Published in Annu Rev Physiol on January 01, 1988
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Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant. J Cell Biol (1997) 1.60
Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway. EMBO J (1993) 1.59
Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway. J Cell Biol (1991) 1.58
The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins. Mol Cell Biol (1996) 1.54
Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport. J Cell Biol (1991) 1.53
Retrieval of resident late-Golgi membrane proteins from the prevacuolar compartment of Saccharomyces cerevisiae is dependent on the function of Grd19p. J Cell Biol (1998) 1.52
Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation. Microbiol Rev (1995) 1.48
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Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. J Virol (1994) 1.41
Human influenza virus hemagglutinin with high sensitivity to proteolytic activation. J Virol (1991) 1.38
The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae. J Cell Biol (1996) 1.37
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Structural requirements for function of yeast GGAs in vacuolar protein sorting, alpha-factor maturation, and interactions with clathrin. Mol Cell Biol (2001) 1.34
A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease. EMBO J (1994) 1.33
Kex2-dependent invertase secretion as a tool to study the targeting of transmembrane proteins which are involved in ER-->Golgi transport in yeast. EMBO J (1994) 1.32
Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Mol Cell Biol (1996) 1.28
Characterization of the yeast KEX1 gene product: a carboxypeptidase involved in processing secreted precursor proteins. Mol Cell Biol (1989) 1.25
The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton. Mol Biol Cell (1999) 1.23
Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor. Genetics (1998) 1.22
Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network. Nat Cell Biol (2012) 1.21
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Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins. Mol Biol Cell (2001) 1.18
Sequence of the clathrin heavy chain from Saccharomyces cerevisiae and requirement of the COOH terminus for clathrin function. J Cell Biol (1991) 1.17
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Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev (2012) 1.13
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The Sec1/Munc18 protein, Vps33p, functions at the endosome and the vacuole of Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.12
Insights from bacterial subtilases into the mechanisms of intramolecular chaperone-mediated activation of furin. Methods Mol Biol (2011) 1.10
Requirement for neo1p in retrograde transport from the Golgi complex to the endoplasmic reticulum. Mol Biol Cell (2003) 1.09
1,4-benzoquinone reductase from Phanerochaete chrysosporium: cDNA cloning and regulation of expression. Appl Environ Microbiol (1999) 1.08
The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. Biochem J (1993) 1.08
Organization of the yeast Golgi complex into at least four functionally distinct compartments. Mol Biol Cell (2000) 1.06
Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast. Proc Natl Acad Sci U S A (1995) 1.06
Prohormone processing in Xenopus oocytes: characterization of cleavage signals and cleavage enzymes. Proc Natl Acad Sci U S A (1991) 1.06
Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins. Mol Biol Cell (2004) 1.02
A novel class of small amphipathic peptides affect aerial hyphal growth and surface hydrophobicity in Ustilago maydis. EMBO J (1996) 1.02
KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth. Mol Cell Biol (1989) 1.02
Isolation and functional expression of a mammalian prohormone processing enzyme, murine prohormone convertase 1. Proc Natl Acad Sci U S A (1991) 1.01
In vivo topological analysis of Ste2, a yeast plasma membrane protein, by using beta-lactamase gene fusions. Mol Cell Biol (1991) 1.00
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Distinct roles for TGN/endosome epsin-like adaptors Ent3p and Ent5p. Mol Biol Cell (2006) 0.99
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Laa1p, a conserved AP-1 accessory protein important for AP-1 localization in yeast. Mol Biol Cell (2006) 0.95
Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. EMBO J (1993) 0.95
COPI selectively drives maturation of the early Golgi. Elife (2015) 0.94
Consequences of altered isoprenylation targets on a-factor export and bioactivity. Proc Natl Acad Sci U S A (1994) 0.92
Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1' site. PLoS One (2013) 0.90
Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc Natl Acad Sci U S A (2007) 0.90
Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr Genet (2007) 0.90
Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system. Proc Natl Acad Sci U S A (1998) 0.90
Mutations within the propeptide, the primary cleavage site or the catalytic site, or deletion of C-terminal sequences, prevents secretion of proPC2 from transfected COS-7 cells. Biochem J (1997) 0.90
Mycovirus cryphonectria hypovirus 1 elements cofractionate with trans-Golgi network membranes of the fungal host Cryphonectria parasitica. J Virol (2006) 0.89
Propeptides are sufficient to regulate organelle-specific pH-dependent activation of furin and proprotein convertase 1/3. J Mol Biol (2012) 0.87
A novel class of peptide pheromone precursors in ascomycetous fungi. Mol Microbiol (2010) 0.87
A modulatory role for clathrin light chain phosphorylation in Golgi membrane protein localization during vegetative growth and during the mating response of Saccharomyces cerevisiae. Mol Biol Cell (1999) 0.86
