Published in Proc Natl Acad Sci U S A on January 20, 1998
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest (2005) 3.99
Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med (2001) 3.37
Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest (2006) 3.25
Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest (1999) 2.48
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A (2002) 2.46
Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection. J Clin Invest (2003) 2.33
Factors influencing T-cell turnover in HIV-1-seropositive patients. J Clin Invest (2000) 2.15
Rapid turnover of effector-memory CD4(+) T cells in healthy humans. J Exp Med (2004) 1.85
In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted? Proc Natl Acad Sci U S A (2002) 1.82
Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proc Natl Acad Sci U S A (2008) 1.62
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. J Clin Invest (2017) 1.40
In vivo T lymphocyte dynamics in humans and the impact of human T-lymphotropic virus 1 infection. Proc Natl Acad Sci U S A (2007) 1.36
Quantifying T lymphocyte turnover. J Theor Biol (2013) 1.35
Fluxome analysis using GC-MS. Microb Cell Fact (2007) 1.31
Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression. J Immunol (2008) 1.24
Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A (2009) 1.23
Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest (2000) 1.19
Estimating average cellular turnover from 5-bromo-2'-deoxyuridine (BrdU) measurements. Proc Biol Sci (2003) 1.11
Regulation of mammalian nucleotide metabolism and biosynthesis. Nucleic Acids Res (2015) 1.08
DNA digestion to deoxyribonucleoside: a simplified one-step procedure. Anal Biochem (2007) 1.08
Longitudinal assessment of de novo T cell production in relation to HIV-associated T cell homeostasis failure. AIDS Res Hum Retroviruses (2006) 1.03
Monitoring the reversible B to A-like transition of DNA in eukaryotic cells using Fourier transform infrared spectroscopy. Nucleic Acids Res (2011) 1.02
Modelling deuterium labelling of lymphocytes with temporal and/or kinetic heterogeneity. J R Soc Interface (2012) 0.97
Measurement of proliferation and disappearance of rapid turnover cell populations in human studies using deuterium-labeled glucose. Nat Protoc (2009) 0.95
Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives. Blood (2016) 0.94
Explicit kinetic heterogeneity: mathematical models for interpretation of deuterium labeling of heterogeneous cell populations. PLoS Comput Biol (2010) 0.91
Modified alternate-day fasting regimens reduce cell proliferation rates to a similar extent as daily calorie restriction in mice. FASEB J (2008) 0.89
Human T cell reconstitution in DiGeorge syndrome and HIV-1 infection. Semin Immunol (2007) 0.84
Multiscale estimation of cell kinetics. Comput Math Methods Med (2010) 0.80
Differences in the regulation of CD4 and CD8 T-cell clones during immune responses. Philos Trans R Soc Lond B Biol Sci (2000) 0.79
Reconciling Estimates of Cell Proliferation from Stable Isotope Labeling Experiments. PLoS Comput Biol (2015) 0.78
Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Disease. J Immunol (2015) 0.78
Cetuximab induces eme1-mediated DNA repair: a novel mechanism for cetuximab resistance. Neoplasia (2014) 0.77
Regulatory T cell kinetics in the peripheral blood of patients with Crohn's disease. Hum Immunol (2012) 0.77
Sensitive GC-MS/MS method to measure deuterium labeled deoxyadenosine in DNA from limited mouse cell populations. Anal Chem (2013) 0.77
Evaluation of in vivo T cell kinetics: use of heavy isotope labelling in type 1 diabetes. Clin Exp Immunol (2013) 0.76
A low alpha-linolenic intake during early life increases adiposity in the adult guinea pig. Nutr Metab (Lond) (2010) 0.76
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation. J Exp Med (2017) 0.75
Influence of Microbes on Neutrophil Life and Death. Front Cell Infect Microbiol (2017) 0.75
Simple Laboratory methods to measure cell proliferation using DNA synthesis property. J Stem Cells Regen Med (2007) 0.75
Human immunodeficiency virus mutation and changes in CD4 T-cell levels during antiretroviral therapy. Eur J Clin Microbiol Infect Dis (1998) 0.75
Physiologically Based Simulations of Deuterated Glucose for Quantifying Cell Turnover in Humans. Front Immunol (2017) 0.75
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97
