Unique targeting of cytosolic phospholipase A2 to plasma membranes mediated by the NADPH oxidase in phagocytes.

PubWeight™: 1.05‹?› | Rank: Top 15%

🔗 View Article (PMC 2173789)

Published in J Cell Biol on August 11, 2003

Authors

Zeev Shmelzer1, Nurit Haddad, Ester Admon, Itai Pessach, Thomas L Leto, Zahit Eitan-Hazan, Michal Hershfinkel, Rachel Levy

Author Affiliations

1: Infectious Diseases Laboratory, Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva 84105, Israel.

Articles citing this

Assembly of the phagocyte NADPH oxidase. Histochem Cell Biol (2004) 2.71

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48

Single-cell Raman and fluorescence microscopy reveal the association of lipid bodies with phagosomes in leukocytes. Proc Natl Acad Sci U S A (2005) 2.02

Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem (2011) 1.27

Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem (2004) 1.22

Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol (2008) 1.15

Reactive oxygen species in phagocytic leukocytes. Histochem Cell Biol (2008) 1.14

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol Biol Cell (2006) 1.14

Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils. J Immunol (2010) 1.11

Regulation of the NADPH-oxidase complex of phagocytic leukocytes. Recent insights from structural biology, molecular genetics, and microscopy. Histochem Cell Biol (2004) 0.99

Targeting NADPH oxidase and phospholipases A2 in Alzheimer's disease. Mol Neurobiol (2010) 0.88

Phospholipases A2 and neural membrane dynamics: implications for Alzheimer's disease. J Neurochem (2011) 0.87

New insights into the regulation of neutrophil NADPH oxidase activity in the phagosome: a focus on the role of lipid and Ca(2+) signaling. Antioxid Redox Signal (2012) 0.85

Phospholipase A2IVα regulates phagocytosis independent of its enzymatic activity. J Biol Chem (2012) 0.84

Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death Dis (2013) 0.84

Amyloid-beta peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A2. Biochim Biophys Acta (2008) 0.83

Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets. Front Immunol (2015) 0.83

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway. J Neuroinflammation (2015) 0.80

The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J Lipid Res (2009) 0.80

Oxidative-stress induced increase in circulating fatty acids does not contribute to phospholipase A2-dependent appetitive long-term memory failure in the pond snail Lymnaea stagnalis. BMC Neurosci (2014) 0.79

Integrating cytosolic phospholipase A₂ with oxidative/nitrosative signaling pathways in neurons: a novel therapeutic strategy for AD. Mol Neurobiol (2012) 0.79

Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production. J Biol Chem (2014) 0.78

Regulation of cytosolic phospholipase A2 (cPLA2alpha) and its association with cell proliferation in human lens epithelial cells. Invest Ophthalmol Vis Sci (2011) 0.78

Polymorphonuclear leukocyte mediated oxidative inactivation of alpha-1-proteinase inhibitor: Modulation by nitric oxide. Indian J Clin Biochem (2005) 0.75

Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia. J Neuroinflammation (2017) 0.75

Articles cited by this

NADPH oxidase: an update. Blood (1999) 7.65

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol (2001) 4.64

Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine (Baltimore) (2000) 4.45

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals. Cell (1998) 3.90

The neutrophil NADPH oxidase. Arch Biochem Biophys (2002) 3.71

Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. J Cell Biol (2000) 3.63

PI(4,5)P(2) regulation of surface membrane traffic. Curr Opin Cell Biol (2001) 3.14

The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci (1993) 3.02

Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains? Protein Sci (1996) 2.40

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40(phox). Nat Cell Biol (2001) 2.39

Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13

Location, location, location: membrane targeting directed by PX domains. Science (2001) 2.09

Signaling and subcellular targeting by membrane-binding domains. Annu Rev Biophys Biomol Struct (2000) 2.00

Assembly of the phagocyte NADPH oxidase: binding of Src homology 3 domains to proline-rich targets. Proc Natl Acad Sci U S A (1994) 1.92

Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components. J Biol Chem (1991) 1.92

Calcium-mediated translocation of cytosolic phospholipase A2 to the nuclear envelope and endoplasmic reticulum. J Biol Chem (1995) 1.90

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937. Proc Natl Acad Sci U S A (1990) 1.87

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain. J Biol Chem (1994) 1.82

The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells. J Biol Chem (1991) 1.79

Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation. J Biol Chem (2000) 1.66

Translocation of the 85-kDa phospholipase A2 from cytosol to the nuclear envelope in rat basophilic leukemia cells stimulated with calcium ionophore or IgE/antigen. J Biol Chem (1995) 1.65

