Published in Genes Dev on March 01, 1998
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. Genes Dev (1999) 7.58
Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev (1998) 4.23
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol (1999) 3.90
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol (2000) 3.86
Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain. J Cell Biol (1999) 3.79
Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57
The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo. Genes Dev (1999) 3.15
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol (1998) 3.13
Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Genes Dev (1999) 2.98
Biochemical analysis of distinct activation functions in p300 that enhance transcription initiation with chromatin templates. Mol Cell Biol (1999) 2.80
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev (2000) 2.77
Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev (2001) 2.55
Inducible gene expression: diverse regulatory mechanisms. Nat Rev Genet (2010) 2.53
Histone acetylation at promoters is differentially affected by specific activators and repressors. Mol Cell Biol (2001) 2.40
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Three yeast proteins related to the human candidate tumor suppressor p33(ING1) are associated with histone acetyltransferase activities. Mol Cell Biol (2000) 2.21
Differential requirement of SAGA components for recruitment of TATA-box-binding protein to promoters in vivo. Mol Cell Biol (2002) 2.16
Epstein-Barr virus nuclear protein 2 interacts with p300, CBP, and PCAF histone acetyltransferases in activation of the LMP1 promoter. Proc Natl Acad Sci U S A (2000) 2.15
Increasing the rate of chromatin remodeling and gene activation--a novel role for the histone acetyltransferase Gcn5. EMBO J (2001) 2.04
p300-mediated acetylation facilitates the transfer of histone H2A-H2B dimers from nucleosomes to a histone chaperone. Genes Dev (2000) 2.03
Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters. Mol Cell Biol (2000) 2.00
The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.00
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. Proc Natl Acad Sci U S A (1999) 1.99
The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway. Mol Cell Biol (2002) 1.98
Transcriptional adaptor and histone acetyltransferase proteins in Arabidopsis and their interactions with CBF1, a transcriptional activator involved in cold-regulated gene expression. Nucleic Acids Res (2001) 1.96
Xenopus NF-Y pre-sets chromatin to potentiate p300 and acetylation-responsive transcription from the Xenopus hsp70 promoter in vivo. EMBO J (1998) 1.85
Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression. Plant Cell (2003) 1.81
Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID. Proc Natl Acad Sci U S A (1999) 1.77
E1A directly binds and regulates the P/CAF acetyltransferase. EMBO J (1998) 1.76
Overlapping roles for the histone acetyltransferase activities of SAGA and elongator in vivo. EMBO J (2000) 1.71
A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics (1999) 1.70
Human SWI-SNF component BRG1 represses transcription of the c-fos gene. Mol Cell Biol (1999) 1.68
Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity. Mol Cell Biol (1999) 1.58
Essential function of p300 acetyltransferase activity in heart, lung and small intestine formation. EMBO J (2003) 1.48
Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res (1998) 1.47
Mutations in both the structured domain and N-terminus of histone H2B bypass the requirement for Swi-Snf in yeast. EMBO J (1999) 1.46
Functional analysis of the p300 acetyltransferase domain: the PHD finger of p300 but not of CBP is dispensable for enzymatic activity. Nucleic Acids Res (2001) 1.40
Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. Mol Cell Biol (2002) 1.38
Acetylation by the transcriptional coactivator Gcn5 plays a novel role in co-transcriptional spliceosome assembly. PLoS Genet (2009) 1.35
The nucleosome remodeling complex, Snf/Swi, is required for the maintenance of transcription in vivo and is partially redundant with the histone acetyltransferase, Gcn5. EMBO J (1999) 1.33
Mechanisms of P/CAF auto-acetylation. Nucleic Acids Res (2003) 1.32
The role of acetylation in rDNA transcription. Nucleic Acids Res (2001) 1.30
Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes. Mol Syst Biol (2011) 1.29
A novel H2A/H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila. Mol Cell Biol (1999) 1.27
Maturation stage-specific regulation of megakaryopoiesis by pointed-domain Ets proteins. Blood (2006) 1.25
The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. Mol Cell Biol (1999) 1.24
Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor. Proc Natl Acad Sci U S A (2002) 1.22
Targeted recruitment of Rpd3 histone deacetylase represses transcription by inhibiting recruitment of Swi/Snf, SAGA, and TATA binding protein. Mol Cell Biol (2002) 1.22
