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C Georgopoulos

Author PubWeight™ 226.50‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK. Proc Natl Acad Sci U S A 1991 5.96
2 The dnaK protein modulates the heat-shock response of Escherichia coli. Cell 1983 5.53
3 The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures. J Bacteriol 1989 4.81
4 Identification, characterization, and mapping of the Escherichia coli htrA gene, whose product is essential for bacterial growth only at elevated temperatures. J Bacteriol 1989 4.71
5 Sequence analysis and regulation of the htrA gene of Escherichia coli: a sigma 32-independent mechanism of heat-inducible transcription. Nucleic Acids Res 1988 4.19
6 Interactions of bacteriophage and host macromolecules in the growth of bacteriophage lambda. Microbiol Rev 1984 4.17
7 The dnaK protein of Escherichia coli possesses an ATPase and autophosphorylating activity and is essential in an in vitro DNA replication system. Proc Natl Acad Sci U S A 1983 3.96
8 Initiation of lambda DNA replication with purified host- and bacteriophage-encoded proteins: the role of the dnaK, dnaJ and grpE heat shock proteins. EMBO J 1989 3.58
9 The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner. Cell 1990 3.51
10 Modulation of the Escherichia coli sigmaE (RpoE) heat-shock transcription-factor activity by the RseA, RseB and RseC proteins. Mol Microbiol 1997 3.51
11 The rpoE gene encoding the sigma E (sigma 24) heat shock sigma factor of Escherichia coli. EMBO J 1995 3.29
12 The HtrA (DegP) protein, essential for Escherichia coli survival at high temperatures, is an endopeptidase. J Bacteriol 1990 3.14
13 The nucleotide sequence of the Escherichia coli K12 dnaJ+ gene. A gene that encodes a heat shock protein. J Biol Chem 1986 3.04
14 Identification of a second Escherichia coli groE gene whose product is necessary for bacteriophage morphogenesis. Proc Natl Acad Sci U S A 1981 2.94
15 Purification and properties of the Escherichia coli dnaK replication protein. J Biol Chem 1984 2.92
16 Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro. EMBO J 1989 2.89
17 The NH2-terminal 108 amino acids of the Escherichia coli DnaJ protein stimulate the ATPase activity of DnaK and are sufficient for lambda replication. J Biol Chem 1994 2.85
18 Purification and properties of the dnaJ replication protein of Escherichia coli. J Biol Chem 1985 2.84
19 Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli. J Biol Chem 1993 2.83
20 Modulation of stability of the Escherichia coli heat shock regulatory factor sigma. J Bacteriol 1989 2.80
21 Identification and characterization of the Escherichia coli gene dsbB, whose product is involved in the formation of disulfide bonds in vivo. Proc Natl Acad Sci U S A 1993 2.70
22 The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor. Proc Natl Acad Sci U S A 1992 2.63
23 The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone. EMBO J 1995 2.63
24 The universally conserved GroE (Hsp60) chaperonins. Annu Rev Microbiol 1991 2.56
25 Escherichia coli grpE gene codes for heat shock protein B25.3, essential for both lambda DNA replication at all temperatures and host growth at high temperature. J Bacteriol 1986 2.55
26 Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis. J Biol Chem 1998 2.53
27 The Escherichia coli DnaK chaperone, the 70-kDa heat shock protein eukaryotic equivalent, changes conformation upon ATP hydrolysis, thus triggering its dissociation from a bound target protein. J Biol Chem 1991 2.47
28 Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage lambda DNA replication. Proc Natl Acad Sci U S A 1988 2.42
29 The grpE protein of Escherichia coli. Purification and properties. J Biol Chem 1987 2.40
30 The Escherichia coli dsbC (xprA) gene encodes a periplasmic protein involved in disulfide bond formation. EMBO J 1994 2.34
31 Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains. Cell 1999 2.33
32 The B66.0 protein of Escherichia coli is the product of the dnaK+ gene. J Bacteriol 1982 2.19
33 Suppression of the Escherichia coli dnaA46 mutation by amplification of the groES and groEL genes. Mol Gen Genet 1986 2.18
34 The heat-shock-regulated grpE gene of Escherichia coli is required for bacterial growth at all temperatures but is dispensable in certain mutant backgrounds. J Bacteriol 1989 2.15