Passive mechanical behavior of human neutrophils: effect of cytochalasin B. Biophys J (1994) 1.62

Gene targeting of X chromosome-linked chronic granulomatous disease locus in a human myeloid leukemia cell line and rescue by expression of recombinant gp91phox. Proc Natl Acad Sci U S A (1993) 1.60

Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase activation. J Biol Chem (1994) 1.58

Characterization of neutrophil NADPH oxidase factors p47-phox and p67-phox from recombinant baculoviruses. J Biol Chem (1991) 1.54

Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox. J Biol Chem (2003) 1.46

Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J Cell Biol (1999) 1.46

The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2. J Biol Chem (2003) 1.44

Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J Biol Chem (1998) 1.39

Subcellular fractionation of human neutrophils on Percoll density gradients. J Immunol Methods (1999) 1.37

Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2. J Biol Chem (1999) 1.37

Nuclear envelope and chromatin compositional differences comparing undifferentiated and retinoic acid- and phorbol ester-treated HL-60 cells. Exp Cell Res (2001) 1.35

Localization and regulation of cytosolic phospholipase A(2). Biochim Biophys Acta (2000) 1.31

Transient association of the nicotinamide adenine dinucleotide phosphate oxidase subunits p47phox and p67phox with phagosomes in neutrophils from patients with X-linked chronic granulomatous disease. Blood (1999) 1.29

Cytoplasmic phospholipase A2 translocates to membrane fraction in human neutrophils activated by stimuli that phosphorylate mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1994) 1.27

Group IV cytosolic phospholipase A2 binds with high affinity and specificity to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity. J Biol Chem (1998) 1.25

The role of calcium and phosphorylation of cytosolic phospholipase A2 in regulating arachidonic acid release in macrophages. J Biol Chem (1998) 1.24

The requirement for phospholipase A2 for activation of the assembled NADPH oxidase in human neutrophils. Biochem J (1994) 1.22

Redistribution of 5-lipoxygenase and cytosolic phospholipase A2 to the nuclear fraction upon macrophage activation. Biochem Biophys Res Commun (1993) 1.22

Induction of the respiratory burst in HL-60 cells. Correlation of function and protein expression. J Immunol (1990) 1.18

Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. J Biol Chem (2001) 1.17

JFC1, a novel tandem C2 domain-containing protein associated with the leukocyte NADPH oxidase. J Biol Chem (2001) 1.14

Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. J Biol Chem (2000) 1.12

Cytosolic phospholipase A2 (cPLA2) regulation of human monocyte NADPH oxidase activity. cPLA2 affects translocation but not phosphorylation of p67(phox) and p47(phox). J Biol Chem (2002) 1.11

Essential requirement of cytosolic phospholipase A(2) for activation of the H(+) channel in phagocyte-like cells. J Biol Chem (1999) 1.07

Treatment of neutrophils with cytochalasins converts rolling to stationary adhesion on P-selectin. J Cell Physiol (1998) 1.05

Mutagenesis of an arginine- and lysine-rich domain in the gp91(phox) subunit of the phagocyte NADPH-oxidase flavocytochrome b558. J Biol Chem (1999) 1.02

Time-dependent alterations in the deformability of human neutrophils in response to chemotactic activation. Blood (1990) 1.01

Activation of cytosolic phospholipase A2 by transforming growth factor-alpha in HEL-30 keratinocytes. J Biol Chem (1993) 1.00

Determination of the calcium-binding sites of the C2 domain of protein kinase Calpha that are critical for its translocation to the plasma membrane. Biochem J (1999) 0.99

Selective inhibition of cytosolic phospholipase A2 in activated human monocytes. Regulation of superoxide anion production and low density lipoprotein oxidation. J Biol Chem (1997) 0.99

Mechanisms of the priming effect of lipopolysaccharides on the biosynthesis of leukotriene B4 in chemotactic peptide-stimulated human neutrophils. FASEB J (1998) 0.98

Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils: its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton. J Immunol (1996) 0.96

The immediate activator of the NADPH oxidase is arachidonate not phosphorylation. Eur J Biochem (1993) 0.95

Differentiation of PLB-985 myeloid cells into mature neutrophils, shown by degranulation of terminally differentiated compartments in response to N-formyl peptide and priming of superoxide anion production by granulocyte-macrophage colony-stimulating factor. Br J Haematol (2002) 0.95

Cytosolic phospholipase A2 and its mode of activation in human neutrophils by opsonized zymosan. Correlation between 42/44 kDa mitogen-activated protein kinase, cytosolic phospholipase A2 and NADPH oxidase. Biochem J (1997) 0.94

