Published in Proc Natl Acad Sci U S A on February 03, 1998
Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signaling. Environ Health Perspect (2004) 2.25
Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase. Proc Natl Acad Sci U S A (2004) 2.02
Functional recovery in traumatic spinal cord injury after transplantation of multineurotrophin-expressing glial-restricted precursor cells. J Neurosci (2005) 1.75
Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling. Cell Mol Neurobiol (2003) 1.69
Cholesterol-dependent separation of the beta2-adrenergic receptor from its partners determines signaling efficacy: insight into nanoscale organization of signal transduction. J Biol Chem (2008) 1.34
Developmental effects of chlorpyrifos extend beyond neurotoxicity: critical periods for immediate and delayed-onset effects on cardiac and hepatic cell signaling. Environ Health Perspect (2004) 1.20
Adenylyl cyclase type VI increases Akt activity and phospholamban phosphorylation in cardiac myocytes. J Biol Chem (2008) 1.15
Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes. Mol Pharmacol (2010) 1.08
Compartmentation of cAMP signaling in cardiac myocytes: a computational study. Biophys J (2007) 1.07
Critical periods for chlorpyrifos-induced developmental neurotoxicity: alterations in adenylyl cyclase signaling in adult rat brain regions after gestational or neonatal exposure. Environ Health Perspect (2004) 1.04
Developmental neurotoxicity elicited by gestational exposure to chlorpyrifos: when is adenylyl cyclase a target? Environ Health Perspect (2003) 1.00
New signaling pathways associated with increased cardiac adenylyl cyclase 6 expression: implications for possible congestive heart failure therapy. Trends Cardiovasc Med (2007) 0.98
Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts. Naunyn Schmiedebergs Arch Pharmacol (2007) 0.89
Galphaq reduces cAMP production by decreasing Galphas protein abundance. Biochem Biophys Res Commun (2008) 0.87
Prospects for gene transfer for clinical heart failure. Gene Ther (2012) 0.87
A kinase-anchoring proteins and adenylyl cyclase in cardiovascular physiology and pathology. J Cardiovasc Pharmacol (2011) 0.84
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev (2017) 0.83
Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends Cardiovasc Med (2013) 0.83
Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase. Am J Physiol Lung Cell Mol Physiol (2010) 0.81
beta(1)-Adrenergic receptor vs adenylyl cyclase 6 expression in cardiac myocytes: differences in transgene localization and intracellular signaling. Cell Signal (2009) 0.80
Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem (2010) 0.79
Effect of overexpressed adenylyl cyclase VI on beta 1- and beta 2-adrenoceptor responses in adult rat ventricular myocytes. Br J Pharmacol (2004) 0.78
Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle. J Pharmacol Exp Ther (2012) 0.78
Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2010) 0.76
Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus. Circ Res (2010) 0.76
Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenergic receptor cell signaling and physiological function in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2014) 0.75
Unanticipated signaling events associated with cardiac adenylyl cyclase gene transfer. J Mol Cell Cardiol (2011) 0.75
Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. Science (1994) 4.84
A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5. Virology (1988) 4.72
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (1995) 4.18
Overexpression of Gs alpha protein in the hearts of transgenic mice. J Clin Invest (1995) 1.50
Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci U S A (1992) 1.37
Stoichiometry of receptor-Gs-adenylate cyclase interactions. FASEB J (1991) 1.30
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. J Clin Invest (1997) 1.27
Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J (1995) 1.25
Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI. J Biol Chem (1992) 1.20
Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest (1995) 1.17
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol (1997) 1.14
Downregulation of adenylylcyclase types V and VI mRNA levels in pacing-induced heart failure in dogs. J Clin Invest (1994) 0.95
Transcriptional control of gene expression by cAMP-response element binding proteins. J Neuroendocrinol (1994) 0.88
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene (2007) 10.79
Phase III trial of gemcitabine plus tipifarnib compared with gemcitabine plus placebo in advanced pancreatic cancer. J Clin Oncol (2004) 3.56
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene. Proc Natl Acad Sci U S A (1999) 3.32
Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone (2005) 3.13
Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol (2000) 3.13
A model of the kinetics of insulin in man. J Clin Invest (1974) 2.97
