Recombinant human endothelin-converting enzyme ECE-1b is located in an intracellular compartment when expressed in polarized Madin-Darby canine kidney cells.

PubWeight™: 0.90‹?›

🔗 View Article (PMC 1219603)

Published in Biochem J on July 15, 1998

Authors

A Azarani1, G Boileau, P Crine

Author Affiliations

1: Department of Biochemistry, Faculty of Medicine, University of Montréal, Montréal, Québec, H3C 3J7, Canada.

Articles cited by this

High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol (1987) 43.61

A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. Proc Natl Acad Sci U S A (1989) 7.41

Evolutionary families of peptidases. Biochem J (1993) 5.81

Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature (1994) 5.00

A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell (1994) 4.35

Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev (1994) 4.19

Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell (1994) 3.95

Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell (1994) 3.66

Angiotensin-converting enzyme: vascular endothelial localization. Science (1976) 3.22

ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell (1994) 2.75

Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol (1992) 2.71

Biotinylation and assessment of membrane polarity: caveats and methodological concerns. Am J Physiol (1995) 2.02

Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. J Biol Chem (1995) 1.73

Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells. J Biol Chem (1994) 1.42

The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis. Neuron (1994) 1.38

Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations. Biochem J (1997) 1.30

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators. Science (1988) 1.30

An ion-transporting ATPase encodes multiple apical localization signals. J Cell Biol (1993) 1.25

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1. Eur J Pharmacol (1990) 1.23

Molecular characterization of human and bovine endothelin converting enzyme (ECE-1). FEBS Lett (1994) 1.16

Organization of the gene encoding the human endothelin-converting enzyme (ECE-1). J Biol Chem (1995) 1.15

Cloning and functional expression of human endothelin-converting enzyme cDNA. Biochem Biophys Res Commun (1995) 1.09

Identification and characterization of two isoforms of an endothelin-converting enzyme-1. FEBS Lett (1995) 1.07

Processing of proendothelin-1 by human furin convertase. FEBS Lett (1995) 1.07

Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells. Biochem J (1995) 1.04

Autocrine motility factor receptor is a marker for a distinct membranous tubular organelle. J Cell Biol (1995) 0.98

Expression and polarized apical secretion in Madin-Darby canine kidney cells of a recombinant soluble form of neutral endopeptidase lacking the cytosolic and transmembrane domains. J Biol Chem (1992) 0.93

Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment. J Cell Sci (1996) 0.90

Neutral endopeptidase, a major brush border protein of the kidney proximal nephron, is directly targeted to the apical domain when expressed in Madin-Darby canine kidney cells. J Biol Chem (1991) 0.88

Endothelins. Essays Biochem (1992) 0.85

Effects of phosphoramidon in endothelial cell cultures on the endogenous synthesis of endothelin-1 and on conversion of exogenous big endothelin-1 to endothelin-1. J Cardiovasc Pharmacol (1993) 0.83

Localization and biochemical characterization of endothelin-converting enzyme. J Cardiovasc Pharmacol (1995) 0.82

gamma-Glutamyl transpeptidase is a polarized alveolar epithelial membrane protein. Am J Physiol (1995) 0.82

A simple method for isolating human endothelin converting enzyme free from contamination by neutral endopeptidase 24.11. Biochem Biophys Res Commun (1995) 0.81

Molecular pharmacology. Endothelin versatility. Nature (1995) 0.81

Endothelins as regulators of growth and function in endocrine tissues. Clin Endocrinol (Oxf) (1993) 0.80

Identification and characterization of endothelin converting activity from EAHY 926 cells: evidence for the physiologically relevant human enzyme. Arch Biochem Biophys (1994) 0.79

Parathyroid hormone and parathyroid hormone-related peptide activate the Na+/H+ exchanger NHE-1 isoform in osteoblastic cells (UMR-106) via a cAMP-dependent pathway. J Biol Chem (1995) 0.78

