Published in Nat Med on May 01, 1998
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J Virol (2000) 3.84
Initial binding of murine leukemia virus particles to cells does not require specific Env-receptor interaction. J Virol (1999) 2.15
Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2. J Virol (2002) 1.77
Cytoplasmic trafficking of the canine parvovirus capsid and its role in infection and nuclear transport. J Virol (2000) 1.34
Adeno-associated virus at 50: a golden anniversary of discovery, research, and gene therapy success--a personal perspective. Hum Gene Ther (2015) 1.27
Scanning surface confocal microscopy for simultaneous topographical and fluorescence imaging: application to single virus-like particle entry into a cell. Proc Natl Acad Sci U S A (2002) 1.24
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients. Transl Psychiatry (2013) 0.86
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions. J Virol (1998) 8.45
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther (1999) 7.96
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus. J Virol (1998) 7.76
Site-specific integration by adeno-associated virus. Proc Natl Acad Sci U S A (1990) 7.06
Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector. J Virol (1996) 6.43
Second-strand synthesis is a rate-limiting step for efficient transduction by recombinant adeno-associated virus vectors. J Virol (1996) 6.22
Cloning of adeno-associated virus into pBR322: rescue of intact virus from the recombinant plasmid in human cells. Proc Natl Acad Sci U S A (1982) 5.73
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Genet (1994) 5.49
Rescue of adeno-associated virus from recombinant plasmids: gene correction within the terminal repeats of AAV. Cell (1983) 5.27
AlphaVbeta5 integrin: a co-receptor for adeno-associated virus type 2 infection. Nat Med (1999) 5.26
Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo. Gene Ther (2003) 4.92
A recombinant plasmid from which an infectious adeno-associated virus genome can be excised in vitro and its use to study viral replication. J Virol (1987) 4.57
Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther (2001) 4.35
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors. J Virol (2000) 3.84
Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther (2000) 3.32
In vitro resolution of covalently joined AAV chromosome ends. Cell (1990) 3.24
Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Res (1996) 3.03
Features of the adeno-associated virus origin involved in substrate recognition by the viral Rep protein. J Virol (1993) 2.69
Cellular recombination pathways and viral terminal repeat hairpin structures are sufficient for adeno-associated virus integration in vivo and in vitro. J Virol (1997) 2.32
Role for highly regulated rep gene expression in adeno-associated virus vector production. J Virol (1997) 2.19
Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome. J Virol (1987) 2.09
Selective and rapid uptake of adeno-associated virus type 2 in brain. Hum Gene Ther (1998) 2.06
Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells. J Virol (1992) 1.86
Regulated high level expression of a human gamma-globin gene introduced into erythroid cells by an adeno-associated virus vector. Proc Natl Acad Sci U S A (1992) 1.82
Insertional mutagenesis of AAV2 capsid and the production of recombinant virus. Virology (1999) 1.76
Recombinant adeno-associated virus-mediated gene transfer into hematopoietic progenitor cells. Blood (1994) 1.75
Immune responses to AAV in a phase I study for Canavan disease. J Gene Med (2006) 1.74
Gene transfer by adeno-associated virus vectors into the central nervous system. Exp Neurol (1997) 1.73
The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radic Biol Med (2001) 1.69
Sustained and complete phenotype correction of hemophilia B mice following intramuscular injection of AAV1 serotype vectors. Mol Ther (2001) 1.65
Rapid purification of covalently closed circular DNAs of bacterial plasmids and animal tumor viruses. Anal Biochem (1980) 1.60
A novel 165-base-pair terminal repeat sequence is the sole cis requirement for the adeno-associated virus life cycle. J Virol (1997) 1.57
Direct intramuscular injection with recombinant AAV vectors results in sustained expression in a dog model of hemophilia. Gene Ther (1998) 1.52
Targeted adeno-associated virus vector transduction of nonpermissive cells mediated by a bispecific F(ab'gamma)2 antibody. Nat Biotechnol (1999) 1.51
Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Ther (2011) 1.47
AAV vectors: is clinical success on the horizon? Gene Ther (2000) 1.47
Adeno-associated virus vectors for gene therapy: more pros than cons? Mol Med Today (2000) 1.45
Phenotypic correction of Fanconi anemia in human hematopoietic cells with a recombinant adeno-associated virus vector. J Clin Invest (1994) 1.39
Roles of adeno-associated virus Rep protein and human chromosome 19 in site-specific recombination. J Virol (2000) 1.37
Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element. J Virol (2000) 1.32
Recombinant adeno-associated virus (rAAV)-mediated expression of a human gamma-globin gene in human progenitor-derived erythroid cells. Proc Natl Acad Sci U S A (1994) 1.28
Adeno-associated viral vectors as gene delivery vehicles. Int J Mol Med (2000) 1.25
Neutralizing antibodies against adeno-associated virus examined prospectively in pediatric patients with hemophilia. Gene Ther (2011) 1.24
New developments in the generation of Ad-free, high-titer rAAV gene therapy vectors. Nat Med (1997) 1.21
Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat. Proc Natl Acad Sci U S A (2001) 1.21
Building a better vector: the manipulation of AAV virions. Virology (2000) 1.19
Factors influencing adeno-associated virus-mediated gene transfer to human cystic fibrosis airway epithelial cells: comparison with adenovirus vectors. J Virol (1998) 1.17
Construction of a recombinant human parvovirus B19: adeno-associated virus 2 (AAV) DNA inverted terminal repeats are functional in an AAV-B19 hybrid virus. Proc Natl Acad Sci U S A (1989) 1.17
Long-term gene transfer in porcine myocardium after coronary infusion of an adeno-associated virus vector. Ann Thorac Surg (1996) 1.16
In vivo expression of therapeutic human genes for dopamine production in the caudates of MPTP-treated monkeys using an AAV vector. Gene Ther (1998) 1.16
Gene therapy for human hemoglobinopathies. Proc Soc Exp Biol Med (1993) 1.15
The use of adeno-associated virus to circumvent the maturation-dependent viral transduction of muscle fibers. Hum Gene Ther (2000) 1.14
Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Ther (1998) 1.09
Zinc-finger nuclease-mediated gene correction using single AAV vector transduction and enhancement by Food and Drug Administration-approved drugs. Gene Ther (2012) 1.09
Gene therapy: targeting the myocardium. Heart (2008) 1.06
Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo. Gene Ther (2007) 1.05
Delivery of MDR1 small interfering RNA by self-complementary recombinant adeno-associated virus vector. Mol Ther (2005) 1.05
NIDDK Workshop on AAV Vectors: Gene Transfer into Quiescent Cells. Hum Gene Ther (1996) 0.98
Kinetics of recombinant adeno-associated virus-mediated gene transfer. J Virol (2000) 0.98
Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology (2001) 0.98
Efficient expression of protein coding genes from the murine U1 small nuclear RNA promoters. Proc Natl Acad Sci U S A (1996) 0.98
Gene transfer in human lymphocytes using a vector based on adeno-associated virus. J Immunother (1991) (1992) 0.98
Adeno-associated virus-mediated gene transfer of the heart/muscle adenine nucleotide translocator (ANT) in mouse. Gene Ther (2005) 0.97
Ex vivo serotype-specific transduction of equine joint tissue by self-complementary adeno-associated viral vectors. Hum Gene Ther (2009) 0.97
Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity. Brain Res (1997) 0.96
Self-complementary AAV mediates gene targeting and enhances endonuclease delivery for double-strand break repair. Gene Ther (2010) 0.95
Heart failure: a silver bullet to treat heart failure. Gene Ther (2006) 0.95
Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF. J Comp Neurol (2009) 0.92
Viral receptors and vector purification: new approaches for generating clinical-grade reagents. Nat Med (1999) 0.91
Preclinical safety evaluation of subretinal AAV2.sFlt-1 in non-human primates. Gene Ther (2011) 0.91
Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. Gene Ther (2008) 0.90
The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5. Gene Ther (2011) 0.90
AAV as a viral vector for human gene therapy. Generation of recombinant virus. Mol Biotechnol (1995) 0.89
AAV2-mediated gene transfer of GDNF to the striatum of MPTP monkeys enhances the survival and outgrowth of co-implanted fetal dopamine neurons. Exp Neurol (2008) 0.88
Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. J Am Soc Nephrol (2001) 0.87
A small regulatory element from chromosome 19 enhances liver-specific gene expression. Gene Ther (2008) 0.87
Comparison of the effect of adenoviral delivery of three superoxide dismutase genes against hepatic ischemia-reperfusion injury. Hum Gene Ther (2001) 0.86
Charge-to-alanine mutagenesis of the adeno-associated virus type 2 Rep78/68 proteins yields temperature-sensitive and magnesium-dependent variants. J Virol (1999) 0.86
Site-specific targeting of DNA plasmids to chromosome 19 using AAV cis and trans sequences. Methods Mol Biol (2000) 0.85
Efficient transduction of vascular smooth muscle cells with a translational AAV2.5 vector: a new perspective for in-stent restenosis gene therapy. Gene Ther (2013) 0.83
Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and 'in vivo' tracing with AAV vector serotype 6. Gene Ther (2012) 0.83
Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFkappaB-dependent mechanisms. Hepatology (2000) 0.80
Expanding the AAV package. Nat Biotechnol (2000) 0.80
Delivery of Cu/Zn-superoxide dismutase genes with a viral vector minimizes liver injury and improves survival after liver transplantation in the rat. Transplantation (2000) 0.80
The genetics of adeno-associated virus. Adv Exp Med Biol (1984) 0.79
Methods for adeno-associated virus-mediated gene transfer into muscle. Methods Mol Biol (2001) 0.79
Delivering multiple gene products in the brain from a single adeno-associated virus vector. Gene Ther (2009) 0.78
Efficient gene transfer into primary and immortalized human fetal glial cells using adeno-associated virus vectors: establishment of a glial cell line with a functional CD4 receptor. J Neurovirol (1997) 0.76
Gene therapy for cardiomyocytes, a heart beat away. Gene Ther (2009) 0.76
Vector biophysics: crystal-clear view. Gene Ther (2002) 0.75
Expression of the human glucocerebrosidase and arylsulfatase A genes in murine and patient primary fibroblasts transduced by an adeno-associated virus vector. Gene Ther (1994) 0.75
Methods for the construction and propagation of recombinant adeno-associated virus vectors. Methods Mol Med (1997) 0.75
Adeno-associated virus vectors for gene transfer into erythroid cells. Curr Top Microbiol Immunol (1996) 0.75