Components of the SAGA histone acetyltransferase complex are required for repressed transcription of ARG1 in rich medium. Mol Cell Biol (2002) 1.19
Plasmodium falciparum histone acetyltransferase, a yeast GCN5 homologue involved in chromatin remodeling. Eukaryot Cell (2004) 1.18
Histone H1 is a specific repressor of core histone acetylation in chromatin. Mol Cell Biol (2000) 1.13
The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis. Mol Cell Biol (2000) 1.12
Targeted histone acetylation and altered nuclease accessibility over short regions of the pea plastocyanin gene. Plant Cell (2001) 1.11
N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif. Proc Natl Acad Sci U S A (2000) 1.10
Genome-wide characterisation of the Gcn5 histone acetyltransferase in budding yeast during stress adaptation reveals evolutionarily conserved and diverged roles. BMC Genomics (2010) 1.09
Plant orthologs of p300/CBP: conservation of a core domain in metazoan p300/CBP acetyltransferase-related proteins. Nucleic Acids Res (2001) 1.08
Systematic analysis of a conserved region of the aminoglycoside 6'-N-acetyltransferase type Ib. Antimicrob Agents Chemother (2001) 1.08
Distinct roles of the Gcn5 histone acetyltransferase revealed during transient stress-induced reprogramming of the genome. BMC Genomics (2013) 1.02
A targeted histone acetyltransferase can create a sizable region of hyperacetylated chromatin and counteract the propagation of transcriptionally silent chromatin. Genetics (2003) 1.01
Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryot Cell (2010) 1.00
Expression and purification of recombinant yeast Ada2/Ada3/Gcn5 and Piccolo NuA4 histone acetyltransferase complexes. Methods (2007) 1.00
Histone chaperones, histone acetylation, and the fluidity of the chromogenome. J Cell Physiol (2010) 0.97
Histone H3 Ser10 phosphorylation-independent function of Snf1 and Reg1 proteins rescues a gcn5- mutant in HIS3 expression. Mol Cell Biol (2005) 0.94
Developmental roles of the Mi-2/NURD-associated protein p66 in Drosophila. Genetics (2005) 0.93
Gcn5 and sirtuins regulate acetylation of the ribosomal protein transcription factor Ifh1. Curr Biol (2013) 0.91
Structure/function analysis of the phosphatidylinositol-3-kinase domain of yeast tra1. Genetics (2007) 0.90
Role of SAGA in the asymmetric segregation of DNA circles during yeast ageing. Elife (2014) 0.90
Acetylation and nuclear receptor action. J Steroid Biochem Mol Biol (2010) 0.89
Duality in bromodomain-containing protein complexes. Front Biosci (2001) 0.89
Molecular requirements for gene expression mediated by targeted histone acetyltransferases. Mol Cell Biol (2004) 0.89
Snf1p regulates Gcn5p transcriptional activity by antagonizing Spt3p. Genetics (2009) 0.87
Transcriptome analysis of chestnut (Castanea sativa) tree buds suggests a putative role for epigenetic control of bud dormancy. Ann Bot (2011) 0.86
GCN5 dependence of chromatin remodeling and transcriptional activation by the GAL4 and VP16 activation domains in budding yeast. Mol Cell Biol (2001) 0.86
Trichoderma reesei histone acetyltransferase Gcn5 regulates fungal growth, conidiation, and cellulase gene expression. Curr Microbiol (2013) 0.84
Chromatin-modifiying enzymes are essential when the Saccharomyces cerevisiae morphogenesis checkpoint is constitutively activated. Genetics (2006) 0.84
AnCF, the CCAAT binding complex of Aspergillus nidulans, is essential for the formation of a DNase I-hypersensitive site in the 5' region of the amdS gene. Mol Cell Biol (1999) 0.83
Unexpected function of the glucanosyltransferase Gas1 in the DNA damage response linked to histone H3 acetyltransferases in Saccharomyces cerevisiae. Genetics (2014) 0.81
C-terminal processing of yeast Spt7 occurs in the absence of functional SAGA complex. BMC Biochem (2007) 0.81
Molecular basis of the acetyltransferase activity of MEC-17 towards α-tubulin. Cell Res (2012) 0.80
Fusions with histone H3 result in highly specific alteration of gene expression. Nucleic Acids Res (2000) 0.78
The histone acetyltransferase GCN5 affects the inflorescence meristem and stamen development in Arabidopsis. Planta (2009) 0.78
Involvement of Hat1p (Kat1p) catalytic activity and subcellular localization in telomeric silencing. J Biol Chem (2008) 0.78
Histone deacetylases inhibitors effects on Cryptococcus neoformans major virulence phenotypes. Virulence (2015) 0.78
Promotion of Cell Viability and Histone Gene Expression by the Acetyltransferase Gcn5 and the Protein Phosphatase PP2A in Saccharomyces cerevisiae. Genetics (2016) 0.75
Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins. J Neurodev Disord (2013) 0.75
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79
The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57
A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains. Genetics (1987) 14.69
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site. Proc Natl Acad Sci U S A (1982) 11.42
