Published in Mol Cell Biol on May 01, 2004
CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization. Cancer Res (2008) 1.64
Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis. Mol Cell Biol (2006) 1.51
Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol (2011) 1.46
ARRDC3 suppresses breast cancer progression by negatively regulating integrin beta4. Oncogene (2010) 1.24
Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption. Mol Biol Cell (2007) 1.22
Plectin-intermediate filament partnership in skin, skeletal muscle, and peripheral nerve. Histochem Cell Biol (2013) 1.17
EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4. J Biol Chem (2010) 1.12
Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell (2008) 1.05
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion. Mol Cell Biol (2010) 1.04
A key tyrosine (Y1494) in the beta4 integrin regulates multiple signaling pathways important for tumor development and progression. Cancer Res (2008) 1.04
Interaction of syndecan and alpha6beta4 integrin cytoplasmic domains: regulation of ErbB2-mediated integrin activation. J Biol Chem (2010) 1.01
Phosphorylation of alpha6-tubulin by protein kinase Calpha activates motility of human breast cells. J Biol Chem (2009) 0.97
Plectin isoform-dependent regulation of keratin-integrin alpha6beta4 anchorage via Ca2+/calmodulin. J Biol Chem (2009) 0.95
CD151 restricts the α6 integrin diffusion mode. J Cell Sci (2012) 0.95
Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly. Mol Biol Cell (2012) 0.93
PhosphoMARCKS drives motility of mouse melanoma cells. Cell Signal (2010) 0.93
Integrin α6β4 in colorectal cancer. World J Gastrointest Pathophysiol (2010) 0.93
Ultrastructural localization of integrin subunits beta4 and alpha3 within the migrating epithelial tongue of in vivo human wounds. J Histochem Cytochem (2008) 0.92
Advances and perspectives of the architecture of hemidesmosomes: lessons from structural biology. Cell Adh Migr (2009) 0.92
Role of β4 integrin phosphorylation in human invasive squamous cell carcinoma: regulation of hemidesmosome stability modulates cell migration. Lab Invest (2011) 0.89
Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival. J Biol Chem (2014) 0.86
Molecular architecture and function of the hemidesmosome. Cell Tissue Res (2014) 0.83
Integrin-blocking antibodies delay keratinocyte re-epithelialization in a human three-dimensional wound healing model. PLoS One (2010) 0.82
The calcium/calcineurin pathway promotes hemidesmosome stability through inhibition of β4 integrin phosphorylation. J Biol Chem (2012) 0.82
Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number. J Cell Sci (2011) 0.81
The rod domain is not essential for the function of plectin in maintaining tissue integrity. Mol Biol Cell (2015) 0.81
A small molecule induces integrin β4 nuclear translocation and apoptosis selectively in cancer cells with high expression of integrin β4. Oncotarget (2016) 0.77
Role of Integrin β4 in Lung Endothelial Cell Inflammatory Responses to Mechanical Stress. Sci Rep (2015) 0.77
Molecular architecture and function of the hemidesmosome. Cell Tissue Res (2015) 0.77
Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells. PLoS One (2015) 0.76
SYK interaction with ITGβ4 suppressed by Epstein-Barr virus LMP2A modulates migration and invasion of nasopharyngeal carcinoma cells. Oncogene (2014) 0.76
PKD2 and RSK1 Regulate Integrin β4 Phosphorylation at Threonine 1736. PLoS One (2015) 0.76
Convergence of Eicosanoid and Integrin Biology: Role of Src in 12-LOX activation. Exp Cell Res (2016) 0.75
Tension in Cancer. Int J Mol Sci (2016) 0.75
Structural insights into Ca2+-calmodulin regulation of Plectin 1a-integrin β4 interaction in hemidesmosomes. Structure (2015) 0.75
Roles of Integrin α6β4 Glycosylation in Cancer. Cancers (Basel) (2017) 0.75
The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J Biol Chem (1993) 7.16
Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu Rev Cell Biol (1993) 6.53
Determination of the specific substrate sequence motifs of protein kinase C isozymes. J Biol Chem (1997) 3.86
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol (1996) 3.68
Structure and function of hemidesmosomes: more than simple adhesion complexes. J Invest Dermatol (1999) 2.64
EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol (2001) 2.46
Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain. EMBO J (1990) 2.23
Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells. EMBO J (1990) 2.16
Wound repair in the context of extracellular matrix. Curr Opin Cell Biol (1994) 2.14
The integrin alpha6beta4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actin-containing motility structures. J Cell Biol (1997) 2.03
Protein kinase C-dependent mobilization of the alpha6beta4 integrin from hemidesmosomes and its association with actin-rich cell protrusions drive the chemotactic migration of carcinoma cells. J Cell Biol (1999) 1.98
The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. Dev Cell (2003) 1.91
Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Nat Genet (1995) 1.90
Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells. J Biol Chem (1987) 1.82
Expression of integrins and basement membrane components by wound keratinocytes. J Clin Invest (1993) 1.80
Linking integrin alpha6beta4-based cell adhesion to the intermediate filament cytoskeleton: direct interaction between the beta4 subunit and plectin at multiple molecular sites. J Cell Biol (1998) 1.79
The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol (1996) 1.73
Desmosomes and hemidesmosomes: structure and function of molecular components. FASEB J (1996) 1.70
Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem (2001) 1.66
Laminin receptors: achieving specificity through cooperation. Trends Cell Biol (1995) 1.62
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180. J Cell Biol (1998) 1.58
Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly. J Cell Sci (2003) 1.52
Protein kinase C alpha (PKC alpha): regulation and biological function. J Biochem (2002) 1.51
The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Mol Biol Cell (1993) 1.45
Deficiency of the integrin beta 4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties. J Cell Sci (1996) 1.37
