Published in Proc Natl Acad Sci U S A on July 21, 1998
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Imaging of the intracellular topography of copper with a fluorescent sensor and by synchrotron x-ray fluorescence microscopy. Proc Natl Acad Sci U S A (2005) 2.30
Global impact of influenza virus on cellular pathways is mediated by both replication-dependent and -independent events. J Virol (2001) 2.13
Nanomaterial cytotoxicity is composition, size, and cell type dependent. Part Fibre Toxicol (2010) 1.75
Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein. Mol Cell Biol (2003) 1.56
Targeting of metallothionein by L-homocysteine: a novel mechanism for disruption of zinc and redox homeostasis. Arterioscler Thromb Vasc Biol (2006) 1.51
Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Genes Dev (2005) 1.46
Examining the specific contributions of individual Arabidopsis metallothioneins to copper distribution and metal tolerance. Plant Physiol (2008) 1.37
Role of metallothionein in nitric oxide signaling as revealed by a green fluorescent fusion protein. Proc Natl Acad Sci U S A (2000) 1.36
Knockout of 'metal-responsive transcription factor' MTF-1 in Drosophila by homologous recombination reveals its central role in heavy metal homeostasis. EMBO J (2003) 1.33
Two major branches of anti-cadmium defense in the mouse: MTF-1/metallothioneins and glutathione. Nucleic Acids Res (2005) 1.30
Chemistry and biology of mammalian metallothioneins. J Biol Inorg Chem (2011) 1.28
The role of metallothionein in the pathogenesis of acute lung injury. Am J Respir Cell Mol Biol (2005) 1.25
Regulatory networks of cadmium stress in plants. Plant Signal Behav (2010) 1.23
Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins. BMC Genomics (2007) 1.23
Arsenite-inducible RNA-associated protein (AIRAP) protects cells from arsenite toxicity. Cell Stress Chaperones (2001) 1.17
Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release. Proc Natl Acad Sci U S A (2003) 1.17
Shaping mechanisms of metal specificity in a family of metazoan metallothioneins: evolutionary differentiation of mollusc metallothioneins. BMC Biol (2011) 1.17
Metallothionein as an anti-inflammatory mediator. Mediators Inflamm (2009) 1.15
Metallothionein protein evolution: a miniassay. J Biol Inorg Chem (2011) 1.14
Cotton metallothionein GhMT3a, a reactive oxygen species scavenger, increased tolerance against abiotic stress in transgenic tobacco and yeast. J Exp Bot (2008) 1.13
Characterization of an 18,166 EST dataset for cassava (Manihot esculenta Crantz) enriched for drought-responsive genes. Plant Cell Rep (2007) 1.08
Evidence for a protective role of metallothionein-1 in focal cerebral ischemia. Proc Natl Acad Sci U S A (1999) 1.06
Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein. J Biol Chem (1999) 1.03
Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J Biol Chem (2008) 1.03
A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity. Proc Natl Acad Sci U S A (2001) 1.02
Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. Antioxid Redox Signal (2007) 1.01
A mediator role for metallothionein in tumor necrosis factor-induced lethal shock. J Exp Med (2001) 1.01
A fungal metallothionein is required for pathogenicity of Magnaporthe grisea. Plant Cell (2004) 0.99
Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc. Biochem J (2004) 0.98
Overexpression of HIF-1α, metallothionein and SLUG is associated with high TNM stage and lymph node metastasis in papillary thyroid carcinoma. Int J Clin Exp Pathol (2013) 0.98
Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. J Bacteriol (2000) 0.98
The crystal structure of yeast copper thionein: the solution of a long-lasting enigma. Proc Natl Acad Sci U S A (2004) 0.97
Induction of metallothionein I by arsenic via metal-activated transcription factor 1: critical role of C-terminal cysteine residues in arsenic sensing. J Biol Chem (2009) 0.95
Clustered metallothionein genes are co-regulated in rice and ectopic expression of OsMT1e-P confers multiple abiotic stress tolerance in tobacco via ROS scavenging. BMC Plant Biol (2012) 0.93
Characterization of MtnE, the fifth metallothionein member in Drosophila. J Biol Inorg Chem (2011) 0.90
