Published in N Engl J Med on June 18, 1998
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest (1999) 2.58
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med (1998) 1.65
Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy. Proc Natl Acad Sci U S A (2001) 1.48
An enigmatic tail of CD28 signaling. Cold Spring Harb Perspect Biol (2010) 1.30
The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity. J Clin Invest (2003) 1.26
CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis. J Clin Invest (2000) 1.22
The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest (2000) 1.19
Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway. Infect Immun (2000) 1.17
Cognate stimulatory B-cell-T-cell interactions are critical for T-cell help recruited by glycoconjugate vaccines. Infect Immun (1999) 1.15
IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses. Am J Transplant (2005) 1.14
Embryonic pig pancreatic tissue transplantation for the treatment of diabetes. PLoS Med (2006) 1.14
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs. Ann Surg (2002) 1.12
Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo. J Clin Invest (2001) 1.11
CD57(+) CD4 T Cells Underlie Belatacept-Resistant Allograft Rejection. Am J Transplant (2016) 1.09
Expansion and tissue infiltration of an allospecific CD4+CD25+CD45RO+IL-7Ralphahigh cell population in solid organ transplant recipients. J Exp Med (2007) 1.04
Challenges to achieving clinical transplantation tolerance. J Clin Invest (2001) 1.03
Composite tissue allotransplantation immunology. Arch Plast Surg (2013) 0.97
The CD154-CD40 T-cell co-stimulation pathway in liver ischemia and reperfusion inflammatory responses. Transplantation (2005) 0.96
Immunosuppression for lung transplantation. Front Biosci (Landmark Ed) (2009) 0.95
Finally, CTLA4Ig graduates to the clinic. J Clin Invest (1999) 0.93
Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. Blood (2010) 0.93
Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. Am J Transplant (2009) 0.93
A rendezvous before rejection: where do T cells meet transplant antigens? Nat Med (2002) 0.92
Costimulatory pathways in transplantation. Semin Immunol (2011) 0.90
Characterisation of synovial fluid and infrapatellar fat pad derived mesenchymal stromal cells: The influence of tissue source and inflammatory stimulus. Sci Rep (2016) 0.90
CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase. Transplantation (2007) 0.90
Inhibition of antigen presentation and T cell costimulation blocks PTH-induced bone loss. Ann N Y Acad Sci (2010) 0.87
Lung transplantation: infection, inflammation, and the microbiome. Semin Immunopathol (2011) 0.86
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. J Immunol (2002) 0.86
Antibodies to MHC class II molecules induce autoimmunity: critical role for macrophages in the immunopathogenesis of obliterative airway disease. PLoS One (2012) 0.86
Dendritic cell-based approaches for therapeutic immune regulation in solid-organ transplantation. J Transplant (2013) 0.85
Targeting the intragraft microenvironment and the development of chronic allograft rejection. Hum Immunol (2012) 0.85
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Inotuzumab ozogamicin murine analog-mediated B-cell depletion reduces anti-islet allo- and autoimmune responses. Diabetes (2011) 0.85
Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases. Arthritis Res Ther (2004) 0.84
Infiltrating cellular pattern in kidney graft biopsies translates into forkhead box protein 3 up-regulation and p16INK4α senescence protein down-regulation in patients treated with belatacept compared to cyclosporin A. Clin Exp Immunol (2012) 0.84
Mycophenolate mofetil inhibits differentiation, maturation and allostimulatory function of human monocyte-derived dendritic cells. Clin Exp Immunol (2003) 0.84
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis. Am J Pathol (2001) 0.83
Inhibition of allorecognition by a human class II MHC-derived peptide through the induction of apoptosis. J Clin Invest (1999) 0.81
Memory T Cells in Transplantation. Curr Transplant Rep (2014) 0.81
