The LIM-homeobox gene Lhx8 is required for the development of many cholinergic neurons in the mouse forebrain.

PubWeight™: 1.85‹?› | Rank: Top 3%

🔗 View Article (PMC 166428)

Published in Proc Natl Acad Sci U S A on July 10, 2003

Authors

Yangu Zhao1, Oscar Marín, Edit Hermesz, Aaron Powell, Nuria Flames, Miklós Palkovits, John L R Rubenstein, Heiner Westphal

Author Affiliations

1: Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, Bethesda, MD 20892,USA.

Articles citing this

Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci (2007) 3.28

The requirement of Nkx2-1 in the temporal specification of cortical interneuron subtypes. Neuron (2008) 2.33

Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol (2008) 2.09

Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A (2006) 1.87

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron (2013) 1.87

Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol (2007) 1.73

Islet-1 controls the differentiation of retinal bipolar and cholinergic amacrine cells. J Neurosci (2007) 1.69

The cell-intrinsic requirement of Sox6 for cortical interneuron development. Neuron (2009) 1.66

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex (2009) 1.57

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci (2010) 1.48

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci (2007) 1.48

Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits. Nat Biotechnol (2013) 1.38

Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron (2011) 1.35

Linking asymmetric cell division to the terminal differentiation program of postmitotic neurons in C. elegans. Dev Cell (2009) 1.35

Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats. Cell Stem Cell (2010) 1.35

REST and CoREST modulate neuronal subtype specification, maturation and maintenance. PLoS One (2009) 1.34

The controlled generation of functional basal forebrain cholinergic neurons from human embryonic stem cells. Stem Cells (2011) 1.32

Annual Research Review: Development of the cerebral cortex: implications for neurodevelopmental disorders. J Child Psychol Psychiatry (2010) 1.30

The lamprey in evolutionary studies. Dev Genes Evol (2008) 1.29

Lim homeobox gene, lhx8, is essential for mouse oocyte differentiation and survival. Biol Reprod (2008) 1.28

Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat Protoc (2013) 1.25

Forging links between human mental retardation-associated CNVs and mouse gene knockout models. PLoS Genet (2009) 1.23

LIM homeodomain transcription factor-dependent specification of bipotential MGE progenitors into cholinergic and GABAergic striatal interneurons. Development (2009) 1.22

Histogenetic compartments of the mouse centromedial and extended amygdala based on gene expression patterns during development. J Comp Neurol (2008) 1.22

The mouse homeobox gene Gbx2 is required for the development of cholinergic interneurons in the striatum. J Neurosci (2010) 1.14

Isl1 directly controls a cholinergic neuronal identity in the developing forebrain and spinal cord by forming cell type-specific complexes. PLoS Genet (2014) 1.12

The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons. J Neurosci (2008) 1.12

Robo1 regulates semaphorin signaling to guide the migration of cortical interneurons through the ventral forebrain. J Neurosci (2011) 1.09

Early evolution of the LIM homeobox gene family. BMC Biol (2010) 1.08

Molecules and mechanisms involved in the generation and migration of cortical interneurons. ASN Neuro (2010) 1.04

Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome Biol (2009) 1.03

Transcriptome Analysis of the Human Striatum in Tourette Syndrome. Biol Psychiatry (2014) 1.02

Stem cell derived basal forebrain cholinergic neurons from Alzheimer's disease patients are more susceptible to cell death. Mol Neurodegener (2014) 1.00

Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position. Neuron (2014) 1.00

Genomic perspectives of transcriptional regulation in forebrain development. Neuron (2015) 0.97

Transcription factor LIM homeobox 7 (Lhx7) maintains subtype identity of cholinergic interneurons in the mammalian striatum. Proc Natl Acad Sci U S A (2012) 0.95

Activin A directs striatal projection neuron differentiation of human pluripotent stem cells. Development (2015) 0.95

Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms. Neuron (2015) 0.93

Ontogenetic expression of sonic hedgehog in the chicken subpallium. Front Neuroanat (2010) 0.91

WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS One (2013) 0.91

Development and specification of GABAergic cortical interneurons. Cell Biosci (2013) 0.89

The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins. Brain Res (2011) 0.89

The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A (2013) 0.89

Neurotrophic factors promote cholinergic differentiation in human embryonic stem cell-derived neurons. J Cell Mol Med (2009) 0.88

Regulation of the protocadherin Celsr3 gene and its role in globus pallidus development and connectivity. Mol Cell Biol (2014) 0.84

Cholinergic circuits and signaling in the pathophysiology of schizophrenia. Int Rev Neurobiol (2007) 0.82

Ldb1 is essential for development of Nkx2.1 lineage derived GABAergic and cholinergic neurons in the telencephalon. Dev Biol (2013) 0.81

