Published in Crit Care Med on December 01, 1998
Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc Natl Acad Sci U S A (2003) 7.14
Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med (2014) 3.82
Structure-function relationship of cytokine induction by lipoteichoic acid from Staphylococcus aureus. J Exp Med (2001) 3.09
Brazilian Sepsis Epidemiological Study (BASES study). Crit Care (2004) 2.49
Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther (2012) 2.34
Epidemiology of severe sepsis. Virulence (2013) 2.26
Symptoms experienced by intensive care unit patients at high risk of dying. Crit Care Med (2010) 1.85
Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages. Infect Immun (1999) 1.60
Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages. J Surg Res (2012) 1.59
Changes in B-type Natriuretic Peptide and Related Hemodynamic Parameters Following a Fluid Challenge in Critically Ill Patients with Severe Sepsis or Septic Shock. Indian J Crit Care Med (2017) 1.40
Toll-like receptor 4 modulation as a strategy to treat sepsis. Mediators Inflamm (2010) 1.35
Assessment of six mortality prediction models in patients admitted with severe sepsis and septic shock to the intensive care unit: a prospective cohort study. Crit Care (2003) 1.34
Clinical review: Hypertonic saline resuscitation in sepsis. Crit Care (2002) 1.24
Novel insights for systemic inflammation in sepsis and hemorrhage. Mediators Inflamm (2010) 1.24
Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice. Am J Physiol Renal Physiol (2008) 1.17
Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care (2007) 1.15
TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury. J Med Genet (2004) 1.15
Pulse high-volume haemofiltration for treatment of severe sepsis: effects on hemodynamics and survival. Crit Care (2005) 1.08
Bench-to-bedside review: sepsis, severe sepsis and septic shock - does the nature of the infecting organism matter? Crit Care (2008) 1.06
Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res (2006) 1.06
Impact of nosocomial polymicrobial bloodstream infections on the outcome in critically ill patients. Eur J Clin Microbiol Infect Dis (2011) 1.03
Activation of MDL-1 (CLEC5A) on immature myeloid cells triggers lethal shock in mice. J Clin Invest (2011) 1.01
Sepsis, complement and the dysregulated inflammatory response. J Cell Mol Med (2009) 1.00
Serum lipopolysaccharide binding protein levels predict severity of lung injury and mortality in patients with severe sepsis. PLoS One (2009) 0.98
Effects of volume resuscitation on splanchnic perfusion in canine model of severe sepsis induced by live Escherichia coli infusion. Crit Care (2004) 0.96
Nosocomial infections in the intensive care unit: Incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of Eastern India. Indian J Crit Care Med (2015) 0.93
Should we inhibit type I interferons in sepsis? Infect Immun (2006) 0.92
Sepsis: from bench to bedside. Clinics (Sao Paulo) (2008) 0.91
Sepsis in the pediatric cardiac intensive care unit. World J Pediatr Congenit Heart Surg (2011) 0.90
Early goal-directed therapy: a UK perspective. Emerg Med J (2006) 0.89
Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases. World J Gastroenterol (2006) 0.89
Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels. Cell Stress Chaperones (2011) 0.88
Vasopressors for the Treatment of Septic Shock: Systematic Review and Meta-Analysis. PLoS One (2015) 0.88
Meta-analysis of protocolized goal-directed hemodynamic optimization for the management of severe sepsis and septic shock in the Emergency Department. West J Emerg Med (2014) 0.87
A myeloid hypoxia-inducible factor 1α-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. J Biol Chem (2011) 0.86
Bench-to-bedside review: future novel diagnostics for sepsis - a systems biology approach. Crit Care (2013) 0.86
Epidemiology and Outcome of Severe Sepsis and Septic Shock in Surgical Intensive Care Units in Northern Taiwan. Medicine (Baltimore) (2015) 0.85
Differential tumor necrosis factor alpha expression and release from peritoneal mouse macrophages in vitro in response to proliferating gram-positive versus gram-negative bacteria. Infect Immun (2000) 0.84
Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection? Am J Reprod Immunol (2010) 0.83
Sepsis and pregnancy: do we know how to treat this situation? Rev Bras Ter Intensiva (2014) 0.83
Hypertonic saline solution drives neutrophil from bystander organ to infectious site in polymicrobial sepsis: a cecal ligation and puncture model. PLoS One (2013) 0.81
