Published in J Biol Chem on December 11, 1998
Phospholipase D: molecular and cell biology of a novel gene family. Biochem J (2000) 2.27
Role for phospholipase D in receptor-mediated endocytosis. Mol Cell Biol (2001) 1.96
Phospholipase D2 localizes to the plasma membrane and regulates angiotensin II receptor endocytosis. Mol Biol Cell (2004) 1.93
Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Mol Cell Biol (2010) 1.25
The elucidation of novel SH2 binding sites on PLD2. Oncogene (2006) 1.15
Transmodulation between phospholipase D and c-Src enhances cell proliferation. Mol Cell Biol (2003) 1.15
Phospholipase D2 is localized to the rims of the Golgi apparatus in mammalian cells. Mol Biol Cell (2002) 1.12
Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes. Cell Physiol Biochem (2005) 1.05
Localization of phospholipase D1 to caveolin-enriched membrane via palmitoylation: implications for epidermal growth factor signaling. Mol Biol Cell (2002) 1.02
A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation. Mol Cell Biol (2010) 0.98
The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF. J Mol Biol (2007) 0.97
Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer. Pharmacol Rev (2014) 0.96
Activation of RBL-2H3 mast cells is dependent on tyrosine phosphorylation of phospholipase D2 by Fyn and Fgr. Mol Cell Biol (2004) 0.95
The uncovering of a novel regulatory mechanism for PLD2: formation of a ternary complex with protein tyrosine phosphatase PTP1B and growth factor receptor-bound protein GRB2. Biochem Biophys Res Commun (2005) 0.94
Heterogeneity of phosphatidic acid levels and distribution at the plasma membrane in living cells as visualized by a Föster resonance energy transfer (FRET) biosensor. J Biol Chem (2010) 0.93
The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF). Cell Signal (2011) 0.91
Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen. Mol Cancer Res (2009) 0.89
Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity. J Biol Chem (2012) 0.88
Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade. Biochem J (2000) 0.84
Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2). J Leukoc Biol (2012) 0.84
A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells. J Biol Chem (2013) 0.82
Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells. Sci Rep (2015) 0.78
A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. J Biol Chem (2015) 0.77
Generation of choline for acetylcholine synthesis by phospholipase D isoforms. BMC Neurosci (2001) 0.77
A Phosphatidic Acid (PA) conveyor system of continuous intracellular transport from cell membrane to nucleus maintains EGF receptor homeostasis. Oncotarget (2016) 0.77
Human papillomavirus type 16 DNA sequence. Virology (1985) 9.44
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell (1995) 6.43
Albuminuria reflects widespread vascular damage. The Steno hypothesis. Diabetologia (1989) 5.68
Phosphatidylinositol 4-phosphate 5-kinase alpha is a downstream effector of the small G protein ARF6 in membrane ruffle formation. Cell (1999) 4.98
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂. Pharmacol Rev (2010) 4.31
Gonococcal pharyngeal infections. Report of 110 cases. Br J Vener Dis (1973) 4.24
Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol (1997) 3.22
Human ADP-ribosylation factor-activated phosphatidylcholine-specific phospholipase D defines a new and highly conserved gene family. J Biol Chem (1995) 3.10
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. Lancet (1992) 3.02
The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res (2001) 2.68
Phospholipase D: a lipid centric review. Cell Mol Life Sci (2005) 2.57
Identification of early proteins of the human papilloma viruses type 16 (HPV 16) and type 18 (HPV 18) in cervical carcinoma cells. EMBO J (1987) 2.56
Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J (1997) 2.49
Pre-operative radiotherapy prolongs survival in operable esophageal carcinoma: a randomized, multicenter study of pre-operative radiotherapy and chemotherapy. The second Scandinavian trial in esophageal cancer. World J Surg (1993) 2.18
A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother Oncol (1998) 2.07
Gonococcal tonsillar infections. Br Med J (1971) 2.06
Evaluation of peak expiratory flow variability in an adolescent population sample. The Odense Schoolchild Study. Am J Respir Crit Care Med (1994) 2.03
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem (1999) 2.02
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci (1993) 2.02
Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. J Antimicrob Chemother (1987) 2.00
Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network. J Cell Biol (1997) 1.97
Phospholipase D signaling is essential for meiosis. Proc Natl Acad Sci U S A (1995) 1.95