The CBP co-activator is a histone acetyltransferase. Nature (1997) 10.91
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature (1996) 10.81
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell (1996) 9.86
A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. Nature (1997) 9.71
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell (1997) 8.72
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35
Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature (1997) 7.66
Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell (1997) 7.64
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex. Science (1994) 7.17
Negative effect of the transcriptional activator GAL4. Nature (1988) 7.15
Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27
A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell (1993) 6.13
What's up and down with histone deacetylation and transcription? Cell (1997) 5.99
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell (1997) 5.83
HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A (1996) 5.61
The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell (1996) 5.20
Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains. Cell (1992) 5.14
Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell (1997) 5.07
Repression and activation by multiprotein complexes that alter chromatin structure. Genes Dev (1996) 4.52
Five SWI/SNF gene products are components of a large multisubunit complex required for transcriptional enhancement. Proc Natl Acad Sci U S A (1994) 4.49
GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem Sci (1997) 3.87
Common themes in assembly and function of eukaryotic transcription complexes. Annu Rev Biochem (1995) 3.60
Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes. Genetics (1997) 3.45
Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: evidence for transcriptional adaptors. Cell (1990) 3.31
SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev (1992) 3.31
Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro. EMBO J (1996) 3.25
RPD3 encodes a second factor required to achieve maximum positive and negative transcriptional states in Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.22
Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet (1996) 3.02
Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J (1994) 3.00
Structure and function of transcriptional activation domains. Curr Opin Genet Dev (1995) 2.94
Reversible histone modifications and the chromosome cell cycle. Bioessays (1992) 2.89
Role of chromatin structure in the regulation of transcription by RNA polymerase II. Annu Rev Biochem (1994) 2.83
Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J (1992) 2.81
Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. EMBO J (1997) 2.58
Structural and functional requirements for the chromatin transition at the PHO5 promoter in Saccharomyces cerevisiae upon PHO5 activation. J Mol Biol (1993) 2.57
Nucleosomes: regulators of transcription. Trends Genet (1990) 2.44
Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein. J Biol Chem (1995) 2.37
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol (1996) 2.30
Yeast transcriptional regulatory mechanisms. Annu Rev Genet (1995) 2.19
The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter. EMBO J (1994) 2.13
Experimental analysis of chromatin function in transcription control. Crit Rev Eukaryot Gene Expr (1994) 2.11
The Saccharomyces cerevisiae SPT8 gene encodes a very acidic protein that is functionally related to SPT3 and TATA-binding protein. Genetics (1994) 2.04
Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo. J Biol Chem (1996) 2.01
ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2. Mol Cell Biol (1993) 2.00
Identification of native complexes containing the yeast coactivator/repressor proteins NGG1/ADA3 and ADA2. J Biol Chem (1997) 1.98
Yeast ADA2 protein binds to the VP16 protein activation domain and activates transcription. Proc Natl Acad Sci U S A (1994) 1.91
Histone acetylation in chromatin and chromosomes. Semin Cell Biol (1995) 1.91
SPT20/ADA5 encodes a novel protein functionally related to the TATA-binding protein and important for transcription in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.89
Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol Cell Biol (1997) 1.85
Histone acetylation: facts and questions. Chromosoma (1994) 1.81
Transcriptional coactivators in yeast and beyond. Trends Biochem Sci (1995) 1.77
ADA5/SPT20 links the ADA and SPT genes, which are involved in yeast transcription. Mol Cell Biol (1996) 1.74
The Saccharomyces cerevisiae SPT7 gene encodes a very acidic protein important for transcription in vivo. Genetics (1995) 1.70
Histone acetyltransferases in control. Curr Biol (1997) 1.68
ADR1 activation domains contact the histone acetyltransferase GCN5 and the core transcriptional factor TFIIB. J Biol Chem (1996) 1.61
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35