Immune responses in transplantation: application to composite tissue allograft. Semin Plast Surg (2007) 0.80
Expression of CD80 on Kupffer cells is enhanced in cadaveric liver transplants. Clin Exp Immunol (2003) 0.80
Allogenic donor splenocytes pretreated with antisense peptide against B7 prolong cardiac allograft survival. Clin Exp Immunol (2004) 0.80
The role of indirect recognition of MHC class I and II allopeptides in a fully mismatched miniature swine model of lung transplantation. Transplant Proc (2006) 0.79
Immunologic mechanisms in RCC and allogeneic renal transplant rejection. Nat Rev Urol (2010) 0.79
The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection. Clinics (Sao Paulo) (2012) 0.79
Characteristics of alloreactive T cells measured before renal transplantation. Clin Exp Immunol (2012) 0.77
Inhibition of arterial allograft intimal hyperplasia using recipient dendritic cells pretreated with B7 antisense peptide. Clin Dev Immunol (2012) 0.77
T-cell co-stimulatory blockade in kidney transplantation: back to the bench. Kidney Int Suppl (2011) (2011) 0.77
CTLA4-Ig in B7-1-positive diabetic and non-diabetic kidney disease. Diabetologia (2015) 0.76
Blockade of CD28 by a synthetical peptoid inhibits T-cell proliferation and attenuates graft-versus-host disease. Cell Mol Immunol (2010) 0.76
Modulation of gene expression by alloimmune networks following murine heart transplantation. Mol Genet Genomics (2004) 0.76
Soluble co-signaling molecules predict long-term graft outcome in kidney-transplanted patients. PLoS One (2014) 0.75
Comparative clinical utility of once-weekly subcutaneous abatacept in the management of rheumatoid arthritis. Ther Clin Risk Manag (2014) 0.75
Methylation of FOXP3 TSDR Underlies the Impaired Suppressive Function of Tregs from Long-term Belatacept-Treated Kidney Transplant Patients. Front Immunol (2017) 0.75
Surgical Outcome of Cerebral Aneurysm Clipping Treated with Immunosuppressants: Report of 11 Cases and Review of the Literature. Neurol Med Chir (Tokyo) (2017) 0.75
Cross-tolerance of recipient-derived transforming growth factor-beta dendritic cells. Transplant Proc (2007) 0.75
Role of NK, NKT cells and macrophages in liver transplantation. World J Gastroenterol (2016) 0.75
Myc and AP-1 expression in T cells and T-cell activation in patients after hematopoietic stem cell transplantation. Clin Exp Med (2014) 0.75
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell (1993) 14.39
Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med (1999) 3.17
Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J Clin Invest (1997) 3.13
Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol (2001) 2.93
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med (1999) 2.74
Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med (1993) 2.62
Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol (1993) 2.55
CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2. J Exp Med (1995) 2.48
Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat Med (1998) 2.43
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A (1996) 2.40
Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. Am J Pathol (1993) 1.94
Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol (1995) 1.91
Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J Immunol (1999) 1.89
Characterization of dermal dendritic cells in psoriasis. Autostimulation of T lymphocytes and induction of Th1 type cytokines. J Clin Invest (1994) 1.71
Keratinocytes: key immunocytes of the integument. Am J Pathol (1993) 1.69
bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation. J Immunol (1993) 1.57
CD4+ CD25+ FOXP3+ regulatory T cells increase de novo in kidney transplant patients after immunodepletion with Campath-1H. Am J Transplant (2008) 1.55
T cell death and transplantation tolerance. Immunity (2001) 1.51
Antibody and B7/BB1-mediated ligation of the CD28 receptor induces tyrosine phosphorylation in human T cells. J Exp Med (1992) 1.44
Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction. Transplantation (2000) 1.43
Accessory cell function of keratinocytes for superantigens. Dependence on lymphocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. J Immunol (1993) 1.42