Isolation and characterization of angiotensin converting enzyme from human kidney. J Biochem (1981) 0.78

The propeptide of anglerfish preprosomatostatin-I rescues prosomatostatin-II from intracellular degradation. J Biol Chem (1995) 0.78

Biosynthesis and polarized distribution of neutral endopeptidase in primary cultures of kidney proximal tubule cells. Biochem J (1994) 0.77

Effects of phosphoramidon on endothelin-1 and big endothelin-1 production in human aortic endothelial cells. Biol Pharm Bull (1995) 0.77

Articles by these authors

Properties of the endonuclease for depurinated DNA from Escherichia coli. Can J Biochem (1972) 1.57

Expression of neutral endopeptidase (enkephalinase) in heterologous COS-1 cells. Characterization of the recombinant enzyme and evidence for a glutamic acid residue at the active site. J Biol Chem (1988) 1.40

Enzyme replacement therapy prevents dental defects in a model of hypophosphatasia. J Dent Res (2011) 1.30

Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers. J Bone Miner Res (2000) 1.30

Exploration of the catalytic site of endopeptidase 24.11 by site-directed mutagenesis. Histidine residues 583 and 587 are essential for catalysis. FEBS Lett (1988) 1.29

Neutral endopeptidase can hydrolyze beta-amyloid(1-40) but shows no effect on beta-amyloid precursor protein metabolism. Peptides (1995) 1.26

Patterns of compliance with once versus twice daily antihypertensive drug therapy in primary care: a randomized clinical trial using electronic monitoring. Can J Cardiol (1997) 1.26

Abundance of sarcoplasmic reticulum calcium pump isoforms in stomach and cardiac muscles. Biochem J (1990) 1.16

Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling. J Clin Invest (2000) 1.15

Concomitant synthesis of beta-endorphin and alpha-melanotropin from two forms of pro-opiomelanocortin in the rat pars intermedia. Proc Natl Acad Sci U S A (1979) 1.13

Biosynthesis of beta-endorphin from beta-lipotropin and a larger molecular weight precursor in rat pars intermedia. Proc Natl Acad Sci U S A (1978) 1.11

Identification of glutamic acid 646 as a zinc-coordinating residue in endopeptidase-24.11. J Biol Chem (1991) 1.08

Direct cross-links between initiation factors 1, 2, and 3 and ribosomal proteins promoted by 2-iminothiolane. Biochemistry (1983) 1.07

Primary structure homologies between two zinc metallopeptidases, the neutral endopeptidase 24.11 ("enkephalinase") and thermolysin, through clustering analysis. Biochemistry (1988) 1.07

In vitro biosynthesis and chemical characterization of beta-lipotropin, gamma-lipotropin, and beta-endorphin in rat pars intermedia. Proc Natl Acad Sci U S A (1978) 1.07

Pex mRNA is localized in developing mouse osteoblasts and odontoblasts. J Histochem Cytochem (1998) 1.06

Immediate inactivation of T7 coliphage treated by monofunctional alkylating agents. Biochim Biophys Acta (1974) 1.06

Fusion of a cleavable signal peptide to the ectodomain of neutral endopeptidase (EC 3.4.24.11) results in the secretion of an active enzyme in COS-1 cells. J Biol Chem (1989) 1.05

Site-specific mutagenesis identifies amino acid residues critical in prohormone processing. EMBO J (1989) 1.04

Radioiodination of microgram quantities of ribosomal proteins from polyacrylamide gels. Anal Biochem (1980) 1.04

The pro-region of the Kex2 endoprotease of Saccharomyces cerevisiae is removed by self-processing. FEBS Lett (1992) 1.03

Cross-links between ribosomal proteins of 30S subunits in 70S tight couples and in 30S subunits. Biochemistry (1983) 1.02

Evidence that both arginine 102 and arginine 747 are involved in substrate binding to neutral endopeptidase (EC 3.4.24.11). J Biol Chem (1991) 1.02