Genetic reassortment of avian, swine, and human influenza A viruses in American pigs. J Virol (1999) 7.72
Expression of human immune interferon cDNA in E. coli and monkey cells. Nature (1982) 6.55
Inhibition of intractable nucleases with ribonucleoside--vanadyl complexes: isolation of messenger ribonucleic acid from resting lymphocytes. Biochemistry (1979) 6.00
The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell (1996) 5.20
p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol (1999) 4.88
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene (1998) 4.88
Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases. Mol Cell (2001) 4.73
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci U S A (1997) 4.07
Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell (2000) 4.05
Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol (1999) 3.90
Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol (2001) 3.86
Production of beta-defensins by human airway epithelia. Proc Natl Acad Sci U S A (1998) 3.85
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron (2000) 3.73
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p. Am J Pathol (1994) 3.66
CDKN2A mutations in multiple primary melanomas. N Engl J Med (1998) 3.52
Risks of untreated and treated isolated systolic hypertension in the elderly: meta-analysis of outcome trials. Lancet (2000) 3.25
Fas-induced caspase denitrosylation. Science (1999) 3.21
Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Proc Natl Acad Sci U S A (2000) 3.11
First-strand cDNA synthesis primed with oligo(dT). Methods Enzymol (1987) 3.06
Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J (1994) 3.00
Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity (1998) 2.95
Central melanocortin receptors regulate insulin action. J Clin Invest (2001) 2.83
A synthetic HIV-1 protease inhibitor with antiviral activity arrests HIV-like particle maturation. Science (1990) 2.80
Presence of depressive symptoms during early pregnancy and the risk of preterm delivery: a prospective cohort study. Hum Reprod (2008) 2.68
The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase. Proc Natl Acad Sci U S A (1996) 2.68
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res (1993) 2.65
Bright light treatment of winter depression: a placebo-controlled trial. Arch Gen Psychiatry (1998) 2.62
The practice of neurology, 2000-2010: report of the AAN Member Research Subcommittee. Neurology (2011) 2.59
Snf1--a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science (2001) 2.58
Histone acetyltransferase activity and interaction with ADA2 are critical for GCN5 function in vivo. EMBO J (1997) 2.58
Disproportionate distribution of Burkholderia cepacia complex species and transmissibility markers in cystic fibrosis. Am J Respir Crit Care Med (2001) 2.55
Structure of Tetrahymena GCN5 bound to coenzyme A and a histone H3 peptide. Nature (1999) 2.50
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
Preparation of cDNA and the generation of cDNA libraries: overview. Methods Enzymol (1987) 2.40
Degradation of transcription factor RFX5 during the inhibition of both constitutive and interferon gamma-inducible major histocompatibility complex class I expression in chlamydia-infected cells. J Exp Med (2000) 2.40
Chlamydia inhibits interferon gamma-inducible major histocompatibility complex class II expression by degradation of upstream stimulatory factor 1. J Exp Med (1999) 2.39
Cutting edge: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity. J Immunol (2001) 2.38
Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein. J Biol Chem (1995) 2.37
Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia (2011) 2.37
Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia. Nat Genet (1996) 2.32
Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol (1996) 2.30
The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes. Trends Cell Biol (1998) 2.28
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene (2009) 2.26
The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Cell (2000) 2.18
Potentially modifiable risk factors associated with myocardial infarction in China: the INTERHEART China study. Heart (2009) 2.16
Catalytic mechanism and function of invariant glutamic acid 173 from the histone acetyltransferase GCN5 transcriptional coactivator. J Biol Chem (1999) 2.13
Identification of Pandoraea species by 16S ribosomal DNA-based PCR assays. J Clin Microbiol (2001) 2.09
Emergence of H3N2 reassortant influenza A viruses in North American pigs. Vet Microbiol (2000) 2.06
Risk of second primary in situ and invasive melanoma in a Dutch population-based cohort: 1989-2008. Br J Dermatol (2012) 2.03
Structural and functional analysis of yeast putative adaptors. Evidence for an adaptor complex in vivo. J Biol Chem (1996) 2.01
Inhibition of TATA-binding protein function by SAGA subunits Spt3 and Spt8 at Gcn4-activated promoters. Mol Cell Biol (2000) 2.00
