Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine.

PubWeight™: 5.46‹?› | Rank: Top 1%

🔗 View Article (PMC 2192397)

Published in J Exp Med on January 01, 1996

Authors

A M de Silva1, S R Telford, L R Brunet, S W Barthold, E Fikrig

Author Affiliations

1: Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8031, USA.

Articles citing this

(truncated to the top 100)

Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J Clin Microbiol (2000) 4.71

Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals. Proc Natl Acad Sci U S A (2004) 3.84

DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirochete. Proc Natl Acad Sci U S A (2002) 3.82

Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathway. Proc Natl Acad Sci U S A (2001) 3.65

A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted state. J Clin Invest (1998) 3.41

Four clones of Borrelia burgdorferi sensu stricto cause invasive infection in humans. Infect Immun (1999) 3.41

OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest (2004) 3.38

Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticks. Proc Natl Acad Sci U S A (2001) 3.28

Essential role for OspA/B in the life cycle of the Lyme disease spirochete. J Exp Med (2004) 3.02

Effects of environmental pH on membrane proteins in Borrelia burgdorferi. Infect Immun (1999) 2.91

Molecular typing of Borrelia burgdorferi sensu lato: taxonomic, epidemiological, and clinical implications. Clin Microbiol Rev (1999) 2.82

Borrelia burgdorferi erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria. Infect Immun (1998) 2.67

Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest (2000) 2.56

The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2003) 2.31

Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect Immun (1998) 2.29

Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defences. Mol Microbiol (2008) 2.23

Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect Immun (1998) 2.23

Cell-density-dependent expression of Borrelia burgdorferi lipoproteins in vitro. Infect Immun (1997) 2.19

Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family. Infect Immun (1999) 2.18

Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. J Clin Invest (1997) 2.13

Arthropod- and host-specific gene expression by Borrelia burgdorferi. J Clin Invest (1997) 2.05

Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect Immun (2000) 2.00

DbpA, but not OspA, is expressed by Borrelia burgdorferi during spirochetemia and is a target for protective antibodies. Infect Immun (1998) 1.99

Differential expression of Borrelia burgdorferi proteins during growth in vitro. Infect Immun (1998) 1.96

Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks. Infect Immun (1999) 1.96

RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants. Infect Immun (2004) 1.94

Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun (1997) 1.93

Outer membrane proteins of pathogenic spirochetes. FEMS Microbiol Rev (2004) 1.87

Vector interactions and molecular adaptations of lyme disease and relapsing fever spirochetes associated with transmission by ticks. Emerg Infect Dis (2002) 1.86

Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides. Infect Immun (1999) 1.84

Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice. Infect Immun (2003) 1.82

Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice. Infect Immun (1998) 1.80

Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc Natl Acad Sci U S A (1997) 1.78

Access of antibody or trypsin to an integral outer membrane protein (P66) of Borrelia burgdorferi is hindered by Osp lipoproteins. Infect Immun (1999) 1.74

bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A (2005) 1.66

Inhibition of Borrelia burgdorferi migration from the midgut to the salivary glands following feeding by ticks on OspC-immunized mice. Infect Immun (2000) 1.65

Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J Clin Microbiol (1998) 1.64

An OspC-specific monoclonal antibody passively protects mice from tick-transmitted infection by Borrelia burgdorferi B31. Infect Immun (1999) 1.60

Molecular characterization of a 6.6-kilodalton Borrelia burgdorferi outer membrane-associated lipoprotein (lp6.6) which appears to be downregulated during mammalian infection. Infect Immun (1997) 1.57

Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect Immun (2006) 1.52

Therapeutic passive vaccination against chronic Lyme disease in mice. Proc Natl Acad Sci U S A (1997) 1.50

Borrelia burgdorferi in tick cell culture modulates expression of outer surface proteins A and C in response to temperature. J Clin Microbiol (1999) 1.49

Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids. J Bacteriol (1997) 1.48

Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferi. J Bacteriol (2005) 1.44

Antigenic composition of Borrelia burgdorferi during infection of SCID mice. Infect Immun (2003) 1.43

Temporal analysis of the antigenic composition of Borrelia burgdorferi during infection in rabbit skin. Infect Immun (2004) 1.42

Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks. Infect Immun (1997) 1.41

Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes. J Bacteriol (2005) 1.40

OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infect Immun (1997) 1.38

Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein. Infect Immun (2000) 1.36

Biology of infection with Borrelia burgdorferi. Infect Dis Clin North Am (2008) 1.35

Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN). J Bacteriol (2006) 1.34

Ehrlichia chaffeensis expresses macrophage- and tick cell-specific 28-kilodalton outer membrane proteins. Infect Immun (2005) 1.32

Interaction of the tick immune system with transmitted pathogens. Front Cell Infect Microbiol (2013) 1.32

Specific expression of Anaplasma marginale major surface protein 2 salivary gland variants occurs in the midgut and is an early event during tick transmission. Infect Immun (2002) 1.30

Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infect Immun (2005) 1.30

Borrelia burgdorferi stimulates the production of interleukin-10 in peripheral blood mononuclear cells from uninfected humans and rhesus monkeys. Infect Immun (1998) 1.29

Constitutive expression of outer surface protein C diminishes the ability of Borrelia burgdorferi to evade specific humoral immunity. Infect Immun (2006) 1.28

Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice. Infect Immun (1997) 1.27

Use of quantitative PCR to measure density of Borrelia burgdorferi in the midgut and salivary glands of feeding tick vectors. J Clin Microbiol (2001) 1.26

Cloning and molecular characterization of plasmid-encoded antigens of Borrelia burgdorferi. Infect Immun (1999) 1.26

Adaptation of Francisella tularensis to the mammalian environment is governed by cues which can be mimicked in vitro. Infect Immun (2008) 1.25

Characterization of VspB of Borrelia turicatae, a major outer membrane protein expressed in blood and tissues of mice. Infect Immun (1999) 1.25

Expression of Anaplasma marginale major surface protein 2 operon-associated proteins during mammalian and arthropod infection. Infect Immun (2002) 1.25

Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks. PLoS Pathog (2007) 1.24

Outer surface lipoproteins of Borrelia burgdorferi activate vascular endothelium in vitro. Infect Immun (1996) 1.22

Distinct regulatory pathways control expression of Borrelia burgdorferi infection-associated OspC and Erp surface proteins. Infect Immun (2001) 1.21

Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato. Infect Immun (1998) 1.21

Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vector. Infect Immun (2008) 1.21

Regulation of expression of the paralogous Mlp family in Borrelia burgdorferi. Infect Immun (2003) 1.21

The pathogenesis of lyme neuroborreliosis: from infection to inflammation. Mol Med (2008) 1.20

Influence of cultivation media on genetic regulatory patterns in Borrelia burgdorferi. Infect Immun (2001) 1.20

Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi. Appl Environ Microbiol (2007) 1.16

The role of Borrelia burgdorferi outer surface proteins. FEMS Immunol Med Microbiol (2012) 1.16

Ingested blood contributes to the specificity of the symbiosis of Aeromonas veronii biovar sobria and Hirudo medicinalis, the medicinal leech. Appl Environ Microbiol (2000) 1.15

Reviewing molecular adaptations of Lyme borreliosis spirochetes in the context of reproductive fitness in natural transmission cycles. Vet Res (2009) 1.14

Protection elicited by native outer membrane protein Oms66 (p66) against host-adapted Borrelia burgdorferi: conformational nature of bactericidal epitopes. Infect Immun (2000) 1.14

Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signals. J Bacteriol (2009) 1.14

Host-adapted Borrelia burgdorferi in mice expresses OspA during inflammation. Infect Immun (2003) 1.13

Borrelia burgdorferi and tick proteins supporting pathogen persistence in the vector. Future Microbiol (2013) 1.12

Borrelia burgdorferi-pulsed dendritic cells induce a protective immune response against tick-transmitted spirochetes. Infect Immun (1997) 1.11

The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. Infect Immun (2000) 1.10

Interleukin-10 modulates proinflammatory cytokines in the human monocytic cell line THP-1 stimulated with Borrelia burgdorferi lipoproteins. Infect Immun (2000) 1.09

Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice. Infect Immun (2006) 1.08

Immunity reduces reservoir host competence of Peromyscus leucopus for Ehrlichia phagocytophila. Infect Immun (2000) 1.07

Total, membrane, and immunogenic proteomes of macrophage- and tick cell-derived Ehrlichia chaffeensis evaluated by liquid chromatography-tandem mass spectrometry and MALDI-TOF methods. Infect Immun (2008) 1.07

Specificity of infection-induced immunity among Borrelia burgdorferi sensu lato species. Infect Immun (1999) 1.05

Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease. J Clin Invest (1997) 1.05

Autocrine and exocrine regulation of interleukin-10 production in THP-1 cells stimulated with Borrelia burgdorferi lipoproteins. Infect Immun (2002) 1.05

Oral immunization with recombinant lactobacillus plantarum induces a protective immune response in mice with Lyme disease. Clin Vaccine Immunol (2008) 1.05

