Published in J Biochem on December 01, 1998
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet (2001) 6.56
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron (2008) 3.08
Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci U S A (2002) 2.93
Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet (2004) 2.70
Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling. Mol Cell Biol (2005) 2.00
Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation (2005) 1.88
Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone. J Bone Miner Res (2009) 1.85
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. Proc Natl Acad Sci U S A (2007) 1.84
LRP5 and LRP6 in development and disease. Trends Endocrinol Metab (2013) 1.21
Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition. PLoS One (2013) 1.08
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells. Biochemistry (2010) 0.98
Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance. Genes Dis (2016) 0.97
LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease. Front Physiol (2012) 0.96
The role of Lrp5/6 in cardiac valve disease: LDL-density-pressure theory. J Cell Biochem (2011) 0.92
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast. Mol Cell Biol (2015) 0.92
Analysis of a two-domain binding site for the urokinase-type plasminogen activator-plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein. Biochem J (2001) 0.90
The generation and function of soluble apoE receptors in the CNS. Mol Neurodegener (2006) 0.89
The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice. J Cell Biochem (2011) 0.87
Mechanisms of aortic valve calcification: the LDL-density-radius theory: a translation from cell signaling to physiology. Am J Physiol Heart Circ Physiol (2009) 0.85
Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia. Clin Exp Med (2007) 0.76
New horizons for lipoprotein receptors: communication by β-propellers. J Lipid Res (2013) 0.75
Shunts, channels and lipoprotein endosomal traffic: a new model of cholesterol homeostasis in the hepatocyte. J Biomed Res (2017) 0.75
Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis. Osteoporos Int (2017) 0.75
Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol (1970) 13.32
The International Registry of Acute Aortic Dissection (IRAD): new insights into an old disease. JAMA (2000) 12.26
Effect of a new immunosuppressive agent, FK 506, on heterotopic cardiac allotransplantation in the rat. Transplant Proc (1987) 12.04
Structural parts involved in activation and inactivation of the sodium channel. Nature (1989) 8.72
Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet (2000) 7.83
New topoisomerase essential for chromosome segregation in E. coli. Cell (1990) 7.19
On the process of cellular division in Escherichia coli: a series of mutants of E. coli altered in the penicillin-binding proteins. Proc Natl Acad Sci U S A (1978) 6.93
Cell-free translation reconstituted with purified components. Nat Biotechnol (2001) 6.55
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature (1997) 5.55
Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1. Nature (1994) 5.00
A two-step mechanism for the interaction of estradiol with rat uterus. Proc Natl Acad Sci U S A (1968) 4.77
On the process of cellular division in Escherichia coli: a mutant of E. coli lacking a murein-lipoprotein. Proc Natl Acad Sci U S A (1977) 4.58
Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nat Genet (1995) 4.45
Mutants of Escherichia coli lacking in highly penicillin-sensitive D-alanine carboxypeptidase activity. Proc Natl Acad Sci U S A (1977) 4.44
Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc Natl Acad Sci U S A (1998) 4.40
Incomplete flagellar structures in nonflagellate mutants of Salmonella typhimurium. J Bacteriol (1978) 4.07
Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J Biol Chem (2000) 4.02
Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med (2000) 3.74
Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels. Br J Pharmacol (1988) 3.66
Gene fliA encodes an alternative sigma factor specific for flagellar operons in Salmonella typhimurium. Mol Gen Genet (1990) 3.49
On the process of cellular division in Escherichia coli: nucleotide sequence of the gene for penicillin-binding protein 3. Mol Gen Genet (1983) 3.43
Microarray fabrication with covalent attachment of DNA using bubble jet technology. Nat Biotechnol (2000) 3.38
Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. Nat Genet (1998) 3.38
A novel transcriptional regulation mechanism in the flagellar regulon of Salmonella typhimurium: an antisigma factor inhibits the activity of the flagellum-specific sigma factor, sigma F. Mol Microbiol (1992) 3.31
Primary structure of the alpha-subunit of transducin and its relationship to ras proteins. Nature (1985) 3.28
Purification and characterization of a novel type of fimbriae from the oral anaerobe Bacteroides gingivalis. J Bacteriol (1984) 3.27
A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc Natl Acad Sci U S A (1999) 3.26
The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery. J Physiol (1977) 3.24
Sialic acid species as a determinant of the host range of influenza A viruses. J Virol (2000) 3.10
Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem (1997) 3.09
Excitation-contraction coupling in the smooth muscle cells of the rabbit main pulmonary artery. J Physiol (1977) 3.06
Sarin poisoning in Tokyo subway. Lancet (1995) 3.06
Genetic mapping with SNP markers in Drosophila. Nat Genet (2001) 3.02
Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol (1997) 3.02
Expression of functional sodium channels from cloned cDNA. Nature (1986) 2.95
NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J (2001) 2.94
Excitation--contraction coupling in smooth muscle cells of the guinea-pig mesenteric artery. J Physiol (1981) 2.92
Murein-lipoprotein of Escherichia coli: a protein involved in the stabilization of bacterial cell envelope. Mol Gen Genet (1978) 2.84
Eight genes in region 5 that form an operon are essential for invasion of epithelial cells by Shigella flexneri 2a. J Bacteriol (1993) 2.82
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Hepatitis B e antigen and infectivity of hepatitis B virus. J Infect Dis (1977) 2.80
