Published in Biochem J on November 01, 1997
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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med (1999) 6.27
Pandemic threat posed by avian influenza A viruses. Clin Microbiol Rev (2001) 3.33
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Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem (2002) 2.86
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection. Proc Natl Acad Sci U S A (2006) 2.64
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Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding. EMBO J (1999) 1.61
Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca(2+) stabilization. EMBO J (2001) 1.52
The intestinal protozoan parasite Entamoeba histolytica contains 20 cysteine protease genes, of which only a small subset is expressed during in vitro cultivation. Eukaryot Cell (2003) 1.51
The secretory proprotein convertases furin, PC5, and PC7 activate VEGF-C to induce tumorigenesis. J Clin Invest (2003) 1.51
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Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. Biochem J (2003) 1.47
Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy. Am J Pathol (2002) 1.46
Fibrillin degradation by matrix metalloproteinases: implications for connective tissue remodelling. Biochem J (1999) 1.45
Polyductin undergoes notch-like processing and regulated release from primary cilia. Hum Mol Genet (2007) 1.44
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J (2002) 1.41
The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation. J Biol Chem (2002) 1.41
Furin processing and proteolytic activation of Semliki Forest virus. J Virol (2003) 1.40
Substrate cleavage analysis of furin and related proprotein convertases. A comparative study. J Biol Chem (2008) 1.40
Soluble hemojuvelin is released by proprotein convertase-mediated cleavage at a conserved polybasic RNRR site. Blood Cells Mol Dis (2007) 1.40
PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Mol Biol Cell (2006) 1.38
The furin protease cleavage recognition sequence of Sindbis virus PE2 can mediate virion attachment to cell surface heparan sulfate. J Virol (1999) 1.35
Receptor-mediated oral delivery of a bioencapsulated green fluorescent protein expressed in transgenic chloroplasts into the mouse circulatory system. FASEB J (2006) 1.35
The highly pathogenic H7N3 avian influenza strain from July 2012 in Mexico acquired an extended cleavage site through recombination with host 28S rRNA. Virol J (2013) 1.33
Furin is involved in baculovirus envelope fusion protein activation. J Virol (2002) 1.32
TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA. Immunol Cell Biol (2008) 1.27
Characterization of a cDNA encoding a novel avian hypothalamic neuropeptide exerting an inhibitory effect on gonadotropin release. Biochem J (2001) 1.27
Alterations of pr-M cleavage and virus export in pr-M junction chimeric dengue viruses. J Virol (2004) 1.27
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. Neoplasia (2008) 1.25
The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments. Mol Biol Cell (2000) 1.25
ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem (2011) 1.25
Basolateral sorting of furin in MDCK cells requires a phenylalanine-isoleucine motif together with an acidic amino acid cluster. Mol Cell Biol (1999) 1.23
Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival. Mol Brain (2009) 1.22
Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing. J Neurochem (2008) 1.21
Crimean-congo hemorrhagic fever virus glycoprotein precursor is cleaved by Furin-like and SKI-1 proteases to generate a novel 38-kilodalton glycoprotein. J Virol (2006) 1.21
Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine. Proc Natl Acad Sci U S A (2006) 1.19
Evidence for a protein tether involved in somatic touch. EMBO J (2010) 1.18
Cloning and expression of mouse legumain, a lysosomal endopeptidase. Biochem J (1998) 1.16
Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia. Proc Natl Acad Sci U S A (2001) 1.15
Increased furin activity enhances the malignant phenotype of human head and neck cancer cells. Am J Pathol (2003) 1.12
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin. Methods Mol Biol (2011) 1.10
Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI2. Brain Pathol (2008) 1.10
The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun (2002) 1.09
The role of furin in papillomavirus infection. Future Microbiol (2009) 1.06
Targeting antibodies to the cytoplasm. MAbs (2011) 1.06
Processing of proaugurin is required to suppress proliferation of tumor cell lines. Mol Endocrinol (2011) 1.06
A pollen-specific RALF from tomato that regulates pollen tube elongation. Plant Physiol (2010) 1.04
Ara12 subtilisin-like protease from Arabidopsis thaliana: purification, substrate specificity and tissue localization. Biochem J (2003) 1.04
Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint. Arthritis Rheum (2007) 1.04
Mutations in endothelin 1 cause recessive auriculocondylar syndrome and dominant isolated question-mark ears. Am J Hum Genet (2013) 1.02
A proteomic approach reveals transient association of reticulocalbin-3, a novel member of the CREC family, with the precursor of subtilisin-like proprotein convertase, PACE4. Biochem J (2006) 1.02
Friendly viruses: the special relationship between endogenous retroviruses and their host. Ann N Y Acad Sci (2009) 1.02
Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus. J Virol (2005) 1.02
A short sequence in the N-terminal region is required for the trimerization of type XIII collagen and is conserved in other collagenous transmembrane proteins. EMBO J (2000) 1.01
Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide. Matrix Biol (2010) 1.00
Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. PLoS One (2010) 1.00
Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity. Anal Biochem (2007) 0.98
Protease nexin-1 promotes secretory granule biogenesis by preventing granule protein degradation. Mol Biol Cell (2005) 0.98
Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A. J Biol Chem (2005) 0.98
Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin. J Exp Med (1998) 0.98
Mutation in spike protein cleavage site and pathogenesis of feline coronavirus. Emerg Infect Dis (2013) 0.98
Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors. Int J Biol Sci (2010) 0.97
Characterization of genotype-specific carboxyl-terminal cleavage sites of hepatitis B virus e antigen precursor and identification of furin as the candidate enzyme. J Virol (2009) 0.96
Characterization of white spot syndrome virus envelope protein VP51A and its interaction with viral tegument protein VP26. J Virol (2008) 0.95
Computational prediction of furin cleavage sites by a hybrid method and understanding mechanism underlying diseases. Sci Rep (2012) 0.94
Dickkopfs and Wnt/β-catenin signalling in liver cancer. World J Clin Oncol (2011) 0.94
Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family. Biochem J (2000) 0.94
'Shed' furin: mapping of the cleavage determinants and identification of its C-terminus. Biochem J (2001) 0.93
Processing of proSAAS in neuroendocrine cell lines. Biochem J (2002) 0.93
Independent subtilases expansions in fungi associated with animals. Mol Biol Evol (2011) 0.93
A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions. Arch Biochem Biophys (2009) 0.93
Synthetic peptides derived from the prosegments of proprotein convertase 1/3 and furin are potent inhibitors of both enzymes. Biochem J (2003) 0.93
Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiol Genomics (2004) 0.93
Disordered cell integrity signaling caused by disruption of the kexB gene in Aspergillus oryzae. Eukaryot Cell (2004) 0.92
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2. Mol Cell Biol (2009) 0.92
Deorphanization of novel peptides and their receptors. AAPS J (2010) 0.92
FurinDB: A database of 20-residue furin cleavage site motifs, substrates and their associated drugs. Int J Mol Sci (2011) 0.91
Domain flexibility modulates the heterogeneous assembly mechanism of anthrax toxin protective antigen. J Mol Biol (2011) 0.91
pH-induced conformational transitions of a molten-globule-like state of the inhibitory prodomain of furin: implications for zymogen activation. Protein Sci (2001) 0.91
Characterization of the kexin-like maturase of Aspergillus niger. Appl Environ Microbiol (2000) 0.91
Cell-specific activity of neprilysin 2 isoforms and enzymic specificity compared with neprilysin. Biochem J (2002) 0.91
Generation and characterization of monoclonal antibodies against the proregion of human desmoglein-2. Hybridoma (Larchmt) (2008) 0.89
Nuclear variants of bone morphogenetic proteins. BMC Cell Biol (2010) 0.89
Identification of a potent antidiuretic factor acting on beetle Malpighian tubules. Proc Natl Acad Sci U S A (2001) 0.89
Glycine decarboxylase mediates a postbinding step in duck hepatitis B virus infection. J Virol (2004) 0.89
Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization. Biochem J (2000) 0.89
Modulation of protease activated receptor 1 influences human metapneumovirus disease severity in a mouse model. PLoS One (2013) 0.88
Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Protein Sci (2003) 0.88
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells. J Med Chem (2012) 0.88
Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion. J Biol Chem (2012) 0.88
Furin overexpression suppresses tumor growth and predicts a better postoperative disease-free survival in hepatocellular carcinoma. PLoS One (2012) 0.88
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