Published in JAKSTAT on February 20, 2014
Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs. J Immunol (2015) 0.91
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. J Allergy Clin Immunol (2017) 0.80
Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer. Oncotarget (2017) 0.77
Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL Leukemia. Cancer Biol Ther (2016) 0.76
E3 ubiquitin ligase NKLAM ubiquitinates STAT1 and positively regulates STAT1-mediated transcriptional activity. Cell Signal (2016) 0.75
Mechanisms and consequences of Jak-STAT signaling in the immune system. Nat Immunol (2017) 0.75
DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro (2017) 0.75
Stat3 as an oncogene. Cell (1999) 17.39
Protein tyrosine phosphatases in the human genome. Cell (2004) 8.09
Protein tyrosine phosphatases: from genes, to function, to disease. Nat Rev Mol Cell Biol (2006) 7.93
Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science (1999) 7.84
The JAK-STAT pathway at twenty. Immunity (2012) 4.41
Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell (1995) 4.32
Serine phosphorylation of STATs. Oncogene (2000) 4.21
Somatic STAT3 mutations in large granular lymphocytic leukemia. N Engl J Med (2012) 4.15
Dual-specificity phosphatases: critical regulators with diverse cellular targets. Biochem J (2009) 3.98
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med (2011) 3.63
Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol Cell Biol (2002) 3.57
Structural and evolutionary relationships among protein tyrosine phosphatase domains. Mol Cell Biol (2001) 3.37
Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation. Mol Cell Biol (1998) 3.23
STAT proteins: from normal control of cellular events to tumorigenesis. J Cell Physiol (2003) 3.04
Identification of JAK/STAT signalling components by genome-wide RNA interference. Nature (2005) 2.90
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity (2012) 2.85
TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem (2001) 2.65
The rapid inactivation of nuclear tyrosine phosphorylated Stat1 depends upon a protein tyrosine phosphatase. EMBO J (1996) 2.50
CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature (2001) 2.47
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell (2011) 2.46
Activation of the JAK-STAT pathway by reactive oxygen species. Am J Physiol (1998) 2.37
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol Cell Biol (1996) 2.30
Roles of unphosphorylated STATs in signaling. Cell Res (2008) 2.27
Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell (2005) 2.26
Protein tyrosine phosphatase function: the substrate perspective. Biochem J (2007) 2.17
The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proc Natl Acad Sci U S A (2009) 2.09
Phosphotyrosine signaling: evolving a new cellular communication system. Cell (2010) 2.09
Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. J Exp Med (2011) 2.03
A phosphorylation-acetylation switch regulates STAT1 signaling. Genes Dev (2009) 1.98
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A (2007) 1.87
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia. Blood (2013) 1.80
The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. Blood (2005) 1.80
Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5. Cancer Cell (2009) 1.78
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A (2009) 1.78
SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev (2009) 1.78
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev (2009) 1.73
Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol Cell Biol (1996) 1.68
Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle. Proc Natl Acad Sci U S A (2005) 1.68
Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transduction. FEBS J (2013) 1.68
Shp1 regulates T cell homeostasis by limiting IL-4 signals. J Exp Med (2013) 1.64
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity (2005) 1.64
Cytosolic tyrosine dephosphorylation of STAT5. Potential role of SHP-2 in STAT5 regulation. J Biol Chem (2000) 1.63
Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell (2008) 1.62
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun (2002) 1.62
Structure, function, and regulation of STAT proteins. Mol Biosyst (2006) 1.58
Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain. Genes Dev (2006) 1.53
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood (2006) 1.50
Regulation of protein tyrosine phosphatases by reversible oxidation. J Biochem (2011) 1.48
Retracted A cytosolic protein-tyrosine phosphatase PTP1B specifically dephosphorylates and deactivates prolactin-activated STAT5a and STAT5b. J Biol Chem (2000) 1.45
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem (2002) 1.44