Anti-colony-stimulating factor-1 antibody staining in primary breast adenocarcinomas correlates with marked inflammatory cell infiltrates and prognosis. J Natl Cancer Inst (1994) 2.58
Intracoronary gene transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nat Med (1996) 2.42
Plasma tumour necrosis factor-alpha and early carotid atherosclerosis in healthy middle-aged men. Eur Heart J (2002) 2.24
Development of a real-time PCR method for Firmicutes and Bacteroidetes in faeces and its application to quantify intestinal population of obese and lean pigs. Lett Appl Microbiol (2008) 2.19
The nitric oxide hypothesis of late preconditioning. Basic Res Cardiol (1998) 2.19
Insulin control of glucose metabolism in man: a new kinetic analysis. J Clin Invest (1975) 2.09
Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem (2001) 2.08
Are there multiple imidazoline binding sites? Trends Pharmacol Sci (1989) 2.07
Clinical trials in coronary angiogenesis: issues, problems, consensus: An expert panel summary. Circulation (2000) 2.07
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking. Science (2001) 2.05
The Physicians' Desk Reference. Problems and possible improvements. Arch Intern Med (1996) 2.03
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem (2000) 2.00
Regulation and inhibition of phospholipase A2. Annu Rev Pharmacol Toxicol (1999) 1.98
Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo. Virology (2000) 1.98
Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice. Diabetologia (2010) 1.87
Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations. N Engl J Med (1982) 1.87
Hepatic microcirculatory perfusion failure is a determinant of liver dysfunction in warm ischemia-reperfusion. Am J Pathol (1994) 1.75
Hemorrhoidectomy with self-retaining retraction. Dis Colon Rectum (1996) 1.73
Problems with intraoperative hyperthermic peritoneal chemotherapy for advanced gastric cancer. Eur J Surg Oncol (2000) 1.73
The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. Mol Pharmacol (1994) 1.71
The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) (2008) 1.66
Family-centered maternity care: the Canadian picture. Dimens Health Serv (1981) 1.65
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors. Oncogene (2007) 1.62
[S3-guideline colorectal cancer version 1.0]. Z Gastroenterol (2013) 1.51
Decreased beta-adrenergic receptors on polymorphonuclear leukocytes after adrenergic therapy. N Engl J Med (1978) 1.51
Cyclic AMP-dependent protein kinase: pivotal role in regulation of enzyme induction and growth. Science (1975) 1.51
Stimulation of forskolin of intact S49 lymphoma cells involves the nucleotide regulatory protein of adenylate cyclase. J Biol Chem (1982) 1.49
Segmental colectomy in the management of colonic inertia. Am Surg (1998) 1.48
Temporary cystogastrostomy with self-expanding metallic stents for pancreatic necrosis. Endoscopy (2010) 1.48
Transgastric appendicectomy. Br J Surg (2013) 1.46
Stimulation of beta-adrenergic receptors of S49 lymphoma cells redistributes the alpha subunit of the stimulatory G protein between cytosol and membranes. Proc Natl Acad Sci U S A (1989) 1.46
Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia. Leukemia (2003) 1.45
Ischaemic preconditioning by partial occlusion without intermittent reperfusion. Cardiovasc Res (1994) 1.44
Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. J Cell Biol (1996) 1.43
The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study. Int J Obes Relat Metab Disord (2004) 1.41
G-protein-coupled receptor-signaling components in membrane raft and caveolae microdomains. Handb Exp Pharmacol (2008) 1.41
Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells. J Biol Chem (1976) 1.39
Direct evidence that protein kinase C plays an essential role in the development of late preconditioning against myocardial stunning in conscious rabbits and that epsilon is the isoform involved. J Clin Invest (1998) 1.39
Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways. J Biol Chem (2000) 1.39
[Elective colon resection in Germany. A survey of the perioperative anesthesiological management]. Anaesthesist (2007) 1.39
Primary colorectal lymphoma. Dis Colon Rectum (2000) 1.38
Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Circ Res (2000) 1.37
Adenylylcyclase increases responsiveness to catecholamine stimulation in transgenic mice. Circulation (1999) 1.37
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells. Proc Natl Acad Sci U S A (1975) 1.36
Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation (1999) 1.35
Interaction of verapamil and other calcium channel blockers with alpha 1- and alpha 2-adrenergic receptors. Circ Res (1983) 1.32
Stoichiometry of receptor-Gs-adenylate cyclase interactions. FASEB J (1991) 1.30
Correlates of carotid artery stiffness in young adults: The Bogalusa Heart Study. Atherosclerosis (2004) 1.28
Presacral tumor: a review of forty-five cases. Am Surg (1995) 1.27
