Published in J Biol Chem on January 23, 1998
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48
Phospholipase A2 biochemistry. Cardiovasc Drugs Ther (2008) 1.93
Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J Cell Biol (1999) 1.46
Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A (2012) 1.25
Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance. Proc Natl Acad Sci U S A (1999) 1.18
50 years of allosteric interactions: the twists and turns of the models. Nat Rev Mol Cell Biol (2013) 1.17
Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2008) 1.14
Inherited human cPLA(2alpha) deficiency is associated with impaired eicosanoid biosynthesis, small intestinal ulceration, and platelet dysfunction. J Clin Invest (2008) 1.12
A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem (2008) 1.12
Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes. J Cell Biol (2003) 1.05
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell (2008) 1.05
Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. J Biol Chem (2009) 1.04
Cytosolic phospholipase A₂: physiological function and role in disease. J Lipid Res (2015) 1.03
Regulation of the Golgi complex by phospholipid remodeling enzymes. Biochim Biophys Acta (2012) 1.01
Localization and function of cytosolic phospholipase A2alpha at the Golgi. Biochimie (2010) 1.01
The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol Biol Cell (2003) 0.97
Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. J Biol Chem (2012) 0.96
Membranes serve as allosteric activators of phospholipase A2, enabling it to extract, bind, and hydrolyze phospholipid substrates. Proc Natl Acad Sci U S A (2015) 0.93
Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells. Mol Biol Cell (2005) 0.91
Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochim Biophys Acta (2008) 0.88
Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. PLoS One (2013) 0.85
JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2. J Biol Chem (2009) 0.85
Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. J Biol Chem (2012) 0.81
Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA. Biochem J (2005) 0.81
TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochim Biophys Acta (2009) 0.81
Engineered nanoparticles mimicking cell membranes for toxin neutralization. Adv Drug Deliv Rev (2015) 0.81
C2 domain membrane penetration by group IVA cytosolic phospholipase A₂ induces membrane curvature changes. J Lipid Res (2012) 0.81
Functional characterization of mutations in inherited human cPLA₂ deficiency. Biochemistry (2011) 0.81
The molecular basis of ceramide-1-phosphate recognition by C2 domains. J Lipid Res (2012) 0.81
The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J Lipid Res (2009) 0.80
Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view. Purinergic Signal (2011) 0.79
Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A2-alpha. Biochem Pharmacol (2005) 0.78
Characterization of serum phospholipase a(2) activity in three diverse species of west african crocodiles. Biochem Res Int (2011) 0.75
Liberating Chiral Lipid Mediators, Inflammatory Enzymes, and LIPID MAPS from Biological Grease. J Biol Chem (2016) 0.75
The expanding superfamily of phospholipase A(2) enzymes: classification and characterization. Biochim Biophys Acta (2000) 4.62
Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proc Natl Acad Sci U S A (1999) 2.85
Monoclonal autoantibodies specific for oxidized phospholipids or oxidized phospholipid-protein adducts inhibit macrophage uptake of oxidized low-density lipoproteins. J Clin Invest (1999) 2.81
Inhibition of phospholipase A2 by "lipocortins" and calpactins. An effect of binding to substrate phospholipids. J Biol Chem (1987) 2.75
Lipid signaling enzymes and surface dilution kinetics. J Biol Chem (1995) 2.41
Inhibition of macrophage Ca(2+)-independent phospholipase A2 by bromoenol lactone and trifluoromethyl ketones. J Biol Chem (1995) 2.23
Solubilization of phospholipids by detergents. Structural and kinetic aspects. Biochim Biophys Acta (1983) 2.05
Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol (1999) 1.98
Scavenger receptors, oxidized LDL, and atherosclerosis. Ann N Y Acad Sci (2001) 1.82
The geometry of the transition state in the hydrolysis of phosphate esters. J Am Chem Soc (1966) 1.81
Intracellular sites of lipid synthesis and the biogenesis of mitochondria. J Lipid Res (1972) 1.66
Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate. Biochim Biophys Acta (1996) 1.62
Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages. Proc Natl Acad Sci U S A (1995) 1.61
Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells. Proc Natl Acad Sci U S A (1999) 1.58
Kinetic analysis of phospholipase A2 activity toward mixed micelles and its implications for the study of lipolytic enzymes. J Biol Chem (1975) 1.55
The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. J Biol Chem (2000) 1.54
Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages. J Biol Chem (1996) 1.54
Acyl and phosphoryl migration in lysophospholipids: importance in phospholipid synthesis and phospholipase specificity. Biochemistry (1982) 1.53
Calcium-independent phospholipase A(2): structure and function. Biochim Biophys Acta (2000) 1.53
Ca(2+)-independent cytosolic phospholipase A2 from macrophage-like P388D1 cells. Isolation and characterization. J Biol Chem (1994) 1.52
The mechanism of action of ribonuclease. Proc Natl Acad Sci U S A (1969) 1.51
Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity. J Biol Chem (1977) 1.44
Evolutionary relationships and implications for the regulation of phospholipase A2 from snake venom to human secreted forms. J Mol Evol (1990) 1.40
Antisense inhibition of group VI Ca2+-independent phospholipase A2 blocks phospholipid fatty acid remodeling in murine P388D1 macrophages. J Biol Chem (1997) 1.37
Interfacial properties and critical micelle concentration of lysophospholipids. Biochemistry (1989) 1.36
Bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse P388D1 macrophages. J Biol Chem (1996) 1.35
Function and inhibition of intracellular calcium-independent phospholipase A2. J Biol Chem (1997) 1.34
Identity between the Ca2+-independent phospholipase A2 enzymes from P388D1 macrophages and Chinese hamster ovary cells. J Biol Chem (1997) 1.31
Bacterial lipopolysaccharide priming of P388D1 macrophage-like cells for enhanced arachidonic acid metabolism. Platelet-activating factor receptor activation and regulation of phospholipase A2. J Biol Chem (1990) 1.30
Analysis of human synovial fluid phospholipase A2 on short chain phosphatidylcholine-mixed micelles: development of a spectrophotometric assay suitable for a microtiterplate reader. Anal Biochem (1992) 1.20
Kinetic dependence of phospholipase A 2 activity on the detergent Triton X-100. J Lipid Res (1973) 1.19
Phospholipase A2 contamination of cobra venom factor preparations. Biologic role in complement-dependent in vivo reactions and inactivation with p-bromophenacyl bromide. Am J Pathol (1978) 1.19
Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine. J Biol Chem (1996) 1.16
Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. Br J Pharmacol (2010) 1.16
Group-specific assays that distinguish between the four major types of mammalian phospholipase A2. Anal Biochem (1999) 1.15
Enzymatic synthesis and decarboxylation of phosphatidylserine in Tetrahymena pyriformis. J Lipid Res (1970) 1.15
Metal ion and salt effects on the phospholipase A2, lysophospholipase, and transacylase activities of human cytosolic phospholipase A2. Biochim Biophys Acta (1993) 1.14
Novel group V phospholipase A2 involved in arachidonic acid mobilization in murine P388D1 macrophages. J Biol Chem (1996) 1.13
Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain. J Neurochem (1999) 1.12
Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. J Biol Chem (1993) 1.06
Phospholipase A2 activity towards phosphatidylcholine in mixed micelles: surface dilution kinetics and the effect of thermotropic phase transitions. Arch Biochem Biophys (1973) 1.06
Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2. Biochemistry (1977) 1.05
Phospholipase A2 from cobra venom (Naja naja naja). Methods Enzymol (1981) 1.04
Mammalian lysophospholipases. Biochim Biophys Acta (1999) 1.04
Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes. Proc Natl Acad Sci U S A (1994) 1.03
Functional coupling between secretory phospholipase A2 and cyclooxygenase-2 and its regulation by cytosolic group IV phospholipase A2. Proc Natl Acad Sci U S A (1998) 1.03
Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A(2): structure-function studies with vesicle, micelle, and membrane assays. Biochim Biophys Acta (1999) 1.00
Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. J Immunol (2000) 1.00
Analysis of phospholipase C (Bacillus cereus) action toward mixed micelles of phospholipid and surfactant. Arch Biochem Biophys (1976) 0.99
Phospholipid activation of cobra venom phospholipase A2. 1. Lipid--lipid or lipid--enzyme interaction. Biochemistry (1979) 0.99
Dual role of interfacial phospholipid in phospholipase A2 catalysis. Proc Natl Acad Sci U S A (1977) 0.98
Phospholipid activation of cobra venom phospholipase A2. 2. Characterization of the phospholipid--enzyme interaction. Biochemistry (1979) 0.98
Assay strategies and methods for phospholipases. Methods Enzymol (1991) 0.98
Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s. J Biol Chem (1999) 0.97
Activation, aggregation, and product inhibition of cobra venom phospholipase A2 and comparison with other phospholipases. J Biol Chem (1985) 0.97
1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2. Anal Biochem (1994) 0.97
Interfacial activation, lysophospholipase and transacylase activity of group VI Ca2+-independent phospholipase A2. Biochim Biophys Acta (1998) 0.96
