Published in J Biol Chem on October 23, 1998
Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J (2003) 10.77
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J (2000) 2.33
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J (2000) 2.24
A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. Proc Natl Acad Sci U S A (1999) 2.07
IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain. Mol Cell Biochem (2006) 1.54
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev (2006) 1.53
Inborn errors of human STAT1: allelic heterogeneity governs the diversity of immunological and infectious phenotypes. Curr Opin Immunol (2012) 1.51
Regulation of Stat3 nuclear export. J Clin Invest (2003) 1.46
Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A (2008) 1.43
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A (2000) 1.28
Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol (2004) 1.25
STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. Exp Hematol (2007) 1.19
Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol Cell Biol (2000) 1.04
Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway. J Biol Chem (2005) 1.01
Alternative ways of modulating JAK-STAT pathway: Looking beyond phosphorylation. JAKSTAT (2012) 0.99
New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain. J Biol Chem (2009) 0.94
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res (1999) 0.87
The Specific Roles of JAK/STAT Signaling Pathway in Sepsis. Inflammation (2015) 0.81
Protein tyrosine phosphatases as wardens of STAT signaling. JAKSTAT (2014) 0.80
Roles of STATs signaling in cardiovascular diseases. JAKSTAT (2012) 0.78
Cytokine-induced nuclear translocation of signaling proteins and their analysis using the inducible translocation trap system. Cytokine (2008) 0.77
Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology (2001) 5.80
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 5.71
The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction. Nature (1993) 5.24
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev (2000) 4.24
Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science (1994) 4.24
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature (1993) 4.20
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice. J Clin Invest (1997) 4.18
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A (1992) 3.74
Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation. Science (1993) 3.57
Requirement of serine phosphorylation for formation of STAT-promoter complexes. Science (1995) 3.07
Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Science (1995) 2.74
Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD. Thorax (2008) 2.71
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene (1995) 2.50
Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med (1997) 2.45
Immune response in Stat2 knockout mice. Immunity (2000) 2.37
Increased incidence of Guillain-Barré syndrome after surgery. Eur J Neurol (2012) 2.32
Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology (2000) 2.21
Interleukin-3 signals through multiple isoforms of Stat5. EMBO J (1995) 2.12
Home versus hospital deliveries: follow up study of matched pairs for procedures and outcome. Zurich Study Team. BMJ (1996) 2.10
Traffic-related air pollution correlates with adult-onset asthma among never-smokers. Thorax (2009) 2.09
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. Eur Respir J (2009) 2.08
The genomic structure of the murine ICSBP gene reveals the presence of the gamma interferon-responsive element, to which an ISGF3 alpha subunit (or similar) molecule binds. Mol Cell Biol (1993) 2.06
Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project. Eur Respir J (2006) 2.00
Candidate genes for the hypoxic tumor phenotype. Cancer Res (2000) 1.94
SAPALDIA: methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults. Soz Praventivmed (1997) 1.88
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc Natl Acad Sci U S A (1994) 1.83
Influence of selenium supplements on the post-traumatic alterations of the thyroid axis: a placebo-controlled trial. Intensive Care Med (2001) 1.78
Neurofilament heavy chain in CSF correlates with relapses and disability in multiple sclerosis. Neurology (2011) 1.75
Plastic neuronal remodeling is impaired in patients with Alzheimer's disease carrying apolipoprotein epsilon 4 allele. J Neurosci (1997) 1.73
The signalling pathways of interleukin-6 and gamma interferon converge by the activation of different transcription factors which bind to common responsive DNA elements. Mol Cell Biol (1994) 1.70
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol Cell Biol (1994) 1.67
Portosystemic hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with cirrhosis: clinical, laboratory, psychometric, and electroencephalographic investigations. Hepatology (1998) 1.65
Long-term ambient air pollution and respiratory symptoms in adults (SAPALDIA study). The SAPALDIA Team. Am J Respir Crit Care Med (1999) 1.65
Stat5 as a target for regulation by extracellular matrix. J Biol Chem (1995) 1.61
Lymphocytes are important in early atherosclerosis. J Clin Invest (2001) 1.57
Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours. Eur J Nucl Med Mol Imaging (2013) 1.54
Early events in signalling by interferons. Trends Biochem Sci (1993) 1.50
Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort. Thorax (2009) 1.49
Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline. Occup Environ Med (2013) 1.47
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals. EMBO J (1996) 1.45
Comparison of the heparin coated vs the uncoated Jostent--no influence on restenosis or clinical outcome. Eur Heart J (2001) 1.43
Regulation of IFN-alpha/beta genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN-alpha/beta. Genes Cells (1996) 1.42
Respiratory health and long-term exposure to air pollutants in Swiss schoolchildren. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate and Pollen. Am J Respir Crit Care Med (1997) 1.41
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res (2000) 1.39
