Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development.

PubWeight™: 2.15‹?› | Rank: Top 2%

🔗 View Article (PMID 9570771)

Published in Development on June 01, 1998

Authors

M Grigoriou1, A S Tucker, P T Sharpe, V Pachnis

Author Affiliations

1: Division of Developmental Neurobiology, The National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.

Articles citing this

Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci (2007) 3.28

Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev (1999) 2.42

Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity. Genes Dev (2002) 2.19

The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16

Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol (2008) 2.09

Olig1 and Olig2 triplication causes developmental brain defects in Down syndrome. Nat Neurosci (2010) 2.08

A blueprint for the spatiotemporal origins of mouse hippocampal interneuron diversity. J Neurosci (2011) 2.07

The developmental integration of cortical interneurons into a functional network. Curr Top Dev Biol (2009) 2.01

The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain. Proc Natl Acad Sci U S A (2003) 1.85

Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc Natl Acad Sci U S A (2001) 1.67

Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4. Genes Dev (1999) 1.61

Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development (2009) 1.59

Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A (1999) 1.54

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci (2010) 1.48

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci (2007) 1.48

Malformations of cortical development. Neurologist (2008) 1.41

Prospective isolation of cortical interneuron precursors from mouse embryonic stem cells. J Neurosci (2010) 1.36

Beta-catenin-mediated Wnt signaling regulates neurogenesis in the ventral telencephalon. Nat Neurosci (2008) 1.32

Multiple origins of human neocortical interneurons are supported by distinct expression of transcription factors. Cereb Cortex (2010) 1.32

Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev (1998) 1.30

Genetics and function of neocortical GABAergic interneurons in neurodevelopmental disorders. Neural Plast (2011) 1.29

Ventralized dorsal telencephalic progenitors in Pax6 mutant mice generate GABA interneurons of a lateral ganglionic eminence fate. Proc Natl Acad Sci U S A (2005) 1.24

LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development (2009) 1.22

Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol (2008) 1.22

Role of homeobox genes in the patterning, specification, and differentiation of ectodermal appendages in mammals. J Cell Physiol (2008) 1.21

A curriculum vitae of teeth: evolution, generation, regeneration. Int J Biol Sci (2009) 1.19

Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol (2007) 1.18

Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. Cell Rep (2012) 1.04

Activin induces cortical interneuron identity and differentiation in embryonic stem cell-derived telencephalic neural precursors. Nat Commun (2012) 1.04

The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. Dev Biol (2009) 1.03

Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron (2014) 1.00

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells. Development (2015) 0.95

Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice. Neural Dev (2012) 0.93

Lim homeobox genes in the Ctenophore Mnemiopsis leidyi: the evolution of neural cell type specification. Evodevo (2012) 0.92

From molecules to mastication: the development and evolution of teeth. Wiley Interdiscip Rev Dev Biol (2012) 0.92

WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS One (2013) 0.91

Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol (2010) 0.91

Expression profiles of cIRF6, cLHX6 and cLHX7 in the facial primordia suggest specific roles during primary palatogenesis. BMC Dev Biol (2006) 0.91

Evolution and development of teeth. J Anat (2001) 0.90

New striatal neurons in a mouse model of progressive striatal degeneration are generated in both the subventricular zone and the striatal parenchyma. PLoS One (2011) 0.89

Expression of LIM-homeodomain transcription factors in the developing and mature mouse retina. Gene Expr Patterns (2013) 0.89

Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. J Cell Mol Med (2009) 0.88

Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cereb Cortex (2011) 0.87

Molars and incisors: show your microarray IDs. BMC Res Notes (2013) 0.87

So-called hybrid central odontogenic fibroma/central giant cell lesion of the jaws. A report on seven additional cases, including an example in a patient with cherubism, and hypotheses on the pathogenesis. Head Neck Pathol (2008) 0.86

Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers. Dev Biol (2014) 0.86

GABAA receptor subunit profiles of tangentially migrating neurons derived from the medial ganglionic eminence. Cereb Cortex (2010) 0.85

A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol (2013) 0.84

A homozygous 237-kb deletion at 1p31 identified as the locus for midline cleft of the upper and lower lip in a consanguineous family. Eur J Hum Genet (2013) 0.84

LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer. Cell Death Dis (2013) 0.82

Rac1 and rac3 GTPases control synergistically the development of cortical and hippocampal GABAergic interneurons. Cereb Cortex (2012) 0.82

The LIM homeodomain transcription factor LHX6: a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis. J Biol Chem (2012) 0.81

Exogenous fibroblast growth factor 8 rescues development of mouse diastemal vestigial tooth ex vivo. Dev Dyn (2011) 0.80

Cleft palate defect of Dlx1/2-/- mutant mice is caused by lack of vertical outgrowth in the posterior palate. Dev Dyn (2012) 0.80