A potential role for alterations of zinc and zinc transport proteins in the progression of Alzheimer's disease. J Alzheimers Dis (2009) 0.90
The Balance between Life and Death of Cells: Roles of Metallothioneins. Biomark Insights (2007) 0.89
Genome-wide transcriptome analysis reveals that cadmium stress signaling controls the expression of genes in drought stress signal pathways in rice. PLoS One (2014) 0.89
Cadmium accumulation and DNA homology with metal resistance genes in sulfate-reducing bacteria. Appl Environ Microbiol (2005) 0.88
Maternally-derived zinc transporters ZIP6 and ZIP10 drive the mammalian oocyte-to-egg transition. Mol Hum Reprod (2014) 0.88
Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate. Biochem J (2001) 0.88
Metals in the "omics" world: copper homeostasis and cytochrome c oxidase assembly in a new light. J Biol Inorg Chem (2007) 0.87
The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). Mol Cell Biol (2011) 0.87
Overexpression of Nelumbo nucifera metallothioneins 2a and 3 enhances seed germination vigor in Arabidopsis. Planta (2011) 0.86
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. Int J Colorectal Dis (2009) 0.86
Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. PLoS One (2010) 0.86
Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. Behav Brain Funct (2009) 0.85
Identification of pharmacological targets in amyotrophic lateral sclerosis through genomic analysis of deregulated genes and pathways. Curr Genomics (2012) 0.84
Nitric oxide and zinc homeostasis in acute lung injury. Proc Am Thorac Soc (2005) 0.84
Characterization of the mouse metal-regulatory-element-binding proteins, metal element protein-1 and metal regulatory transcription factor-1. Biochem J (2001) 0.83
Probing mercury(II)-DNA interactions by nanopore stochastic sensing. J Phys Chem B (2013) 0.83
Development of a compartmental model of zinc kinetics in mice. J Nutr (2008) 0.83
Dumpy-30 family members as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. BMC Dev Biol (2008) 0.83
Heavy metal and abiotic stress inducible metallothionein isoforms from Prosopis juliflora (SW) D.C. show differences in binding to heavy metals in vitro. Mol Genet Genomics (2008) 0.83
The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people. Mol Med (2007) 0.82
Oxidative dimerization in metallothionein is a result of intermolecular disulphide bonds between cysteines in the alpha-domain. Biochem J (2001) 0.82
Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals. Biomolecules (2014) 0.81
Recent Progress in Fluorescent Imaging Probes. Sensors (Basel) (2015) 0.81
Metallothionein is crucial for safe intracellular copper storage and cell survival at normal and supra-physiological exposure levels. Biochem J (2004) 0.81
Alzheimer's disease: A hypothesis on pathogenesis. J Am Aging Assoc (2000) 0.81
Hints for metal-preference protein sequence determinants: different metal binding features of the five tetrahymena thermophila metallothioneins. Int J Biol Sci (2015) 0.81
Protein and metal cluster structure of the wheat metallothionein domain γ-E(c)-1: the second part of the puzzle. J Biol Inorg Chem (2011) 0.80
Novel promoter sequence required for manganese regulation of manganese peroxidase isozyme 1 gene expression in Phanerochaete chrysosporium. Eukaryot Cell (2004) 0.80
Killifish metallothionein messenger RNA expression following temperature perturbation and cadmium exposure. Cell Stress Chaperones (2001) 0.80
Differential gene expression in mouse retina related to regional differences in vulnerability to hyperoxia. Mol Vis (2010) 0.80
Oxidation reactivity of zinc-cysteine clusters in metallothionein. J Biol Inorg Chem (2013) 0.80
Synthesis of a highly Zn(2+)-selective cyanine-based probe and its use for tracing endogenous zinc ions in cells and organisms. Nat Protoc (2014) 0.80
Mucosal tolerance to E-selectin and response to systemic inflammation. J Cereb Blood Flow Metab (2006) 0.79
High glucose increases metallothionein expression in renal proximal tubular epithelial cells. Exp Diabetes Res (2011) 0.79
Proteomic responses of oceanic Synechococcus WH8102 to phosphate and zinc scarcity and cadmium additions. Front Microbiol (2013) 0.79
