Published in EMBO J on January 15, 1998
Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J (1998) 3.79
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev (1998) 3.71
SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. Mol Cell Biol (1999) 3.18
At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation. Mol Cell Biol (1998) 2.79
Posttranscriptional control of gene expression in yeast. Microbiol Mol Biol Rev (1998) 2.54
NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.08
mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization? RNA (1999) 1.89
SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J (2003) 1.83
Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay. RNA (2001) 1.70
SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans. Mol Cell Biol (2004) 1.62
T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J (2002) 1.43
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs. EMBO J (2001) 1.41
Nonsense-mediated decay of human HEXA mRNA. Mol Cell Biol (2001) 1.35
Evolutionarily conserved and diverged alternative splicing events show different expression and functional profiles. Nucleic Acids Res (2005) 1.34
Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stability. EMBO J (1999) 1.30
Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution. Mol Cell Biol (2003) 1.27
Ribosomal protein L3 mutants alter translational fidelity and promote rapid loss of the yeast killer virus. Mol Cell Biol (1999) 1.21
Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues. Mol Biol Cell (2001) 1.18
A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus. RNA (2005) 1.16
Systems-level analyses identify extensive coupling among gene expression machines. Mol Syst Biol (2006) 1.12
Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay. RNA (1999) 1.07
RNA interference: advances and questions. Philos Trans R Soc Lond B Biol Sci (2002) 1.06
The Upf-dependent decay of wild-type PPR1 mRNA depends on its 5'-UTR and first 92 ORF nucleotides. Nucleic Acids Res (2003) 1.04
The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). Nucleic Acids Res (2006) 1.03
Regulation of AUF1 expression via conserved alternatively spliced elements in the 3' untranslated region. Mol Cell Biol (1999) 1.03
Nuclear import of Upf3p is mediated by importin-alpha/-beta and export to the cytoplasm is required for a functional nonsense-mediated mRNA decay pathway in yeast. Genetics (2002) 1.03
A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region. Mol Cell Biol (2003) 1.01
Evidence against a direct role for the Upf proteins in frameshifting or nonsense codon readthrough. RNA (2004) 1.00
Competency for nonsense-mediated reduction in collagen X mRNA is specified by the 3' UTR and corresponds to the position of mutations in Schmid metaphyseal chondrodysplasia. Am J Hum Genet (2008) 0.97
Deletion of the Hsp70 chaperone gene SSB causes hypersensitivity to guanidine toxicity and curing of the [PSI+] prion by increasing guanidine uptake in yeast. Mol Genet Genomics (2003) 0.96
Infrequent translation of a nonsense codon is sufficient to decrease mRNA level. Mol Biol Cell (1999) 0.96
The structure and function of the rous sarcoma virus RNA stability element. J Cell Biochem (2011) 0.88
Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay. RNA (2015) 0.88
Is there a classical nonsense-mediated decay pathway in trypanosomes? PLoS One (2011) 0.88
Stress-sensitive regulation of IFRD1 mRNA decay is mediated by an upstream open reading frame. J Biol Chem (2010) 0.86
Novel and recurrent mutations in the laminin-5 genes causing lethal junctional epidermolysis bullosa: molecular basis and clinical course of Herlitz disease. Hum Genet (2004) 0.86
Combined molecular and clinical approaches for the identification of families with familial adenomatous polyposis coli. Ann Surg (1999) 0.86
Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1. Nucleic Acids Res (2013) 0.86
Evolution of coding microsatellites in primate genomes. Genome Biol Evol (2013) 0.83
Regulation of glucose-dependent gene expression by the RNA helicase Dbp2 in Saccharomyces cerevisiae. Genetics (2014) 0.83
Control of human beta-globin mRNA stability and its impact on beta-thalassemia phenotype. Haematologica (2011) 0.83
NMD mechanism and the functions of Upf proteins in plant. Plant Cell Rep (2015) 0.77
High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier. Curr Genet (1989) 31.80
Multiple upstream AUG codons mediate translational control of GCN4. Cell (1986) 8.48
Evidence for translational regulation of the activator of general amino acid control in yeast. Proc Natl Acad Sci U S A (1984) 7.23
Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem (1996) 7.08
Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. J Biol Chem (1983) 6.88
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev (1991) 6.18
Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae. Microbiol Rev (1988) 6.13
Eucaryotic RNA polymerase conditional mutant that rapidly ceases mRNA synthesis. Mol Cell Biol (1987) 5.93
When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells. RNA (1995) 5.76
Translation is required for regulation of histone mRNA degradation. Cell (1987) 4.41