Conformational nature of the Borrelia burgdorferi B31 outer surface protein C protective epitope. Infect Immun (1999) 1.05

Borrelia burgdorferi BmpA is a laminin-binding protein. Infect Immun (2009) 1.04

Killing of Borrelia burgdorferi by antibody elicited by OspA vaccine is inefficient in the absence of complement. Infect Immun (1999) 1.01

Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (strain N40) in mouse and tick reservoirs. Vaccine (2005) 1.01

Duration of immunity to reinfection with tick-transmitted Borrelia burgdorferi in naturally infected mice. Infect Immun (1997) 1.01

Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host adaptation. Mol Microbiol (2014) 1.00

Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination. Infect Immun (2007) 0.99

Dissociation of infectivity and pathogenicity in Borrelia burgdorferi. Infect Immun (2001) 0.99

Outer surface protein C is a dissemination-facilitating factor of Borrelia burgdorferi during mammalian infection. PLoS One (2010) 0.99

Quantitative analysis of Borrelia burgdorferi gene expression in naturally (tick) infected mouse strains. Med Microbiol Immunol (2005) 0.98

Articles by these authors

Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science (1990) 7.33

Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med (1998) 6.18

Ixodes dammini as a potential vector of human granulocytic ehrlichiosis. J Infect Dis (1995) 5.26

Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med (1997) 4.06

Babesiosis. Clin Microbiol Rev (2000) 3.97

Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect Immun (1994) 3.59

Atovaquone and azithromycin for the treatment of babesiosis. N Engl J Med (2000) 3.56

Borrelia burgdorferi genes selectively expressed in the infected host. Proc Natl Acad Sci U S A (1995) 3.42

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect Immun (1992) 3.04

Growth and migration of Borrelia burgdorferi in Ixodes ticks during blood feeding. Am J Trop Med Hyg (1995) 3.04

Detection of Babesia microti by polymerase chain reaction. J Clin Microbiol (1992) 3.03

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc Natl Acad Sci U S A (1992) 2.99

Concurrent Lyme disease and babesiosis. Evidence for increased severity and duration of illness. JAMA (1996) 2.88

Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect Immun (1995) 2.86

Sera from patients with chronic Lyme disease protect mice from Lyme borreliosis. J Infect Dis (1994) 2.72

Molecular mapping of Osp-A mediated immunity against Borrelia burgdorferi, the agent of Lyme disease. J Immunol (1991) 2.61

Detection of Borrelia burgdorferi DNA in museum specimens of Ixodes dammini ticks. Science (1990) 2.58

Carditis in Lyme disease susceptible and resistant strains of laboratory mice infected with Borrelia burgdorferi. Am J Trop Med Hyg (1992) 2.57

Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J Clin Invest (2000) 2.56

Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity (2000) 2.54

Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J Immunol (1992) 2.49

Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF-immunized mice. Infect Immun (1994) 2.42

Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity (1997) 2.38

Infectivity of Borrelia burgdorferi relative to route of inoculation and genotype in laboratory mice. J Infect Dis (1991) 2.37

Coexistence of antibodies to tick-borne pathogens of babesiosis, ehrlichiosis, and Lyme borreliosis in human sera. J Clin Microbiol (1995) 2.32

Diagnosis of babesiosis: evaluation of a serologic test for the detection of Babesia microti antibody. J Infect Dis (1994) 2.24

Standardization of medium for culturing Lyme disease spirochetes. J Clin Microbiol (1993) 2.19

Concurrent Borrelia burgdorferi and Babesia microti infection in nymphal Ixodes dammini. J Clin Microbiol (1986) 2.17

Images in clinical medicine. Placental malaria. N Engl J Med (1996) 2.14

Temporal pattern of Borrelia burgdorferi p21 expression in ticks and the mammalian host. J Clin Invest (1997) 2.13

Transmissible murine colonic hyperplasia. Vet Pathol (1978) 2.11

The ultrastructure of transmissible murine colonic hyperplasia. Am J Pathol (1979) 2.11

Nonspecific proliferative responses of murine lymphocytes to Borrelia burgdorferi antigens. J Infect Dis (1992) 2.11

Fate of Borrelia burgdorferi DNA in tissues of infected mice after antibiotic treatment. J Infect Dis (1994) 2.09

Arthropod- and host-specific gene expression by Borrelia burgdorferi. J Clin Invest (1997) 2.05

Genetic heterogeneity of Borrelia burgdorferi in the United States. J Infect Dis (1997) 2.04

The etiology of transmissible murine colonic hyperplasia. Lab Anim Sci (1976) 1.98