35 Heat shock regulatory gene rpoH mRNA level increases after heat shock in Escherichia coli. J Bacteriol 1986 2.04
36 The Escherichia coli heat shock gene htpY: mutational analysis, cloning, sequencing, and transcriptional regulation. J Bacteriol 1993 2.03
37 Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33 degrees C in rich media. J Bacteriol 1991 2.02
38 NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain. Proc Natl Acad Sci U S A 1994 2.00
39 Purification and properties of the groES morphogenetic protein of Escherichia coli. J Biol Chem 1986 2.00
40 Identification and characterization of HsIV HsIU (ClpQ ClpY) proteins involved in overall proteolysis of misfolded proteins in Escherichia coli. EMBO J 1996 1.98
41 Biological role and regulation of the universally conserved heat shock proteins. J Biol Chem 1991 1.97
42 The T/t common exon of simian virus 40, JC, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone. Proc Natl Acad Sci U S A 1997 1.95
43 Autoregulation of the Escherichia coli heat shock response by the DnaK and DnaJ heat shock proteins. Proc Natl Acad Sci U S A 1993 1.93
44 Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein. Nucleic Acids Res 1988 1.87
45 NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone. J Mol Biol 1996 1.85
46 Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J Bacteriol 1992 1.81
47 A new Escherichia coli heat shock gene, htrC, whose product is essential for viability only at high temperatures. J Bacteriol 1990 1.76
48 Characterization of a functionally important mobile domain of GroES. Nature 1993 1.74
49 Escherichia coli DnaK and GrpE heat shock proteins interact both in vivo and in vitro. J Bacteriol 1989 1.74
50 The essential Escherichia coli msbA gene, a multicopy suppressor of null mutations in the htrB gene, is related to the universally conserved family of ATP-dependent translocators. Mol Microbiol 1993 1.73
51 Structure-function analysis of the zinc finger region of the DnaJ molecular chaperone. J Biol Chem 1996 1.72
52 The conserved G/F motif of the DnaJ chaperone is necessary for the activation of the substrate binding properties of the DnaK chaperone. J Biol Chem 1995 1.71
53 Isolation and characterization of dnaJ null mutants of Escherichia coli. J Bacteriol 1990 1.70
54 A mitochondrial homolog of bacterial GrpE interacts with mitochondrial hsp70 and is essential for viability. EMBO J 1994 1.60
55 Initiation of DNA replication on single-stranded DNA templates catalyzed by purified replication proteins of bacteriophage lambda and Escherichia coli. Proc Natl Acad Sci U S A 1985 1.59
56 Physical interactions between bacteriophage and Escherichia coli proteins required for initiation of lambda DNA replication. J Biol Chem 1990 1.59
57 Both the Escherichia coli chaperone systems, GroEL/GroES and DnaK/DnaJ/GrpE, can reactivate heat-treated RNA polymerase. Different mechanisms for the same activity. J Biol Chem 1993 1.58
58 Role of Escherichia coli heat shock proteins DnaK and HtpG (C62.5) in response to nutritional deprivation. J Bacteriol 1990 1.57
59 Recognition, targeting, and hydrolysis of the lambda O replication protein by the ClpP/ClpX protease. J Biol Chem 1999 1.55
60 Identification and transcriptional analysis of the Escherichia coli htrE operon which is homologous to pap and related pilin operons. J Bacteriol 1993 1.52
61 The Escherichia coli heat shock proteins GroEL and GroES modulate the folding of the beta-lactamase precursor. EMBO J 1990 1.50
62 Functional domains of the Escherichia coli dnaK heat shock protein as revealed by mutational analysis. J Biol Chem 1989 1.49
63 Escherichia coli DnaK protein possesses a 5'-nucleotidase activity that is inhibited by AppppA. J Bacteriol 1986 1.46
64 Mutational analysis and properties of the msbA gene of Escherichia coli, coding for an essential ABC family transporter. Mol Microbiol 1996 1.44
65 The htrM gene, whose product is essential for Escherichia coli viability only at elevated temperatures, is identical to the rfaD gene. Nucleic Acids Res 1991 1.43
66 On the mechanism of FtsH-dependent degradation of the sigma 32 transcriptional regulator of Escherichia coli and the role of the Dnak chaperone machine. Mol Microbiol 1999 1.42
