Published in EMBO J on May 01, 1998
Structural evolution of the protein kinase-like superfamily. PLoS Comput Biol (2005) 2.48
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J (2001) 1.77
Evolutionary constraints associated with functional specificity of the CMGC protein kinases MAPK, CDK, GSK, SRPK, DYRK, and CK2alpha. Protein Sci (2004) 1.33
Crystal structure of the human protein kinase CK2 regulatory subunit reveals its zinc finger-mediated dimerization. EMBO J (1999) 1.25
Interactions of UNC-34 Enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration. Genetics (2005) 1.19
Mitogen-activated protein kinase (MAPK)-docking sites in MAPK kinases function as tethers that are crucial for MAPK regulation in vivo. Cell Signal (2005) 1.14
Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits. Mol Cell Biol (2003) 1.12
The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. Int J Biochem Cell Biol (2009) 1.05
Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole. Protein Sci (2001) 1.00
Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. Biochem J (2003) 0.95
Autocatalytic tyrosine-phosphorylation of protein kinase CK2 alpha and alpha' subunits: implication of Tyr182. Biochem J (2001) 0.94
CK2 protein kinase is stimulated and redistributed by functional herpes simplex virus ICP27 protein. J Virol (2003) 0.94
Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2. J Proteome Res (2011) 0.85
Bovine prion protein as a modulator of protein kinase CK2. Biochem J (2000) 0.84
Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment. Mol Cell Biochem (2008) 0.83
The interaction of CK2alpha and CK2beta, the subunits of protein kinase CK2, requires CK2beta in a preformed conformation and is enthalpically driven. Protein Sci (2008) 0.81
Drosophila Protein Kinase CK2: Genetics, Regulatory Complexity and Emerging Roles during Development. Pharmaceuticals (Basel) (2016) 0.80
Structural Hypervariability of the Two Human Protein Kinase CK2 Catalytic Subunit Paralogs Revealed by Complex Structures with a Flavonol- and a Thieno[2,3-d]pyrimidine-Based Inhibitor. Pharmaceuticals (Basel) (2017) 0.79
Role of plant-specific N-terminal domain of maize CK2β1 subunit in CK2β functions and holoenzyme regulation. PLoS One (2011) 0.75
Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.75
Identification and temporal expression of putative circadian clock transcripts in the amphipod crustacean Talitrus saltator. PeerJ (2016) 0.75
Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr A (1991) 119.63
The Protein Data Bank: a computer-based archival file for macromolecular structures. J Mol Biol (1977) 90.57
The SWISS-PROT protein sequence data bank. Nucleic Acids Res (1992) 17.72
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol (1991) 9.39
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex. Nature (1995) 9.03
Active and inactive protein kinases: structural basis for regulation. Cell (1996) 7.98
Crystal structure of cyclin-dependent kinase 2. Nature (1993) 5.21
The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature (1993) 4.83
Casein kinase 2: an 'eminence grise' in cellular regulation? Biochim Biophys Acta (1990) 4.51
Slow-cooling protocols for crystallographic refinement by simulated annealing. Acta Crystallogr A (1990) 4.11
How do protein kinases recognize their substrates? Biochim Biophys Acta (1996) 3.66
Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation. FASEB J (1995) 3.19
Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. Science (1995) 2.92
Three protein kinase structures define a common motif. Structure (1994) 2.88
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44
Crystal structure of casein kinase-1, a phosphate-directed protein kinase. EMBO J (1995) 1.78
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition. EMBO J (1997) 1.68
Regulation of protein phosphatase 2A by direct interaction with casein kinase 2alpha. Science (1997) 1.58
Casein kinases: pleiotropic mediators of cellular regulation. Pharmacol Ther (1993) 1.53
Two structures of the catalytic domain of phosphorylase kinase: an active protein kinase complexed with substrate analogue and product. Structure (1995) 1.41
Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue. Eur J Biochem (1990) 1.38
Substrate specificity of protein kinase CK2. Cell Mol Biol Res (1994) 1.33
Interactions between the subunits of casein kinase II. J Biol Chem (1995) 1.15
Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J Biol Chem (1997) 1.15
Protein kinase CK2 mutants defective in substrate recognition. Purification and kinetic analysis. J Biol Chem (1996) 1.11
Cloning and sequencing of the casein kinase 2 alpha subunit from Zea mays. Biochim Biophys Acta (1991) 0.96
Characterization of the phosphotransferase domain of casein kinase II by site-directed mutagenesis and expression in Escherichia coli. J Biol Chem (1992) 0.92
Expression and characterization of a recombinant maize CK-2 alpha subunit. Biochim Biophys Acta (1993) 0.86
Expression, purification and crystallization of the catalytic subunit of protein kinase CK2 from Zea mays. Acta Crystallogr D Biol Crystallogr (1998) 0.82
Kinase conformations: a computational study of the effect of ligand binding. Protein Sci (1997) 0.81
Site-directed mutagenesis and structure/function studies of casein kinase II correlate stimulation of activity by the beta subunit with changes in conformation and ATP/GTP utilization. Eur J Biochem (1995) 0.79
Mapping the residues of protein kinase CK2 alpha subunit responsible for responsiveness to polyanionic inhibitors. FEBS Lett (1996) 0.78
Crystal structure of glucose oxidase from Aspergillus niger refined at 2.3 A resolution. J Mol Biol (1993) 2.48
Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'). FEBS Lett (2001) 2.27
Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis (1999) 2.16
Diversity of glutathione peroxidases. Methods Enzymol (1995) 2.15
Prenatal indicators of congenital cytomegalovirus infection. J Pediatr (2000) 2.12
Amino acid similarity coefficients for protein modeling and sequence alignment derived from main-chain folding angles. J Mol Biol (1991) 2.04
Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ (2005) 2.03
Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology (2001) 1.94
Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J (2001) 1.77
The substrate specificity of the protein kinase induced in cells infected with herpesviruses: studies with synthetic substrates [corrected] indicate structural requirements distinct from other protein kinases. Biochim Biophys Acta (1986) 1.71
Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem (1995) 1.69
Role of the large hepatitis B virus envelope protein in infectivity of the hepatitis delta virion. J Virol (1993) 1.65
1.8 and 1.9 A resolution structures of the Penicillium amagasakiense and Aspergillus niger glucose oxidases as a basis for modelling substrate complexes. Acta Crystallogr D Biol Crystallogr (1999) 1.60
Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching data bases of representative protein fragments using geometric scoring criteria. J Mol Biol (1995) 1.59
An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A. Biochim Biophys Acta (1990) 1.56
Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain? Euro Surveill (2010) 1.51
Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J Virol (2001) 1.50
ProClust: improved clustering of protein sequences with an extended graph-based approach. Bioinformatics (2002) 1.47
GTP plus water mimic ATP in the active site of protein kinase CK2. Nat Struct Biol (1999) 1.45
The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystals in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2. Proc Natl Acad Sci U S A (1995) 1.45
Birth defects in a national cohort of pregnant women with HIV infection in Italy, 2001-2011. BJOG (2013) 1.44
Site specificity of casein kinase-2 (TS) from rat liver cytosol. A study with model peptide substrates. Eur J Biochem (1986) 1.43
Virulence and resistance determinants of German Staphylococcus aureus ST398 isolates from nonhuman sources. Appl Environ Microbiol (2011) 1.42
Further definition of the substrate specificity of the alpha-herpesvirus protein kinase and comparison with protein kinases A and C. Biochim Biophys Acta (1991) 1.41