[Gastrointestinal bleeding during low dose acetylsalicylic acid. Is Godamed-100 TAH an alternative to conventional ASS preparations?]. Dtsch Med Wochenschr (2005) 1.38
[Fractures of vital teeth under chronic pain therapy with oxycodone]. Dtsch Med Wochenschr (2006) 1.38
Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science (1993) 1.37
Activation of the transcription factor ISGF3 by interferon-gamma. Biol Chem (1999) 1.35
Distribution of the mammalian Stat gene family in mouse chromosomes. Genomics (1995) 1.31
Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study. Thorax (2006) 1.30
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction. Proc Natl Acad Sci U S A (2000) 1.28
Lung function in healthy never smoking adults: reference values and lower limits of normal of a Swiss population. Thorax (1996) 1.26
IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population. SAPALDIA (Swiss Study on Air Pollution and Lung Diseases in Adults) Team. Int Arch Allergy Immunol (1996) 1.26
Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction. FEBS Lett (1995) 1.26
Role of current and childhood exposure to cat and atopic sensitization. European Community Respiratory Health Survey. J Allergy Clin Immunol (1999) 1.25
Murine Stat2 is uncharacteristically divergent. Nucleic Acids Res (1999) 1.25
Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Swiss Study on Air Pollution and Lung Diseases in Adults. Int Arch Allergy Immunol (1995) 1.23
Functionally distinct isoforms of STAT5 are generated by protein processing. Immunity (1997) 1.22
Validity of annoyance scores for estimation of long term air pollution exposure in epidemiologic studies: the Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Epidemiol (2000) 1.22
Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial. Am J Clin Nutr (1998) 1.21
Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophages. Mol Cell Biol (1995) 1.20
Prevalence of airflow obstruction in smokers and never-smokers in Switzerland. Eur Respir J (2010) 1.20
Relationship of physical activity with motor skills, aerobic fitness and body fat in preschool children: a cross-sectional and longitudinal study (Ballabeina). Int J Obes (Lond) (2011) 1.18
Clinical diagnosis of current asthma: predictive value of respiratory symptoms in the SAPALDIA study. Swiss Study on Air Pollution and Lung Diseases in Adults. Eur Respir J (2001) 1.18
Reference equations for lung function screening of healthy never-smoking adults aged 18-80 years. Eur Respir J (2007) 1.16
Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells. Endocrinology (1996) 1.13
The temporal pattern of mortality responses to ambient ozone in the APHEA project. J Epidemiol Community Health (2009) 1.13
Short-term effects of ambient particles on mortality in the elderly: results from 28 cities in the APHEA2 project. Eur Respir J Suppl (2003) 1.12
The response of gamma interferon activation factor is under developmental control in cells of the macrophage lineage. Mol Cell Biol (1993) 1.11
Mutant cell lines unresponsive to alpha/beta and gamma interferon are defective in tyrosine phosphorylation of ISGF-3 alpha components. Mol Cell Biol (1994) 1.10
Personal exposure to nitrogen dioxide in Switzerland. SAPALDIA team. Swiss Study on Air Pollution and Lung Diseases in Adults. Sci Total Environ (1998) 1.08
Protein transport in intact, purified pea etioplasts. Arch Biochem Biophys (1986) 1.06
Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors. Am J Ind Med (2001) 1.05
Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study. Osteoporos Int (2008) 1.05
The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor. J Biol Chem (1993) 1.04
A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site. Mol Cell Biol (1994) 1.02
Long-term effects of a partially supervised conditioning programme in cystic fibrosis. Eur Respir J (2009) 1.01
Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults. Thorax (2007) 1.01
Re-estimated equations for 5th percentiles of lung function variables. Thorax (2000) 1.00
Variability of FVC and FEV1 due to technician, team, device and subject in an eight centre study: three quality control studies in SAPALDIA. Swiss Study on Air Pollution and Lung Disease in Adults. Eur Respir J (1995) 0.99
Myeloid differentiation of FdCP1 cells is dependent on Stat5 processing. Blood (2000) 0.99
Reduced cardiorespiratory fitness, low physical activity and an urban environment are independently associated with increased cardiovascular risk in children. Diabetologia (2008) 0.98
Retinoic acid enhances the expression of interferon-induced proteins: evidence for multiple mechanisms of action. Oncogene (1997) 0.97
Growth hormone specifically regulates serine protease inhibitor gene transcription via gamma-activated sequence-like DNA elements. J Biol Chem (1994) 0.94
Clinically "small" effects of air pollution on FVC have a large public health impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - team. Eur Respir J (2000) 0.92
Agreement between spirometers: a challenge in the follow-up of patients and populations? Respiration (2013) 0.92
Alterations of thymus cortical epithelium and interdigitating dendritic cells but no increase of thymocyte cell death in the early course of simian immunodeficiency virus infection. Am J Pathol (1993) 0.92
Pattern of prescriptions issued by nursing home-based physicians versus office-based physicians for frail elderly patients in German nursing homes. Pharmacoepidemiol Drug Saf (2003) 0.92
Visual and motor evoked potentials in the course of multiple sclerosis. Brain (2001) 0.90
Prediction of long-term disability in multiple sclerosis. Mult Scler (2011) 0.90
Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells. Endocrinology (1996) 0.90
HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. Eur Respir J (2010) 0.89
Effects of infused sodium acetate, sodium lactate, and sodium beta-hydroxybutyrate on energy expenditure and substrate oxidation rates in lean humans. Am J Clin Nutr (1993) 0.89
Sensitisation to Ambrosia in Switzerland: a public health threat on the wait. Swiss Med Wkly (2009) 0.89