Inflammatory response to cardiopulmonary bypass: mechanisms involved and possible therapeutic strategies.

Effects of FP15, a peroxynitrite decomposition catalyst on cardiac and pulmonary function after cardiopulmonary bypass. Eur J Cardiothorac Surg (2012) 1.48

Lung inflammatory response syndrome after cardiac-operations and treatment of lornoxicam. J Thorac Dis (2014) 1.40

Sheep (Ovis aries) as a model for cardiovascular surgery and management before, during, and after cardiopulmonary bypass. J Am Assoc Lab Anim Sci (2014) 1.31

Transcatheter versus surgical aortic valve replacement in patients with diabetes and severe aortic stenosis at high risk for surgery: an analysis of the PARTNER Trial (Placement of Aortic Transcatheter Valve). J Am Coll Cardiol (2013) 1.26

Effect of lornoxicam in lung inflammatory response syndrome after operations for cardiac surgery with cardiopulmonary bypass. J Thorac Dis (2014) 1.22

Mechanisms of critical illness--classifying microcirculatory flow abnormalities in distributive shock. Crit Care (2006) 1.21

Strategies to prevent intraoperative lung injury during cardiopulmonary bypass. J Cardiothorac Surg (2010) 1.18

Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child (2005) 1.13

Plasma angiopoietin-2 levels increase in children following cardiopulmonary bypass. Intensive Care Med (2008) 1.10

Early postoperative statin therapy is associated with a lower incidence of acute kidney injury after cardiac surgery. J Cardiothorac Vasc Anesth (2010) 1.04

Glucocorticoid therapy for hypotension in the cardiac intensive care unit. Pediatr Cardiol (2007) 0.97

Recipient-related clinical risk factors for primary graft dysfunction after lung transplantation: a systematic review and meta-analysis. PLoS One (2014) 0.96

Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J (2012) 0.94

Factors prolonging length of stay in the cardiac intensive care unit following the arterial switch operation. Cardiol Young (2007) 0.93

Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function. Cardiovasc Res (2010) 0.91

High postoperative blood levels of macrophage migration inhibitory factor are associated with less organ dysfunction in patients after cardiac surgery. Mol Med (2012) 0.89

Impairment of diaphragm muscle force and neuromuscular transmission after normothermic cardiopulmonary bypass: effect of low-dose inhaled CO. Am J Physiol Regul Integr Comp Physiol (2010) 0.89

Toll-like receptor and its roles in myocardial ischemic/reperfusion injury. Med Sci Monit (2011) 0.88

Interleukin-8 and acute kidney injury following cardiopulmonary bypass: a prospective cohort study. Nephron Clin Pract (2009) 0.88

Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation. PLoS One (2010) 0.87

Pulmonary hypertension in cardiac surgery. Curr Cardiol Rev (2010) 0.87

Autotransfusion management during and after cardiopulmonary bypass alters fibrin degradation and transfusion requirements. J Extra Corpor Technol (2007) 0.87

Current state of surgical myocardial revascularization. Circ J (2010) 0.87

Angiopoietin-2 is a potential mediator of endothelial barrier dysfunction following cardiopulmonary bypass. Cytokine (2012) 0.86

Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A(2A) receptor activation. J Thorac Cardiovasc Surg (2008) 0.85

Pump or no pump for coronary artery bypass: current best available evidence. Tex Heart Inst J (2005) 0.84

Dexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypass. Braz J Med Biol Res (2016) 0.84

An increase in macrophage migration inhibitory factor release in patients with cardiopulmonary bypass surgery. Surg Today (2000) 0.83

Protective lung ventilation during general anesthesia: is there any evidence? Crit Care (2014) 0.82

Protective effect of silymarin during coronary artery bypass grafting surgery. Exp Clin Cardiol (2012) 0.82

Unchanged plasma levels of the soluble urokinase plasminogen activator receptor in elective coronary artery bypass graft surgery patients and cardiopulmonary bypass use. PLoS One (2014) 0.82

Effect of different dosages of nitroglycerin infusion on arterial blood gas tensions in patients undergoing on- pump coronary artery bypass graft surgery. J Res Med Sci (2012) 0.82

Alpha lipoic acid attenuates inflammatory response during extracorporeal circulation. Cardiovasc J Afr (2013) 0.82

Late pharmacologic conditioning with volatile anesthetics after cardiac surgery. Crit Care (2012) 0.81