Crosstalk between intracellular and extracellular signals regulating interneuron production, migration and integration into the cortex. Front Cell Neurosci (2015) 0.81

Transcriptomic and epigenomic characterization of the developing bat wing. Nat Genet (2016) 0.81

Directed neural differentiation of mouse embryonic stem cells is a sensitive system for the identification of novel Hox gene effectors. PLoS One (2011) 0.80

Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline. Neuron (2016) 0.80

Transcription factors in the maintenance and survival of primordial follicles. Clin Exp Reprod Med (2012) 0.79

Lhx8 mediated Wnt and TGFβ pathways in tooth development and regeneration. Biomaterials (2015) 0.78

Radial and tangential migration of telencephalic somatostatin neurons originated from the mouse diagonal area. Brain Struct Funct (2015) 0.77

Dynamic expression of tyrosine hydroxylase mRNA and protein in neurons of the striatum and amygdala of mice, and experimental evidence of their multiple embryonic origin. Brain Struct Funct (2013) 0.76

Targeted Differentiation of Regional Ventral Neuroprogenitors and Related Neuronal Subtypes from Human Pluripotent Stem Cells. Stem Cell Reports (2016) 0.76

Lhx6 and Lhx8: cell fate regulators and beyond. FASEB J (2015) 0.76

The Evolutionarily Conserved LIM Homeodomain Protein LIM-4/LHX6 Specifies the Terminal Identity of a Cholinergic and Peptidergic C. elegans Sensory/Inter/Motor Neuron-Type. PLoS Genet (2015) 0.76

GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain. Cereb Cortex (2013) 0.75

Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. PLoS One (2015) 0.75

Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. Neuron (2016) 0.75

Crosstalk among electrical activity, trophic factors and morphogenetic proteins in the regulation of neurotransmitter phenotype specification. J Chem Neuroanat (2015) 0.75

WNK Kinases in Development and Disease. Curr Top Dev Biol (2016) 0.75

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop. J Biol Chem (2013) 0.75

Ldb1 Is Essential for the Development of Isthmic Organizer and Midbrain Dopaminergic Neurons. Stem Cells Dev (2016) 0.75

Coup-TF1&2 (Nr2f1 and Nr2f2) control subtype and laminar identity of MGE-derived neocortical interneurons. Development (2017) 0.75

FGF-dependent, context-driven role for FRS adapters in the early telencephalon. J Neurosci (2017) 0.75

Articles cited by this

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry (1993) 7.78

Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (1982) 5.63

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation. Cell (1996) 5.27

Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum. Development (1999) 4.26

A long, remarkable journey: tangential migration in the telencephalon. Nat Rev Neurosci (2001) 3.99

Central cholinergic systems and cognition. Annu Rev Psychol (1997) 3.80

Striatal interneurones: chemical, physiological and morphological characterization. Trends Neurosci (1995) 3.65

Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1-Ch6). Neuroscience (1983) 3.26

Origin and molecular specification of striatal interneurons. J Neurosci (2000) 3.24

Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol (1981) 3.18

The medial ganglionic eminence gives rise to a population of early neurons in the developing cerebral cortex. J Neurosci (1999) 3.03

Distinct cortical migrations from the medial and lateral ganglionic eminences. Development (2001) 3.00

LIM factor Lhx3 contributes to the specification of motor neuron and interneuron identity through cell-type-specific protein-protein interactions. Cell (2002) 2.94

LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell (1998) 2.50

Cholinergic systems in mammalian brain and spinal cord. Prog Neurobiol (1991) 2.45

Inductive interactions direct early regionalization of the mouse forebrain. Development (1997) 2.43

Coordinate roles for LIM homeobox genes in directing the dorsoventral trajectory of motor axons in the vertebrate limb. Cell (2000) 2.19

Expression and regulation of Lhx6 and Lhx7, a novel subfamily of LIM homeodomain encoding genes, suggests a role in mammalian head development. Development (1998) 2.15

Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci (1993) 2.02

Coordinate expression of Fgf8, Otx2, Bmp4, and Shh in the rostral prosencephalon during development of the telencephalic and optic vesicles. Neuroscience (2001) 1.82

Induction and maintenance of the neuronal cholinergic phenotype in the central nervous system by BMP-9. Science (2000) 1.68

Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system. Genes Dev (1999) 1.61

Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A (1999) 1.54

Cognitive functions of the basal forebrain. Curr Opin Neurobiol (1999) 1.52

Cholinergic projections from the basal forebrain to frontal, parietal, temporal, occipital, and cingulate cortices: a combined fluorescent tracer and acetylcholinesterase analysis. Brain Res Bull (1982) 1.51

