Published in Biochem J on October 15, 1998
Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) (2008) 2.14
Mechanism of suppression of insulin signalling with lignocaine. Br J Pharmacol (2002) 0.79
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science (1992) 7.00
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature (1994) 5.33
Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes (1994) 4.30
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule. Science (1991) 3.24
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
IGF-I is required for normal embryonic growth in mice. Genes Dev (1993) 3.17
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature (1995) 3.04
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem (1993) 3.02
Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet (1997) 2.97
Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.86
Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol (1994) 2.65
Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature (1992) 2.59
Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci U S A (1993) 2.58
GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nat Med (1997) 2.37
Mouse mutants lacking the type 2 IGF receptor (IGF2R) are rescued from perinatal lethality in Igf2 and Igf1r null backgrounds. Dev Biol (1996) 2.15
Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A (1997) 2.15
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest (1976) 2.12
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol (1997) 2.02
Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis. Cell (1995) 1.99
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol (1996) 1.95
Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J (1996) 1.95
Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol (1996) 1.81
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol (1997) 1.80
Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1994) 1.71
Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose. J Biol Chem (1995) 1.69
Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice. J Clin Invest (1995) 1.65
A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family. J Biol Chem (1997) 1.63
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem (1995) 1.56
New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes (1997) 1.56
Evidence from transgenic mice that glucose transport is rate-limiting for glycogen deposition and glycolysis in skeletal muscle. J Biol Chem (1993) 1.54
Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem (1995) 1.49
The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling. Diabetologia (1994) 1.47
Altering mice by homologous recombination using embryonic stem cells. J Biol Chem (1994) 1.47
Development of non-insulin-dependent diabetes mellitus in the double knockout mice with disruption of insulin receptor substrate-1 and beta cell glucokinase genes. Genetic reconstitution of diabetes as a polygenic disease. J Clin Invest (1997) 1.45
A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway. Proc Natl Acad Sci U S A (1988) 1.40
Hypoglycemic effect of insulin-like growth factor-1 in mice lacking insulin receptors. J Clin Invest (1997) 1.36
Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest (1995) 1.35
Enhanced insulin action due to targeted GLUT4 overexpression exclusively in muscle. Diabetes (1996) 1.34
Germline manipulation of glucose homeostasis via alteration of glucose transporter levels in skeletal muscle. J Biol Chem (1993) 1.32
The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diabetes Metab Rev (1992) 1.31
Correction of diabetic alterations by glucokinase. Proc Natl Acad Sci U S A (1996) 1.30
Insulin binding to liver plasm membranes in the obese hyperglycemic (ob/ob) mouse. Demonstration of a decreased number of functionally normal receptors. J Biol Chem (1975) 1.28
Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency. Biochem J (1996) 1.27
Hormonal/metabolic regulation of the human GLUT4/muscle-fat facilitative glucose transporter gene in transgenic mice. J Biol Chem (1993) 1.24
The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction. Horm Res (1994) 1.21
Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci U S A (1997) 1.19
Mammalian glucokinase. Annu Rev Nutr (1993) 1.18
Enhanced peripheral glucose utilization in transgenic mice expressing the human GLUT4 gene. J Biol Chem (1994) 1.17
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest (1998) 1.17
Increased glycogen accumulation in transgenic mice overexpressing glycogen synthase in skeletal muscle. Proc Natl Acad Sci U S A (1996) 1.13
Regulation of human insulin gene expression in transgenic mice. Nature (1986) 1.12
Identification of a 190-kDa protein as a novel substrate for the insulin receptor kinase functionally similar to insulin receptor substrate-1. J Biol Chem (1995) 1.11
