Published in Blood on June 06, 2006
ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. Blood (2009) 2.45
miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia. Genes Dev (2010) 2.05
Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome. Blood (2009) 1.84
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J (2009) 1.66
Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood (2012) 1.35
Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development. Mol Cell Biol (2009) 1.31
Transcription factor networks in erythroid cell and megakaryocyte development. Blood (2011) 1.29
Cyclin D-Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization. Blood (2007) 1.28
Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis. Genome Res (2014) 1.19
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. J Exp Med (2012) 1.18
Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage. Proc Natl Acad Sci U S A (2009) 1.18
Combinatorial regulation of tissue specification by GATA and FOG factors. Development (2012) 1.06
Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models. Blood (2014) 1.02
Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression. Mol Cell (2012) 1.00
Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood. Haematologica (2009) 0.95
Transcription factors in late megakaryopoiesis and related platelet disorders. J Thromb Haemost (2013) 0.93
Thrombocytopenia in mice lacking the carboxy-terminal regulatory domain of the Ets transcription factor Fli1. Mol Cell Biol (2010) 0.85
Normal and malignant megakaryopoiesis. Expert Rev Mol Med (2011) 0.84
Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application. Cell Mol Life Sci (2012) 0.84
Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression. Haematologica (2015) 0.83
Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site. PLoS One (2011) 0.82
Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction. Blood (2011) 0.81
Effect of increased HoxB4 on human megakaryocytic development. Biochem Biophys Res Commun (2010) 0.80
Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy. J Hematol Oncol (2015) 0.78
A screen for Fli-1 transcriptional modulators identifies PKC agonists that induce erythroid to megakaryocytic differentiation and suppress leukemogenesis. Oncotarget (2016) 0.75
Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis. Sci Rep (2017) 0.75
Fli-1 overexpression in erythroleukemic cells promotes erythroid de-differentiation while Spi-1/PU.1 exerts the opposite effect. Int J Oncol (2017) 0.75
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature (2000) 16.75
FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell (1997) 5.78
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77
Transcriptional activation and DNA binding by the erythroid factor GF-1/NF-E1/Eryf 1. Genes Dev (1990) 4.35
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo. Blood (2002) 3.59
CD41 expression defines the onset of primitive and definitive hematopoiesis in the murine embryo. Development (2003) 3.09
Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG. Genes Dev (1998) 3.00
Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev (1998) 2.76
Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Mol Cell Biol (2000) 2.69
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
Consequences of GATA-1 deficiency in megakaryocytes and platelets. Blood (1999) 2.61
Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia. Immunity (2000) 2.59
Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev (2004) 2.56
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
Expression of CD41 on hematopoietic progenitors derived from embryonic hematopoietic cells. Development (2002) 2.16
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol Cell Biol (2003) 2.09
GA-binding protein transcription factor: a review of GABP as an integrator of intracellular signaling and protein-protein interactions. Blood Cells Mol Dis (2004) 1.95
Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood (1973) 1.93
Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J (2002) 1.84
Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development (1999) 1.83
GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis. Proc Natl Acad Sci U S A (2002) 1.77
Thrombopoietin signal transduction in purified murine megakaryocytes. Blood (1997) 1.75
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol (2004) 1.75
Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood (2005) 1.72
Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development. Blood (2005) 1.64
The ETS transcription factor GABPalpha is essential for early embryogenesis. Mol Cell Biol (2004) 1.46
Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood (2003) 1.45
Protein-protein interaction between Fli-1 and GATA-1 mediates synergistic expression of megakaryocyte-specific genes through cooperative DNA binding. Mol Cell Biol (2003) 1.44
The role of Fli-1 in normal cell function and malignant transformation. Oncogene (2000) 1.43
Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice. Int J Hematol (2001) 1.32
Ets-dependent regulation of target gene expression during megakaryopoiesis. J Biol Chem (2004) 1.30
Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype. Cell Growth Differ (1996) 1.30
Transcriptional regulation of the rat platelet factor 4 gene: interaction between an enhancer/silencer domain and the GATA site. Mol Cell Biol (1991) 1.28
