Generation of transmissible hepatitis C virions from a molecular clone in chimpanzees.

PubWeight™: 1.18‹?› | Rank: Top 10%

🔗 View Article (PMID 10087224)

Published in Virology on March 30, 1999

Authors

Z Hong1, M Beaudet-Miller, R E Lanford, B Guerra, J Wright-Minogue, A Skelton, B M Baroudy, G R Reyes, J Y Lau

Author Affiliations

1: Antiviral Therapy, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA. zhi.hong@spcorp.com

Articles citing this

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J Virol (2000) 5.26

Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees. Proc Natl Acad Sci U S A (2002) 3.43

Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol (2007) 2.18

The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity. J Virol (2003) 1.90

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies. J Virol (2010) 1.55

Full-length GB virus C (Hepatitis G virus) RNA transcripts are infectious in primary CD4-positive T cells. J Virol (2000) 1.29

Meta-analysis of hepatitis C virus vaccine efficacy in chimpanzees indicates an importance for structural proteins. Gastroenterology (2010) 1.28

Development of a primary tamarin hepatocyte culture system for GB virus-B: a surrogate model for hepatitis C virus. J Virol (2000) 1.24

Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17

Hepatitis C virus JFH-1 strain infection in chimpanzees is associated with low pathogenicity and emergence of an adaptive mutation. Hepatology (2008) 1.14

Virus-specific cofactor requirement and chimeric hepatitis C virus/GB virus B nonstructural protein 3. J Virol (2000) 1.10

Hepatitis C virus experimental model systems and antiviral drug research. Virol Sin (2010) 0.87

Circulating viral core and E1 antigen levels as supplemental markers for HCV chronic hepatitis. Virol J (2006) 0.79

Articles by these authors

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein. Nature (1986) 8.36

Endoproteolytic cleavage of gp160 is required for the activation of human immunodeficiency virus. Cell (1988) 7.01

Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology (1991) 6.38

Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen. Cell (1984) 5.81

The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med (2000) 5.73

AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigen. Science (1986) 5.58

Association of diabetes mellitus and chronic hepatitis C virus infection. Hepatology (1999) 4.59

Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal. Cell (1986) 4.56

Complete nucleotide sequence of wild-type hepatitis A virus: comparison with different strains of hepatitis A virus and other picornaviruses. J Virol (1987) 4.49

Distinctive nucleotide sequences adjacent to multiple initiation and termination sites of an early vaccinia virus gene. Cell (1981) 4.42

Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J Exp Med (2000) 4.33

DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection. J Virol (2001) 4.22

Direct mapping of adeno-associated virus capsid proteins B and C: a possible ACG initiation codon. Proc Natl Acad Sci U S A (1985) 3.31

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes. J Virol (2000) 3.26

The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol (1999) 3.25

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25

Computer-assisted assignment of functional domains in the nonstructural polyprotein of hepatitis E virus: delineation of an additional group of positive-strand RNA plant and animal viruses. Proc Natl Acad Sci U S A (1992) 3.24

Transactivation induced by human T-lymphotropic virus type III (HTLV III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificity. Virology (1986) 3.15

Preventing recurrent upper gastrointestinal bleeding in patients with Helicobacter pylori infection who are taking low-dose aspirin or naproxen. N Engl J Med (2001) 3.02

Atrophy and intestinal metaplasia one year after cure of H. pylori infection: a prospective, randomized study. Gastroenterology (2000) 2.99

Molecular cloning and characterization of hepatitis A virus cDNA. Proc Natl Acad Sci U S A (1983) 2.92

Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology (1992) 2.92

The effects of variations in the number and sequence of targeting signals on nuclear uptake. J Cell Biol (1988) 2.89

Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology (2000) 2.83

New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78

Incompletely base-paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain. Cell (1982) 2.76

SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrob Agents Chemother (2006) 2.75

Purification and characterization of a DNA-dependent RNA polymerase from vaccinia virions. J Biol Chem (1980) 2.66

Characterization of a prototype strain of hepatitis E virus. Proc Natl Acad Sci U S A (1992) 2.64

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci U S A (2001) 2.49

The isolation and characterization of a Norwalk virus-specific cDNA. J Clin Invest (1991) 2.42

Randomised comparison between adrenaline injection alone and adrenaline injection plus heat probe treatment for actively bleeding ulcers. BMJ (1997) 2.42

Characterization of soluble hepatitis C virus RNA-dependent RNA polymerase expressed in Escherichia coli. J Virol (1999) 2.37

Small-bowel perforations related to endoscopic retrograde cholangiopancreatography (ERCP) in patients with Billroth II gastrectomy. Endoscopy (1999) 2.24

A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology (2001) 2.21

De novo initiation of RNA synthesis by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 2.19

Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egyptian children. Lancet (1992) 2.14

Prenatal indicators of congenital cytomegalovirus infection. J Pediatr (2000) 2.12

Morphological transformation by DNA fragments of human herpesviruses: evidence for two distinct transforming regions in herpes simplex virus types 1 and 2 and lack of correlation with biochemical transfer of the thymidine kinase gene. Cold Spring Harb Symp Quant Biol (1980) 1.99

Evidence that hepatitis D virus needs hepatitis B virus to cause hepatocellular damage. Am J Clin Pathol (1992) 1.98

Identification of four nuclear transport signal-binding proteins that interact with diverse transport signals. Mol Cell Biol (1989) 1.97

Hepatitis E virus: identification of type-common epitopes. J Virol (1991) 1.95

Protective immune response to hepatitis C virus in chimpanzees rechallenged following clearance of primary infection. Hepatology (2001) 1.94

Factors predictive of a beneficial response to therapy of hepatitis C. Hepatology (1997) 1.90