High fat diet-induced hyperglycemia: prevention by low level expression of a glucose transporter (GLUT4) minigene in transgenic mice. Proc Natl Acad Sci U S A (1995) 1.09
Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice. J Biol Chem (1994) 1.05
High level overexpression of glucose transporter-4 driven by an adipose-specific promoter is maintained in transgenic mice on a high fat diet, but does not prevent impaired glucose tolerance. Endocrinology (1995) 1.01
Pancreatic expression of human insulin gene in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.01
Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. J Biol Chem (1997) 1.01
Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle. Diabetes (1996) 1.00
Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology (1994) 0.99
Glucose transport activity in skeletal muscles from transgenic mice overexpressing GLUT1. Increased basal transport is associated with a defective response to diverse stimuli that activate GLUT4. J Biol Chem (1994) 0.99
The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry (1997) 0.96
Hyperinsulinemia in transgenic mice carrying multiple copies of the human insulin gene. Dev Genet (1989) 0.95
Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia. Endocrinology (1996) 0.93
Expression of human GLUT4 in mice results in increased insulin action. Diabetologia (1994) 0.92
Insulin decreases phosphoenolpyruvate carboxykinase (GTP) mRNA activity by a receptor-mediated process. J Biol Chem (1982) 0.92
Differential effects of GLUT-1 or GLUT-4 overexpression on insulin responsiveness in transgenic mice. Am J Physiol (1994) 0.91
Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism. J Clin Invest (1997) 0.91
Mechanisms of hormone resistance: lessons from insulin-resistant patients. Acta Paediatr Suppl (1994) 0.89
Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis. Diabetologia (1998) 0.88
Insulin receptor autophosphorylation occurs asymmetrically. J Biol Chem (1993) 0.87
Transgenic approaches to the pathogenesis of NIDDM. Diabetes (1994) 0.87
Expression of an insulin-responsive glucose transporter (GLUT4) minigene in transgenic mice: effect of exercise and role in glucose homeostasis. Proc Natl Acad Sci U S A (1995) 0.86
Insulin stimulation of mitogen-activated protein kinase, p90rsk, and p70 S6 kinase in skeletal muscle of normal and insulin-resistant mice. Implications for the regulation of glycogen synthase. J Biol Chem (1995) 0.86
Regulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice. Proc Natl Acad Sci U S A (1993) 0.85
Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors. FEBS Lett (1998) 0.85
The diabetogenes concept of NIDDM. Adv Exp Med Biol (1993) 0.84
Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling. Ann N Y Acad Sci (1995) 0.83
Impaired insulin signaling in skeletal muscles from transgenic mice expressing kinase-deficient insulin receptors. J Biol Chem (1995) 0.81
A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells. Proc Natl Acad Sci U S A (1995) 0.80
The obese strain chicken as a model for human Hashimoto's thyroiditis. Exp Clin Endocrinol Diabetes (1996) 0.79
Genetically engineered mice as animal models for NIDDM. FEBS Lett (1997) 0.79
Phenotype of transgenic mice overexpressing GLUT4 and hexokinase II in muscle. FASEB J (1997) 0.79
Insulin dependence of murine lymphoid T-cell leukemia. Int J Cancer (1992) 0.79
A new transgenic mouse model of chronic hyperglycemia. Diabetes (1994) 0.78
Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice. Gene (1994) 0.77
Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation. J Clin Invest (1993) 0.77
Mitogenic potential of insulin on lymphoma cells lacking IGF-1 receptor. Ann N Y Acad Sci (1995) 0.76
Constitutive (pro)insulin release from pancreas of transgenic mice expressing monomeric insulin. Endocrinology (1995) 0.76
Genetic manipulation of insulin action and beta-cell function in mice. Mol Cell Biochem (1998) 0.76
Muscle-specific expression of human insulin receptor in transgenic mice. Diabetes (1993) 0.75
Phenotypic alterations in insulin-deficient mutant mice. Proc Natl Acad Sci U S A (1997) 2.15
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest (1976) 2.12
Physiological functions of protein kinase B/Akt. Biochem Soc Trans (2004) 2.00
Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J (1996) 1.95
Cooperativity in ligand binding: a new graphic analysis. Biochem Biophys Res Commun (1975) 1.87
Compensatory responses in mice carrying a null mutation for Ins1 or Ins2. Diabetes (2001) 1.72
Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. Proc Natl Acad Sci U S A (1993) 1.66
Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases. Clin Exp Immunol (2014) 1.66
Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem (2000) 1.66