Redistribution of the hemidesmosome components alpha 6 beta 4 integrin and bullous pemphigoid antigens during epithelial wound healing. Exp Cell Res (1993) 1.22
Monoclonal antibody to human carcinoma-associated protein complex: quantitation in normal and tumor tissue. Cancer Res (1988) 1.20
Extracellular matrix components and integrins in relationship to human intestinal epithelial cell differentiation. Prog Histochem Cytochem (1997) 1.17
A minimal region on the integrin beta4 subunit that is critical to its localization in hemidesmosomes regulates the distribution of HD1/plectin in COS-7 cells. J Cell Sci (1997) 1.17
Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line, BMGE-H. J Biochem (1994) 1.14
Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cells. Mol Biol Cell (1997) 1.09
The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. J Cell Sci (1992) 1.07
The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J Cell Biol (1997) 1.07
Ligand-independent role of the beta 4 integrin subunit in the formation of hemidesmosomes. J Cell Sci (1998) 1.01
Tumor cell motility. Semin Cancer Biol (1991) 0.99
Formation of hemidesmosome-like structures in the absence of ligand binding by the (alpha)6(beta)4 integrin requires binding of HD1/plectin to the cytoplasmic domain of the (beta)4 integrin subunit. J Cell Sci (2000) 0.98
Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. Cancer Res (2001) 0.95
Polarized expression of HD1: relationship with the cytoskeleton in cultured human colonic carcinoma cells. Exp Cell Res (1997) 0.94
Cloning and sequence of the cDNA encoding the beta 4 integrin subunit in rat peripheral nerve. Gene (1997) 0.85
ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell (2010) 3.25
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol (2005) 2.88
VEGF targets the tumour cell. Nat Rev Cancer (2013) 2.71
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest (2005) 2.61
IAP regulation of metastasis. Cancer Cell (2010) 2.47
Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res (2002) 2.20
Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell (2003) 2.11
The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol Ther (2005) 2.10
Competing autocrine pathways involving alternative neuropilin-1 ligands regulate chemotaxis of carcinoma cells. Cancer Res (2003) 1.95
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res (2004) 1.83
Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells. J Cell Biol (2002) 1.66
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin. Cancer Res (2005) 1.61
Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. Cancer Metastasis Rev (2005) 1.58
Proteases, extracellular matrix, and cancer: a workshop of the path B study section. Am J Pathol (2004) 1.52
Transcriptional regulation of VEGF-A by the unfolded protein response pathway. PLoS One (2010) 1.52
Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Cancer Res (2005) 1.49
miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem (2010) 1.41
Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significance. Clin Cancer Res (2008) 1.40
Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol (2003) 1.36
GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med (2013) 1.33
Regulation of beta 4-integrin expression by epigenetic modifications in the mammary gland and during the epithelial-to-mesenchymal transition. J Cell Sci (2009) 1.25
A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res (2005) 1.24
ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci (2003) 1.21
The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp Cell Res (2004) 1.16
ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem (2002) 1.16
Role of JNK in mammary gland development and breast cancer. Cancer Res (2011) 1.14
The alpha6beta4 integrin maintains the survival of human breast carcinoma cells in vivo. Cancer Res (2005) 1.14
Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2. J Biol Chem (2008) 1.14
IMP3, a new biomarker to predict progression of cervical intraepithelial neoplasia into invasive cancer. Am J Surg Pathol (2011) 1.13
The Met receptor and alpha 6 beta 4 integrin can function independently to promote carcinoma invasion. J Biol Chem (2004) 1.06
VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov (2012) 1.06
The alpha6beta4 integrin can regulate ErbB-3 expression: implications for alpha6beta4 signaling and function. Cancer Res (2007) 1.04
Intrinsic signaling functions of the beta4 integrin intracellular domain. J Biol Chem (2007) 1.00
Use of RNA interference to inhibit integrin (alpha6beta4)-mediated invasion and migration of breast carcinoma cells. Clin Exp Metastasis (2003) 0.99
ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res (2011) 0.99
Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling. J Cell Sci (2012) 0.98
Contributions of the alpha6 integrins to breast carcinoma survival and progression. Mol Cells (2004) 0.97
Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell (2012) 0.97
Insulin receptor substrate-2 regulates aerobic glycolysis in mouse mammary tumor cells via glucose transporter 1. J Biol Chem (2008) 0.95
Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription. Proc Natl Acad Sci U S A (2013) 0.93
Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs (2007) 0.93
Hypoxia-induced vascular endothelial growth factor transcription and protection from apoptosis are dependent on alpha6beta1 integrin in breast carcinoma cells. Cancer Res (2004) 0.91
Integrin β4 regulates SPARC protein to promote invasion. J Biol Chem (2012) 0.91
IMP3 protein promotes chemoresistance in breast cancer cells by regulating breast cancer resistance protein (ABCG2) expression. J Biol Chem (2013) 0.91
Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB. J Biol Chem (2005) 0.90
Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin β4. Mol Cell Biol (2013) 0.89
Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr (2012) 0.88
Effects of β4 integrin expression on microRNA patterns in breast cancer. Biol Open (2012) 0.85
Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells. Cancer Res (2006) 0.85
Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development (2011) 0.84
Expression of the beta 4 integrin subunit induces monocytic differentiation of 32D/v-Abl cells. Blood (2002) 0.76