Solubilization, purification, and characterization of a membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line. J Biol Chem (1988) 0.96
Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association. Proc Natl Acad Sci U S A (1993) 0.96
Regulation of arachidonic acid mobilization in lipopolysaccharide-activated P388D(1) macrophages by adenosine triphosphate. J Biol Chem (1999) 0.95
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid. J Biol Chem (1988) 0.95
Structures of two novel crystal forms of Naja naja naja phospholipase A2 lacking Ca2+ reveal trimeric packing. J Mol Biol (1998) 0.94
Identification of a third pathway for arachidonic acid mobilization and prostaglandin production in activated P388D1 macrophage-like cells. J Biol Chem (2000) 0.93
Kinetic analysis of the dual phospholipid model for phospholipase A2 action. J Biol Chem (1984) 0.93
Mammalian calcium-independent phospholipase A2. Biochim Biophys Acta (1995) 0.93
Affinity chromatography of phospholipase A2 from Naja naja naja (Indian cobra) venom. Toxicon (1985) 0.93
The specificity of phospholipase A2 and phospholipase C in a mixed micellar system. J Biol Chem (1978) 0.92
Cobra venom phospholipase A2 inhibition by manoalide. A novel type of phospholipase inhibitor. J Biol Chem (1985) 0.92
Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells. J Biol Chem (1999) 0.91
Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amnionic WISH cells. J Biol Chem (1998) 0.91
Immobilized phospholipase A2 from cobra venom. Prevention of substrate interfacial and activator effects. J Biol Chem (1985) 0.91
Biological relevance of lipocortins and related proteins as inhibitors of phospholipase A2. Biochem Pharmacol (1989) 0.90
Action of cobra venom phospholipase A2 on the gel and liquid crystalline states of dimyristoyl and dipalmitoyl phosphatidylcholine vesicles. J Biol Chem (1979) 0.90
The interaction of phospholipase A2 with phospholipid analogues and inhibitors. J Biol Chem (1990) 0.89
Differential regulation of phospholipase D and phospholipase A2 by protein kinase C in P388D1 macrophages. Biochem J (1997) 0.89
VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A2. Br J Pharmacol (2001) 0.89
Regiospecificity and catalytic triad of lysophospholipase I. J Biol Chem (1997) 0.89
Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience (2005) 0.89
Spectral perturbations of the histidine and tryptophan in cobra venom phospholipase A2 upon metal ion and mixed micelle binding. J Biol Chem (1977) 0.89
Characterization and physical properties of the major form of phospholipase A2 from cobra venom (Naja naja naja) that has a molecular weight of 11,000. J Biol Chem (1975) 0.89
Conformation of micellar phospholipid bound to the active site of phospholipase A2. Biochemistry (1995) 0.89
Expression and characterization of human group V phospholipase A2. Biochim Biophys Acta (1998) 0.89
Lysophospholipases I and II from P388D1 macrophage-like cell line. Methods Enzymol (1991) 0.89
Cloning, expression, and catalytic mechanism of murine lysophospholipase I. J Biol Chem (1997) 0.88
Purification and characterization of a lysophospholipase from a macrophage-like cell line P388D1. J Biol Chem (1988) 0.88
A phospholipase D-mediated pathway for generating diacylglycerol in nuclei from Madin-Darby canine kidney cells. J Biol Chem (1995) 0.88
Activation, aggregation, inhibition and the mechanism of phospholipase A2. Adv Exp Med Biol (1990) 0.88
Proton magnetic resonance relaxation studies on the structure of mixed micelles of Triton X-100 and dimyristoylphosphatidylcholine. Biochemistry (1975) 0.88
Formation and characterization of mixed micelles of the nonionic surfactant Triton X-100 with egg, dipalmitoyl, and dimyristoyl phosphatidylcholines. Arch Biochem Biophys (1974) 0.87
Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. J Biol Chem (1997) 0.87
Group V phospholipase A(2)-dependent induction of cyclooxygenase-2 in macrophages. J Biol Chem (1999) 0.87
Critical role of a hydrogen bond in the interaction of phospholipase A2 with transition-state and substrate analogues. Proc Natl Acad Sci U S A (1991) 0.87
A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. Biochim Biophys Acta (1999) 0.87
Action of the highly purified, membrane-bound enzyme phosphatidylserine decarboxylase Escherichia coli toward phosphatidylserine in mixed micelles and erythrocyte ghosts in the presence of surfactant. J Biol Chem (1975) 0.86
The biosynthesis of phospholipids. Methods Enzymol (1992) 0.86
Purification and characterization of a lysophospholipase from human amnionic membranes. J Biol Chem (1984) 0.86
Exploring the action and specificity of cobra venom phospholipase A2 toward human erythrocytes, ghost membranes, and lipid mixtures. J Biol Chem (1978) 0.85
Action of cobra venom phospholipase A2 toward lipids of erythrocyte membranes. Prog Clin Biol Res (1979) 0.85
Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells. Biochem J (1994) 0.84