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev (1996) 4.34
Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Genes Dev (1992) 4.20
Gene products that promote mRNA turnover in Saccharomyces cerevisiae. Mol Cell Biol (1992) 4.00
A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae. Mol Cell Biol (1985) 3.98
Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev (1995) 3.86
Protein quality control: triage by chaperones and proteases. Genes Dev (1997) 3.85
Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol (1991) 3.83
mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor. Genes Dev (1993) 3.60
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem (1994) 3.37
Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev (1995) 3.24
Evidence for instability of mRNAs containing AUUUA motifs mediated through translation-dependent assembly of a > 20S degradation complex. Genes Dev (1992) 3.14
Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J (1995) 2.87
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein. Mol Cell Biol (1996) 2.78
Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway. Mol Cell Biol (1997) 2.63
Protein phosphorylation controls translation rates. J Biol Chem (1989) 2.62
Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control. Genes Dev (1989) 2.57
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol Cell Biol (1995) 2.55
Four novel FBN1 mutations: significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome. Genomics (1993) 2.43
Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol (1995) 2.36
Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol Cell Biol (1996) 2.35
Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol Cell Biol (1995) 2.31
Translation and a 42-nucleotide segment within the coding region of the mRNA encoded by the MAT alpha 1 gene are involved in promoting rapid mRNA decay in yeast. Proc Natl Acad Sci U S A (1990) 2.30
Selective destabilization of short-lived mRNAs with the granulocyte-macrophage colony-stimulating factor AU-rich 3' noncoding region is mediated by a cotranslational mechanism. Mol Cell Biol (1993) 2.27
Identification of an additional gene required for eukaryotic nonsense mRNA turnover. Proc Natl Acad Sci U S A (1995) 2.10
Making sense of nonsense in yeast. Trends Biochem Sci (1996) 2.09
Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region. Mol Cell Biol (1995) 2.04
An intron in the genes for U3 small nucleolar RNAs of the yeast Saccharomyces cerevisiae. Science (1990) 2.02
ATP-dependent proteases that also chaperone protein biogenesis. Trends Biochem Sci (1997) 1.85
Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J (1997) 1.79
Inhibition of nascent-peptide release at translation termination. Mol Cell Biol (1996) 1.71
Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. Mol Microbiol (1993) 1.70
Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation. Nucleic Acids Res (1995) 1.66
Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay. EMBO J (1996) 1.43
The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1. EMBO J (1996) 1.36
Rapid mRNA degradation mediated by the c-fos 3' AU-rich element and that mediated by the granulocyte-macrophage colony-stimulating factor 3' AU-rich element occur through similar polysome-associated mechanisms. Mol Cell Biol (1995) 1.35
A quantitative model for translational control of the GCN4 gene of Saccharomyces cerevisiae. New Biol (1991) 1.33
Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5' to the ARE. Mol Cell Biol (1995) 1.30
cis- and trans-acting suppressors of a translation initiation defect at the cyc1 locus of Saccharomyces cerevisiae. Genetics (1992) 1.20
The question of heterogeneity in Marfan syndrome. Nat Genet (1995) 1.10
Initiation of translation can occur only in a restricted region of the CYC1 mRNA of Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.05
Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem (1996) 7.08
The cap-to-tail guide to mRNA turnover. Nat Rev Mol Cell Biol (2001) 6.67
The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon. Genes Dev (1991) 6.18
The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell (2000) 4.59
Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant. Proc Natl Acad Sci U S A (1993) 4.18
The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev (1998) 3.71
The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol Cell Biol (1989) 3.69
Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon. Genes Dev (1995) 3.24
Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein. Mol Cell Biol (1996) 2.78
A novel mRNA-decapping activity in HeLa cytoplasmic extracts is regulated by AU-rich elements. EMBO J (2001) 2.63
Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation. RNA (1995) 2.57
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover. Mol Cell Biol (1995) 2.55
The yeast hnRNP-like protein Hrp1/Nab4 marks a transcript for nonsense-mediated mRNA decay. Mol Cell (2000) 2.50
Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover. Mol Cell Biol (1996) 2.35
Identification and characterization of a sequence motif involved in nonsense-mediated mRNA decay. Mol Cell Biol (1995) 2.31
Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover. Bioessays (1999) 2.27