Zinc-gene interaction related to inflammatory/immune response in ageing. Genes Nutr (2008) 0.79
Zinc in Early Life: A Key Element in the Fetus and Preterm Neonate. Nutrients (2015) 0.78
Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans. Immun Ageing (2007) 0.78
Impact of overexpression of metallothionein-1 on cell cycle progression and zinc toxicity. Am J Physiol Cell Physiol (2008) 0.78
Role of metallothioneins in benign and malignant thyroid lesions. Thyroid Res (2012) 0.78
Molecular evolution and functional divergence of the metallothionein gene family in vertebrates. J Mol Evol (2014) 0.78
The molecular basis of memory. ACS Chem Neurosci (2012) 0.78
Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT. Int J Mol Sci (2016) 0.78
Cadmium resistance and uptake by bacterium, Salmonella enterica 43C, isolated from industrial effluent. AMB Express (2016) 0.77
Heterologous expression of a rice metallothionein isoform (OsMTI-1b) in Saccharomyces cerevisiae enhances cadmium, hydrogen peroxide and ethanol tolerance. Braz J Microbiol (2017) 0.77
Metallothionein-1 and metallothionein-2 gene expression and localisation of apoptotic cells in Zn-treated LEC rat liver. Histochem Cell Biol (2003) 0.77
The effect of nitric oxide on metal release from metallothionein-3: gradual unfolding of the protein. J Biol Inorg Chem (2007) 0.77
Redox and trace metal regulation of ion channels in the pain pathway. Biochem J (2015) 0.76
Atrophy of large myelinated axons in metallothionein-I, II knockout mice. Cell Mol Neurobiol (2005) 0.76
Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice. Endocrinol Metab (Seoul) (2016) 0.76
cDNA sequence encoding metallothionein protein from Aegiceras corniculatum and its gene expression induced by Pb²⁺ and Cd²⁺ stresses. Environ Monit Assess (2013) 0.76
Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction. Mar Drugs (2015) 0.76
Influence of NH-Sgamma bonding interactions on the structure and dynamics of metallothioneins. J Mol Model (2009) 0.75
Yeast CUP1 protects HeLa cells against copper-induced stress. Braz J Med Biol Res (2015) 0.75
Serotonin 1A Receptors on Astrocytes as a Potential Target for the Treatment of Parkinson's Disease. Curr Med Chem (2016) 0.75
Dysregulated mechanisms underlying Duchenne muscular dystrophy from co-expression network preservation analysis. BMC Res Notes (2015) 0.75
Genetic variation in metallothionein and metal-regulatory transcription factor 1 in relation to urinary cadmium, copper, and zinc. Toxicol Appl Pharmacol (2015) 0.75
The interactome of the copper transporter ATP7A belongs to a network of neurodevelopmental and neurodegeneration factors. Elife (2017) 0.75
Variations in hepatic biomarkers in American alligators (Alligator mississippiensis) from three sites in Florida, USA. Chemosphere (2016) 0.75
The zn- or cu-thionein character of a metallothionein determines its metal load when synthesized in physiological (metal-unsupplemented) conditions. Bioinorg Chem Appl (2010) 0.75
Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity. Int J Mol Sci (2017) 0.75
Unravelling the Role of Metallothionein on Development, Reproduction and Detoxification in the Wall Lizard Podarcis sicula. Int J Mol Sci (2017) 0.75
The promoter and the 5'-untranslated region of rice metallothionein OsMT2b gene are capable of directing high-level gene expression in germinated rice embryos. Plant Cell Rep (2014) 0.75
Shapes of Differential Pulse Voltammograms and Level of Metallothionein at Different Animal Species. Sensors (Basel) (2007) 0.75
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The glutathione redox couple modulates zinc transfer from metallothionein to zinc-depleted sorbitol dehydrogenase. Proc Natl Acad Sci U S A (1998) 1.42
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Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J Nutr (1996) 1.10
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Reversible zinc exchange between metallothionein and the estrogen receptor zinc finger. FEBS Lett (1996) 0.97
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Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol Appl Pharmacol (1995) 0.93
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