Decreased adreno-cortical suppression utilizing the Nebuhaler for inhalation of steroid aerosols. Clin Allergy (1987) 1.95
Population based study of risk factors for underdiagnosis of asthma in adolescence: Odense schoolchild study. BMJ (1998) 1.75
Antibodies against the human papillomavirus type 16 early proteins in human sera: correlation of anti-E7 reactivity with cervical cancer. J Natl Cancer Inst (1989) 1.72
The cystic fibrosis mutation (delta F508) does not influence the chloride channel activity of CFTR. Nat Genet (1993) 1.72
Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC gamma. EMBO J (1994) 1.68
Phospholipase D1: a key factor for the exocytotic machinery in neuroendocrine cells. EMBO J (2001) 1.67
Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. Lancet (1986) 1.60
Cardiolipin deficiency releases cytochrome c from the inner mitochondrial membrane and accelerates stimuli-elicited apoptosis. Cell Death Differ (2006) 1.55
Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J (1999) 1.54
Measurement of phospholipase D activity. Anal Biochem (1997) 1.53
Secular trends in physical fitness and obesity in Danish 9-year-old girls and boys: Odense School Child Study and Danish substudy of the European Youth Heart Study. Scand J Med Sci Sports (2004) 1.50
Molecular analysis of mammalian phospholipase D2. J Biol Chem (1999) 1.47
Outbreaks of gastroenteritis linked to lettuce, Denmark, January 2010. Euro Surveill (2010) 1.45
Ambulatory blood pressure in 570 Danes aged 19-21 years: the Odense Schoolchild Study. J Hum Hypertens (1998) 1.44
Effect of improved metabolic control on loss of kidney function in type 1 (insulin-dependent) diabetic patients: an update of the Steno studies. Diabetologia (1991) 1.43
Phosphotyrosine 1173 mediates binding of the protein-tyrosine phosphatase SHP-1 to the epidermal growth factor receptor and attenuation of receptor signaling. J Biol Chem (1998) 1.43
Low physical fitness in childhood is associated with the development of asthma in young adulthood: the Odense schoolchild study. Eur Respir J (2000) 1.43
Distinct determinants of human immunodeficiency virus type 1 RNA and DNA loads in vaginal and cervical secretions. J Infect Dis (1998) 1.43
Coronary heart disease in young type 1 (insulin-dependent) diabetic patients with and without diabetic nephropathy: incidence and risk factors. Diabetologia (1987) 1.41
Gestational age in relation to marine n-3 fatty acids in maternal erythrocytes: a study of women in the Faroe Islands and Denmark. Am J Obstet Gynecol (1991) 1.39
Nasal and sinonasal cancer. Connection with occupational exposures in Denmark, Finland and Sweden. Scand J Work Environ Health (1983) 1.38
Structure and regulation of phospholipase D. Trends Pharmacol Sci (1996) 1.37
15-hydroxyprostaglandin dehydrogenase. A review. Prostaglandins (1976) 1.35
Biological cardiovascular risk factors cluster in Danish children and adolescents: the European Youth Heart Study. Prev Med (2003) 1.32
Back pain reporting pattern in a Danish population-based sample of children and adolescents. Spine (Phila Pa 1976) (2001) 1.32
Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects. Eur Neuropsychopharmacol (2008) 1.28
Relationship between blood pressure and urinary albumin excretion in development of microalbuminuria. Diabetes (1990) 1.26
Management of Pseudomonas aeruginosa lung infection in Danish cystic fibrosis patients. Acta Paediatr Scand (1987) 1.24
Osteoradionecrosis of the jaws: clinical characteristics and relation to the field of irradiation. J Oral Maxillofac Surg (2000) 1.24
Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. Br J Nutr (1995) 1.22
Gestation length and birth weight in relation to intake of marine n-3 fatty acids. Br J Nutr (1995) 1.21
Structural analysis of human phospholipase D1. J Biol Chem (1999) 1.21
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. J Cell Biol (2000) 1.21
A role for phospholipase D1 in neurotransmitter release. Proc Natl Acad Sci U S A (2001) 1.20
Melanomas of the mucosa in the oral cavity and the upper respiratory passages. Cancer (1984) 1.20
Single-dose oral treatment of gonorrhea in men and women, using ampicillin alone and combined with probenecid. Br J Vener Dis (1971) 1.19
Interleukin-1beta-induced rat pancreatic islet nitric oxide synthesis requires both the p38 and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinases. J Biol Chem (1998) 1.19
Staining of celiac disease-relevant T cells by peptide-DQ2 multimers. J Immunol (2001) 1.19
Regulation of CFTR expression and function during differentiation of intestinal epithelial cells. EMBO J (1992) 1.18
