Published in Philos Trans R Soc Lond B Biol Sci on June 29, 1998
CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proc Natl Acad Sci U S A (2001) 2.15
High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading. Proc Natl Acad Sci U S A (2002) 1.95
Lineage selection and the evolution of multistage carcinogenesis. Proc Biol Sci (1999) 1.72
A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol (2004) 1.63
Skin squamous cell carcinoma propagating cells increase with tumour progression and invasiveness. EMBO J (2012) 1.11
Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation. Cancer Res (2009) 1.04
PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma. J Oncol (2010) 1.01
Delineating Molecular Mechanisms of Squamous Tissue Homeostasis and Neoplasia: Focus on p63. J Skin Cancer (2013) 0.80
Establishment and characterization of an osteopontin-null cutaneous squamous cell carcinoma cell line. In Vitro Cell Dev Biol Anim (2010) 0.78
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
The retinoblastoma protein and cell cycle control. Cell (1995) 20.21
Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev (1995) 13.66
p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (1993) 13.46
A cell cycle regulator potentially involved in genesis of many tumor types. Science (1994) 13.00
Role of the INK4a locus in tumor suppression and cell mortality. Cell (1996) 11.41
p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest. Nature (1994) 10.95
Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (1993) 10.72
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature (1996) 10.14
Mutation selection and the natural history of cancer. Nature (1975) 9.73
Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell (1991) 9.73
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med (1995) 9.10
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell (1991) 8.75
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest. Cell (1995) 7.34
Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol (1989) 6.31
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev (1996) 5.71
Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (1994) 5.54
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev (1995) 4.94
p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature (1994) 4.77
Inactivation of the retinoblastoma susceptibility gene in human breast cancers. Science (1988) 4.15
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res (1996) 3.89
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell (1996) 3.73
Deletion of p16 and p15 genes in brain tumors. Cancer Res (1994) 3.03
Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene (1996) 2.83
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62
Stem cells: the generation and maintenance of cellular diversity. Development (1989) 2.54
Induction of cyclin D1 overexpression by activated ras. Oncogene (1994) 2.35
E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35
Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell (1990) 2.34
D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene (1991) 2.21
A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis. J Cell Biol (1991) 2.18
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell (1990) 2.16
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer. Oncogene (1996) 1.89
Regulation and significance of apoptosis in the stem cells of the gastrointestinal epithelium. Stem Cells (1997) 1.78
Ras gene mutation and amplification in human nonmelanoma skin cancers. Mol Carcinog (1991) 1.70
p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following gamma-irradiation. Oncogene (1994) 1.69
Food-derived mutagens and carcinogens. Cancer Res (1992) 1.69
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet (1994) 1.66
Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene. Proc Natl Acad Sci U S A (1988) 1.62
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression. Proc Natl Acad Sci U S A (1990) 1.56
Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression. Cancer Res (1995) 1.50
The p53 response to ionising radiation in adult and developing murine tissues. Oncogene (1996) 1.46
Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet (1995) 1.41
Inherited predisposition to cancer. Trends Genet (1990) 1.41
Deletion and altered regulation of p16INK4a and p15INK4b in undifferentiated mouse skin tumors. Cancer Res (1995) 1.32
A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis (1992) 1.32
Hair follicular stem cells: the bulge-activation hypothesis. J Invest Dermatol (1991) 1.25
Overexpression of cyclin D1 in mouse skin carcinogenesis. Oncogene (1993) 1.22
Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci U S A (1990) 1.20
The conversion of mouse skin squamous cell carcinomas to spindle cell carcinomas is a recessive event. J Cell Biol (1993) 1.18
Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype. Cell Growth Differ (1995) 1.16
Anti-apoptotic activity of low levels of wild-type p53. EMBO J (1996) 1.13