The effects of anisodamine and dobutamine on gut mucosal blood flow during gut ischemia/ reperfusion. World J Gastroenterol (2002) 0.81
[The cost of sepsis]. Anaesthesist (2006) 0.80
Neonatal programming by neuroimmune challenge: effects on responses and tolerance to septic doses of lipopolysaccharide in adult male and female rats. J Neuroendocrinol (2010) 0.80
Early diagnosis of sepsis using serum hemoglobin subunit Beta. Inflammation (2015) 0.80
The shock index as a predictor of vasopressor use in emergency department patients with severe sepsis. West J Emerg Med (2014) 0.79
Comparative analysis of hepatic CD14 expression between two different endotoxin shock model mice: relation between hepatic injury and CD14 expression. PLoS One (2013) 0.79
Retrospective analysis of outcome of women with breast or gynaecological cancer in the intensive care unit. JRSM Short Rep (2013) 0.79
Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry. Crit Care (2013) 0.79
Myocardial dysfunction in sepsis: no role for NO? Heart (2002) 0.78
Blockade of the N-Methyl-D-Aspartate Glutamate Receptor Ameliorates Lipopolysaccharide-Induced Renal Insufficiency. PLoS One (2015) 0.78
Effects of high-volume hemofiltration on alveolar-arterial oxygen exchange in patients with refractory septic shock. World J Emerg Med (2011) 0.78
Prevention of sepsis in children: a new paradigm for public policy. Crit Care Res Pract (2011) 0.77
Current knowledge and future directions of TLR and NOD signaling in sepsis. Mil Med Res (2015) 0.77
The effect of methylprednisolone on treatment in rats with induced sepsis. Clin Exp Med (2008) 0.77
Phagocytosis and digestion of pH-sensitive fluorescent dye (Eos-FP) transfected E. coli in whole blood assays from patients with severe sepsis and septic shock. J Cell Commun Signal (2011) 0.76
Drotrecogin alfa (activated): a novel therapeutic strategy for severe sepsis. Postgrad Med J (2003) 0.76
Demystifying critical care: a new series provides a succinct, modern approach aimed at primary care physicians. West J Med (2001) 0.76
Epidemiology, prognosis, and evolution of management of septic shock in a French intensive care unit: a five years survey. Crit Care Res Pract (2010) 0.76
Lymphocyte count as a sign of immunoparalysis and its correlation with nutritional status in pediatric intensive care patients with sepsis: A pilot study. Clinics (Sao Paulo) (2016) 0.75
Streptococcus pneumoniae causing septic arthritis with shock and revealing multiple myeloma. BMJ Case Rep (2011) 0.75
Effects of Safflower Yellow on the Treatment of Severe Sepsis and Septic Shock: A Randomized Controlled Clinical Trial. Evid Based Complement Alternat Med (2016) 0.75
Polyclonal intravenous immunoglobulin for the prophylaxis and treatment of infection in critically ill adults. Can J Infect Dis (2002) 0.75
Effect of Septimeb(TM) as a new natural extract on severe sepsis: A randomized clinical trial. Caspian J Intern Med (2017) 0.75
Melatonin protects from, but does not reverse, the effects of mediators of sepsis on liver bioenergetics. Pediatr Surg Int (2004) 0.75
Reduced mortality from septic shock--lessons for the future. Crit Care Med (1998) 0.75
Post-ICU discharge and outcome: rationale and methods of the The French and euRopean Outcome reGistry in Intensive Care Units (FROG-ICU) observational study. BMC Anesthesiol (2015) 0.75
A Prospective Study of Comparison of APACHE-IV & SAPS-II Scoring Systems and Calculation of Standardised Mortality Rate in Severe Sepsis and Septic Shock Patients. J Clin Diagn Res (2014) 0.75
Seeking Sepsis in the Emergency Department- Identifying Barriers to Delivery of the Sepsis 6. BMJ Qual Improv Rep (2016) 0.75
Efficacy of single-dose intravenous immunoglobulin administration for severe sepsis and septic shock. J Intensive Care (2013) 0.75
Hydrogen sulfide modulates chromatin remodeling and inflammatory mediator production in response to endotoxin, but does not play a role in the development of endotoxin tolerance. J Inflamm (Lond) (2016) 0.75
Surgical Site Infection Following Fixation of Acetabular Fractures. Hip Pelvis (2017) 0.75
Raftlin: a new biomarker in human sepsis. Inflammation (2014) 0.75
Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70
Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA (2001) 10.03
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med (1997) 4.86
Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med (2000) 4.74
The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med (1999) 3.93
Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg (1996) 3.31
Erythropoietin response is blunted in critically ill patients. Intensive Care Med (1997) 3.20
Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med (1999) 2.93
Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med (1993) 2.84
Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest (1993) 2.79
Sedative and analgesic practice in the intensive care unit: the results of a European survey. Br J Anaesth (2001) 2.75
A profile of European intensive care unit physiotherapists. European Society of Intensive Care Medicine. Intensive Care Med (2000) 2.72
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med (2001) 2.56
Methylene blue administration in septic shock: a clinical trial. Crit Care Med (1995) 2.50
Predictive value of microalbuminuria in medical ICU patients: results of a pilot study. Chest (2001) 2.43
Use of early corticosteroid therapy on ICU admission in patients affected by severe pandemic (H1N1)v influenza A infection. Intensive Care Med (2010) 2.42
The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med (2001) 2.34
An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med (1999) 2.33
Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J Infect Dis (1999) 2.32
Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med (2008) 2.31
Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) (2005) 2.30
Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest (1991) 2.25
Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery. Anesth Analg (1993) 2.12
Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies. Chest (1997) 2.07
Interleukin-10 production during septicaemia. Lancet (1994) 2.05
How to use an article on therapy or prevention: pneumonia prevention using subglottic secretion drainage. Crit Care Med (1997) 2.03
Association of Streptococcus bovis bacteremia with bowel disease. J Clin Microbiol (1983) 2.01
Relationship between oxygen uptake and oxygen delivery in septic patients: effects of prostacyclin versus dobutamine. Crit Care Med (1993) 2.00
Effects of methylene blue on oxygen availability and regional blood flow during endotoxic shock. Crit Care Med (1995) 1.97
Serial lactate determinations during circulatory shock. Crit Care Med (1983) 1.93
European participation in major intensive care journals. Intensive Care Med (1995) 1.93
Strong vasopressor support may be futile in the intensive care unit patient with multiple organ failure. Crit Care Med (2000) 1.84
Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol (2005) 1.83
Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med (1998) 1.77
Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med (2000) 1.70
Application of SOFA score to trauma patients. Sequential Organ Failure Assessment. Intensive Care Med (1999) 1.66
Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection (2009) 1.64
Human cytokine responses to cardiac transplantation and coronary artery bypass grafting. J Thorac Cardiovasc Surg (1996) 1.63
The Brussels sedation scale: use of a simple clinical sedation scale can avoid excessive sedation in patients undergoing mechanical ventilation in the intensive care unit. Br J Anaesth (1999) 1.63
Hemodynamic responses to successful weaning from mechanical ventilation after cardiovascular surgery. Intensive Care Med (2000) 1.62
Estimating left ventricular filling pressure during positive end-expiratory pressure in humans. Am Rev Respir Dis (1991) 1.61
Effects of propofol on human microcirculation. Br J Anaesth (2008) 1.56
Pertussis in Massachusetts, 1981-1991: incidence, serologic diagnosis, and vaccine effectiveness. J Infect Dis (1994) 1.56
Correlation of serial blood lactate levels to organ failure and mortality after trauma. Am J Emerg Med (1995) 1.53
Do established prognostic factors explain the different mortality rates in ICU septic patients around the world? Minerva Anestesiol (2012) 1.53
Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance. J Clin Microbiol (1997) 1.51
Pesticides in Portuguese surface and ground waters. Water Res (2003) 1.50
Sepsis, severe sepsis or sepsis syndrome: need for clarification. Intensive Care Med (1992) 1.48
Terminology of endocrine tumors of the uterine cervix: results of a workshop sponsored by the College of American Pathologists and the National Cancer Institute. Arch Pathol Lab Med (1997) 1.48
Coagulopathy induced by hydroxyethyl starch. Anesth Analg (1997) 1.47
Roundtable Conference on Clinical Trials for the Treatment of Sepsis. Brussels, March 12-14, 1994. Chest (1995) 1.47
Comparison of cellulose diacetate and polysulfone membranes in the outcome of acute renal failure. A prospective randomized study. Nephrol Dial Transplant (2000) 1.46