Secretion of a foreign protein from budding yeasts is enhanced by cotranslational translocation and by suppression of vacuolar targeting. Microb Cell Fact (2014) 0.85
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Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell (1984) 5.53
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell (1984) 5.26
Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell (1983) 4.24
Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells. EMBO J (1989) 4.10
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell (1989) 3.99
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A (1983) 3.95
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (1989) 3.90
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell (1990) 3.87
Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae. Nature (1992) 3.77
Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science (1989) 3.61
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proc Natl Acad Sci U S A (1989) 3.49
Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev (1994) 3.45
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Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell (1986) 3.17
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
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Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem (1999) 2.72
Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol Cell Biol (1996) 2.57
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol (1999) 2.56
A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.56
Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.54
Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev (1996) 2.49
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A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem (2000) 1.96
Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase. Nat Cell Biol (1999) 1.94
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The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae. J Biol Chem (1988) 1.92
Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev (1998) 1.92
Thymidine 5'-monophosphate-requiring mutants of Saccharomyces cerevisiae are deficient in thymidylate synthetase. J Bacteriol (1977) 1.90
Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science (1997) 1.88
The yeast repeated element sigma contains a hormone-inducible promoter. Mol Cell Biol (1987) 1.88
Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science (1993) 1.86
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Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science (1988) 1.64
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A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol (1983) 1.45
Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. EMBO J (1991) 1.43
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Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae. Biochemistry (2000) 1.32
Purification and characterization of VDE, a site-specific endonuclease from the yeast Saccharomyces cerevisiae. J Biol Chem (1993) 1.29
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Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science (1990) 1.28
Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Mol Biol Cell (2000) 1.25
Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases. EMBO J (1990) 1.23
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VDE endonuclease cleaves Saccharomyces cerevisiae genomic DNA at a single site: physical mapping of the VMA1 gene. Nucleic Acids Res (1992) 1.19
A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. J Cell Biol (1994) 1.19
Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1992) 1.17
Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Mol Gen Genet (1995) 1.15
Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J Biol Chem (1997) 1.15
Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. J Biol Chem (1992) 1.12
Saccharomyces cerevisiae STE14 gene is required for COOH-terminal methylation of a-factor mating pheromone. J Biol Chem (1990) 1.10
Mutations in the pho80 gene confer permeability to 5'-mononucleotides in Saccharomyces cerevisiae. Genetics (1982) 1.08
High-throughput screening for drug discovery. Nature (1996) 1.08
An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae. Genetics (1998) 1.08
Isolation of the yeast calmodulin gene using synthetic oligonucleotide probes. Methods Enzymol (1987) 1.05
Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae. J Biol Chem (1996) 1.03
High affinity interaction of yeast transcriptional regulator, Mot1, with TATA box-binding protein (TBP). J Biol Chem (2001) 1.03
Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1993) 1.03
Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J Biol Chem (1993) 1.03
Purification and enzymic properties of Mot1 ATPase, a regulator of basal transcription in the yeast Saccharomyces cerevisiae. J Biol Chem (2000) 1.02
Complete nucleotide sequence of the gene encoding the regulatory subunit of 3',5'-cyclic AMP-dependent protein kinase from the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1987) 0.98
An essential role for cyclic AMP in growth control: the case for yeast. Cell (1982) 0.96
The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J Cell Biol (1996) 0.96
Thymidylate synthetase from Saccharomyces cerevisiae. Purification and enzymic properties. J Biol Chem (1981) 0.96
Receptor-G protein signaling in yeast. Annu Rev Physiol (1991) 0.95
The MF alpha 1 gene of Saccharomyces cerevisiae: genetic mapping and mutational analysis of promoter elements. Genetics (1989) 0.93
Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae. Mol Biol Cell (1994) 0.92
Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone? Science (1982) 0.91