A rapid and highly sensitive method of non radioactive colorimetric in situ hybridization for the detection of mRNA on tissue sections. PLoS One (2012) 0.79

Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns (2016) 0.78

Defining cell-matrix combination products in the era of pluripotency. Biomatter (2013) 0.78

Lhx8 mediated Wnt and TGFβ pathways in tooth development and regeneration. Biomaterials (2015) 0.78

The COUP-TFII/Neuropilin-2 is a molecular switch steering diencephalon-derived GABAergic neurons in the developing mouse brain. Proc Natl Acad Sci U S A (2015) 0.78

Identification of a face enhancer reveals direct regulation of LIM homeobox 8 (Lhx8) by wingless-int (WNT)/β-catenin signaling. J Biol Chem (2014) 0.78

Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2. Hum Mol Genet (2015) 0.77

Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy. Prog Brain Res (2016) 0.76

Lhx6 and Lhx8: cell fate regulators and beyond. FASEB J (2015) 0.76

Alternative splicing of the LIM-homeodomain transcription factor Isl1 in the mouse retina. Mol Cell Neurosci (2015) 0.75

Thalamo-cortical axons regulate the radial dispersion of neocortical GABAergic interneurons. Elife (2016) 0.75

Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. PLoS One (2015) 0.75

Chromosome 1p31.1p31.3 Deletion in a Patient with Craniosynostosis, Central Nervous System and Renal Malformation: Case Report and Review of the Literature. Mol Syndromol (2016) 0.75

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop. J Biol Chem (2013) 0.75

HSPC280, a winged helix protein expressed in the subventricular zone of the developing ganglionic eminences, inhibits neuronal differentiation. Histochem Cell Biol (2015) 0.75

Articles by these authors

Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature (1994) 5.61

The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci (1999) 3.03

Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol (1997) 2.71

Analysis of the tandem repeat locus D4Z4 associated with facioscapulohumeral muscular dystrophy. Hum Mol Genet (1994) 2.60

The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development (1998) 2.26

Evaluation of a prophylactic and therapeutic program for patients with cystic fibrosis. Pediatrics (1965) 2.18

Stem-cell-based tissue engineering of murine teeth. J Dent Res (2004) 2.17

Transformation of tooth type induced by inhibition of BMP signaling. Science (1998) 2.16

Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature (1996) 2.09

Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech Dev (1995) 2.09

Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development (1997) 2.05

Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development. Development (1996) 1.96

Gene defect in ectodermal dysplasia implicates a death domain adapter in development. Nature (2002) 1.95

Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. Proc Natl Acad Sci U S A (1984) 1.80

Course of cystic fibrosis in 95 patients. J Pediatr (1976) 1.78

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts. Development (1996) 1.75

Canine distemper virus transcripts sequenced from pagetic bone. Bone Miner (1992) 1.59

Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Dev Dyn (1997) 1.59

The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, especially tooth development in vivo and in vitro. Development (1991) 1.55

The effect of early diagnosis and treatment in cystic fibrosis: a seven-year study of 16 sibling pairs. Am J Dis Child (1977) 1.55

eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus. Development (1996) 1.53

Tooth agenesis: from molecular genetics to molecular dentistry. J Dent Res (2008) 1.52

Role of Dlx-1 and Dlx-2 genes in patterning of the murine dentition. Development (1997) 1.51

Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev (2001) 1.51

Mox2 is a component of the genetic hierarchy controlling limb muscle development. Nature (1999) 1.50

Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. Development (1992) 1.49

Expression of Wnt signalling pathway genes during tooth development. Mech Dev (1999) 1.48

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development (1999) 1.46

Fgf-8 determines rostral-caudal polarity in the first branchial arch. Development (1999) 1.46

Two regulatory domains flank the mouse H19 gene. Mol Cell Biol (1988) 1.44

Interactions between Bmp-4 and Msx-1 act to restrict gene expression to odontogenic mesenchyme. Dev Dyn (1998) 1.41

Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development (2000) 1.39

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development (1996) 1.36

The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol (2004) 1.36

Early regression of the dental lamina underlies the development of diphyodont dentitions. J Dent Res (2012) 1.35

Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth. Development (1993) 1.35

Independent regulation of Dlx2 expression in the epithelium and mesenchyme of the first branchial arch. Development (2000) 1.30

Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. Genes Dev (1998) 1.30

Temporospatial cell interactions regulating mandibular and maxillary arch patterning. Development (2000) 1.28

Wnt/Shh interactions regulate ectodermal boundary formation during mammalian tooth development. Proc Natl Acad Sci U S A (2000) 1.28

Targeted disruption of the galanin gene reduces the number of sensory neurons and their regenerative capacity. Proc Natl Acad Sci U S A (2000) 1.27

Preventing the loss of competence for neural induction: HGF/SF, L5 and Sox-2. Development (1997) 1.26