The open conformation of a Pseudomonas lipase. Structure (1997) 1.39
Casein kinase II is elevated in solid human tumours and rapidly proliferating non-neoplastic tissue. Eur J Biochem (1990) 1.38
Extracellular lipase of Pseudomonas sp. strain ATCC 21808: purification, characterization, crystallization, and preliminary X-ray diffraction data. J Bacteriol (1991) 1.36
Methicillin-resistant Staphylococcus aureus (MRSA) in three dairy herds in southwest Germany. Zoonoses Public Health (2010) 1.36
Structural relationship between a bacterial developmental protein and eukaryotic PP2C protein phosphatases. Mol Microbiol (1997) 1.35
Similarities between protein 3-D structures. Protein Eng (1994) 1.34
Substrate specificity of protein kinase CK2. Cell Mol Biol Res (1994) 1.33
Clustering protein sequences--structure prediction by transitive homology. Bioinformatics (2001) 1.33
Anticytomegalovirus (anti-CMV) immunoglobulin G avidity in identification of pregnant women at risk of transmitting congenital CMV infection. Clin Diagn Lab Immunol (1999) 1.29
Kinase CK2 inhibition: an update. Curr Med Chem (2013) 1.29
Protein kinase CK2: evidence for a protein kinase CK2beta subunit fraction, devoid of the catalytic CK2alpha subunit, in mouse brain and testicles. FEBS Lett (1999) 1.27
Characterization of the cDNA and three processed pseudogenes from the murine protein kinase CK2 alpha subunit. Biochim Biophys Acta (1995) 1.27
Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. J Virol (2000) 1.24
Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase. J Biol Chem (2000) 1.23
Asymmetric expression of protein kinase CK2 subunits in human kidney tumors. Biochem Biophys Res Commun (1994) 1.23
Dephosphorylation of phosphopeptides by calcineurin (protein phosphatase 2B). Eur J Biochem (1994) 1.23
Phosphorylation of osteopontin by Golgi apparatus casein kinase. Biochem Biophys Res Commun (1997) 1.18
Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees. Virology (1999) 1.18
Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. J Biol Chem (1998) 1.17
Isolation and characterization of recombinant human casein kinase II subunits alpha and beta from bacteria. Eur J Biochem (1991) 1.17
Protein kinase CK2 in hematologic malignancies: reliance on a pivotal cell survival regulator by oncogenic signaling pathways. Leukemia (2012) 1.16
Infectious cDNA clone of the hepatitis C virus genotype 1 prototype sequence. J Gen Virol (2001) 1.16
Golgi apparatus mammary gland casein kinase: monitoring by a specific peptide substrate and definition of specificity determinants. FEBS Lett (1996) 1.16
The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2. FEBS Lett (1992) 1.14
The incidence of complications after caesarean section in 156 HIV-positive women. AIDS (1995) 1.13
Inhibition of protein kinase CK2 suppresses angiogenesis and hematopoietic stem cell recruitment to retinal neovascularization sites. Mol Cell Biochem (2008) 1.12
Novel consensus sequence for the Golgi apparatus casein kinase, revealed using proline-rich protein-1 (PRP1)-derived peptide substrates. Biochem J (2000) 1.12
Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution. J Mol Biol (1997) 1.12
SH2 domains mediate the sequential phosphorylation of HS1 protein by p72syk and Src-related protein tyrosine kinases. Biochemistry (1996) 1.11
Protein kinase CK2 mutants defective in substrate recognition. Purification and kinetic analysis. J Biol Chem (1996) 1.11
Synthetic peptides including acidic clusters as substrates and inhibitors of rat liver casein kinase TS (type-2). J Biol Chem (1984) 1.11
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1. Eur J Biochem (1990) 1.10
Endogenous phosphate acceptor proteins for rat liver cytosolic casein kinases. J Biol Chem (1981) 1.10
Prenatal diagnosis of congenital cytomegalovirus infection. J Clin Microbiol (1998) 1.10
Analysis of the catalytic mechanism of a fungal lipase using computer-aided design and structural mutants. Protein Eng (1996) 1.10