Viral dynamics in human immunodeficiency virus type 1 infection. Nature (1995) 28.54
Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science (1982) 10.61
Interactions between deoxyribonucleotide and DNA synthesis. Annu Rev Biochem (1988) 4.79
Preparation and enzymatic hydrolysis of DNA and RNA for mass spectrometry. Methods Enzymol (1990) 3.02
ESTIMATION OF PATHWAYS OF CARBOHYDRATE METABOLISM. Biochem Z (1963) 2.62
T cell telomere length in HIV-1 infection: no evidence for increased CD4+ T cell turnover. Science (1996) 2.12
Lifespans of naive, memory and effector lymphocytes. Curr Opin Immunol (1993) 1.82
Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am J Physiol (1992) 1.81
Accumulation of bromodeoxyuridine-labeled cells in central and peripheral lymphoid organs: minimal estimates of production and turnover rates of mature lymphocytes. Eur J Immunol (1990) 1.74
Purine and pyrimidine metabolism in human T lymphocytes. Regulation of deoxyribonucleotide metabolism. J Biol Chem (1983) 1.74
Neutrophil kinetics in man. J Clin Invest (1976) 1.72
Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8-oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection. Methods Enzymol (1994) 1.62
Changes in the structure and regeneration mode of the rat small intestinal mucosa following benzalkonium chloride treatment. Gastroenterology (1991) 1.54
A comparison between bromodeoxyuridine and 3H thymidine labeling in human breast tumors. Mod Pathol (1991) 1.50
The turnover of the epithelium of the small intestine. Br Med Bull (1967) 1.38
From deoxynucleotides to DNA synthesis. Fed Proc (1978) 1.36
Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc Natl Acad Sci U S A (1986) 1.24
HIV results in the frame. CD4+ cell turnover. Nature (1995) 1.24
HIV results in the frame. CD4+ cell turnover. Nature (1995) 1.19
Isolation of intestinal epithelial cells for the study of differential gene expression along the crypt-villus axis. Am J Physiol (1991) 1.15
The aetiology and pathogenesis of human breast cancer. Mutat Res (1995) 1.11
Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J Biol Chem (1995) 1.02
Uses of 13C- and 15N-labeled RNA in NMR of RNA-protein complexes. Methods Enzymol (1995) 0.98
Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy. II. Induction of non-classic apoptosis ("para-apoptosis") by tritiated thymidine. Leuk Lymphoma (1995) 0.95
Method for the analysis of oxidized nucleosides by gas chromatography/mass spectrometry. Anal Biochem (1993) 0.87
Electron ionization mass spectra of trimethylsilyl derivatives of nucleosides. Methods Enzymol (1990) 0.86
Concentration dependence of methyl palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry. Biol Mass Spectrom (1993) 0.84
A stable isotope method for measurement of thymidine incorporation into DNA. Cell Tissue Kinet (1977) 0.80
Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia. N Engl J Med (2001) 5.33
Molecular mechanism for duplication 17p11.2- the homologous recombination reciprocal of the Smith-Magenis microdeletion. Nat Genet (2000) 3.80
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme. J Biol Chem (1986) 3.39
Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. J Exp Med (2001) 3.37
Endobronchial tuberculosis. Clinical and bronchoscopic features in 121 cases. Chest (1992) 2.83
Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. JAMA (1999) 2.56
Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS (2001) 2.47
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA. Proc Natl Acad Sci U S A (2002) 2.46
De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption. Am J Clin Nutr (1999) 2.28
Pollen tube guidance by the female gametophyte. Development (1997) 2.22
D-Fucose as a gratuitous inducer of the L-arabinose operon in strains of Escherichia coli B-r mutant in gene araC. J Bacteriol (1971) 2.18
Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol (1999) 2.08
Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr (2000) 2.02
Adipose tissue triglyceride turnover, de novo lipogenesis, and cell proliferation in humans measured with 2H2O. Am J Physiol Endocrinol Metab (2003) 2.00
Burkitt lymphoma in the mouse. J Exp Med (2000) 1.96
The liposhaver in facial plastic surgery. A multi-institutional experience. Arch Otolaryngol Head Neck Surg (1996) 1.91
Mitochondrial DNA content is decreased in autosomal dominant optic atrophy. Neurology (2005) 1.81
Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers. Am J Physiol (1992) 1.81
Effect of bile acid sequestrants on glucose metabolism, hepatic de novo lipogenesis, and cholesterol and bile acid kinetics in type 2 diabetes: a randomised controlled study. Diabetologia (2011) 1.80
Effects of isoenergetic overfeeding of either carbohydrate or fat in young men. Br J Nutr (2000) 1.77
Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest (1999) 1.70
The evolutionary chromosome translocation 4;19 in Gorilla gorilla is associated with microduplication of the chromosome fragment syntenic to sequences surrounding the human proximal CMT1A-REP. Genome Res (2001) 1.64
Myocardial metabolism of free fatty acids. Studies with 14C-labeled substrates in humans. J Clin Invest (1987) 1.59
Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments. J Clin Invest (1988) 1.58
Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest (1995) 1.55
Measurement of TG synthesis and turnover in vivo by 2H2O incorporation into the glycerol moiety and application of MIDA. Am J Physiol Endocrinol Metab (2003) 1.51
Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr (1996) 1.50
Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res (2000) 1.42
Pulmonary function studies in patients with upper airway obstruction. Am Rev Respir Dis (1972) 1.39
False-positive growth of Mycobacterium tuberculosis attributable to laboratory contamination confirmed by restriction fragment length polymorphism analysis. Int J Tuberc Lung Dis (2001) 1.38
Advances in the stable isotope-mass spectrometric measurement of DNA synthesis and cell proliferation. Anal Biochem (2001) 1.37
Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study. J Clin Invest (1997) 1.27
Retention of membrane proteins by the endoplasmic reticulum. J Cell Biol (1985) 1.26
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome. J Med Genet (2000) 1.26
Metabolic fate of extracted glucose in normal human myocardium. J Clin Invest (1985) 1.26
Glycoconjugates as noninvasive probes of intrahepatic metabolism: pathways of glucose entry into compartmentalized hepatic UDP-glucose pools during glycogen accumulation. Proc Natl Acad Sci U S A (1986) 1.24
Ethanol induces CYP2E1 by protein stabilization. Role of ubiquitin conjugation in the rapid degradation of CYP2E1. J Biol Chem (1995) 1.23
Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization. J Biol Chem (1989) 1.20
Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J Clin Invest (2000) 1.19
Lactate extraction during net lactate release in legs of humans during exercise. J Appl Physiol (1985) (1986) 1.17
Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase. Biochem J (1992) 1.17
Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers. J Clin Invest (1994) 1.16
Relative value of various spirometric tests in the early detection of chronic obstructive pulmonary disease. Am Rev Respir Dis (1973) 1.16
Model for measuring absolute rates of hepatic de novo lipogenesis and reesterification of free fatty acids. Am J Physiol (1993) 1.16
Autogenous tissue-engineered cartilage: evaluation as an implant material. Arch Otolaryngol Head Neck Surg (1998) 1.15
Measuring protein synthesis by mass isotopomer distribution analysis (MIDA). Anal Biochem (1999) 1.13
Monoclonal antibodies that inhibit enzyme activity of 3-methylcholanthrene-induced cytochrome P-450. Cancer Res (1982) 1.10
Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients. Int J Cancer (1991) 1.10
Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA. Am J Physiol (1993) 1.09
A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J Biol Chem (2000) 1.08
Relationships between stages of change in cigarette smokers and healthy lifestyle behaviors in a population of young military personnel during forced smoking abstinence. J Consult Clin Psychol (1998) 1.08
Phenotyping of cytochromes P-450 in human tissues with monoclonal antibodies. Proc Natl Acad Sci U S A (1982) 1.06
Dissociation between adipose tissue fluxes and lipogenic gene expression in ob/ob mice. Am J Physiol Endocrinol Metab (2006) 1.06
Genomic disorders: genome architecture results in susceptibility to DNA rearrangements causing common human traits. Cold Spring Harb Symp Quant Biol (2003) 1.06
Diagnostic accuracy of Xpert® MTB/RIF on bronchoscopy specimens in patients with suspected pulmonary tuberculosis. Int J Tuberc Lung Dis (2013) 1.06