Arachidonic acid increases the activity of the assembled NADPH oxidase in cytoplasmic membranes and endosomes. Biochim Biophys Acta (1993) 0.94

Involvement of cytosolic phospholipase A2 and secretory phospholipase A2 in arachidonic acid release from human neutrophils. J Immunol (2000) 0.93

"Cytosolic" phospholipase A2 is in the nucleus of subconfluent endothelial cells but confined to the cytoplasm of confluent endothelial cells and redistributes to the nuclear envelope and cell junctions upon histamine stimulation. Lab Invest (1996) 0.91

Functional analysis of NADPH oxidase in granulocytic cells expressing a delta488-497 gp91(phox) deletion mutant. Blood (1999) 0.91

The requirement of p47 phosphorylation for activation of NADPH oxidase by opsonized zymosan in human neutrophils. Biochim Biophys Acta (1994) 0.88

Diverse effects of neutrophil integrin occupation on respiratory burst activation. Cell Immunol (1999) 0.88

Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells. J Biol Chem (1999) 0.86

Structural changes are induced in human neutrophil cytochrome b by NADPH oxidase activators, LDS, SDS, and arachidonate: intermolecular resonance energy transfer between trisulfopyrenyl-wheat germ agglutinin and cytochrome b(558). Biochim Biophys Acta (2002) 0.86

Essential requirement of cytosolic phospholipase A(2) for stimulation of NADPH oxidase-associated diaphorase activity in granulocyte-like cells. J Biol Chem (2001) 0.85

The requirement of both extracellular regulated kinase and p38 mitogen-activated protein kinase for stimulation of cytosolic phospholipase A(2) activity by either FcgammaRIIA or FcgammaRIIIB in human neutrophils. A possible role for Pyk2 but not for the Grb2-Sos-Shc complex. J Biol Chem (2000) 0.85

Epidermal growth factor (EGF) induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic phospholipase A2. Eur J Biochem (1995) 0.84

Independent functioning of cytosolic phospholipase A2 and phospholipase D1 in Trp-Lys-Tyr-Met-Val-D-Met-induced superoxide generation in human monocytes. J Immunol (2000) 0.83

Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets. Thromb Res (1998) 0.81

Acceleration by ceramide of calcium-dependent translocation of phospholipase A2 from cytosol to membranes in platelets. Arch Biochem Biophys (2000) 0.80

Translocation of annexin I to plasma membranes and phagosomes in human neutrophils upon stimulation with opsonized zymosan: possible role in phagosome function. Biochem J (1996) 0.77

Ultracytochemical study on the localization of superoxide producing sites in stimulated rat neutrophils. Anat Rec (2000) 0.77

Involvement of intracellular pH elevation in the effect of 1,25-dihydroxyvitamin D3 on HL-60 cells. Cancer Res (1989) 0.76

Articles by these authors

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J (2003) 3.44

Oxidative innate immune defenses by Nox/Duox family NADPH oxidases. Contrib Microbiol (2008) 2.50

The Nox family of NAD(P)H oxidases: host defense and beyond. J Biol Chem (2004) 2.48

NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc Natl Acad Sci U S A (2009) 2.36

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res (2008) 2.33

Involvement of Rac1 in activation of multicomponent Nox1- and Nox3-based NADPH oxidases. Mol Cell Biol (2006) 1.80

Subcellular localization and function of alternatively spliced Noxo1 isoforms. Free Radic Biol Med (2006) 1.76

Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem (2003) 1.70

Role of GPR40 in fatty acid action on the beta cell line INS-1E. Biochem Biophys Res Commun (2005) 1.69

Endothelial ICAM-1 protein induction is regulated by cytosolic phospholipase A2α via both NF-κB and CREB transcription factors. J Immunol (2011) 1.57

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis. Eur J Immunol (2008) 1.54

The neurophysiology and pathology of brain zinc. J Neurosci (2011) 1.46

PLA2G6 mutation underlies infantile neuroaxonal dystrophy. Am J Hum Genet (2006) 1.44

Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus. J Neurosci (2009) 1.41

NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes. J Immunol (2003) 1.38

Duox maturation factors form cell surface complexes with Duox affecting the specificity of reactive oxygen species generation. FASEB J (2008) 1.36

Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency. J Exp Med (2010) 1.35

The Pseudomonas toxin pyocyanin inhibits the dual oxidase-based antimicrobial system as it imposes oxidative stress on airway epithelial cells. J Immunol (2008) 1.35

Obesity leads to higher risk of sperm DNA damage in infertile patients. Asian J Androl (2013) 1.34

Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells. Free Radic Biol Med (2012) 1.31

Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter. J Biol Chem (2009) 1.28