Bradykinin B(2) receptor-mediated mitogen-activated protein kinase activation in COS-7 cells requires dual signaling via both protein kinase C pathway and epidermal growth factor receptor transactivation. Mol Cell Biol (1999) 1.18
Interrelationships between diagnosed asthma, asthma-like symptoms, and abnormal airway behaviour in adolescence: the Odense Schoolchild Study. Thorax (1996) 1.17
Expression of the human papillomavirus type 18 E7 gene by a cassette-vector system for the transcription and translation of open reading frames in eukaryotic cells. EMBO J (1987) 1.17
Differential expression of the mouse homeobox-containing gene Hox-1.4 during male germ cell differentiation and embryonic development. Proc Natl Acad Sci U S A (1987) 1.17
Phase II study of docetaxel and cisplatin in patients with recurrent or disseminated squamous-cell carcinoma of the head and neck. Ann Oncol (2000) 1.17
Human adenosine deaminase and its binding protein in normal and adenosine deaminase-deficient fibroblast cell strains. J Biol Chem (1980) 1.17
RalA interacts directly with the Arf-responsive, PIP2-dependent phospholipase D1. Biochem Biophys Res Commun (1997) 1.16
Implantable cardioverter defibrillator in a 4-month-old infant with cardiac arrest associated with a vascular heart tumor. Pacing Clin Electrophysiol (2001) 1.15
Identification of human papillomavirus type 16 E7 protein by monoclonal antibodies. J Gen Virol (1987) 1.14
Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner. J Biol Chem (2000) 1.14
Anandamide, but not 2-arachidonoylglycerol, accumulates during in vivo neurodegeneration. J Neurochem (2001) 1.13
Primary radiotherapy of larynx and pharynx carcinoma--an analysis of some factors influencing local control and survival. Int J Radiat Oncol Biol Phys (1986) 1.12
The mouse tissue plasminogen activator gene 5' flanking region directs appropriate expression in development and a seizure-enhanced response in the CNS. Development (1994) 1.11
Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J Immunol (1999) 1.11
Malignant epithelial tumors in the minor salivary glands, the submandibular gland, and the sublingual gland. Prognostic factors and treatment results. Cancer (1991) 1.11
Cloning and expression analysis of murine phospholipase D1. Biochem J (1997) 1.10
Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Evidence from feeding studies with oleate, linoleate, arachidonate, columbinate and alpha-linolenate. Biochim Biophys Acta (1985) 1.10
Dual requirement for rho and protein kinase C in direct activation of phospholipase D1 through G protein-coupled receptor signaling. Mol Biol Cell (2000) 1.10
Adrenocortical function in children on high-dose steroid aerosol therapy. Results of serum cortisol, ACTH stimulation test and 24 hour urinary free cortical excretion. Allergy (1987) 1.10
Effects of marked hyperthermia with and without dehydration on VO(2) kinetics during intense exercise. J Appl Physiol (1985) (2001) 1.09
Preoperative radiotherapy for esophageal carcinoma. Cochrane Database Syst Rev (2005) 1.08
Immunoglobulin A and immunoglobulin G antibody responses to alginates from Pseudomonas aeruginosa in patients with cystic fibrosis. J Clin Microbiol (1990) 1.08
Cohort study of predictive value of urinary albumin excretion for atherosclerotic vascular disease in patients with insulin dependent diabetes. BMJ (1996) 1.07
Does centralized treatment of cystic fibrosis increase the risk of Pseudomonas aeruginosa infection? Acta Paediatr Scand (1986) 1.07
Cervical human immunodeficiency virus type 1 shedding is associated with genital beta-chemokine secretion. J Infect Dis (1998) 1.06
Mammalian phospholipase D physiological and pathological roles. Acta Physiol (Oxf) (2011) 1.06
Chemotherapy versus chemotherapy plus irradiation in limited small cell lung cancer. Results of a controlled trial with 5 years follow-up. Br J Cancer (1986) 1.05
Cumulative and acute toxicity of repeated high-dose tobramycin treatment in cystic fibrosis. Antimicrob Agents Chemother (1987) 1.05
High-sensitive C-reactive protein is associated with reduced lung function in young adults. Eur Respir J (2008) 1.03
Loss of receptor regulation by a phospholipase D1 mutant unresponsive to protein kinase C. EMBO J (1999) 1.03
Both alpha and beta chain polymorphisms determine the specificity of the disease-associated HLA-DQ2 molecules, with beta chain residues being most influential. Immunogenetics (1996) 1.02
A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I-II non-Hodgkin's lymphomas. Cancer (1983) 1.02
Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. J Biol Chem (2000) 1.02
Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation. Radiother Oncol (1997) 1.01
Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett (1996) 1.00
Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J Biol Chem (1999) 1.00