Role of transcription factors C/EBPalpha and PU.1 in normal hematopoiesis and leukemia. Int J Hematol (2005) 1.26
Megakaryocyte biology and related disorders. J Clin Invest (2005) 1.23
Analysis of the thrombopoietin receptor (MPL) promoter implicates GATA and Ets proteins in the coregulation of megakaryocyte-specific genes. Blood (1996) 1.16
Regulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1. Blood (1999) 1.12
BSAP can repress enhancer activity by targeting PU.1 function. Mol Cell Biol (2000) 1.12
Markedly reduced expression of platelet c-mpl receptor in essential thrombocythemia. Blood (1997) 1.09
The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol (1994) 1.05
Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis, and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin- primitive progenitor cells. Blood (1996) 1.04
Biological and biochemical characteristics of murine megakaryoblastic cell line L8057. Exp Hematol (1993) 1.01
GA-binding protein factors, in concert with the coactivator CREB binding protein/p300, control the induction of the interleukin 16 promoter in T lymphocytes. Proc Natl Acad Sci U S A (1999) 1.00
Diversity in structure and function of the Ets family PNT domains. J Mol Biol (2004) 0.99
Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression. Eur J Biochem (1998) 0.98
GABP cooperates with c-Myb and C/EBP to activate the neutrophil elastase promoter. Blood (1997) 0.97
The alpha(IIb)beta(3) integrin and GPIb-V-IX complex identify distinct stages in the maturation of CD34(+) cord blood cells to megakaryocytes. Blood (2000) 0.94
GA-binding protein and p300 are essential components of a retinoic acid-induced enhanceosome in myeloid cells. Mol Cell Biol (2006) 0.92
Characterization of regulatory elements in the 5'-flanking region of the rat GPIIb gene by studies in a primary rat marrow culture system. Blood (1994) 0.91
The platelet glycoprotein Ib-V-IX system: regulation of gene expression. Stem Cells (1996) 0.85
Inducible expression of the megakaryocyte-specific gene glycoprotein IX is mediated through an Ets binding site and involves upstream activation of extracellular signal-regulated kinase. Cell Growth Differ (2001) 0.84
An enhancer located between the neutrophil elastase and proteinase 3 promoters is activated by Sp1 and an Ets factor. J Biol Chem (1999) 0.83
Transcriptional regulation in megakaryocytes: the thrombopoietin receptor gene as a model. Stem Cells (1996) 0.83
The ETS family member Tel antagonizes the Fli-1 phenotype in hematopoietic cells. Blood Cells Mol Dis (2000) 0.80
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol (2007) 16.21
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell (2005) 5.96
Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell (2005) 5.77
New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol (2009) 5.57
Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress. Plant Physiol (2002) 5.43
Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol (2006) 5.01
Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol (2008) 4.90
Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function. J Exp Med (2005) 4.60
Expression profile matrix of Arabidopsis transcription factor genes suggests their putative functions in response to environmental stresses. Plant Cell (2002) 4.58
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol (2008) 4.56
Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J Immunol (2004) 4.43
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med (2007) 4.42
Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22
An encyclopedia of mouse DNA elements (Mouse ENCODE). Genome Biol (2012) 4.15
A role for TSLP in the development of inflammation in an asthma model. J Exp Med (2005) 4.08
IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells. J Immunol (2005) 4.04
Activating RNAs associate with Mediator to enhance chromatin architecture and transcription. Nature (2013) 3.98
Transcriptional profiling reveals novel interactions between wounding, pathogen, abiotic stress, and hormonal responses in Arabidopsis. Plant Physiol (2002) 3.92
IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest (2011) 3.59
ETS transcription factors and their emerging roles in human cancer. Eur J Cancer (2005) 3.55
IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy. Blood (2008) 3.52
Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1. Immunity (2010) 3.49
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature (2012) 3.48
Genomic analyses identify distinct patterns of selection in domesticated pigs and Tibetan wild boars. Nat Genet (2013) 3.41
Vascular endothelial growth factor B controls endothelial fatty acid uptake. Nature (2010) 3.40
Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo. Circulation (2005) 3.25
Exchange of GATA factors mediates transitions in looped chromatin organization at a developmentally regulated gene locus. Mol Cell (2008) 3.24
Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2003) 3.01
Transcriptional control of adipose lipid handling by IRF4. Cell Metab (2011) 2.95
The molecular basis of IL-21-mediated proliferation. Blood (2007) 2.90
Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice. Crit Care Med (2011) 2.89
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity (2009) 2.89
Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor. Cell (2012) 2.87
IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A (2009) 2.83
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system. Cytokine Growth Factor Rev (2006) 2.71
Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity (2013) 2.69
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression. Genome Res (2009) 2.64
Globin gene activation during haemopoiesis is driven by protein complexes nucleated by GATA-1 and GATA-2. EMBO J (2004) 2.62
NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity. Proc Natl Acad Sci U S A (2009) 2.56
FOG-1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA-1. EMBO J (2005) 2.53
GATA-1-mediated proliferation arrest during erythroid maturation. Mol Cell Biol (2003) 2.52
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol (2011) 2.47
In vivo dual cross-linking for identification of indirect DNA-associated proteins by chromatin immunoprecipitation. Biotechniques (2006) 2.46
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. Proc Natl Acad Sci U S A (2009) 2.46
Super-resolution fluorescence imaging of organelles in live cells with photoswitchable membrane probes. Proc Natl Acad Sci U S A (2012) 2.46
IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation. Curr Opin Immunol (2011) 2.44
Repetitive antigen stimulation induces stepwise transcriptome diversification but preserves a core signature of memory CD8(+) T cell differentiation. Immunity (2010) 2.38
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells. J Exp Med (2009) 2.38
An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature (2002) 2.33
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expression. Nat Immunol (2008) 2.31
Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature (2012) 2.25
Ets proteins in biological control and cancer. J Cell Biochem (2004) 2.24
SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood (2008) 2.19
Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev (2004) 2.18
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity (2010) 2.16
Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity (2012) 2.16
The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15
The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol (2004) 2.13
Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV. AIDS (2003) 2.12
Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1. Mol Cell Biol (2003) 2.09
Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression. Cancer Res (2003) 2.07
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. Genome Res (2011) 2.07
Diverse RNA viruses elicit the expression of common sets of genes in susceptible Arabidopsis thaliana plants. Plant J (2003) 2.05
Cutting edge: direct action of thymic stromal lymphopoietin on activated human CD4+ T cells. J Immunol (2007) 2.03
Context-dependent regulation of GATA-1 by friend of GATA-1. Proc Natl Acad Sci U S A (2003) 2.01
IL-21 mediates suppressive effects via its induction of IL-10. J Immunol (2009) 2.00
BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature (2012) 2.00
IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.96
Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol (2006) 1.94
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain. Proc Natl Acad Sci U S A (2002) 1.91
Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters. Thromb Haemost (2003) 1.91
GATA Transcription Factors and Cancer. Genes Cancer (2010) 1.88
Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem (2002) 1.85
Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Mol Cell Biol (2007) 1.84
Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors. EMBO J (2002) 1.84
In vivo antitumor activity of interleukin 21 mediated by natural killer cells. Cancer Res (2003) 1.81
Expression profiling of phyB mutant demonstrates substantial contribution of other phytochromes to red-light-regulated gene expression during seedling de-etiolation. Plant J (2004) 1.79
GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol (2004) 1.75
Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell (2012) 1.74
IL-21 signaling is critical for the development of type I diabetes in the NOD mouse. Proc Natl Acad Sci U S A (2008) 1.74
Cooperative integrin/ITAM signaling in platelets enhances thrombus formation in vitro and in vivo. Blood (2012) 1.72
Monodisperse magnetic single-crystal ferrite microspheres. Angew Chem Int Ed Engl (2005) 1.69
Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood (2008) 1.68
The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex. J Biol Chem (2002) 1.68
Hepatic proprotein convertases modulate HDL metabolism. Cell Metab (2007) 1.68
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J (2009) 1.66
Attenuated rabies virus activates, while pathogenic rabies virus evades, the host innate immune responses in the central nervous system. J Virol (2005) 1.65
A role for Stat5 in CD8+ T cell homeostasis. J Immunol (2003) 1.64
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. Blood (2004) 1.63
Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood (2003) 1.62
Dynamic antibody-binding properties in the pathogenesis of HIT. Blood (2012) 1.59
Role of platelet surface PF4 antigenic complexes in heparin-induced thrombocytopenia pathogenesis: diagnostic and therapeutic implications. Blood (2005) 1.59