Published in Oncogene on June 04, 1998
Promyelocytic leukemia (PML) nuclear bodies are protein structures that do not accumulate RNA. J Cell Biol (2000) 2.11
Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies. J Virol (2001) 2.07
The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein. Mol Cell Biol (1998) 1.69
Structure, organization, and dynamics of promyelocytic leukemia protein nuclear bodies. Am J Hum Genet (1998) 1.64
WRAP53 is essential for Cajal body formation and for targeting the survival of motor neuron complex to Cajal bodies. PLoS Biol (2010) 1.57
Deconstructing PML-induced premature senescence. EMBO J (2002) 1.56
Contribution of the C-terminal regions of promyelocytic leukemia protein (PML) isoforms II and V to PML nuclear body formation. J Biol Chem (2012) 0.87
Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth. Oncotarget (2015) 0.86
The function, regulation and therapeutic implications of the tumor suppressor protein, PML. Cell Biosci (2015) 0.82
PML3 Orchestrates the Nuclear Dynamics and Function of TIP60. J Biol Chem (2009) 0.81
Immunohistochemical expression of promyelocytic leukemia body in soft tissue sarcomas. J Exp Clin Cancer Res (2008) 0.77
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods (1991) 16.64
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol (1982) 11.87
Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science (1998) 9.90
The tripartite motif family identifies cell compartments. EMBO J (2001) 9.64
The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature (1999) 7.85
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell (1992) 6.86
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. EMBO J (2001) 6.85
Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria. Science (1993) 6.29
Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (1992) 5.47
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia. Nature (1998) 5.30
Cytoplasmic pH and free Mg2+ in lymphocytes. J Cell Biol (1982) 5.30
Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin. Nature (1992) 5.17
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 4.90
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes. Nature (1982) 4.83
Measurement of cytosolic free Ca2+ with quin2. Methods Enzymol (1989) 4.33
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature (1998) 4.03
Is cytosolic ionized calcium regulating neutrophil activation? Science (1983) 3.97
The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J (2001) 3.85
Receptor-activated Ca2+ influx: how many mechanisms for how many channels? Trends Pharmacol Sci (1994) 3.63
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein. Cancer Res (1998) 3.56
Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells. Curr Biol (1995) 3.44
Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells. J Cell Biol (2000) 3.35
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+. J Biol Chem (1985) 3.31
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 3.20
Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ. J Neurosci (1997) 3.18
Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol (1998) 3.13
Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev (1997) 3.01
"Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells? Proc Natl Acad Sci U S A (1988) 2.99
The acute promyelocytic leukemia-specific PML-RAR alpha fusion protein inhibits differentiation and promotes survival of myeloid precursor cells. Cell (1993) 2.96
Transfected aequorin in the measurement of cytosolic Ca2+ concentration ([Ca2+]c). A critical evaluation. J Biol Chem (1995) 2.91
Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1. Nature (1999) 2.88
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation properties. Oncogene (1991) 2.86
The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene (1995) 2.80
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst (1998) 2.75
Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences. Blood (1997) 2.72
Anti-immunoglobulin, cytoplasmic free calcium, and capping in B lymphocytes. J Cell Biol (1982) 2.67
Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J (1997) 2.62
Fura-2 measurement of cytosolic free Ca2+ in monolayers and suspensions of various types of animal cells. J Cell Biol (1987) 2.57
Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons. Proc Natl Acad Sci U S A (1987) 2.54
Protein kinase C activation of physiological processes in human neutrophils at vanishingly small cytosolic Ca2+ levels. Nature (1984) 2.49
Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice. Proc Natl Acad Sci U S A (1997) 2.47
Mitochondria as all-round players of the calcium game. J Physiol (2000) 2.47
Numb is an endocytic protein. J Cell Biol (2000) 2.39
ALK+ lymphoma: clinico-pathological findings and outcome. Blood (1999) 2.38
The endoplasmic reticulum Ca2+ store: a view from the lumen. Trends Biochem Sci (1998) 2.37
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Subcellular imaging of intramitochondrial Ca2+ with recombinant targeted aequorin: significance for the regulation of pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A (1996) 2.33
Mitochondrial Ca2+ homeostasis in intact cells. J Cell Biol (1994) 2.28
Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene (1994) 2.27
Ca2+ influx following receptor activation. Trends Pharmacol Sci (1991) 2.24
Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils. J Cell Biol (1984) 2.15
T-cell receptor gene rearrangements as markers of lineage and clonality in T-cell neoplasms. Proc Natl Acad Sci U S A (1985) 2.10
Double labelling of subcellular structures with organelle-targeted GFP mutants in vivo. Curr Biol (1996) 2.10
Acute promyelocytic leukemia: from genetics to treatment. Blood (1994) 2.09
Chromosomal breakpoints and structural alterations of the c-myc locus differ in endemic and sporadic forms of Burkitt lymphoma. Proc Natl Acad Sci U S A (1986) 2.09
The Golgi apparatus is an inositol 1,4,5-trisphosphate-sensitive Ca2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J (1998) 2.07
The inositol 1,4,5,-trisphosphate receptor in cerebellar Purkinje cells: quantitative immunogold labeling reveals concentration in an ER subcompartment. J Cell Biol (1990) 2.03
Cap formation by various ligands on lymphocytes shows the same dependence on high cellular ATP levels. Biochim Biophys Acta (1980) 2.03
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation. Mol Cell (2000) 2.02
eps15 and eps15R are essential components of the endocytic pathway. Cancer Res (1997) 1.99
Nuclear Ca2+ concentration measured with specifically targeted recombinant aequorin. EMBO J (1993) 1.98
Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc. Nature (1994) 1.97
Monitoring dynamic changes in free Ca2+ concentration in the endoplasmic reticulum of intact cells. EMBO J (1995) 1.96
Acute perforation of colonic diverticula associated with short-term indomethacin. Lancet (1978) 1.94
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J (1994) 1.94
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. Proc Natl Acad Sci U S A (1992) 1.93
Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur J Cancer (1993) 1.92
Capacitative Ca2+ entry is closely linked to the filling state of internal Ca2+ stores: a study using simultaneous measurements of ICRAC and intraluminal [Ca2+]. J Cell Biol (1998) 1.91
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus. Proc Natl Acad Sci U S A (1991) 1.90
Domains of high Ca2+ beneath the plasma membrane of living A7r5 cells. EMBO J (1997) 1.90
A protein-binding domain, EH, identified in the receptor tyrosine kinase substrate Eps15 and conserved in evolution. Proc Natl Acad Sci U S A (1995) 1.87
Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J Biol Chem (1993) 1.86
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis. Proc Natl Acad Sci U S A (2001) 1.84
Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils. J Cell Biol (1986) 1.82
A role for calcium influx in the regulation of mitochondrial calcium in endothelial cells. J Biol Chem (1996) 1.81