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7. Cancer Res (1991) 1.11
The role of p21ras in receptor tyrosine kinase signaling. Crit Rev Oncog (1993) 1.09
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo. Carcinogenesis (1991) 1.07
Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma. Cancer Res (1994) 1.05
Loss of P16INK4 expression is frequent in high grade gliomas. Cancer Res (1995) 1.01
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system. Mol Cell Biol (1988) 0.96
Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res (1996) 0.93
The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse. Mamm Genome (1991) 0.91
Allelotype analysis of mouse skin tumors using polymorphic microsatellites: sequential genetic alterations on chromosomes 6, 7, and 11. Cancer Res (1993) 0.89
Induction of different genetic changes by different classes of chemical carcinogens during progression of mouse skin tumors. Mol Carcinog (1994) 0.88
Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes. Cancer Res (1994) 0.86
Epithelial cell plasticity in neoplasia. Cancer Cells (1991) 0.86
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities. Carcinogenesis (1994) 0.81
Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature (1999) 23.62
TGF-beta signaling in tumor suppression and cancer progression. Nat Genet (2001) 11.64
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet (2013) 9.46
Structure, regulation and function of NF-kappa B. Annu Rev Cell Biol (1994) 8.98
Guidelines for the welfare and use of animals in cancer research. Br J Cancer (2010) 6.97
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature (1986) 6.14
The three-dimensional structure of foot-and-mouth disease virus at 2.9 A resolution. Nature (1989) 5.87
Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta (2000) 5.39
Guidelines for the management of hemophilia. Haemophilia (2012) 5.16
Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14
Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012. Euro Surveill (2012) 4.96
Idiopathic pulmonary fibrosis: relationship between histopathologic features and mortality. Am J Respir Crit Care Med (2001) 4.45
Activation of the mouse cellular Harvey-ras gene in chemically induced benign skin papillomas. Nature (1984) 4.28
Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci U S A (1992) 4.13
Nucleotide sequence of the leader region of the phenylalanine operon of Escherichia coli. Proc Natl Acad Sci U S A (1978) 4.01
Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89
TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell (1996) 3.73
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site. Mol Cell Biol (1992) 3.63
Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Aliment Pharmacol Ther (2011) 3.63
Increase in asthma: a more toxic environment or a more susceptible population? Thorax (1994) 3.52
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell (1993) 3.35
Racism and the physical and mental health status of African Americans: a thirteen year national panel study. Ethn Dis (1996) 3.34
The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res (1994) 3.28
Dose-related neurocognitive effects of marijuana use. Neurology (2002) 3.25
Use of component analyses to identify active variables in treatment packages for children with feeding disorders. J Appl Behav Anal (1995) 3.24
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science (1999) 3.22
Inappropriate reattendances in out-patient departments. J Public Health Med (1992) 3.14
Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2). Hum Mol Genet (2001) 3.12
Mycobacterium ulcerans infection on Phillip Island, Victoria. Med J Aust (1994) 3.12
Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature (1983) 3.09
Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem (1999) 3.06
Mitomycin C-induced expression of trpA of Salmonella typhimurium inserted into the plasmid ColE1. J Bacteriol (1977) 3.06
Dissociation of centrosome replication events from cycles of DNA synthesis and mitotic division in hydroxyurea-arrested Chinese hamster ovary cells. J Cell Biol (1995) 3.05
High resolution structures of HIV-1 RT from four RT-inhibitor complexes. Nat Struct Biol (1995) 3.04
Recurrent BRCA2 6174delT mutations in Ashkenazi Jewish women affected by breast cancer. Nat Genet (1996) 2.93
Primary eosinophilic esophagitis in children: successful treatment with oral corticosteroids. J Pediatr Gastroenterol Nutr (1998) 2.87
Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture. J Exp Med (1998) 2.80
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat Struct Biol (1995) 2.67
A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization. J Biol Chem (1986) 2.65
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell (1993) 2.62
p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet (1994) 2.61