Early subdivisions in the neural plate define distinct competence for inductive signals. Development (2002) 1.38

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science (2000) 1.38

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J Neurosci (1995) 1.35

Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci U S A (2001) 1.33

Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol (1991) 1.26

Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. J Neurosci (2002) 1.24

Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A (2000) 1.17

Fate map of the avian anterior forebrain at the four-somite stage, based on the analysis of quail-chick chimeras. Dev Biol (2001) 1.15

Developmental restriction of the LIM homeodomain transcription factor Islet-1 expression to cholinergic neurons in the rat striatum. Neuroscience (2001) 1.13

Cholinergic systems in the rat brain: I. projections to the limbic telencephalon. Brain Res Bull (1984) 1.10

The nodal pathway acts upstream of hedgehog signaling to specify ventral telencephalic identity. Neuron (2001) 1.10

Cholinergic projections from the basal forebrain to the frontal cortex: a combined fluorescent tracer and immunohistochemical analysis in the rat. Neurosci Lett (1983) 0.96

L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett (1996) 0.96

The homeobox genes Lhx7 and Gbx1 are expressed in the basal forebrain cholinergic system. Neuroscience (2002) 0.96

Different times of origin of choline acetyltransferase- and somatostatin-immunoreactive neurons in the rat striatum. J Neurosci (1988) 0.81

Neurogenesis of basal forebrain cholinergic neurons in rat. Brain Res Dev Brain Res (1989) 0.79

Articles by these authors

Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci (2002) 5.68

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature (2010) 5.11

Cell migration in the forebrain. Annu Rev Neurosci (2003) 4.59

Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci (2005) 4.18

New neurons follow the flow of cerebrospinal fluid in the adult brain. Science (2006) 3.98

Developmental functions of the Distal-less/Dlx homeobox genes. Development (2002) 3.89

Forebrain gene expression domains and the evolving prosomeric model. Trends Neurosci (2003) 3.64

Specification of jaw subdivisions by Dlx genes. Science (2002) 3.33

Patterning and plasticity of the cerebral cortex. Science (2005) 3.30

Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes. J Neurosci (2007) 3.28

Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J Neurosci (2005) 3.19

Tangential neuronal migration controls axon guidance: a role for neuregulin-1 in thalamocortical axon navigation. Cell (2006) 3.12

Spatial genetic patterning of the embryonic neuroepithelium generates GABAergic interneuron diversity in the adult cortex. J Neurosci (2007) 2.90

Dlx transcription factors promote migration through repression of axon and dendrite growth. Neuron (2007) 2.79

Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. Cell Stem Cell (2013) 2.74

Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain. Neuron (2002) 2.71

CXCR4 and CXCR7 have distinct functions in regulating interneuron migration. Neuron (2011) 2.69

New insights into the classification and nomenclature of cortical GABAergic interneurons. Nat Rev Neurosci (2013) 2.65

Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res (2003) 2.57

Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1. Neuron (2004) 2.51

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature (2010) 2.51

Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development (2006) 2.50

Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex. Proc Natl Acad Sci U S A (2010) 2.45

Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci (2005) 2.34

A high-resolution enhancer atlas of the developing telencephalon. Cell (2013) 2.34

Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Neuropsychopharmacology (2004) 2.26

Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain. Neuron (2007) 2.23

New neurons clear the path of astrocytic processes for their rapid migration in the adult brain. Neuron (2010) 2.12

Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression. Development (2002) 2.10

Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants. J Comp Neurol (2008) 2.09

Characterization of a mouse strain expressing Cre recombinase from the 3' untranslated region of the dopamine transporter locus. Genesis (2006) 2.08

Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. J Neurosci (2006) 2.08

Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice. Proc Natl Acad Sci U S A (2009) 2.06

Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants. Development (2003) 2.04

GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes. Biol Psychiatry (2008) 2.04

Beyond laminar fate: toward a molecular classification of cortical projection/pyramidal neurons. Dev Neurosci (2003) 2.02

Autism and brain development. Cell (2008) 2.01

A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo. J Am Soc Nephrol (2004) 1.97

Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon. Development (2002) 1.95

A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci (2007) 1.94

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res (2005) 1.94

Reassessing the Dlx code: the genetic regulation of branchial arch skeletal pattern and development. J Anat (2005) 1.93

Frontal cortex subdivision patterning is coordinately regulated by Fgf8, Fgf17, and Emx2. J Comp Neurol (2008) 1.90

Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A (2006) 1.87

Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons. Neuron (2013) 1.87

Frcp1 and Frcp2, two novel fibronectin type III repeat containing genes. Gene (2002) 1.83