Paradoxical response in HIV-negative patients with pleural tuberculosis: a retrospective multicentre study. Int J Tuberc Lung Dis (2012) 1.05
Monoclonal antibody-directed characterization of cytochrome P450 isozymes responsible for toluene metabolism in rat liver. Biochem Pharmacol (1991) 1.04
Interactions among cytochromes P-450 in the endoplasmic reticulum. Detection of chemically cross-linked complexes with monoclonal antibodies. J Biol Chem (1991) 1.03
Isolation and characterization of immune-related genes from the fall webworm, Hyphantria cunea, using PCR-based differential display and subtractive cloning. Insect Biochem Mol Biol (1998) 1.02
Cyclin D1 overexpression is an indicator of poor prognosis in resectable non-small cell lung cancer. Br J Cancer (1999) 1.02
Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes. J Biol Chem (1999) 1.02
Gluconeogenesis and intrahepatic triose phosphate flux in response to fasting or substrate loads. Application of the mass isotopomer distribution analysis technique with testing of assumptions and potential problems. J Biol Chem (1995) 1.02
Monoclonal antibodies to liver microsomal cytochrome P-450E of the marine fish Stenotomus chrysops (scup): cross reactivity with 3-methylcholanthrene induced rat cytochrome P-450. Arch Biochem Biophys (1986) 1.01
Systematic review and meta-analysis of robotic surgery compared with conventional laparoscopic and open resections for gastric carcinoma. Br J Surg (2013) 1.00
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content. J Pharmacol Exp Ther (1992) 1.00
Dopamine transporter density measured by [123I]beta-CIT single-photon emission computed tomography is normal in dopa-responsive dystonia. Ann Neurol (1998) 1.00
In vitro neutralization of hepatitis B virus by monoclonal antibodies against the viral surface antigen. J Med Virol (1997) 1.00
The inhibition of gluconeogenesis following alcohol in humans. Am J Physiol (1998) 1.00
Variations of the ventral rami of the brachial plexus. J Korean Med Sci (1992) 0.99
Effects of modified alternate-day fasting regimens on adipocyte size, triglyceride metabolism, and plasma adiponectin levels in mice. J Lipid Res (2007) 0.99
Myocardial lactate release during ischemia in swine. Relation to regional blood flow. Circulation (1990) 0.98
Effect of omeprazole on the pharmacokinetics of moclobemide according to the genetic polymorphism of CYP2C19. Clin Pharmacol Ther (2001) 0.98
Stabilization of cytochrome P450j messenger ribonucleic acid in the diabetic rat. Mol Endocrinol (1987) 0.97
Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: correlation between macular morphology and visual function. Eye (Lond) (2011) 0.97
Sources of plasma glucose and liver glycogen in fasted ob/ob mice. Acta Diabetol (2005) 0.97
Effect of pinitol treatment on insulin action in subjects with insulin resistance. Diabetes Care (2000) 0.97
Expression and prognostic implications of cell cycle regulatory molecules, p16, p21, p27, p14 and p53 in germinal centre and non-germinal centre B-like diffuse large B-cell lymphomas. Histopathology (2005) 0.96
Systemic lactate kinetics during graded exercise in man. Am J Physiol (1985) 0.96
Monoclonal antibodies to phenobarbital-induced rat liver cytochrome P-450. Biochem Pharmacol (1984) 0.96
Effects of nicotinic acid on fatty acid kinetics, fuel selection, and pathways of glucose production in women. Am J Physiol Endocrinol Metab (2000) 0.95
Magnetic resonance imaging in hemospermia. J Urol (1997) 0.95
Effect of dietary energy restriction on glucose production and substrate utilization in type 2 diabetes. Diabetes (2000) 0.95
Monoclonal antibody phenotyping of interindividual differences in cytochrome P-450-dependent reactions of single and twin human placenta. Cancer Res (1984) 0.95
Spinocerebellar ataxia type 17 mutation as a causative and susceptibility gene in parkinsonism. Neurology (2009) 0.94
Comparison of retinal nerve fibre layers between 11778 and 14484 mutations in Leber's hereditary optic neuropathy. Eye (Lond) (2009) 0.94
Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochem J (1999) 0.94
Identification and quantitation of a 2.0-kilobase messenger ribonucleic acid coding for 3-methylcholanthrene-induced cytochrome P-450 using cloned cytochrome P-450 complementary deoxyribonucleic acid. Biochemistry (1982) 0.94
Use of bacitracin therapy for infection due to vancomycin-resistant Enterococcus faecium. Clin Infect Dis (1995) 0.94