Reactive oxygen species mediate virus-induced STAT activation: role of tyrosine phosphatases. J Biol Chem (2003) 1.42
The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5. J Biol Chem (2003) 1.42
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood (2008) 1.32
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Mol Cell Biol (2006) 1.32
Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol (2006) 1.31
Identification of Shp-2 as a Stat5A phosphatase. J Biol Chem (2003) 1.23
Amino-terminal signal transducer and activator of transcription (STAT) domains regulate nuclear translocation and STAT deactivation. J Biol Chem (1998) 1.22
Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab (2011) 1.21
T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Mol Cell Biol (2007) 1.20
Suppression of cytokine signaling: the SOCS perspective. Cytokine Growth Factor Rev (2013) 1.20
Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3. Mol Cancer Ther (2011) 1.19
MAPPIT: a protein interaction toolbox built on insights in cytokine receptor signaling. Cytokine Growth Factor Rev (2011) 1.17
Protein tyrosine phosphatases: regulatory mechanisms. FEBS J (2008) 1.15
Regulation of the dephosphorylation of Stat6. Participation of Tyr-713 in the interleukin-4 receptor alpha, the tyrosine phosphatase SHP-1, and the proteasome. J Biol Chem (2002) 1.13
STAT3-stathmin interactions control microtubule dynamics in migrating T-cells. J Biol Chem (2009) 1.13
Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase. J Biol Chem (2002) 1.10
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity (2007) 1.09
Constitutive activation of STAT5 by a point mutation in the SH2 domain. J Biol Chem (2000) 1.09
SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood (2011) 1.08
PTP1B and TC-PTP: regulators of transformation and tumorigenesis. Cancer Metastasis Rev (2008) 1.07
Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase. J Immunol (2007) 1.05
Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem (2006) 1.05
Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase. Development (2008) 1.04
A Mutation in the SH2 domain of STAT2 prolongs tyrosine phosphorylation of STAT1 and promotes type I IFN-induced apoptosis. Mol Biol Cell (2007) 1.01
Protein tyrosine phosphatases: functional inferences from mouse models and human diseases. FEBS J (2008) 1.01
High-throughput RNAi screening to dissect cellular pathways: a how-to guide. Biotechnol J (2010) 1.00
Regulation of STAT signaling by acetylation. Cell Signal (2013) 0.99
Modulation of leptin resistance by protein tyrosine phosphatases. Cell Metab (2012) 0.99
Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities. Biochim Biophys Acta (2013) 0.98
Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling. Biochem J (2002) 0.97
Acetylation modulates the STAT signaling code. Cytokine Growth Factor Rev (2012) 0.97
Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. J Biol Chem (2009) 0.96
A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells. Blood (2011) 0.96
Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation (2012) 0.96
Central regulation of metabolism by protein tyrosine phosphatases. Front Neurosci (2013) 0.96
Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. Biol Chem (2010) 0.94
Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS One (2012) 0.94
From the nucleus to the mitochondria and back: the odyssey of a multitask STAT3. Cell Cycle (2011) 0.93
TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers. Mol Cell Biol (2012) 0.93
TULA-family proteins: a new class of cellular regulators. J Cell Physiol (2013) 0.90
Primary familial polycythaemia associated with a novel point mutation in the erythropoietin receptor. Br J Haematol (1997) 0.90
Local axonal function of STAT3 rescues axon degeneration in the pmn model of motoneuron disease. J Cell Biol (2012) 0.90
Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene (2012) 0.90
Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases. Endocr J (2009) 0.89
Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3. Hepatology (2012) 0.89
Protein tyrosine phosphatase epsilon affects body weight by downregulating leptin signaling in a phosphorylation-dependent manner. Cell Metab (2011) 0.88
Identification and expression of the family of classical protein-tyrosine phosphatases in zebrafish. PLoS One (2010) 0.87
Identification of the kinase that activates a nonmetazoan STAT gives insights into the evolution of phosphotyrosine-SH2 domain signaling. Proc Natl Acad Sci U S A (2012) 0.84
Computational analysis of protein tyrosine phosphatases: practical guide to bioinformatics and data resources. Methods (2005) 0.83
Identification of STAT2 serine 287 as a novel regulatory phosphorylation site in type I interferon-induced cellular responses. J Biol Chem (2012) 0.82