67 Evidence that the two Escherichia coli groE morphogenetic gene products interact in vivo. J Bacteriol 1982 1.37
68 The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the sigma 32 heat shock transcriptional regulator. Proc Natl Acad Sci U S A 1995 1.35
69 The lethal phenotype caused by null mutations in the Escherichia coli htrB gene is suppressed by mutations in the accBC operon, encoding two subunits of acetyl coenzyme A carboxylase. J Bacteriol 1992 1.35
70 arc-dependent thermal regulation and extragenic suppression of the Escherichia coli cytochrome d operon. J Bacteriol 1992 1.31
71 Positive control of the two-component RcsC/B signal transduction network by DjlA: a member of the DnaJ family of molecular chaperones in Escherichia coli. Mol Microbiol 1997 1.29
72 Identification of the heat-inducible protein C15.4 as the groES gene product in Escherichia coli. J Bacteriol 1983 1.29
73 Bacteriophage lambda replication proteins: formation of a mixed oligomer and binding to the origin of lambda DNA. Mol Gen Genet 1984 1.27
74 Bacteriophage T4 encodes a co-chaperonin that can substitute for Escherichia coli GroES in protein folding. Nature 1994 1.26
75 Sequencing, mutational analysis, and transcriptional regulation of the Escherichia coli htrB gene. Mol Microbiol 1991 1.24
76 Enzymology of the pre-priming steps in lambda dv DNA replication in vitro. J Biol Chem 1987 1.23
77 Initiation of lambda DNA replication. The Escherichia coli small heat shock proteins, DnaJ and GrpE, increase DnaK's affinity for the lambda P protein. J Biol Chem 1993 1.20
78 The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP. J Bacteriol 1991 1.16
79 Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype. J Bacteriol 1990 1.12
80 Synthesis of a select group of proteins by Neisseria gonorrhoeae in response to thermal stress. Infect Immun 1990 1.11
81 The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli. J Biol Chem 2000 1.11
82 Interplay of structure and disorder in cochaperonin mobile loops. Proc Natl Acad Sci U S A 1996 1.10
83 ATP hydrolysis is required for the DnaJ-dependent activation of DnaK chaperone for binding to both native and denatured protein substrates. J Biol Chem 1995 1.10
84 Sequence analysis and phenotypic characterization of groEL mutations that block lambda and T4 bacteriophage growth. J Bacteriol 1993 1.08
85 The ins and outs of a molecular chaperone machine. Trends Biochem Sci 1998 1.07
86 The essential Escherichia coli msgB gene, a multicopy suppressor of a temperature-sensitive allele of the heat shock gene grpE, is identical to dapE. J Bacteriol 1992 1.05
87 Isolation and characterization of the Escherichia coli htrD gene, whose product is required for growth at high temperatures. J Bacteriol 1992 1.04
88 DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction. J Biol Chem 2000 1.01
89 Isolation and characterization of point mutations in the Escherichia coli grpE heat shock gene. J Bacteriol 1994 1.00
90 The E. coli dnaA initiation protein: a protein for all seasons. Trends Genet 1989 1.00
91 Both ambient temperature and the DnaK chaperone machine modulate the heat shock response in Escherichia coli by regulating the switch between sigma 70 and sigma 32 factors assembled with RNA polymerase. EMBO J 1995 0.99
92 Genetic and biochemical characterization of mutations affecting the carboxy-terminal domain of the Escherichia coli molecular chaperone DnaJ. Mol Microbiol 1998 0.98
93 Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone. J Biol Chem 2001 0.98
94 Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction. J Biol Chem 1999 0.98
95 The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth. J Bacteriol 2001 0.97
96 The oligomeric structure of GroEL/GroES is required for biologically significant chaperonin function in protein folding. Nat Struct Biol 1998 0.96
97 Structure-function analyses of the Ssc1p, Mdj1p, and Mge1p Saccharomyces cerevisiae mitochondrial proteins in Escherichia coli. J Bacteriol 1997 0.96
98 Bacteriophage lambda cloning vehicles for studies of genetic recombination. Gene 1980 0.96
99 Purification and properties of the Escherichia coli heat shock protein, HtpG. J Biol Chem 1989 0.96