Chemokine signaling controls intracortical migration and final distribution of GABAergic interneurons. J Neurosci (2008) 1.82

The embryonic preoptic area is a novel source of cortical GABAergic interneurons. J Neurosci (2009) 1.81

Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci (2002) 1.81

Tbr1 and Fezf2 regulate alternate corticofugal neuronal identities during neocortical development. J Neurosci (2011) 1.81

Postmitotic Nkx2-1 controls the migration of telencephalic interneurons by direct repression of guidance receptors. Neuron (2008) 1.81

Cxcr7 controls neuronal migration by regulating chemokine responsiveness. Neuron (2011) 1.76

Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. Development (2003) 1.73

Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci (2011) 1.73

Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons. Mol Cell Neurosci (2008) 1.72

Distinct cis-regulatory elements from the Dlx1/Dlx2 locus mark different progenitor cell populations in the ganglionic eminences and different subtypes of adult cortical interneurons. J Neurosci (2007) 1.69

Regional distribution of cortical interneurons and development of inhibitory tone are regulated by Cxcl12/Cxcr4 signaling. J Neurosci (2008) 1.67

A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol (2004) 1.64

Neuronal migration mechanisms in development and disease. Curr Opin Neurobiol (2010) 1.64

Patterning of frontal cortex subdivisions by Fgf17. Proc Natl Acad Sci U S A (2007) 1.63

Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci (2007) 1.63

Deriving excitatory neurons of the neocortex from pluripotent stem cells. Neuron (2011) 1.62

Automated screening for mutants affecting dopaminergic-neuron specification in C. elegans. Nat Methods (2008) 1.61

A peculiar constellation of tau pathology defines a subset of dementia in the elderly. Acta Neuropathol (2011) 1.60

Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain. Nat Neurosci (2008) 1.60

Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways. Cereb Cortex (2009) 1.57

Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling. Nat Neurosci (2006) 1.57

Patterning of the basal telencephalon and hypothalamus is essential for guidance of cortical projections. Development (2002) 1.57

Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other. J Comp Neurol (2002) 1.56

Dosage of Fgf8 determines whether cell survival is positively or negatively regulated in the developing forebrain. Proc Natl Acad Sci U S A (2003) 1.56

Robo1 and Robo2 cooperate to control the guidance of major axonal tracts in the mammalian forebrain. J Neurosci (2007) 1.52

Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways. J Comp Neurol (2009) 1.52

Tuberoinfundibular peptide of 39 residues is activated during lactation and participates in the suckling-induced prolactin release in rat. Endocrinology (2010) 1.51

Subcortical visual shell nuclei targeted by ipRGCs develop from a Sox14+-GABAergic progenitor and require Sox14 to regulate daily activity rhythms. Neuron (2012) 1.51

Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb Cortex (2002) 1.49

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons. J Neurosci (2010) 1.48

Inactivation of Arx, the murine ortholog of the X-linked lissencephaly with ambiguous genitalia gene, leads to severe disorganization of the ventral telencephalon with impaired neuronal migration and differentiation. J Neurosci (2007) 1.48

Expression from a Dlx gene enhancer marks adult mouse cortical GABAergic neurons. Cereb Cortex (2002) 1.46

Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development (2008) 1.46

Patterning of the lateral ganglionic eminence by the Gsh1 and Gsh2 homeobox genes regulates striatal and olfactory bulb histogenesis and the growth of axons through the basal ganglia. J Comp Neurol (2003) 1.45

Generation of interneuron diversity in the mouse cerebral cortex. Eur J Neurosci (2010) 1.44

Nuclear adaptor Ldb1 regulates a transcriptional program essential for the maintenance of hematopoietic stem cells. Nat Immunol (2010) 1.43

Nitric oxide negatively regulates mammalian adult neurogenesis. Proc Natl Acad Sci U S A (2003) 1.42

Arx is a direct target of Dlx2 and thereby contributes to the tangential migration of GABAergic interneurons. J Neurosci (2008) 1.41

Azoospermia in patients heterozygous for a mutation in SYCP3. Lancet (2003) 1.41

LIM-homeodomain proteins Lhx1 and Lhx5, and their cofactor Ldb1, control Purkinje cell differentiation in the developing cerebellum. Proc Natl Acad Sci U S A (2007) 1.41

Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol (2008) 1.41

Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium. Development (2006) 1.41

Impaired neutrophil activity and increased susceptibility to bacterial infection in mice lacking glucose-6-phosphatase-beta. J Clin Invest (2007) 1.41

FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev (2008) 1.40

Biased selection of leading process branches mediates chemotaxis during tangential neuronal migration. Development (2009) 1.37

Analysis of the in vivo functions of Mrp3. Mol Pharmacol (2005) 1.37