Casein kinase 2 down-regulation and activation by polybasic peptides are mediated by acidic residues in the 55-64 region of the beta-subunit. A study with calmodulin as phosphorylatable substrate. Biochemistry (1994) 1.10
Solution structure of the cytoplasmic domain of the human immunodeficiency virus type 1 encoded virus protein U (Vpu). Int J Pept Protein Res (1996) 1.08
The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2. J Biol Chem (2000) 1.08
Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. J Biol Chem (1999) 1.08
Pharmacological inhibition of protein kinase CK2 reverts the multidrug resistance phenotype of a CEM cell line characterized by high CK2 level. Oncogene (2007) 1.07
GRP94 (endoplasmin) co-purifies with and is phosphorylated by Golgi apparatus casein kinase. FEBS Lett (2000) 1.07
CK2: a protein kinase in need of control. Pharmacol Ther (1999) 1.07
Role of the beta subunit of casein kinase-2 on the stability and specificity of the recombinant reconstituted holoenzyme. Eur J Biochem (1992) 1.07
Prevalence of MRSA types in slaughter pigs in different German abattoirs. Vet Rec (2009) 1.06
Solution structure of the hydrophilic region of HIV-1 encoded virus protein U (Vpu) by CD and 1H NMR spectroscopy. Int J Pept Protein Res (1995) 1.06
Rat liver Golgi apparatus contains a protein kinase similar to the casein kinase of lactating mammary gland. Eur J Biochem (1997) 1.06
ATP site-directed inhibitors of protein kinase CK2: an update. Curr Top Med Chem (2011) 1.05
Crystal structure of a bacterial lipase from Chromobacterium viscosum ATCC 6918 refined at 1.6 angstroms resolution. J Mol Biol (1996) 1.05
A membrane-bound protein phosphatase type 2C from Paramecium tetraurelia. Purification, characterization, and cloning. J Biol Chem (1994) 1.05
Treatment of P190 Bcr/Abl lymphoblastic leukemia cells with inhibitors of the serine/threonine kinase CK2. Leukemia (2006) 1.04
Site specificity of p72syk protein tyrosine kinase: efficient phosphorylation of motifs recognized by Src homology 2 domains of the Src family. FEBS Lett (1995) 1.04
X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 A resolution. J Mol Biol (1999) 1.04
Hydrogen bonding and molecular surface shape complementarity as a basis for protein docking. J Mol Biol (1996) 1.03
Subunit structure and autophosphorylation mechanism of casein kinase-TS (type-2) from rat liver cytosol. Eur J Biochem (1984) 1.03
Phosphorylation in vitro of eukaryotic initiation factors IF-E2 and IF-E3 by protein kinases. J Biol Chem (1976) 1.03
The regulatory beta-subunit of protein kinase CK2 regulates cell-cycle progression at the onset of mitosis. Oncogene (2008) 1.02
Characterization of the first CTX-M-14-producing Salmonella enterica serotype Enteritidis isolate. J Antimicrob Chemother (2004) 1.02
Potential of three-Way randomly amplified polymorphic DNA analysis as a typing method for twelve Salmonella serotypes. Appl Environ Microbiol (1999) 1.01
The middle hepatitis B virus envelope protein is not necessary for infectivity of hepatitis delta virus. J Virol (1994) 1.01
Biochemical evidence that Saccharomyces cerevisiae YGR262c gene, required for normal growth, encodes a novel Ser/Thr-specific protein kinase. FEBS Lett (1997) 1.01
Retracted 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc Natl Acad Sci U S A (1994) 1.01
The effect of polylysine on casein-kinase-2 activity is influenced by both the structure of the protein/peptide substrates and the subunit composition of the enzyme. Eur J Biochem (1992) 1.00
A synthetic beta-casein phosphopeptide and analogues as model substrates for casein kinase-1, a ubiquitous, phosphate directed protein kinase. FEBS Lett (1991) 1.00
Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole. Protein Sci (2001) 1.00
In vivo and in vitro "phenotypic mixing" with amber mutants of phages T3 and T7. Mol Gen Genet (1973) 0.99
BrEPS: a flexible and automatic protocol to compute enzyme-specific sequence profiles for functional annotation. BMC Bioinformatics (2010) 0.99
Dephosphorylation of phosphoproteins and synthetic phosphopeptides. Study of the specificity of the polycation-stimulated and MgATP-dependent phosphorylase phosphatases. J Biol Chem (1987) 0.99