Biochemical methods for detection and measurement of cyclic AMP and adenylyl cyclase activity. Methods Mol Biol (2000) 1.27
Enhanced PKC beta II translocation and PKC beta II-RACK1 interactions in PKC epsilon-induced heart failure: a role for RACK1. Am J Physiol Heart Circ Physiol (2001) 1.27
Overexpression of cyclin D2 in chronic B-cell malignancies. Blood (1995) 1.26
Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbits. Circ Res (2000) 1.26
Characterization of alpha 2-adrenergic receptors on human platelets using [3H]yohimbine. Biochem Biophys Res Commun (1980) 1.25
Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes. Eur J Immunol (1990) 1.25
Quantification of signalling components and amplification in the beta-adrenergic-receptor-adenylate cyclase pathway in isolated adult rat ventricular myocytes. Biochem J (1995) 1.25
Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic SCID mouse model. Br J Cancer (2007) 1.23
Stoichiometry and compartmentation in G protein-coupled receptor signaling: implications for therapeutic interventions involving G(s). J Pharmacol Exp Ther (2000) 1.23
Selective enhancement of beta-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Mol Pharmacol (2000) 1.23
Regulation of adenylate cyclase of human platelet membranes by forskolin. J Biol Chem (1982) 1.22
[3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol (1989) 1.22
In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans. Pharmacogenetics (2001) 1.21
Associations of risk factors with segment-specific intimal-medial thickness of the extracranial carotid artery. Stroke (1999) 1.20
The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res (2000) 1.18
Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. Ann Oncol (2006) 1.18
Alimentary lipemia, postprandial triglyceride-rich lipoproteins, and common carotid intima-media thickness in healthy, middle-aged men. Circulation (1999) 1.18
Quantitation of the guanine nucleotide binding regulatory protein Gs in S49 cell membranes using antipeptide antibodies to alpha s. J Biol Chem (1988) 1.17
Reduced beta-adrenergic receptor activation decreases G-protein expression and beta-adrenergic receptor kinase activity in porcine heart. J Clin Invest (1995) 1.17
Enamel demineralization in primary and permanent teeth. J Dent Res (2006) 1.16
Alpha 1-adrenergic receptors promote phosphatidylcholine hydrolysis in MDCK-D1 cells. A mechanism for rapid activation of protein kinase C. J Biol Chem (1988) 1.16
PKCepsilon activation induces dichotomous cardiac phenotypes and modulates PKCepsilon-RACK interactions and RACK expression. Am J Physiol Heart Circ Physiol (2001) 1.15
Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2. J Biol Chem (1987) 1.15
Adenylyl cyclase and G protein receptor kinase expression during development of heart failure. Am J Physiol (1997) 1.14
Value of carcinoembryonic antigen in the management of colorectal cancer. Dis Colon Rectum (1994) 1.14
Cellular growth state differentially regulates enterocyte gene expression in butyrate-treated HT-29 cells. Cell Growth Differ (1996) 1.13
Peripheral adrenergic receptors in hypertension. Hypertension (1990) 1.13
Heredity and the autonomic nervous system in human hypertension. Curr Hypertens Rep (2000) 1.12
PKCepsilon modulates NF-kappaB and AP-1 via mitogen-activated protein kinases in adult rabbit cardiomyocytes. Am J Physiol Heart Circ Physiol (2000) 1.12
Time-dependent decreases in binding affinity of agonists for beta-adrenergic receptors of intact S49 lymphoma cells. A mechanism of desensitization. J Biol Chem (1983) 1.12
Role of microcirculatory derangements in manifestation of portal triad cross-clamping-induced hepatic reperfusion injury. J Surg Res (1996) 1.11
Cloning, expression, and characterization of a human inosine triphosphate pyrophosphatase encoded by the itpa gene. J Biol Chem (2001) 1.10
Metabolism of alpha- and beta-adrenergic receptors in vitro and in vivo. Annu Rev Pharmacol Toxicol (1987) 1.09
Butyrate inhibits colon carcinoma cell growth through two distinct pathways. Surgery (1998) 1.09
Genetic analysis of beta-adrenergic receptor internalization and down-regulation. Proc Natl Acad Sci U S A (1985) 1.09
Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes. J Biol Chem (1988) 1.09
Verapamil competitively inhibits alpha 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium. J Cardiovasc Pharmacol (1982) 1.09
Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. Annu Rev Pharmacol Toxicol (2001) 1.08
Beta adrenergic receptors of polymorphonuclear particulates in bronchial asthma. J Clin Invest (1980) 1.08
Influence of sodium on the alpha 2-adrenergic receptor system of human platelets. Role for intraplatelet sodium in receptor binding. J Biol Chem (1983) 1.08
Protein kinase C epsilon-Src modules direct signal transduction in nitric oxide-induced cardioprotection: complex formation as a means for cardioprotective signaling. Circ Res (2001) 1.06
Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest (1990) 1.06