tRNA-like structures of plant viral RNAs: conformational requirements for adenylation and aminoacylation. EMBO J (1983) 1.59
Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin. Nature (1978) 1.55
Insulin-induced dissociation of its receptor into subunits: possible molecular concomitant of negative cooperativity. Biochem Biophys Res Commun (1976) 1.51
Thermosensitive block of the Sabin strain of poliovirus type I. J Virol (1972) 1.48
Receptors for insulin, NSILA-s, and growth hormone: applications to disease states in man. Recent Prog Horm Res (1975) 1.47
Mitogenic properties of insulin and insulin analogues mediated by the insulin receptor. Diabetologia (1997) 1.45
Cooperative properties of hormone receptors in cell membranes. J Supramol Struct (1976) 1.43
Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose. J Biol Chem (1998) 1.41
Glucose-dependent liver gene expression in upstream stimulatory factor 2 -/- mice. J Biol Chem (1997) 1.34
Promoter, enhancer and silencer elements regulate rearrangement of an immunoglobulin transgene. EMBO J (1993) 1.34
Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone. Endocrinology (1978) 1.18
Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin. Endocrinology (2002) 1.16
Intracellular potassium depletion in IM-9 lymphocytes suppresses the slowly dissociating component of human growth hormone binding and the down-regulation of its receptors but does not affect insulin receptors. Proc Natl Acad Sci U S A (1986) 1.15
Binding and degradation of insulin by human peripheral granulocytes. Demonstration of specific receptors with high affinity. J Biol Chem (1976) 1.13
Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice. Nature (1987) 1.11
Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins. Biochem Biophys Res Commun (1981) 1.10
Cell surface receptors for insulin and human growth hormone. Effect of microtubule and microfilament modifiers. J Biol Chem (1976) 1.09
Inhibition of poliovirus RNA synthesis by supraoptimal temperatures. J Gen Virol (1970) 1.06
Mechanism of synthesis of turnip yellow mosaic virus coat protein subgenomic RNA in vivo. Virology (1989) 1.03
Purification of the Sabin strain of poliovirus type I through treatment with sarkozyl. J Virol (1971) 1.01
Pancreatic expression of human insulin gene in transgenic mice. Proc Natl Acad Sci U S A (1986) 1.01
Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways. Biochem J (1997) 1.01
Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes. Endocrinology (1994) 0.99
Ionic conditions for the cleavage of the tRNA-like structure of turnip yellow mosaic virus by the catalytic RNA of RNase P. J Biol Chem (1988) 0.98
Thermodynamics of the interaction of insulin with its receptor. J Biol Chem (1979) 0.97
Imprinting at the mouse Ins2 locus: evidence for cis- and trans-allelic interactions. Genomics (1998) 0.96
Carbohydrate metabolism in women who used oral contraceptives containing levonorgestrel or desogestrel: a 6-month prospective study. Fertil Steril (1986) 0.96
Altered structure of HLA class I heavy chains associated with mouse beta-2 microglobulin. Immunogenetics (1985) 0.95
An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events. Diabetologia (2002) 0.95
A new 'sense' RNA approach to block viral RNA replication in vitro. Nucleic Acids Res (1987) 0.94
Regulatory regions of rat insulin I gene necessary for expression in transgenic mice. Nucleic Acids Res (1991) 0.94
Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice. Mol Endocrinol (1990) 0.94
Identification of determinants that confer ligand specificity on the insulin receptor. J Biol Chem (1992) 0.94
The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model. Diabetologia (1994) 0.93
Biosensor measurement of the binding of insulin-like growth factors I and II and their analogues to the insulin-like growth factor-binding protein-3. J Biol Chem (1996) 0.92
Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16. Transl Psychiatry (2011) 0.92
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. Curr Biol (1995) 0.91
Differential expression of two linked selection genes (HSVI-tk and Eco.gpt) in transformed teratocarcinoma and in L cells. J Cell Physiol (1985) 0.90
Chromosome localization of the human insulin gene in transgenic mouse lines. Hum Genet (1988) 0.90
Tissue-specific expression of the rat insulin 1 gene in vivo requires both the enhancer and promoter regions. Differentiation (1995) 0.90
Inhibition by insulin of glucocorticoid-induced gene transcription: involvement of the ligand-binding domain of the glucocorticoid receptor and independence from the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways. Mol Endocrinol (1998) 0.90
Sphingosine, an inhibitor of protein kinase C, suppresses the insulin-like effects of growth hormone in rat adipocytes. Proc Natl Acad Sci U S A (1989) 0.90