100 Structure-function analysis of the Escherichia coli GrpE heat shock protein. EMBO J 1996 0.95
101 Identification of important amino acid residues that modulate binding of Escherichia coli GroEL to its various cochaperones. Genetics 2001 0.95
102 Two classes of extragenic suppressor mutations identify functionally distinct regions of the GroEL chaperone of Escherichia coli. J Bacteriol 1994 0.95
103 Genetic analysis of bacteriophage-encoded cochaperonins. Annu Rev Genet 2000 0.94
104 The Escherichia coli heat shock response and bacteriophage lambda development. FEMS Microbiol Rev 1995 0.93
105 Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31. J Biol Chem 2000 0.93
106 Heat shock proteins as carrier molecules: in vivo helper effect mediated by Escherichia coli GroEL and DnaK proteins requires cross-linking with antigen. Clin Exp Immunol 1994 0.92
107 Identification of the Escherichia coli sohB gene, a multicopy suppressor of the HtrA (DegP) null phenotype. J Bacteriol 1991 0.92
108 Complex phenotypes of null mutations in the htr genes, whose products are essential for Escherichia coli growth at elevated temperatures. Res Microbiol 1991 0.92
109 Identification of the E. coli groNB(nusB) gene product. Mol Gen Genet 1981 0.91
110 Mutational analysis of the phage T4 morphogenetic 31 gene, whose product interacts with the Escherichia coli GroEL protein. Gene 1990 0.91
111 Purification and biochemical properties of Saccharomyces cerevisiae Mdj1p, the mitochondrial DnaJ homologue. J Biol Chem 1997 0.89
112 Molecular characterization of the Escherichia coli htrD gene: cloning, sequence, regulation, and involvement with cytochrome d oxidase. J Bacteriol 1993 0.88
113 Analysis of an Escherichia coli dnaB temperature-sensitive insertion mutation and its cold-sensitive extragenic suppressor. J Biol Chem 1991 0.88
114 The nucleotide sequence of the Escherichia coli K12 nusB (groNB) gene. Nucleic Acids Res 1984 0.88
115 Formation of the preprimosome protects lambda O from RNA transcription-dependent proteolysis by ClpP/ClpX. Proc Natl Acad Sci U S A 1998 0.88
116 Purification and biochemical properties of Saccharomyces cerevisiae's Mge1p, the mitochondrial cochaperone of Ssc1p. J Biol Chem 1996 0.87
117 Biochemical properties of the Escherichia coli dnaK heat shock protein and its mutant derivatives. Biochimie 1990 0.85
118 The purification and properties of the scaffolding protein of bacteriophage lambda. J Biol Chem 1992 0.85
119 Physical map locations of the trxB, htrD, cydC, and cydD genes of Escherichia coli. J Bacteriol 1992 0.84
120 Purification and properties of the NusB protein of Escherichia coli. J Biol Chem 1988 0.84
121 Studies on Escherichia coli mutants which block bacteriophage morphogenesis. Prog Clin Biol Res 1981 0.83
122 Initiation of lambda DNA replication reconstituted with purified lambda and Escherichia coli replication proteins. Biochim Biophys Acta 1988 0.83
123 An IS4 transposition causes a 13-bp duplication of phage lambda DNA and results in the constitutive expression of the cI and cro gene products. Gene 1982 0.83
124 The head genes of bacteriophage 21. Virology 1983 0.82
125 Mutants in the y region of bacteriophage lambda constitutive for repressor synthesis: their isolation and the characterization of the Hyp phenotype. Gene 1982 0.82
126 In vivo protein folding: suppressor analysis of mutations in the groES cochaperone gene of Escherichia coli. FASEB J 1996 0.81
127 Chaperones and protein folding. Curr Opin Cell Biol 1992 0.81
128 Genetic analysis of the bacteriophage T4-encoded cochaperonin Gp31. Genetics 1999 0.81
129 Function of the GrpE heat shock protein in bidirectional unwinding and replication from the origin of phage lambda. J Biol Chem 1993 0.80
130 Variations in the structure of radiolabeled glycopeptides from the glycoprotein of vesicular stomatitis virus grown in four mouse teratocarcinoma cell lines. J Biol Chem 1981 0.79
131 Bacteriophage T4 mutants which propagate on E. coli K12 but not on E. coli B. Experientia 1977 0.77
132 [Comparison of the genome for phylogenetically related bacteriophages phiKZ and EL of Pseudomonas aeruginosa: evolutionary aspects and minimal genome size]. Genetika 2005 0.76
133 Bacteriophage-host interactions in assembly. Prog Clin Biol Res 1981 0.75