A closer look at homeostatic proliferation of CD4+ T cells: costimulatory requirements and role in memory formation. J Immunol (2001) 1.39
Bcl-2 expression during T-cell development: early loss and late return occur at specific stages of commitment to differentiation and survival. Proc Natl Acad Sci U S A (1994) 1.31
Psoriatic skin-derived dendritic cell function is inhibited by exogenous IL-10. Differential modulation of B7-1 (CD80) and B7-2 (CD86) expression. J Immunol (1995) 1.27
CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system. J Immunol (1995) 1.25
The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity. J Immunol (1990) 1.22
Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes. Immunol Today (1994) 1.21
Lymphodepletion and homeostatic proliferation: implications for transplantation. Am J Transplant (2012) 1.19
Blunting of immune responses to adenoviral vectors in mouse liver and lung with CTLA4Ig. Gene Ther (1998) 1.18
Donor-specific indirect pathway analysis reveals a B-cell-independent signature which reflects outcomes in kidney transplant recipients. Am J Transplant (2011) 1.18
Suppression of murine allergic contact dermatitis by CTLA4Ig. Tolerance induction of Th2 responses requires additional blockade of CD40-ligand. J Immunol (1996) 1.18
CD28-independent costimulation of T cells in alloimmune responses. J Immunol (2001) 1.16
The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol (1999) 1.16
Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. J Clin Invest (1997) 1.15
Signaling through CD28 and CTLA-4 controls two distinct forms of T cell anergy. J Clin Invest (2001) 1.14
Regulation of interleukin 3 gene induction in normal human T cells. J Clin Invest (1989) 1.10
Donor antigen is necessary for the prevention of chronic rejection in CTLA4Ig-treated murine cardiac allograft recipients. Transplantation (1997) 1.08
Functional characterization of soluble and membrane-bound forms of vaccinia virus complement control protein (VCP). Mol Immunol (1999) 1.08
T cell effector function and anergy avoidance are quantitatively linked to cell division. J Immunol (2000) 1.06
T cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction. J Am Soc Nephrol (1995) 1.06
The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol (1997) 1.02
CD28-B7 T cell costimulatory blockade by CTLA4Ig in the rat renal allograft model: inhibition of cell-mediated and humoral immune responses in vivo. Transplantation (1996) 1.01
Direct and indirect control of T-cell activation by keratinocytes. J Invest Dermatol (1995) 0.98
Alveolar epithelial cells block lymphocyte proliferation in vitro without inhibiting activation. Am J Respir Cell Mol Biol (1991) 0.98
CD28 and staphylococcal enterotoxins synergize to induce MHC-independent T-cell proliferation. Cell Immunol (1992) 0.96
Induction of allograft tolerance in the absence of Fas-mediated apoptosis. J Immunol (1999) 0.94
Keratinocyte interleukin-10 expression is upregulated in tape-stripped skin, poison ivy dermatitis, and Sezary syndrome, but not in psoriatic plaques. Clin Immunol Immunopathol (1994) 0.93
Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. Am J Transplant (2009) 0.93
The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival. J Surg Res (1994) 0.93
Critical role of proinflammatory cytokine IL-6 in allograft rejection and tolerance. Am J Transplant (2011) 0.92
T lymphocytes in skin lesions of psoriasis and mycosis fungoides express B7-1: a ligand for CD28. Blood (1994) 0.92
The role of T cell apoptosis in transplantation tolerance. Curr Opin Immunol (2000) 0.91
Immunosuppression through blockade of CD28:B7-mediated costimulatory signals. Immunol Res (1996) 0.90
Tissue-specific consequences of the anti-adenoviral immune response: implications for cardiac transplants. Nat Med (1999) 0.90
T cell costimulatory blockade: new therapies for transplant rejection. J Am Soc Nephrol (1999) 0.89
Activated keratinocytes present bacterial-derived superantigens to T lymphocytes: relevance to psoriasis. J Dermatol Sci (1993) 0.89
The in vivo mechanism of action of CTLA4Ig. J Immunol (1996) 0.89
Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-gamma. J Immunol (1994) 0.88
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model. J Immunol (1997) 0.86
A factor secreted by a human pulmonary alveolar epithelial-like cell line blocks T-cell proliferation between G1 and S phase. Am J Respir Cell Mol Biol (1992) 0.86
Adenovirus-mediated gene transfer into cold-preserved liver allografts: survival pattern and unresponsiveness following transduction with CTLA4Ig. Nat Med (1998) 0.86
The role of peripheral T-cell deletion in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2001) 0.86
Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism. Mol Pharmacol (1992) 0.86
Role of passive T-cell death in chronic experimental autoimmune encephalomyelitis. J Clin Invest (2000) 0.85
Ex vivo treatment of antigen-presenting cells with CTLA4Ig and encephalitogenic peptide prevents experimental autoimmune encephalomyelitis in the Lewis rat. J Immunol (1996) 0.85
T cell receptor stimulation, but not CD28 costimulation, is dependent on LFA-1-mediated events. Eur J Immunol (1994) 0.84
c-myb effects on kinetic events during MEL cell differentiation. Oncogene (1992) 0.84
Differential expression of Op18 phosphoprotein during human thymocyte maturation. J Clin Invest (1992) 0.83
CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis. Am J Pathol (2001) 0.83
Blocking costimulatory signals to induce transplantation tolerance and prevent autoimmune disease. Int Rev Immunol (1999) 0.83
Comparative strategies to induce long-term graft acceptance in fully allogeneic renal versus cardiac allograft models by CD28-B7 T cell costimulatory blockade: role of thymus and spleen. J Am Soc Nephrol (1998) 0.83
Blockade of CD40-CD40 ligand pathway induces tolerance in murine contact hypersensitivity. Eur J Immunol (1997) 0.82
Differential down-regulation of CD28 by B7-1 and B7-2 engagement. Transplantation (1997) 0.82
Differential NF-kappaB and IkappaB gene expression during development of cardiac allograft rejection versus CD154 monoclonal antibody-induced tolerance. Transplantation (2001) 0.81
Enhanced surface TCR replenishment mediated by CD28 leads to greater TCR engagement during primary stimulation. Int Immunol (2000) 0.81
Costimulation of superantigen-activated T lymphocytes by autologous dendritic cells is dependent on B7. Cell Immunol (1994) 0.80
Blocking T-cell costimulation to prevent transplant rejection. Transplant Proc (1998) 0.80
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The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology. J Am Soc Nephrol (1999) 0.79
Utility of adenoviral-mediated Fas ligand gene transfer to modulate islet allograft survival. Transplantation (1998) 0.78
Generation of protective immunity against an immunogenic carcinoma requires CD40/CD40L and B7/CD28 interactions but not CD4(+) T cells. Cancer Immunol Immunother (1999) 0.78
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Cloning the rat homolog of the CD28/CTLA-4-ligand B7-1: structural and functional analysis. Int Immunol (1995) 0.78
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Individual T cells hold unexpected clues to the nature of anergy and memory. Immunol Res (1998) 0.77
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The time course of CTLAIg effect on cardiac allograft rejection. J Surg Res (1996) 0.76
Will tolerance become a clinical reality? Am J Med Sci (1997) 0.76
Adoptive transfer enables tumor rejection targeted against a self-antigen without the induction of autoimmunity. Cancer Res (2001) 0.76
Keratinocytes and the danger model. Science (1996) 0.75
The tolerant recipient: looking great in someone else's genes. J Clin Invest (2001) 0.75
Review of CTLA4Ig use for allograft immunosuppression. Transplant Proc (1994) 0.75
Death of alloreactive T cells sets the stage for immunoregulation to act. Transplant Proc (2001) 0.75
Excision products of TCR V alpha recombination contain in-frame rearrangements: evidence for continued V(D)J recombination in TCR+ thymocytes. Int Immunol (1993) 0.75
Keratinocytes and the danger model. Science (1996) 0.75