The insulin receptor in vertebrates is functionally more conserved during evolution than insulin itself. Endocrinology (1979) 0.89
"Endless" viral DNA in cells infected with channel catfish virus. J Virol (1983) 0.89
Negative cooperativity in the insulin-like growth factor-I receptor and a chimeric IGF-I/insulin receptor. Endocrinology (1994) 0.89
Interaction of p85 subunit of PI 3-kinase with insulin and IGF-1 receptors analysed by using the two-hybrid system. FEBS Lett (1995) 0.88
Pancreatic hormone receptors on islet cells. Endocrinology (1985) 0.88
Short stature associated with a novel heterozygous mutation in the insulin-like growth factor 1 gene. J Clin Endocrinol Metab (2010) 0.87
Allelic exclusion in transgenic mice expressing a heavy chain disease-like human mu protein. Eur J Immunol (1991) 0.87
The insulin-like growth factors and insulin-signalling systems: an appealing target for breast cancer therapy? Horm Metab Res (2004) 0.87
Glycosylation of cell surface receptors: tunicamycin treatment decreases insulin and growth hormone binding to different levels in cultured lymphocytes. Biochem Biophys Res Commun (1981) 0.87
Receptor binding properties and insulin-like effects of human growth hormone and its 20 kDa-variant in rat adipocytes. J Biol Chem (1987) 0.87
Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytes. Biochem Biophys Res Commun (1987) 0.86
Inhibition of HIV-1 multiplication in a human CD4+ lymphocytic cell line expressing antisense and sense RNA molecules containing HIV-1 packaging signal and Rev response element(s). Antisense Res Dev (1994) 0.86
IGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells. FEBS Lett (2001) 0.86
Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor. Biochem Biophys Res Commun (1988) 0.86
SysBioMed report: advancing systems biology for medical applications. IET Syst Biol (2009) 0.86
Insulin receptor-deficient cells as a new tool for dissecting complex interplay in insulin and insulin-like growth factors. FEBS Lett (1998) 0.85
Modelling of the disulphide-swapped isomer of human insulin-like growth factor-1: implications for receptor binding. Protein Eng (1999) 0.85
Negative and positive site-site interactions, and their modulation by pH, insulin analogs, and monoclonal antibodies, are preserved in the purified insulin receptor. Proc Natl Acad Sci U S A (1988) 0.84
Conformational requirements of tobacco mosaic virus RNA for aminoacylation and adenylation. Nucleic Acids Res (1985) 0.83
Mitogenic and antiadipogenic properties of human growth hormone in differentiating human adipocyte precursor cells in primary culture. Pediatr Res (1996) 0.83
Insulin and insulin-like growth factor-I receptor mediated differentiation of 3T3-F442A cells into adipocytes: effect of PI 3-kinase inhibition. Biochem Biophys Res Commun (1998) 0.82
A rapid method for the preparation of 125I-labelled human growth hormone for receptor studies, using reverse-phase high performance liquid chromatography. Biochem Biophys Res Commun (1986) 0.82
Structural features in aminoacyl-tRNAs required for recognition by elongation factor Tu. FEBS Lett (1987) 0.82
Acridine orange, an inhibitor of protein kinase C, abolishes insulin and growth hormone stimulation of lipogenesis in rat adipocytes. FEBS Lett (1989) 0.81
The receptor binding properties of the 20K variant of human growth hormone explain its discrepant insulin-like and growth promoting activities. Biochem Biophys Res Commun (1986) 0.81
Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: application to the Tyr----Phe 960 insulin receptor mutant. Biochem Biophys Res Commun (1989) 0.81
Biological effects of human growth hormone in rat adipocyte precursor cells and newly differentiated adipocytes in primary culture. Metabolism (1996) 0.81
Regulation of receptor by homologous hormone enhances sensitivity and broadens scope of radioreceptor assay for human growth hormone. J Clin Endocrinol Metab (1979) 0.81
Human insulin gene insertion in mice. Effects on the sleep-wake cycle? J Sleep Res (1999) 0.81
Engineering the C-region of human insulin-like growth factor-1: implications for receptor binding. Protein Eng (1996) 0.81
Transgenic expression of Fas ligand on thyroid follicular cells prevents autoimmune thyroiditis. J Immunol (2000) 0.80
Human growth hormone increases cytosolic free calcium in cultured human IM-9 lymphocytes: a novel mechanism of growth hormone transmembrane signalling. Biochem Biophys Res Commun (1994) 0.80
Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding. Biochem J (1999) 0.80
Expression of human F8B, a gene nested within the coagulation factor VIII gene, produces multiple eye defects and developmental alterations in chimeric and transgenic mice. Hum Mol Genet (1999) 0.80