Short-term effect of pudendal nerve electrical stimulation on detrusor hyperreflexia in spinal cord injury patients: importance of current strength. Paraplegia (1996) 1.01

In vitro repair of apurinic sites in DNA. Proc Natl Acad Sci U S A (1974) 1.00

The production and characterization of a monoclonal antibody specific for the 94,000 dalton enkephalin-degrading peptidase from rabbit kidney brush border. Biochem Biophys Res Commun (1985) 1.00

Role of amino acid sequences flanking dibasic cleavage sites in precursor proteolytic processing. The importance of the first residue C-terminal of the cleavage site. Eur J Biochem (1995) 0.99

From beta-lipotropin to beta-endorphin and 'pro-opio-melanocortin'. Can J Biochem (1979) 0.99

Antibodies specific to the plasma membrane of rat lung microvascular endothelium. Exp Cell Res (1997) 0.98

Determination of single-strand breaks in DNA using neutral sucrose gradients. Anal Biochem (1976) 0.98

Isolation and characterisation of a murine cDNA clone highly homologous to the yeast L29 ribosomal protein gene. Nucleic Acids Res (1987) 0.98

The yeast KEX-2-processing endoprotease is active in the Golgi apparatus of transfected NIH 3T3 fibroblasts. Mol Endocrinol (1990) 0.96

Reassembly of active 30S ribosomal subunits with an unmethylated in vitro transcribed 16S rRNA. Biochem Cell Biol (1987) 0.95

Complete structure of the porcine pro-opiomelanocortin mRNA derived from the nucleotide sequence of cloned cDNA. Nucleic Acids Res (1983) 0.94

Molecular cloning and biochemical characterization of a new mouse testis soluble-zinc-metallopeptidase of the neprilysin family. Biochem J (2000) 0.94

Higher order structures of the 5'-proximal region decrease the efficiency of translation of the porcine pro-opiomelanocortin mRNA. J Biol Chem (1988) 0.93

Expression and polarized apical secretion in Madin-Darby canine kidney cells of a recombinant soluble form of neutral endopeptidase lacking the cytosolic and transmembrane domains. J Biol Chem (1992) 0.93

Isolation and partial characterization of a biosynthetic N-terminal methionyl peptide of bovine pars intermedia: relationship to ubiquitin. Biochem Biophys Res Commun (1978) 0.93

In vitro biosynthesis of beta-endorphin, gamma-lipoprotein, and beta-lipotropin by the pars intermedia of beef pituitary glands. Proc Natl Acad Sci U S A (1977) 0.93

Malignant immunoblastoma: immunoglobulin synthesis and the progression to leukemia in heterotransplanted acute lymphoblastic leukemia, chronic lymphatic leukemia, lymphoma, and infectious mononucleosis. Cancer (1973) 0.93

The use of a monoclonal antibody for the rapid purification of kidney neutral endopeptidase ("enkephalinase") solubilized in octyl glucoside. Biochem Cell Biol (1987) 0.92

Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. Eur J Biochem (1994) 0.92

In vitro biosynthesis of beta-endorphin in pituitary glands. Proc Natl Acad Sci U S A (1977) 0.91

Proteolytic processing of the alpha-subunit of rat endopeptidase-24.18 by furin. Biochem J (1995) 0.90

Expression of porcine pro-opiomelanocortin cDNA in heterologous monkey kidney cells. Biosynthesis and secretion of the prohormone without processing. J Biol Chem (1987) 0.90

Levels of ribosomal protein S1 and elongation factor G in the growth cycle of Escherichia coli. J Bacteriol (1983) 0.90

Cross-linking of streptomycin to the 30S subunit of Escherichia coli with phenyldiglyoxal. Biochemistry (1984) 0.89

Characterization of PHEX endopeptidase catalytic activity: identification of parathyroid-hormone-related peptide107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors. Biochem J (2001) 0.89

Rat endopeptidase-24.18 alpha subunit is secreted into the culture medium as a zymogen when expressed by COS-1 cells. FEBS Lett (1993) 0.89

