Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surface.

PubWeight™: 1.17‹?› | Rank: Top 10%

🔗 View Article (PMID 9733724)

Published in J Biol Chem on September 18, 1998

Authors

Y Itoh1, A Ito, K Iwata, K Tanzawa, Y Mori, H Nagase

Author Affiliations

1: Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, Kansas City, Kansas 66160-7421, USA.

Articles citing this

How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol (2001) 14.05

Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities. Sci Signal (2008) 2.97

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J (2001) 2.23

New functional roles for non-collagenous domains of basement membrane collagens. J Cell Sci (2002) 1.58

The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2. Cancer Metastasis Rev (2008) 1.52

MMP induction and inhibition in myocardial infarction. Heart Fail Rev (2004) 1.35

Extracellular matrix roles during cardiac repair. Life Sci (2010) 1.32

Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. FASEB J (2008) 1.32

Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP. Mol Biol Cell (2006) 1.26

TIMP-2 (tissue inhibitor of metalloproteinase-2) regulates MMP-2 (matrix metalloproteinase-2) activity in the extracellular environment after pro-MMP-2 activation by MT1 (membrane type 1)-MMP. Biochem J (2003) 1.13

Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation. J Biol Chem (2012) 1.05

The second dimer interface of MT1-MMP, the transmembrane domain, is essential for ProMMP-2 activation on the cell surface. J Biol Chem (2008) 0.99

The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor. J Biol Chem (2010) 0.89

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics. Arthritis Res (2002) 0.87

MT-LOOP-dependent localization of membrane type I matrix metalloproteinase (MT1-MMP) to the cell adhesion complexes promotes cancer cell invasion. J Biol Chem (2013) 0.87

Induction of tissue inhibitor of matrix metalloproteinase-2 by cholesterol depletion leads to the conversion of proMMP-2 into active MMP-2 in human dermal fibroblasts. Exp Mol Med (2010) 0.85

Proteolytically Derived Endogenous Angioinhibitors Originating from the Extracellular Matrix. Pharmaceuticals (Basel) (2011) 0.84

Enhanced cell surface expression of matrix metalloproteinases and their inhibitors, and tumor-induced host response in progression of human gastric carcinoma. Dig Dis Sci (2004) 0.83

Membrane-type 1 matrix metalloproteinase-mediated progelatinase A activation in non-tumorigenic and tumorigenic human keratinocytes. Br J Cancer (2000) 0.81

Extracellular regulated kinase 1/2 signaling is a critical regulator of interleukin-1β-mediated astrocyte tissue inhibitor of metalloproteinase-1 expression. PLoS One (2013) 0.81

Expression of the matrix metalloproteases 2, 14, 24, and 25 and tissue inhibitor 3 as potential molecular markers in advanced human gastric cancer. Dis Markers (2014) 0.80

Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2. Biochem J (2000) 0.78

Dissection of the human multipotent adult progenitor cell secretome by proteomic analysis. Stem Cells Transl Med (2013) 0.77

Balance between activation and inhibition of matrix metalloproteinase-2 (MMP-2) is altered in colorectal tumors compared to normal colonic epithelium. Dig Dis Sci (2002) 0.77

Tissue Inhibitor of Metalloproteinase-2 Suppresses Collagen Synthesis in Cultured Keloid Fibroblasts. Plast Reconstr Surg Glob Open (2015) 0.75

Articles by these authors

In vitro antibacterial activity of AM-715, a new nalidixic acid analog. Antimicrob Agents Chemother (1980) 26.28

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol (2000) 13.29

Comparative activities of AM-715 and pipemidic and nalidixic acids against experimentally induced systemic and urinary tract infections. Antimicrob Agents Chemother (1981) 8.59

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance. Nature (1988) 6.35

Tissue inhibitors of metalloproteinases: evolution, structure and function. Biochim Biophys Acta (2000) 5.39

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel. Nature (1989) 5.21

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Hum Mol Genet (1992) 5.14

The transient receptor potential protein homologue TRP6 is the essential component of vascular alpha(1)-adrenoceptor-activated Ca(2+)-permeable cation channel. Circ Res (2001) 5.04

Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature (1994) 4.34

The naming of voltage-gated calcium channels. Neuron (1994) 4.31

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc Natl Acad Sci U S A (1992) 4.13

Prevalence of serum and salivary antibodies to HTLV-1 in Sjögren's syndrome. Lancet (1994) 3.83

Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76

Plasma (1-->3)-beta-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes. Lancet (1995) 3.64

Implantation of bone marrow mononuclear cells into ischemic myocardium enhances collateral perfusion and regional function via side supply of angioblasts, angiogenic ligands, and cytokines. Circulation (2001) 3.50

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. FEBS Lett (1976) 3.35

The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit. Nat Genet (1998) 3.31

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science (1999) 3.22

Nomenclature of voltage-gated calcium channels. Neuron (2000) 3.09

Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion. J Biol Chem (1999) 3.06

Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors affecting the toxin and antitoxin titration. J Biol Stand (1974) 3.02

Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. J Biol Chem (1999) 2.74

Effects of statin therapy on abdominal aortic aneurysm growth: a meta-analysis and meta-regression of observational comparative studies. Eur J Vasc Endovasc Surg (2012) 2.72

The I-II loop of the Ca2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit. Neuron (2000) 2.72

Distribution of hepatic sulfite oxidase among subcellular organelles and its intraorganelle localization. J Biochem (1977) 2.71

Macromolecular Organization of the Cellulolytic Enzyme Complex of Clostridium thermocellum as Revealed by Electron Microscopy. Appl Environ Microbiol (1987) 2.67

A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. Purification and characterization. J Biol Chem (1986) 2.65

ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature (1991) 2.60

Monoclonal antibody against pertussis toxin: effect on toxin activity and pertussis infections. Infect Immun (1984) 2.59

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5). J Biol Chem (2001) 2.58

Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals. J Immunol (1999) 2.44

Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9. J Biol Chem (1992) 2.43

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family. J Biol Chem (1999) 2.33

Presence of NADPH-cytochrome P-450 reductase in rat liver Golgi membranes. Evidence obtained by immunoadsorption method. J Cell Biol (1978) 2.32

The Alzheimer's peptide a beta adopts a collapsed coil structure in water. J Struct Biol (2000) 2.26

Growth-promoting activity of tissue inhibitor of metalloproteinases-1 (TIMP-1) for a wide range of cells. A possible new growth factor in serum. FEBS Lett (1992) 2.21

Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of Smad 3. J Invest Dermatol (1999) 2.20

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. Nature (1997) 2.17

Distinctive biophysical and pharmacological properties of class A (BI) calcium channel alpha 1 subunits. Neuron (1993) 2.14

Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response. Nat Cell Biol (1999) 2.14

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties. Eur J Biochem (1990) 2.13

Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest (1999) 2.09

Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin). Biochemistry (1990) 2.06

Endoplasmic reticulum marker enzymes in Golgi fractions--what does this mean? J Cell Biol (1978) 2.05

A molecular phylogeny of the genus Echinococcus inferred from complete mitochondrial genomes. Parasitology (2006) 2.05

Mitomycin C bladder instillation therapy for bladder tumors. J Urol (1975) 2.03

Mode of action of clotrimazole. Sabouraudia (1973) 2.01

Location of a delta-subunit region determining ion transport through the acetylcholine receptor channel. Nature (1987) 1.99

The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness. Anticancer Res (1998) 1.94

Evidence for biochemically different types of vesicles in the hepatic microsomal fraction. J Biochem (1966) 1.93

The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun (2000) 1.91

Molecular cloning and functional characterization of a novel receptor-activated TRP Ca2+ channel from mouse brain. J Biol Chem (1998) 1.90

Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol (1998) 1.90

Role of collagen enzymatic and glycation induced cross-links as a determinant of bone quality in spontaneously diabetic WBN/Kob rats. Osteoporos Int (2006) 1.87

An epidemiological and ecological study of human alveolar echinococcosis transmission in south Gansu, China. Acta Trop (2000) 1.86

Matrix metalloproteinase 9 (92-kDa gelatinase/type IV collagenase) from HT 1080 human fibrosarcoma cells. Purification and activation of the precursor and enzymic properties. J Biol Chem (1992) 1.82

Proteolytic microdissection of smooth-surfaced vesicles of liver microsomes. J Cell Biol (1969) 1.82

Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences. Structure (2001) 1.81

The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem (2001) 1.81

Structural determinants of ion selectivity in brain calcium channel. FEBS Lett (1993) 1.76

Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J Virol (1999) 1.76

Regulation of matrix metalloproteinases (MMP-2, -3, -9, and -13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption. Endocrinology (1998) 1.75

Purification by means of detergents and properties of cytochrome b5 from liver microsomes. J Biol Chem (1968) 1.74

Localization of matrix metalloproteinase 3 (stromelysin) in osteoarthritic cartilage and synovium. Lab Invest (1992) 1.74

Degradation of chromosomal DNA during apoptosis. Cell Death Differ (2003) 1.73

A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N Engl J Med (1994) 1.72

Immunolocalization of matrix metalloproteinase 3 (stromelysin) in rheumatoid synovioblasts (B cells): correlation with rheumatoid arthritis. Ann Rheum Dis (1989) 1.71

A phylogenetic hypothesis for the distribution of two genotypes of the pig tapeworm Taenia solium worldwide. Parasitology (2002) 1.70

Degradation of interleukin 1beta by matrix metalloproteinases. J Biol Chem (1996) 1.69

Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med (1997) 1.68

Increase in tumor necrosis factor alpha- and interleukin-6-secreting cells in peripheral blood mononuclear cells from subjects infected with Mycobacterium tuberculosis. Infect Immun (1991) 1.67

Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. Leukemia (2010) 1.64

Retracted Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation. Circ Res (2001) 1.64

The precore/core promoter mutant (T1762A1764) of hepatitis B virus: clinical significance and an easy method for detection. J Gen Virol (1995) 1.64

Changes in reversal of cupping in experimental glaucoma. Longitudinal study. Ophthalmology (1992) 1.61

Effect of monoclonal antibody to pertussis toxin on toxin activity. Infect Immun (1987) 1.61

Limb salvage using distraction osteogenesis. A classification of the technique. J Bone Joint Surg Br (1997) 1.59

Use of loop-mediated isothermal amplification of the IS900 sequence for rapid detection of cultured Mycobacterium avium subsp. paratuberculosis. J Clin Microbiol (2003) 1.59

Identification and analysis of the K5 gene of Kaposi's sarcoma-associated herpesvirus. J Virol (2000) 1.58

Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A. Infect Immun (1984) 1.57

Earlier loss of hepatitis C virus RNA in interferon therapy can predict a long-term response in chronic hepatitis C. J Gastroenterol Hepatol (1997) 1.57

Antiproliferative effects of isoflavones on human cancer cell lines established from the gastrointestinal tract. Cancer Res (1993) 1.56

Inhibition of the release of acetylcholine from isolated guinea-pig ileum by crystalline tetrodotoxin. J Pharmacol Exp Ther (1966) 1.55

Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart (2005) 1.55

Frequent somatic mutations of the APC gene in human pancreatic cancer. Cancer Res (1992) 1.55

WHHL-rabbit: a low density lipoprotein receptor-deficient animal model for familial hypercholesterolemia. FEBS Lett (1980) 1.55

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species. Biochim Biophys Acta (1986) 1.55

Antagonistic regulation of type I collagen gene expression by interferon-gamma and transforming growth factor-beta. Integration at the level of p300/CBP transcriptional coactivators. J Biol Chem (2000) 1.55

Transcriptional profiling suggests that Barrett's metaplasia is an early intermediate stage in esophageal adenocarcinogenesis. Oncogene (2006) 1.55

Global gene expression profiling in Barrett's esophagus and esophageal cancer: a comparative analysis using cDNA microarrays. Oncogene (2002) 1.54

The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin. J Biol Chem (1988) 1.54

Usefulness of contrast-enhanced endoscopic ultrasonography with intravenous injection of sonicated serum albumin. Gastrointest Endosc (1997) 1.54

Synthesis and antifungal activity of coumarins and angular furanocoumarins. Bioorg Med Chem (1999) 1.54

Human plasma kallikrein. A rapid purification method with high yield. Biochem J (1981) 1.53

Preventive effects of cyclosporin on diabetes in NOD mice. Diabetologia (1986) 1.52