Hepatitis C virus (HCV) proteins induce NADPH oxidase 4 expression in a transforming growth factor beta-dependent manner: a new contributor to HCV-induced oxidative stress. J Virol (2009) 1.27

Lithium-calcium exchange is mediated by a distinct potassium-independent sodium-calcium exchanger. J Biol Chem (2004) 1.27

Mechanism and regulation of cellular zinc transport. Mol Med (2007) 1.25

Pyocyanin effects on respiratory epithelium: relevance in Pseudomonas aeruginosa airway infections. Trends Microbiol (2012) 1.18

Synaptic release of zinc from brain slices: factors governing release, imaging, and accurate calculation of concentration. J Neurosci Methods (2006) 1.17

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox. Mol Biol Cell (2006) 1.14

Sequential binding of cytosolic Phox complex to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green System and live imaging of phagocytosis. J Immunol (2008) 1.10

Extracellular zinc triggers ERK-dependent activation of Na+/H+ exchange in colonocytes mediated by the zinc-sensing receptor. J Biol Chem (2004) 1.09

Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor. J Neurosci (2011) 1.08

MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia. Hum Reprod (2012) 1.06

The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal (2010) 1.06

Double-stranded RNA induces shedding of the 34-kDa soluble TNFR1 from human airway epithelial cells via TLR3-TRIF-RIP1-dependent signaling: roles for dual oxidase 2- and caspase-dependent pathways. J Immunol (2010) 1.04

Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant. J Biol Chem (2004) 1.04

Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant (2007) 1.02

Pyocyanin-enhanced neutrophil extracellular trap formation requires the NADPH oxidase. PLoS One (2013) 1.02

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. Proc Natl Acad Sci U S A (2012) 1.01

Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase. J Biol Chem (2007) 1.01

Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair. J Biol Chem (2010) 0.98

Ketamine attenuates neutrophil activation after cardiopulmonary bypass. Anesth Analg (2002) 0.97

Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain. J Comp Neurol (2002) 0.96

Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin. Immunol Res (2009) 0.96

Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells. Carcinogenesis (2008) 0.95

Characterization of hydrogen peroxide production by Duox in bronchial epithelial cells exposed to Pseudomonas aeruginosa. FEBS Lett (2010) 0.95

A sodium zinc exchange mechanism is mediating extrusion of zinc in mammalian cells. J Biol Chem (2003) 0.94

Zinc influx and physiological consequences in the beta-insulinoma cell line, Min6. Biochem Biophys Res Commun (2006) 0.94

Peroxiredoxin 6 translocates to the plasma membrane during neutrophil activation and is required for optimal NADPH oxidase activity. Biochim Biophys Acta (2011) 0.94

Phosphatidylserine externalization in human sperm induced by calcium ionophore A23187: relationship with apoptosis, membrane scrambling and the acrosome reaction. Hum Reprod (2005) 0.93

The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion. PLoS One (2012) 0.92

Cryopreservation induces an apoptosis-like mechanism in bull sperm. Biol Reprod (2004) 0.92

Abnormal neutrophil chemotactic activity in children with congenital insensitivity to pain with anhidrosis (CIPA): the role of nerve growth factor. Clin Immunol (2008) 0.92

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis. J Neurosci (2013) 0.92

Release of cystic fibrosis airway inflammatory markers from Pseudomonas aeruginosa-stimulated human neutrophils involves NADPH oxidase-dependent extracellular DNA trap formation. J Immunol (2014) 0.91

Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2. PLoS One (2012) 0.89

ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. Glia (2004) 0.89

Induction of cytosolic phospholipase a2α is required for adipose neutrophil infiltration and hepatic insulin resistance early in the course of high-fat feeding. Diabetes (2013) 0.89

The extracellular zinc-sensing receptor mediates intercellular communication by inducing ATP release. Biochem Biophys Res Commun (2005) 0.88

Silencing of ZnT-1 expression enhances heavy metal influx and toxicity. J Mol Med (Berl) (2006) 0.88

Rapid and reactive nitric oxide production by astrocytes in mouse neocortical slices. Glia (2005) 0.88

Radical generation and alterations of erythrocyte integrity as bioindicators of diagnostic or prognostic value in COPD? Antioxid Redox Signal (2008) 0.88

Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin. PLoS One (2012) 0.87

NLRP3 inflammasome activation and interleukin-1β release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm Res (2014) 0.87

HT-29 human colon cancer cell proliferation is regulated by cytosolic phospholipase A(2)α dependent PGE(2)via both PKA and PKB pathways. Biochim Biophys Acta (2012) 0.87