Cost effectiveness of shortening screening interval or extending age range of NHS breast screening programme: computer simulation study. BMJ (1998) 2.61
ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature (1991) 2.60
TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem (2001) 2.58
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res (2001) 2.51
QALYs for resource allocation: probably not and certainly not now. Aust J Public Health (1993) 2.46
Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J Biol Chem (1992) 2.43
Germline BRCA1 185delAG mutations in Jewish women with breast cancer. Lancet (1996) 2.40
Seven deaths in Darwin: case studies under the Rights of the Terminally Ill Act, Northern Territory, Australia. Lancet (1998) 2.40
Maximizing health benefits vs egalitarianism: an Australian survey of health issues. Soc Sci Med (1995) 2.39
Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell (1990) 2.34
Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem (1999) 2.33
Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc Natl Acad Sci U S A (1998) 2.32
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature (1997) 2.17
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell (1990) 2.16
Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem (1990) 2.13
The effects of presession exposure to attention on the results of assessments of attention as a reinforcer. J Appl Behav Anal (2000) 2.12
Caspase-2 mediates neuronal cell death induced by beta-amyloid. J Neurosci (2000) 2.10
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry (1990) 2.06
Drainage is unnecessary after elective liver resection. Am J Surg (1996) 2.03
The pharmacokinetics of sodium cromoglycate in man after intravenous and inhalation administration. Br J Clin Pharmacol (1986) 2.03
Solid organ transplantation from hepatitis B virus-positive donors: consensus guidelines for recipient management. Am J Transplant (2015) 2.03
Evaluation of four real-time PCR assays for detection of influenza A(H1N1)v viruses. Euro Surveill (2009) 2.01
Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis. Nature (1988) 1.99
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion. Cell Growth Differ (1998) 1.98
Activation of NF-kappa B requires proteolysis of the inhibitor I kappa B-alpha: signal-induced phosphorylation of I kappa B-alpha alone does not release active NF-kappa B. Proc Natl Acad Sci U S A (1995) 1.95
UKCCCR guidelines for the welfare of animals in experimental neoplasia. Lab Anim (1988) 1.95
The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res (1998) 1.94
Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (1998) 1.90
Risk of morbidity from renovascular disease in elderly patients with congestive cardiac failure. Lancet (1998) 1.88
Structural and serological evidence for a novel mechanism of antigenic variation in foot-and-mouth disease virus. Nature (1990) 1.86
Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol (1994) 1.85
Nerves on magnetic resonance imaging. J Natl Med Assoc (1989) 1.85
The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. Cell (1995) 1.84
Factors associated with participation, attrition, and outcome in a smoking cessation program at the workplace. Health Psychol (1988) 1.83
Atm deficiency results in severe meiotic disruption as early as leptonema of prophase I. Development (1998) 1.81
Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha. J Biol Chem (1996) 1.78
v-ras genes from Harvey and BALB murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis. Cell (1986) 1.76
Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology (1998) 1.75
Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest (1992) 1.74
Degradation of chromosomal DNA during apoptosis. Cell Death Differ (2003) 1.73
Oncogene activation in chemical carcinogenesis. Adv Cancer Res (1988) 1.72
Radioimmunoassay of sodium cromoglycate in human plasma. Ann Clin Biochem (1983) 1.72
Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. Ann Rheum Dis (1989) 1.71
Practical problems of improving records. Br Med J (Clin Res Ed) (1981) 1.70
Prospective study of new-onset seizures presenting as status epilepticus in childhood. Neurology (2010) 1.69
Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem (1996) 1.69
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol (1998) 1.69
Transfusion practice and guidelines in Australian and New Zealand intensive care units. Intensive Care Med (2010) 1.68
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV. Phys Rev Lett (2010) 1.67
One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes. Mol Cell Biol (1987) 1.66
The impact of nursing home patients on general practitioners' workload. Br J Gen Pract (2000) 1.64
A prescription for improvement? An observational study to identify how general practices vary in their growth in prescribing costs. BMJ (2000) 1.64
Physical Aspects of Fruit Growth : THEORETICAL ANALYSIS OF DISTRIBUTION OF SURFACE GROWTH FORCES IN FRUIT IN RELATION TO CRACKING AND SPLITTING. Plant Physiol (1981) 1.62