Solid-phase enzyme-linked immunosorbent assay for hepatitis E virus IgG and IgM antibodies utilizing recombinant antigens and synthetic peptides. J Virol Methods (1992) 1.85

Serum interleukin 4 and interleukin 10 levels in patients with chronic hepatitis C virus infection. J Hepatol (1997) 1.82

Genetic analysis of human immunodeficiency virus type 1 envelope V3 region isolates from mothers and infants after perinatal transmission. J Virol (1995) 1.77

Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme. EMBO J (2001) 1.77

Cloned hepatitis delta virus cDNA is infectious in the chimpanzee. J Virol (1989) 1.75

Different susceptibility of protein kinases to staurosporine inhibition. Kinetic studies and molecular bases for the resistance of protein kinase CK2. Eur J Biochem (1995) 1.69

Evaluation of a novel serotyping system for hepatitis C virus: strong correlation with standard genotyping methodologies. J Clin Microbiol (1995) 1.65

A longitudinal analysis of hepatitis C virus replication following liver transplantation. Gastroenterology (1996) 1.65

Role of the large hepatitis B virus envelope protein in infectivity of the hepatitis delta virion. J Virol (1993) 1.65

Template/primer requirements and single nucleotide incorporation by hepatitis C virus nonstructural protein 5B polymerase. J Virol (2000) 1.63

The role of hepatitis C virus-specific cytotoxic T lymphocytes in chronic hepatitis C. J Immunol (1997) 1.63

High prevalence of Helicobacter pylori infection in duodenal ulcer perforations not caused by non-steroidal anti-inflammatory drugs. Br J Surg (1996) 1.62

Carboxy-terminal truncations of the HBV core protein affect capsid formation and the apparent size of encapsidated HBV RNA. Virology (1993) 1.62

Antigenic relationship of SV40 early proteins to purified large T polypeptide. Virology (1979) 1.61

Identification of a minimal hydrophobic domain in the herpes simplex virus type 1 scaffolding protein which is required for interaction with the major capsid protein. J Virol (1996) 1.56

Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis. Lancet (1994) 1.55

Ribavirin inhibits West Nile virus replication and cytopathic effect in neural cells. J Infect Dis (2000) 1.52

Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes. Structure (1997) 1.52

Variation in course of hepatitis E in experimentally infected cynomolgus monkeys. J Infect Dis (1993) 1.52

Multiresistant Salmonella enterica serovar 4,[5],12:i:- in Europe: a new pandemic strain? Euro Surveill (2010) 1.51

Comparison of two-dimensional vs three-dimensional camera systems in laparoscopic surgery. Surg Endosc (1997) 1.50

Hepatitis C virus antigen in hepatocytes: immunomorphologic detection and identification. Gastroenterology (1992) 1.50

Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J Virol (2001) 1.50

Constrained evolution with respect to gene overlap of hepatitis B virus. J Mol Evol (1997) 1.49

Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles. J Virol (1998) 1.48

Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. J Virol (2000) 1.47

GTP plus water mimic ATP in the active site of protein kinase CK2. Nat Struct Biol (1999) 1.45

Production of infectious hepatitis delta virus in vitro and neutralization with antibodies directed against hepatitis B virus pre-S antigens. J Virol (1992) 1.45

A controlled trial of interferon with or without prednisone priming for chronic hepatitis B. Gastroenterology (1992) 1.44

Simple fluorescent enzyme immunoassay for detection and quantification of hepatitis C viremia. J Hepatol (1995) 1.44

Birth defects in a national cohort of pregnant women with HIV infection in Italy, 2001-2011. BJOG (2013) 1.44

Activation of tumor necrosis factor-alpha system in chronic hepatitis C virus infection. Dig Dis Sci (1997) 1.44

Severe recurrent cholestatic hepatitis C following orthotopic liver transplantation. Hepatology (1996) 1.42

Virulence and resistance determinants of German Staphylococcus aureus ST398 isolates from nonhuman sources. Appl Environ Microbiol (2011) 1.42

Cyclic appearance of defective interfering particles of herpes simplex virus and the concomitant accumulation of early polypeptide VP175. Intervirology (1975) 1.40

Viral persistence, antibody to E1 and E2, and hypervariable region 1 sequence stability in hepatitis C virus-inoculated chimpanzees. J Virol (1999) 1.40

Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J Virol (1996) 1.38

Eradication of Helicobacter pylori prevents recurrence of ulcer after simple closure of duodenal ulcer perforation: randomized controlled trial. Ann Surg (2000) 1.37

Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase. J Virol (1999) 1.37

Suppression of human immunodeficiency virus type 1 activity in vitro by oligonucleotides which form intramolecular tetrads. J Biol Chem (1995) 1.36

Structure and replication of vaccinia virus telomeres. Cold Spring Harb Symp Quant Biol (1983) 1.36

Methicillin-resistant Staphylococcus aureus (MRSA) in three dairy herds in southwest Germany. Zoonoses Public Health (2010) 1.36

Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am J Pathol (1996) 1.35

Cloning and characterization of human astrovirus immunoreactive epitopes. J Virol (1993) 1.34

Quantitative detection of hepatitis C virus RNA with a solid-phase signal amplification method: definition of optimal conditions for specimen collection and clinical application in interferon-treated patients. Hepatology (1994) 1.34

A human monoclonal antibody that recognizes viral polypeptides and in vitro translation products of the genome of the hepatitis D virus. J Infect Dis (1987) 1.32

Expression and diagnostic utility of hepatitis E virus putative structural proteins expressed in insect cells. J Clin Microbiol (1993) 1.32

Expression of human beta-interferon cDNA under the control of a thymidine kinase promoter from herpes simplex virus. Nature (1982) 1.32