Regulation and role of Sox9 in cartilage formation. Dev Dyn (1999) 1.24

Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development (1999) 1.22

Hox-7 expression during murine craniofacial development. Development (1991) 1.20

Antagonistic regulation of Dlx2 expression by PITX2 and Msx2: implications for tooth development. Gene Expr (2001) 1.18

Adult human gingival epithelial cells as a source for whole-tooth bioengineering. J Dent Res (2013) 1.15

Treatment and prognosis of massive hemoptysis in cystic fibrosis. Am Rev Respir Dis (1978) 1.15

Specification of the hypaxial musculature. Development (1998) 1.15

Galanin regulates prolactin release and lactotroph proliferation. Proc Natl Acad Sci U S A (1998) 1.15

Open thoracotomy for pneumothorax in cystic fibrosis. Am Rev Respir Dis (1975) 1.15

Homeotic transformation of branchial arch identity after Hoxa2 overexpression. Development (2000) 1.15

Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res (1994) 1.11

Molecular genetics of tooth morphogenesis and patterning: the right shape in the right place. J Dent Res (1999) 1.09

Course of cystic fibrosis in black patients. J Pediatr (1976) 1.09

The evolution of WT1 sequence and expression pattern in the vertebrates. Oncogene (1995) 1.08

RET-deficient mice: an animal model for Hirschsprung's disease and renal agenesis. J Intern Med (1995) 1.08

Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J Dent Res (2001) 1.07

Canine distemper virus localised in bone cells of patients with Paget's disease. Bone (1991) 1.06

cSox21 exhibits a complex and dynamic pattern of transcription during embryonic development of the chick central nervous system. Mech Dev (1997) 1.02

Conserved regulation of mesenchymal gene expression by Fgf-8 in face and limb development. Development (1999) 1.00

The role of effectors of the activin signalling pathway, activin receptors IIA and IIB, and Smad2, in patterning of tooth development. Development (2001) 0.98

Imaging and quantification of anomaly volume using an eight-electrode 'hemiarray' EIT reconstruction method. Physiol Meas (2008) 0.97

Odontogenic epithelium induces similar molecular responses in chick and mouse mandibular mesenchyme. Dev Dyn (1998) 0.96

The contribution of the ganglionic eminence to the neuronal cell types of the cerebral cortex. Novartis Found Symp (2000) 0.95

The murine homeobox gene Msx-3 shows highly restricted expression in the developing neural tube. Mech Dev (1996) 0.95

Death in the life of a tooth. J Dent Res (2004) 0.95

Development of the mammalian enteric nervous system. Curr Opin Genet Dev (1999) 0.95

Tricho-rhino-phalangeal syndrome with supernumerary teeth. J Dent Res (2008) 0.94

Cell lineage of primary and secondary enamel knots. Dev Dyn (2005) 0.93

Sequence and embryonic expression of the murine Hox-3.5 gene. Development (1992) 0.92

An alternatively spliced transcript, p65 delta 2, of the gene encoding the p65 subunit of the transcription factor NF-kappa B. Gene (1994) 0.91

Molecular cloning, chromosomal mapping, and developmental expression of a novel protein tyrosine phosphatase-like gene. Genomics (1999) 0.91

Patterning of the murine dentition by homeobox genes. Eur J Oral Sci (1998) 0.91

Evolution and development of teeth. J Anat (2001) 0.90

Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesis. J Dent Res (2004) 0.90

Development of the enteric nervous system: bringing together cells, signals and genes. Neurogastroenterol Motil (2009) 0.90

Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network. Development (1990) 0.90

Developmental genetics and early hominid craniodental evolution. Bioessays (2001) 0.90

Defects and rescue of the minor salivary glands in Eda pathway mutants. Dev Biol (2010) 0.89

A mathematical model for mechanotransduction at the early steps of suture formation. Proc Biol Sci (2013) 0.89

Characterisation of the murine Hox-3.3 gene and its promoter. Mech Dev (1991) 0.89

Expression of the chicken Sox9 gene marks the onset of cartilage differentiation. Ann N Y Acad Sci (1996) 0.89

Inhibition of Wnt signaling by exogenous Mfrzb1 protein affects molar tooth size. J Dent Res (2000) 0.89

Biological tooth replacement and repair. J Oral Rehabil (2007) 0.88

Canine distemper virus transcripts detected in the bone cells of dogs with metaphyseal osteopathy. Bone (1993) 0.88

Organized tooth-specific cellular differentiation stimulated by BMP4. J Dent Res (2005) 0.88

Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex. Genomics (1999) 0.87

Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors. FEBS Lett (2001) 0.87

Cystic fibrosis diagnosed after age 13. Twenty-five teenage and adult patients including three asymptomatic men. Ann Intern Med (1977) 0.87

The molecular anatomy of Hox gene expression. J Anat (1994) 0.87