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin. Cancer Res (2000) 2.00
The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.00
Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator. Proc Natl Acad Sci U S A (1999) 1.99
Pulse pressure not mean pressure determines cardiovascular risk in older hypertensive patients. Arch Intern Med (2000) 1.99
The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation. Proc Natl Acad Sci U S A (1998) 1.98
Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg (2006) 1.91
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage. Cancer Res (1984) 1.88
Effects of pyrethroid insecticides on subjects engaged in packaging pyrethroids. Br J Ind Med (1988) 1.87
Virus-encoded serine proteinase inhibitor SERP-1 inhibits atherosclerotic plaque development after balloon angioplasty. Circulation (1996) 1.86
Hepatic cytochrome P450s metabolize aristolochic acid and reduce its kidney toxicity. Kidney Int (2008) 1.86
Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures. J Virol (1997) 1.86
Histone acetyltransferase activity is conserved between yeast and human GCN5 and is required for complementation of growth and transcriptional activation. Mol Cell Biol (1997) 1.85
During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription. J Virol (2004) 1.84
Localization of human intestinal defensin 5 in Paneth cell granules. Infect Immun (1997) 1.84
Dual MET-EGFR combinatorial inhibition against T790M-EGFR-mediated erlotinib-resistant lung cancer. Br J Cancer (2008) 1.83
Coronary heart disease in China. Heart (2008) 1.82
Crystal structure of yeast Esa1 suggests a unified mechanism for catalysis and substrate binding by histone acetyltransferases. Mol Cell (2000) 1.80
Causes of death among people with convulsive epilepsy in rural West China: a prospective study. Neurology (2011) 1.77
Activation of the NF-kappaB pathway by caspase 8 and its homologs. Oncogene (2000) 1.76
Bone marrow failure in the Fanconi anemia group C mouse model after DNA damage. Blood (1998) 1.74
Subsite-specific incidence rate and stage of disease in colorectal cancer by race, gender, and age group in the United States, 1992-1997. Cancer (2001) 1.73
Differential activation of RNA polymerase III-transcribed genes by the polyomavirus enhancer and the adenovirus E1A gene products. Nucleic Acids Res (1985) 1.72
Absence of Gcn5 HAT activity defines a novel state in the opening of chromatin at the PHO5 promoter in yeast. Mol Cell (1998) 1.71
Side chains that influence fidelity at the polymerase active site of Escherichia coli DNA polymerase I (Klenow fragment). J Biol Chem (1999) 1.71
Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity. Oncogene (1997) 1.70
CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein. Cancer Res (1997) 1.70
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease. Neurology (2003) 1.70
Chinese trial on isolated systolic hypertension in the elderly. Systolic Hypertension in China (Syst-China) Collaborative Group. Arch Intern Med (2000) 1.69
The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J Biol Chem (1998) 1.67
Ribonuclease H activities associated with viral reverse transcriptases are endonucleases. Proc Natl Acad Sci U S A (1989) 1.67
Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene (1997) 1.64
RIZ1, but not the alternative RIZ2 product of the same gene, is underexpressed in breast cancer, and forced RIZ1 expression causes G2-M cell cycle arrest and/or apoptosis. Cancer Res (1998) 1.62
The association of cardiovascular disease risk factors with abdominal obesity in Canada. Canadian Heart Health Surveys Research Group. CMAJ (1997) 1.61
Drosophila mushroom bodies are dispensable for visual, tactile, and motor learning. Learn Mem (1999) 1.60
Merosin-deficient congenital muscular dystrophy. Partial genetic correction in two mouse models. J Clin Invest (1998) 1.60
Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. J Biol Chem (1993) 1.60
Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res (1997) 1.60
Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood (1993) 1.60
Distribution of CD133 reveals glioma stem cells self-renew through symmetric and asymmetric cell divisions. Cell Death Dis (2011) 1.59
Cholesterol-lowering effect of garlic extracts and organosulfur compounds: human and animal studies. J Nutr (2001) 1.59
Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. J Pharmacol Exp Ther (1989) 1.59
Rapid nitric oxide-induced desensitization of the cGMP response is caused by increased activity of phosphodiesterase type 5 paralleled by phosphorylation of the enzyme. J Cell Biol (2001) 1.58
Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification. Oncogene (1994) 1.58
Productivity and carcass characteristics of pure and crossbred Chinese Yellow Cattle. Meat Sci (2001) 1.57
A conserved motif present in a class of helix-loop-helix proteins activates transcription by direct recruitment of the SAGA complex. Mol Cell (1999) 1.55