Postnatal regulation of ZnT-1 expression in the mouse brain. Brain Res Dev Brain Res (2002) 0.87

The synergistic anti-inflammatory effects of lycopene, lutein, β-carotene, and carnosic acid combinations via redox-based inhibition of NF-κB signaling. Free Radic Biol Med (2012) 0.86

Single alpha-domain constructs of the Na+/Ca2+ exchanger, NCLX, oligomerize to form a functional exchanger. Biochemistry (2006) 0.86

The N-formylpeptide receptor (FPR) and a second G(i)-coupled receptor mediate fMet-Leu-Phe-stimulated activation of NADPH oxidase in murine neutrophils. Cell Immunol (2002) 0.86

Two different pathways are involved in peroxynitrite-induced senescence and apoptosis of human erythrocytes. Free Radic Biol Med (2006) 0.86

Cell death induced by zinc and cadmium is mediated by clusterin in cultured mouse seminiferous tubules. J Cell Physiol (2009) 0.86

Direct effect of human immunodeficiency virus protease inhibitors on neutrophil function and apoptosis via calpain inhibition. Clin Vaccine Immunol (2007) 0.85

Detection and characterization of hepatitis C virus RNA in seminal plasma and spermatozoon fractions of semen from patients attempting medically assisted conception. J Clin Microbiol (2002) 0.85

Stimulation of NADPH oxidase by angiotensin II in human neutrophils is mediated by ERK, p38 MAP-kinase and cytosolic phospholipase A2. J Hypertens (2005) 0.85

The lipophilic zinc chelator DP-b99 prevents zinc induced neuronal death. Eur J Pharmacol (2009) 0.85

Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod (2010) 0.85

Histamine stimulates hydrogen peroxide production by bronchial epithelial cells via histamine H1 receptor and dual oxidase. Am J Respir Cell Mol Biol (2014) 0.85

Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis. J Histochem Cytochem (2005) 0.84

Inhibitory mechanism of store-operated Ca2+ channels by zinc. J Biol Chem (2004) 0.84

Posttesticular sperm maturation, infertility, and hypercholesterolemia. Asian J Androl (2015) 0.84

Sofosbuvir for treatment of chronic hepatitis C. Hepatol Int (2015) 0.84

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding. J Biol Chem (2011) 0.84

Plasmodium falciparum merozoite surface protein 1 blocks the proinflammatory protein S100P. Proc Natl Acad Sci U S A (2012) 0.84

Complement receptor 3 (CD11b/CD18) is implicated in the elimination of β-amyloid peptides. Fundam Clin Pharmacol (2011) 0.84

Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger. J Biol Chem (2012) 0.84

Biological predictive criteria for clinical pregnancy after elective single embryo transfer. Fertil Steril (2011) 0.83

A role for ZnT-1 in regulating cellular cation influx. Biochem Biophys Res Commun (2004) 0.83

Hypoparathyroidism, retardation, and dysmorphism syndrome: impaired early growth and increased susceptibility to severe infections due to hyposplenism and impaired polymorphonuclear cell functions. Pediatr Res (2007) 0.83

Clioquinol effects on tissue chelatable zinc in mice. J Mol Med (Berl) (2003) 0.83

Cytosolic phospholipase A2alpha is targeted to the p47phox-PX domain of the assembled NADPH oxidase via a novel binding site in its C2 domain. J Biol Chem (2008) 0.82

The requirement of cytosolic phospholipase A2 for the PMA activation of proton efflux through the N-terminal 230-amino-acid fragment of gp91phox. Biochem J (2003) 0.82

Multicenter quality control for the detection of hepatitis C virus RNA in seminal plasma specimens. J Clin Microbiol (2003) 0.81

Induction of Fc gammaRIIA expression in myeloid PLB cells during differentiation depends on cytosolic phospholipase A2 activity and is regulated via activation of CREB by PGE2. Blood (2006) 0.81

Risk of venous thromboembolism in pediatric patients with brain tumors. Pediatr Blood Cancer (2004) 0.81

Targeting lipid rafts inhibits protein kinase B by disrupting calcium homeostasis and attenuates malignant properties of melanoma cells. Carcinogenesis (2008) 0.81

Characterization of surface structure and p47phox SH3 domain-mediated conformational changes for human neutrophil flavocytochrome b. Biochemistry (2007) 0.81

Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo. J Cell Physiol (2014) 0.81

The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia. J Cell Physiol (2014) 0.81

Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. J Immunol (2004) 0.80

The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene. Free Radic Biol Med (2013) 0.80

Glutamate regulates the activity of topoisomerase I in mouse cerebellum. Mol Neurobiol (2008) 0.80