Polarized distribution of neutral endopeptidase 24.11 at the cell surface of cultured human intestinal epithelial Caco-2 cells. Biochem J (1992) 0.88

Neutral endopeptidase, a major brush border protein of the kidney proximal nephron, is directly targeted to the apical domain when expressed in Madin-Darby canine kidney cells. J Biol Chem (1991) 0.88

Identification of proteins at the binding site for protein S1 in 70 S ribosomes and 30 S subunits by cross-linking with 2-iminothiolane. J Biol Chem (1981) 0.88

Kinetic evidence that His-711 of neutral endopeptidase 24.11 is involved in stabilization of the transition state. FEBS Lett (1993) 0.88

Prohormone processing by yeast proteases. Enzyme (1991) 0.88

Expression of rat endopeptidase-24.18 in COS-1 cells: membrane topology and activity. Biochem J (1994) 0.88

Processing of two forms of the common precursor to alpha-melanotropin and beta-endorphin in the rat pars intermedia. Evidence for and partial characterization of new pituitary peptides. Eur J Biochem (1980) 0.87

Molecular cloning, tissue distribution, and chromosomal localization of MMEL2, a gene coding for a novel human member of the neutral endopeptidase-24.11 family. DNA Cell Biol (2001) 0.87

Partial N-terminal amino acid sequence of pro-opio-melanocortin (ACTH/beta-LPH precursor) from rat pars intermedia. Biochem Biophys Res Commun (1980) 0.87

Comparative proteolytic processing of rat prosomatostatin by the convertases PC1, PC2, furin, PACE4 and PC5 in constitutive and regulated secretory pathways. FEBS Lett (1995) 0.87

Evidence that Asn542 of neprilysin (EC 3.4.24.11) is involved in binding of the P2' residue of substrates and inhibitors. Biochem J (1995) 0.86

A cleavable N-terminal signal peptide is not a prerequisite for the biosynthesis of glycosylphosphatidylinositol-anchored proteins. J Biol Chem (1994) 0.86

Transformation of the signal peptide/membrane anchor domain of a type II transmembrane protein into a cleavable signal peptide. J Biol Chem (1993) 0.86

Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides. J Bone Miner Res (2000) 0.86

Molecular cloning of the alpha-subunit of rat endopeptidase-24.18 (endopeptidase-2) and co-localization with endopeptidase-24.11 in rat kidney by in situ hybridization. FEBS Lett (1992) 0.85

Expression of variant forms of proopiomelanocortin, the common precursor to corticotropin and beta-lipotropin in the rat pars intermedia. Biochemistry (1981) 0.85

Mechanism of Kex2p inhibition by its proregion. FEBS Lett (2001) 0.85

Monoclonal antibodies as probes for the transmembrane structure of neutral endopeptidase 24.11 ('enkephalinase'). Biochim Biophys Acta (1988) 0.85

Disease-causing missense mutations in the PHEX gene interfere with membrane targeting of the recombinant protein. Hum Mol Genet (2001) 0.85

Recombinant neutral endopeptidase-24.11 expressed in mouse neuroblastoma cells is associated with neurite membranes. Biochem J (1990) 0.85

Expression of porcine pro-opiomelanocortin in mouse neuroblastoma (Neuro2A) cells: targeting of the foreign neuropeptide to dense-core vesicles. Mol Cell Endocrinol (1991) 0.85

The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N-terminal glycopeptide segment of porcine POMC. FEBS Lett (1992) 0.84

Secretion of a functional soluble form of neutral endopeptidase-24.11 from a baculovirus-infected insect cell line. Biochem J (1992) 0.84

Complete sequence of rabbit kidney aminopeptidase N and mRNA localization in rabbit kidney by in situ hybridization. Biochem Cell Biol (1994) 0.84

The Kex2p proregion is essential for the biosynthesis of an active enzyme and requires a C-terminal basic residue for its function. Mol Biol Cell (2000) 0.84