The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts. EMBO J (2001) 2.23
Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases. Genome Res (1999) 2.21
Measurement of mRNA decay rates in Saccharomyces cerevisiae. Methods Enzymol (1991) 2.17
Making sense of nonsense in yeast. Trends Biochem Sci (1996) 2.09
Histone mRNA degradation in vivo: the first detectable step occurs at or near the 3' terminus. Mol Cell Biol (1986) 2.07
Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. RNA (2000) 2.01
Curbing the nonsense: the activation and regulation of mRNA surveillance. Genes Dev (2001) 1.87
Mof4-1 is an allele of the UPF1/IFS2 gene which affects both mRNA turnover and -1 ribosomal frameshifting efficiency. EMBO J (1996) 1.81
Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene (2001) 1.75
Regulated ARE-mediated mRNA decay in Saccharomyces cerevisiae. Mol Cell (2001) 1.75
Properties of the exonuclease activity that degrades H4 histone mRNA. J Biol Chem (1987) 1.74
Bioactivities, estrogen receptor interactions, and plasminogen activator-inducing activities of tamoxifen and hydroxy-tamoxifen isomers in MCF-7 human breast cancer cells. Cancer Res (1984) 1.66
Monitoring mRNA decapping activity. Methods (1999) 1.64
The Mof2/Sui1 protein is a general monitor of translational accuracy. Mol Cell Biol (1998) 1.62
Poly(A)-binding proteins regulate both mRNA deadenylation and decapping in yeast cytoplasmic extracts. RNA (2001) 1.59
Polysome-associated mRNAs are substrates for the nonsense-mediated mRNA decay pathway in Saccharomyces cerevisiae. RNA (1997) 1.58
Peptidyl-transferase inhibitors have antiviral properties by altering programmed -1 ribosomal frameshifting efficiencies: development of model systems. Proc Natl Acad Sci U S A (1997) 1.57
ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities. RNA (1998) 1.50
Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay. EMBO J (1996) 1.43
Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents. Trends Biotechnol (1998) 1.42
Mutations in VPS16 and MRT1 stabilize mRNAs by activating an inhibitor of the decapping enzyme. Mol Cell Biol (1999) 1.23
Substrate specificity of the exonuclease activity that degrades H4 histone mRNA. J Biol Chem (1987) 1.23
The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. Proc Natl Acad Sci U S A (1998) 1.20
STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun (2008) 1.18
Turnover of mRNA in prokaryotes and lower eukaryotes. Curr Opin Genet Dev (1992) 1.07
Mutations in the MOF2/SUI1 gene affect both translation and nonsense-mediated mRNA decay. RNA (1999) 1.07
A quantitative assay for the activation of plasminogen by transformed cells in situ and by urokinase. Biochemistry (1981) 1.02
Positive regulation of activation of plasminogen by urokinase: differences in Km for (glutamic acid)-plasminogen and lysine-plasminogen and effect of certain alpha, omega-amino acids. Biochemistry (1982) 0.95
Nonsense-mediated mRNA decay in Saccharomyces cerevisiae: a quality control mechanism that degrades transcripts harboring premature termination codons. Cold Spring Harb Symp Quant Biol (2001) 0.94
Plasminogen activators in tissues of the immature and estrogen-stimulated rat uterus and in uterine luminal fluid: characterization and properties. Endocrinology (1983) 0.90
Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1)). J Biol Chem (1999) 0.90
Characterization of reverse transcriptase activity of the L1Tc retroelement from Trypanosoma cruzi. Cell Mol Life Sci (2003) 0.88
Synthesis and characterization of a new fluorogenic active-site titrant of serine proteases. Biochemistry (1981) 0.86
Interleukin 4, interleukin 4 receptor-α and interleukin 10 gene polymorphisms in Chagas disease. Parasite Immunol (2011) 0.84
Polymorphisms of pro-inflammatory cytokine genes and the risk for acute suppurative or chronic nonsuppurative apical periodontitis in a Colombian population. Int Endod J (2012) 0.84
Characterization of a general stabilizer element that blocks deadenylation-dependent mRNA decay. J Biol Chem (2001) 0.82
Lack of association between IL-6-174G/C gene polymorphism and Chagas disease. Tissue Antigens (2010) 0.80
Thermosensitivity of a DNA recognition site: activity of a truncated nutL antiterminator of coliphage lambda. Science (1985) 0.79
Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection. Tissue Antigens (2007) 0.78
Tools for turnover: methods for analysis of mRNA stability in eukaryotic cells. Methods (1999) 0.78
Modulation of the plasminogen activator activity of a transformed cell line by cell density. Mol Cell Biol (1982) 0.77
Current findings in the pathological evaluation of breast reduction specimens. Bol Asoc Med P R (1989) 0.77
Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. J Proteomics (2011) 0.77
[Primitive neuroectodermal tumors: difficult tumors versus modern oncology]. Cir Pediatr (1998) 0.75
A new active-site titrant of serine proteases. Methods Enzymol (1981) 0.75
[Merkel cell carcinoma. On one case]. An Sist Sanit Navar (2008) 0.75
Adaptation of acyl-enzyme kinetic theory and an experimental method for evaluating the kinetics of fast-acting, irreversible protease inhibitors. Biochim Biophys Acta (1983) 0.75