Detection of Borrelia burgdorferi infection in Ixodes dammini ticks with the polymerase chain reaction. J Clin Microbiol (1990) 1.96

Influence of outer surface protein A antibody on Borrelia burgdorferi within feeding ticks. Infect Immun (1999) 1.96

Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect Immun (1997) 1.93

Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infect Immun (1998) 1.92

Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. Proc Natl Acad Sci U S A (1993) 1.84

Persistent parasitemia after acute babesiosis. N Engl J Med (1998) 1.81

Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice. Infect Immun (1998) 1.80

Microbes, immunoregulation, and the gut. Gut (2005) 1.80

The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect Immun (1999) 1.79

Lyme borreliosis in laboratory animals: effect of host species and in vitro passage of Borrelia burgdorferi. Am J Trop Med Hyg (1990) 1.77

Geographical and temporal distribution of babesial infection in Connecticut. J Clin Microbiol (1991) 1.76

Cutting edge: CD1d deficiency impairs murine host defense against the spirochete, Borrelia burgdorferi. J Immunol (2000) 1.76

Identification of Rickettsia spp. and Bartonella spp. in ffrom the Thai-Myanmar border. Ann N Y Acad Sci (2003) 1.76

Long-term protection of mice from Lyme disease by vaccination with OspA. Infect Immun (1992) 1.75

Protective and arthritis-resolving activity in sera of mice infected with Borrelia burgdorferi. Clin Infect Dis (1997) 1.74

Babesiosis in Washington State: a new species of Babesia? Ann Intern Med (1993) 1.71

Diverse Lyme disease spirochetes bind integrin alpha IIb beta 3 on human platelets. Infect Immun (1994) 1.71

The early humoral response in human granulocytic ehrlichiosis. J Infect Dis (1997) 1.67

Acquisition and transmission of the agent of human granulocytic ehrlichiosis by Ixodes scapularis ticks. J Clin Microbiol (1998) 1.64

Arthropod- and host-specific Borrelia burgdorferi bbk32 expression and the inhibition of spirochete transmission. J Immunol (2000) 1.63

Infectious but nonpathogenic isolate of Borrelia burgdorferi. J Clin Microbiol (1990) 1.63

Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of lyme borreliosis. J Clin Microbiol (1996) 1.62

Immunization of mice against West Nile virus with recombinant envelope protein. J Immunol (2001) 1.60

T-cell-independent responses to Borrelia burgdorferi are critical for protective immunity and resolution of lyme disease. Infect Immun (2000) 1.60

Dietary, bacterial, and host genetic interactions in the pathogenesis of transmissible murine colonic hyperplasia. Lab Anim Sci (1977) 1.60

Experimental chronic Lyme borreliosis in Lewis rats. Am J Trop Med Hyg (1990) 1.59

Inhibition of Borrelia burgdorferi-tick interactions in vivo by outer surface protein A antibody. J Immunol (2001) 1.58

Expression and gene sequence of outer surface protein C of Borrelia burgdorferi reisolated from chronically infected mice. Infect Immun (1994) 1.57

Cutting edge: infection by the agent of human granulocytic ehrlichiosis prevents the respiratory burst by down-regulating gp91phox. J Immunol (2000) 1.57

Immunization against the agent of human granulocytic ehrlichiosis in a murine model. J Clin Invest (1997) 1.56

Human granulocytic ehrlichiosis in western Europe. N Engl J Med (1999) 1.55

A subtropical case of human babesiosis. Acta Trop (1997) 1.54

Delayed dissemination of Lyme disease spirochetes from the site of deposition in the skin of mice. J Infect Dis (1992) 1.53

Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens. J Clin Microbiol (2000) 1.53

Borrelia burgdorferi gene expression in vivo and spirochete pathogenicity. Infect Immun (2000) 1.53

Cosegregation of a novel Bartonella species with Borrelia burgdorferi and Babesia microti in Peromyscus leucopus. J Infect Dis (1998) 1.52

Immune evasion by tickborne and host-adapted Borrelia burgdorferi. J Infect Dis (1998) 1.52

Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies. Lab Anim Sci (1998) 1.51

T-helper-cell cytokines in the early evolution of murine Lyme arthritis. Infect Immun (1997) 1.51

Target imbalance: disparity of Borrelia burgdorferi genetic material in synovial fluid from Lyme arthritis patients. J Infect Dis (1994) 1.50

Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Mol Microbiol (1999) 1.50

Diversity of Babesia infecting deer ticks (Ixodes dammini). Am J Trop Med Hyg (1998) 1.47