Hypertonic saline solution-hetastarch for fluid resuscitation in experimental septic shock. Anesth Analg (1989) 1.44
A randomized clinical trial of cryotherapy, laser vaporization, and loop electrosurgical excision for treatment of squamous intraepithelial lesions of the cervix. Obstet Gynecol (1998) 1.43
Doctors' perceptions of the effects of interventions tested in prospective, randomised, controlled, clinical trials: results of a survey of ICU physicians. Intensive Care Med (2001) 1.41
Pericentric inversion of chromosome 1 in three sterile brothers. Hum Genet (1981) 1.39
Thermodilution for measurement of cardiac output during artificial ventilation. Intensive Care Med (1988) 1.39
Atropine administration in experimental electromechanical dissociation. Am J Emerg Med (1992) 1.39
Rapid tranquillisation in isolated units, i.m. medication preferable to i.v. J Psychopharmacol (1999) 1.39
Bretylium tosylate versus lidocaine in experimental cardiac arrest. Am J Emerg Med (1990) 1.39
In vivo diagnosis of cervical intraepithelial neoplasia using 337-nm-excited laser-induced fluorescence. Proc Natl Acad Sci U S A (1994) 1.38
Piroxicam-beta-cyclodextrin and photosensitivity reactions. Contact Dermatitis (1998) 1.38
Cardiac tamponade due to spontaneous rupture of right coronary artery aneurysm. Ann Thorac Surg (1996) 1.37
Lay person's perception of smile aesthetics in dental and facial views. J Orthod (2004) 1.33
Interethnic differences in the accuracy of anthropometric indicators of obesity in screening for high risk of coronary heart disease. Int J Obes (Lond) (2009) 1.30
Effects of nitric oxide in septic shock. Am J Respir Crit Care Med (2000) 1.27
Veno-arterial carbon dioxide gradient in human septic shock. Chest (1992) 1.26
Evolution of rabbit haemorrhagic disease virus (RHDV) in the European rabbit (Oryctolagus cuniculus) from the Iberian Peninsula. Vet Microbiol (2008) 1.25
Lactate production by the lungs in acute lung injury. Am J Respir Crit Care Med (1997) 1.25
Is outcome from ARDS related to the severity of respiratory failure? Eur Respir J (1997) 1.25
Reflectance spectroscopy for in vivo characterization of ovarian tissue. Lasers Surg Med (2001) 1.24
Stimulation of hepatic mitochondrial alpha-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine. Characteristics of the response with specific nuclear thyroid hormone binding sites fully saturated. J Clin Invest (1977) 1.22
Merkel cell carcinoma (endocrine carcinoma of the skin) of the head and neck. Arch Otolaryngol (1984) 1.22
Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg (1996) 1.14
A novel locus for Leber congenital amaurosis maps to chromosome 6q. Am J Hum Genet (2000) 1.14
A profile of European ICU nursing. Intensive Care Med (1998) 1.13
Pertussis outbreaks in groups claiming religious exemptions to vaccinations. Am J Dis Child (1992) 1.13
Essential genes in proximal 3L heterochromatin of Drosophila melanogaster. Mol Gen Genet (2001) 1.10
Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism (1999) 1.10
Blood interleukin 10 levels parallel the severity of septic shock. J Crit Care (1997) 1.09
Combined measurements of blood lactate concentrations and gastric intramucosal pH in patients with severe sepsis. Crit Care Med (1995) 1.09
Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2. Oncogene (2007) 1.09
Arteriovenous differences in PCO2 and pH are good indicators of critical hypoperfusion. Am Rev Respir Dis (1993) 1.08
Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation. Ann Thorac Surg (1997) 1.07
Disseminated aspergillosis in intensive care unit patients: an autopsy study. J Chemother (2003) 1.07
Is ARDS usually associated with right ventricular dysfunction or failure? Intensive Care Med (1995) 1.07
Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest (1998) 1.07
Thermodilution measurement of right ventricular ejection fraction with a modified pulmonary artery catheter. Intensive Care Med (1986) 1.06
Noxious colorectal distention induced-c-Fos protein in limbic brain structures in the rat. Neurosci Lett (1996) 1.05
Fluorescence spectroscopy: a diagnostic tool for cervical intraepithelial neoplasia (CIN). Gynecol Oncol (1994) 1.05
Effect of positive end-expiratory pressure on right ventricular function in humans. Am Rev Respir Dis (1992) 1.05
Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med (2000) 1.04
Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock. Intensive Care Med (1996) 1.04
Oxygen supply dependency can characterize septic shock. Intensive Care Med (1998) 1.03
Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol (1995) 1.02