin disease. Proc Natl Acad Sci U S A (2003) 0.89
Fibroblast growth factor-10 signals development of von Brunn's nests in the exstrophic bladder. Am J Physiol Renal Physiol (2010) 0.87
BMP-FGF signaling axis mediates Wnt-induced epidermal stratification in developing mammalian skin. PLoS Genet (2014) 0.84
Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4. Infect Immun (2002) 0.83
Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS One (2012) 0.81
Keratinocyte growth factor is a bifunctional regulator of HPV16 DNA-immortalized cervical epithelial cells. J Cell Biol (1995) 0.81
Pten loss induces autocrine FGF signaling to promote skin tumorigenesis. Cell Rep (2014) 0.80
An in vitro culture system for long-term expansion of epithelial and mesenchymal salivary gland cells: role of TGF-β1 in salivary gland epithelial and mesenchymal differentiation. Biomed Res Int (2013) 0.80
Animal models of skin disease for drug discovery. Expert Opin Drug Discov (2013) 0.79
Epithelial expression of keratinocytes growth factor in oral precancer lesions. Dent Res J (Isfahan) (2016) 0.75
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A (2016) 0.75
Immunolocalization of FGF-2, -7, -8, -10 and FGFR-1-4 during regeneration of the rat submandibular gland. J Mol Histol (2015) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
How does the extracellular matrix direct gene expression? J Theor Biol (1982) 6.38
Competitive PCR. Nature (1992) 5.96
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science (1989) 4.79
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature (1987) 4.19
Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell (1990) 4.05
Monoclonal antibody analysis of keratin expression in epidermal diseases: a 48- and 56-kdalton keratin as molecular markers for hyperproliferative keratinocytes. J Cell Biol (1984) 4.00
Epimorphin: a mesenchymal protein essential for epithelial morphogenesis. Cell (1992) 3.63
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor. Cell (1987) 3.26
Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci U S A (1992) 2.89
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
Induction of hair growth by implantation of cultured dermal papilla cells. Nature (1984) 2.84
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78
The 50- and 58-kdalton keratin classes as molecular markers for stratified squamous epithelia: cell culture studies. J Cell Biol (1983) 2.58
Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells. J Biol Chem (1983) 2.42
Two FGF receptor genes are differentially expressed in epithelial and mesenchymal tissues during limb formation and organogenesis in the mouse. Development (1992) 2.34
Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development (1991) 2.16
Expression of epidermal keratins and filaggrin during human fetal skin development. J Cell Biol (1985) 1.68
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev (1989) 1.62
Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem (1990) 1.62
Antibodies to cell surface ganglioside GD3 perturb inductive epithelial-mesenchymal interactions. Cell (1988) 1.47
Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells. J Biol Chem (1983) 1.38
Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol (1990) 1.32
TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regul (1990) 1.28
The development of mouse vibrissae in vivo and in vitro. J Anat (1952) 1.19
Sequence and expression of a type II keratin, K5, in human epidermal cells. Mol Cell Biol (1988) 1.15
Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis. Mol Cell Biol (1992) 1.08
Distribution and number of epidermal growth factor receptors in skin is related to epithelial cell growth. Dev Biol (1983) 1.06
Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis. Cancer Res (1989) 1.02
Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity. Ann N Y Acad Sci (1991) 1.01
Development of hair coat and skin glands in fetal porcine integument. J Anat (1986) 0.98
Nonproliferation in dermal condensations of mouse vibrissae and pelage hairs. Dev Biol (1965) 0.97
The specification of feather and scale protein synthesis in epidermal-dermal recombinations. Dev Biol (1978) 0.97
Distribution of epidermal growth factor receptors in rat tissues during embryonic skin development, hair formation, and the adult hair growth cycle. J Invest Dermatol (1984) 0.93
Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures. Cell Regul (1991) 0.90
Localization of profilaggrin mRNA in newborn rat skin by in situ hybridization. J Invest Dermatol (1987) 0.88
Characterization of cytoskeletal proteins in basal cells of human parotid salivary gland ducts. Virchows Arch A Pathol Anat Histopathol (1988) 0.84
Basal lamina changes during tissue interactions in hair follicles--an in vitro study of normal dermal papillae and vitamin A-induced glandular morphogenesis. J Invest Dermatol (1983) 0.79
Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development (1999) 9.82
Directed actin polymerization is the driving force for epithelial cell-cell adhesion. Cell (2000) 8.13
De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell (1998) 7.95
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc Natl Acad Sci U S A (1999) 7.67
Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa. Lancet (1993) 5.99
Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet (1999) 5.91
Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83
Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell (2001) 5.01
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev (2001) 4.62
Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci (1997) 4.00
A common human skin tumour is caused by activating mutations in beta-catenin. Nat Genet (1999) 3.93
Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet (2000) 3.92
Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc Natl Acad Sci U S A (1988) 3.73
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61
Programming gene expression in developing epidermis. Development (1994) 3.60
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci U S A (1998) 3.53
Point mutations in human keratin 14 genes of epidermolysis bullosa simplex patients: genetic and functional analyses. Cell (1991) 3.49
Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol (2000) 3.38
Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol (2001) 3.31
The cDNA sequence of a human epidermal keratin: divergence of sequence but conservation of structure among intermediate filament proteins. Cell (1982) 3.08
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A (2001) 3.01
Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev (1995) 2.99
Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell (1991) 2.98
The cDNA sequence of a Type II cytoskeletal keratin reveals constant and variable structural domains among keratins. Cell (1983) 2.92
Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. J Cell Biol (1988) 2.88
Initiation of DNA-dependent RNA synthesis and the effect of heparin on RNA polymerase. Eur J Biochem (1967) 2.87
The expression of keratin genes in epidermis and cultured epidermal cells. Cell (1978) 2.87
Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev (1996) 2.82
The initiation of translation in E. coli: apparent base pairing between the 16srRNA and downstream sequences of the mRNA. Nucleic Acids Res (1990) 2.81
Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation. Genes Dev (1991) 2.78
Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration. Cell (1995) 2.75
Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci (1996) 2.73
High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization. Breast Cancer Res (2005) 2.72
Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62
The expression of mutant epidermal keratin cDNAs transfected in simple epithelial and squamous cell carcinoma lines. J Cell Biol (1987) 2.61
Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors. Mol Ther (2001) 2.53
The C terminus of human immunodeficiency virus type 1 matrix protein is involved in early steps of the virus life cycle. J Virol (1992) 2.51
A randomized controlled trial of a reduced daily dose of zidovudine in patients with the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med (1990) 2.50
Hippocampal neurogenesis in adult Old World primates. Proc Natl Acad Sci U S A (1999) 2.37
Stress revisited: a critical evaluation of the stress concept. Neurosci Biobehav Rev (2011) 2.37
Complementary DNA sequence of a human cytoplasmic actin. Interspecies divergence of 3' non-coding regions. J Mol Biol (1983) 2.25
An Epstein-Barr virus transforming protein associates with vimentin in lymphocytes. Mol Cell Biol (1987) 2.22
Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules. Cell (1979) 2.18
The vpx gene of simian immunodeficiency virus facilitates efficient viral replication in fresh lymphocytes and macrophage. J Virol (1991) 2.18
Actin dynamics and cell-cell adhesion in epithelia. Curr Opin Cell Biol (2001) 2.15
Desmoplakin is required early in development for assembly of desmosomes and cytoskeletal linkage. J Cell Biol (1998) 2.14
An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments. Cell (1996) 2.09
Inhibition of skin development by targeted expression of a dominant-negative retinoic acid receptor. Nature (1995) 2.09
CD28/B7 regulation of Th1 and Th2 subsets in the development of autoimmune diabetes. Immunity (1996) 2.09
Remarkable conservation of structure among intermediate filament genes. Cell (1984) 2.07
The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J Cell Biol (1995) 2.06
Purification of recombinant adeno-associated virus vectors by column chromatography and its performance in vivo. Hum Gene Ther (2000) 1.97
Evidence for posttranscriptional regulation of the keratins expressed during hyperproliferation and malignant transformation in human epidermis. J Cell Biol (1986) 1.89
Expression of mutant keratin cDNAs in epithelial cells reveals possible mechanisms for initiation and assembly of intermediate filaments. J Cell Biol (1989) 1.89
Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol (1994) 1.87
Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. Eur Neuropsychopharmacol (2010) 1.85
A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. J Cell Biol (1991) 1.80
Filovirus-pseudotyped lentiviral vector can efficiently and stably transduce airway epithelia in vivo. Nat Biotechnol (2001) 1.80
Elucidating the early stages of keratin filament assembly. J Cell Biol (1990) 1.80
FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development (1999) 1.79
The ovo gene required for cuticle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice. Genes Dev (1998) 1.78
Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene. Proc Natl Acad Sci U S A (1985) 1.78
Defining the interactions between intermediate filaments and desmosomes. J Cell Biol (1998) 1.78
Genetic and clinical mosaicism in a type of epidermal nevus. N Engl J Med (1994) 1.72
The downstream box: an efficient and independent translation initiation signal in Escherichia coli. EMBO J (1996) 1.70
Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci U S A (1991) 1.70
Transgenic studies with a keratin promoter-driven growth hormone transgene: prospects for gene therapy. Proc Natl Acad Sci U S A (1997) 1.68
INS(GFP/w) human embryonic stem cells facilitate isolation of in vitro derived insulin-producing cells. Diabetologia (2011) 1.68
Cachexia and graft-vs.-host-disease-type skin changes in keratin promoter-driven TNF alpha transgenic mice. Genes Dev (1992) 1.68
Unraveling the structure of the intermediate filaments. Cell (1983) 1.67
A human keratin 14 "knockout": the absence of K14 leads to severe epidermolysis bullosa simplex and a function for an intermediate filament protein. Genes Dev (1994) 1.65
Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J Cell Biol (1989) 1.64
A new look into an old problem: keratins as tools to investigate determination, morphogenesis, and differentiation in skin. Genes Dev (1989) 1.62
Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin. Proc Natl Acad Sci U S A (1983) 1.61
A dysfunctional desmin mutation in a patient with severe generalized myopathy. Proc Natl Acad Sci U S A (1998) 1.61
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development (2001) 1.60
An epidermal plakin that integrates actin and microtubule networks at cellular junctions. J Cell Biol (2000) 1.60
Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney. Am J Physiol (1995) 1.60
Probing keratinocyte and differentiation specificity of the human K5 promoter in vitro and in transgenic mice. Mol Cell Biol (1993) 1.59
Integrators of the cytoskeleton that stabilize microtubules. Cell (1999) 1.56
Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol (1989) 1.56
Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation. J Cell Biol (1996) 1.55
High-titer protamine-specific IgG antibody associated with anaphylaxis: report of a case and quantitative analysis of antibody in vasectomized men. Anesthesiology (1993) 1.54
Role of conserved gp41 cysteine residues in the processing of human immunodeficiency virus envelope precursor and viral infectivity. J Virol (1991) 1.52
The sequence of a type II keratin gene expressed in human skin: conservation of structure among all intermediate filament genes. Proc Natl Acad Sci U S A (1985) 1.52
The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. Cell (1992) 1.51
Deletions in epidermal keratins leading to alterations in filament organization in vivo and in intermediate filament assembly in vitro. J Cell Biol (1990) 1.49
PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene (2006) 1.48