The Arabidopsis AHK4 histidine kinase is a cytokinin-binding receptor that transduces cytokinin signals across the membrane. Plant Cell Physiol (2001) 2.79
Phase-field model for binary alloys. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics (1999) 2.79
Incomplete flagellar structures in Escherichia coli mutants. J Bacteriol (1981) 2.77
Long-term clinical outcomes after unprotected left main trunk percutaneous revascularization in 279 patients. Circulation (2001) 2.77
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II. FEBS Lett (1989) 2.73
Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro. Proc Natl Acad Sci U S A (1996) 2.69
Innervation and properties of the smooth muscle of the dog trachea. Jpn J Physiol (1976) 2.65
Factors modifying contraction-relaxation cycle in vascular smooth muscles. Am J Physiol (1982) 2.63
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res (1999) 2.62
Cortical mapping of gait in humans: a near-infrared spectroscopic topography study. Neuroimage (2001) 2.59
The role of cAMP in flagellation of Salmonella typhimurium. Mol Gen Genet (1976) 2.54
Purification and characterization of DNA topoisomerase IV in Escherichia coli. J Biol Chem (1992) 2.50
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans: coronary angiographic findings within 1 week before the onset of infarction. Circulation (2000) 2.42
Isolation and characterization of fra-2, an additional member of the fos gene family. Proc Natl Acad Sci U S A (1990) 2.40
Rhamnolipids produced by Pseudomonas aeruginosa grown on n-paraffin (mixture of C 12 , C 13 and C 14 fractions). J Antibiot (Tokyo) (1971) 2.39
Specific inhibition of adherence of an oral strain of Bacteroides gingivalis 381 to epithelial cells by monoclonal antibodies against the bacterial fimbriae. Arch Oral Biol (1988) 2.39
Differences in sialic acid-galactose linkages in the chicken egg amnion and allantois influence human influenza virus receptor specificity and variant selection. J Virol (1997) 2.38
Diverse molecular interactions of the hnRNP K protein. FEBS Lett (1997) 2.35
Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line. Mol Cell Biol (1986) 2.33
Gene organization in the region containing a new gene involved in chromosome partition in Escherichia coli. J Bacteriol (1988) 2.31
The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med (1997) 2.28
Metabolism of pentachlorophenol by a soil microbe. J Environ Sci Health B (1977) 2.28
Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J (2000) 2.27
Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery. J Physiol (1983) 2.26
Network theory in autoimmunity. In vitro suppression of serum anti-DNA antibody binding to DNA by anti-idiotypic antibody in systemic lupus erythematosus. J Clin Invest (1981) 2.24
The effects of acetylcholine on the membrane and contractile properties of smooth muscle cells of the rabbit superior mesenteric artery. Br J Pharmacol (1978) 2.23
Surgical significance of anatomic variations of the hepatic artery. Am J Surg (1971) 2.23
Synthetic ColE1 plasmids carrying genes for cell division in Escherichia coli. Plasmid (1977) 2.22
Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea-pig antrum. J Physiol (1999) 2.18
Cultivated corneal epithelial stem cell transplantation in ocular surface disorders. Ophthalmology (2001) 2.16
Effects of endogenous and exogenous noradrenaline on the smooth muscle of guinea-pig mesenteric vein. J Physiol (1981) 2.16
In vitro peptidoglycan polymerization catalysed by penicillin binding protein 1b of Escherichia coli K-12. FEBS Lett (1980) 2.14
Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra. Br J Pharmacol (1996) 2.11
Congenital progressive muscular dystrophy of the Fukuyama type - clinical, genetic and pathological considerations. Brain Dev (1981) 2.11
Absence of messenger ribonucleic acid specific for flagellin in non-flagellate mutants of Salmonella. J Mol Biol (1975) 2.10
Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability. Cancer Res (1999) 2.09
Primary structure of chicken skeletal muscle and fibroblast alpha-actinins deduced from cDNA sequences. Eur J Biochem (1988) 2.08
Nucleotide sequence of the streptothricin acetyltransferase gene from Streptomyces lavendulae and its expression in heterologous hosts. J Bacteriol (1987) 2.08
White ball appearance in endoscopic ligation of bleeding esophageal varices. Gastrointest Endosc (1998) 2.08
Role of the scavenger receptor MARCO in alveolar macrophage binding of unopsonized environmental particles. J Exp Med (1999) 2.08
Point mutations in the WD40 domain of Eed block its interaction with Ezh2. Mol Cell Biol (1998) 2.08
Role of Norwalk virus in outbreaks of nonbacterial gastroenteritis. J Infect Dis (1979) 2.05
Structure and function of chicken gizzard myosin. J Biochem (1978) 2.05
Streptococcal cytoplasmic pH is regulated by changes in amount and activity of a proton-translocating ATPase. J Biol Chem (1986) 2.03
Effects of combination treatment with FK506 and cyclosporine on survival time and vascular changes in renal-allograft-recipient dogs. Transplantation (1989) 2.03
Adrenergic transmissions in the guinea-pig mesenteric artery and their cholinergic modulations. J Physiol (1981) 2.02
LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology (2001) 2.02
Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor. Proc Natl Acad Sci U S A (1987) 2.02
Catabolite repression of cellulase formation in Trichoderma viride. J Biochem (1972) 2.00
Walking speed as a good predictor for the onset of functional dependence in a Japanese rural community population. Age Ageing (2000) 1.99
Genetic heterogeneity of the human glutathione transferases: a complex of gene families. Pharmacol Ther (1990) 1.99
Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. J Immunol (1992) 1.99
Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation. Cell (1996) 1.98
Predictors for functional decline among nondisabled older Japanese living in a community during a 3-year follow-up. J Am Geriatr Soc (2000) 1.98
Hyperpolarization of arterial smooth muscle induced by endothelial humoral substances. Am J Physiol (1991) 1.98
In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Biochem Biophys Res Commun (2000) 1.97
Expression of glucose transporter-1 in human gastric carcinoma: association with tumor aggressiveness, metastasis, and patient survival. Cancer (2001) 1.96