Effects of half-dose aprotinin in off-pump coronary artery bypass grafting. World J Surg (2006) 0.81

Genomics: risk and outcomes in cardiac surgery. Anesthesiol Clin (2008) 0.81

Use of leukocyte-depleting filters during cardiac surgery with cardiopulmonary bypass: a review. J Extra Corpor Technol (2008) 0.81

Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg (2013) 0.80

Obstacles in haemocompatibility testing. Scientifica (Cairo) (2013) 0.79

Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery. Pediatr Crit Care Med (2015) 0.79

Effects of ulinastatin on postoperative blood loss and hemostasis in atrioventricular valve surgery with cardiopulmonary bypass. Korean J Thorac Cardiovasc Surg (2013) 0.79

COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery. Dis Markers (2013) 0.79

Comparison of inflammatory response following coronary revascularization with or without cardiopulmonary bypass. Exp Clin Cardiol (2004) 0.78

Normothermic cardiopulmonary bypass increases cerebral tissue oxygenation during combined valve surgery: a single-centre, randomized trial. Interact Cardiovasc Thorac Surg (2013) 0.78

Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study. Biomarkers (2010) 0.78

The utility of lung epithelium specific biomarkers in cardiac surgery: a comparison of biomarker profiles in on- and off-pump coronary bypass surgery. J Cardiothorac Surg (2013) 0.78

Does cardiac surgery in newborn infants compromise blood cell reactivity to endotoxin? Crit Care (2005) 0.78

Systemic inflammatory response syndrome after transcatheter or surgical aortic valve replacement. Heart (2015) 0.78

Genetic susceptibility to inflammatory injury and various adverse outcomes. J Extra Corpor Technol (2009) 0.78

A novel minimal invasive mouse model of extracorporeal circulation. Mediators Inflamm (2015) 0.78

Shock - A reappraisal: The holistic approach. J Emerg Trauma Shock (2012) 0.77

Using pump for bypass surgery--on-off-on again? Crit Care (2010) 0.77

Oxygenator Is the Main Responsible for Leukocyte Activation in Experimental Model of Extracorporeal Circulation: A Cautionary Tale. Mediators Inflamm (2015) 0.76

Mid-term outcomes of off-pump versus on-pump coronary artery bypass graft surgery. Can J Cardiol (2008) 0.76

The comparative efficacy of percutaneous and surgical coronary revascularization in 2009: a review. Tex Heart Inst J (2009) 0.76

Prognostic value of sCD14-ST (presepsin) in cardiac surgery. Kardiochir Torakochirurgia Pol (2015) 0.75

The effects of early high-volume hemofiltration on prolonged cardiac arrest in rats with reperfusion by cardiopulmonary bypass: a randomized controlled animal study. Intensive Care Med Exp (2016) 0.75

Impact of Cardiopulmonary Bypass on Respiratory Mucociliary Function in an Experimental Porcine Model. PLoS One (2015) 0.75

A Novel Centrifugation Method Using a Cell Salvage Device Offers an Alternative to the Use of Leukocyte-Depleting Filters for Autologous Blood Transfusions. J Extra Corpor Technol (2016) 0.75

The efficacy of parecoxib on systemic inflammatory response associated with cardiopulmonary bypass during cardiac surgery. Br J Clin Pharmacol (2013) 0.75

Prognostic value of procalcitonin in patients after elective cardiac surgery: a prospective cohort study. Ann Intensive Care (2016) 0.75

Preparation of sustained-release composite coating formed by dexamethasone and oxidated sodium alginate. Int J Clin Exp Med (2014) 0.75

Perioperative management of the bleeding patient. Br J Anaesth (2016) 0.75

Humoral immune response and coated or uncoated oxygenators during cardiopulmonary bypass surgery. Cardiovasc J Afr (2016) 0.75

Clinical outcome and quality of life after reoperative CABG: off-pump versus on-pump - observational pilot study. J Cardiothorac Surg (2013) 0.75

Prevention of infectious complications after heart surgery in children: procalcitonin-guided strategy. Kardiochir Torakochirurgia Pol (2014) 0.75

Systemic angiopoietin-1/2 dysregulation following cardiopulmonary bypass in adults. Future Sci OA (2017) 0.75

Effects of potassium channel opener KRN4884 on human conduit arteries used as coronary bypass grafts. Br J Clin Pharmacol (2000) 0.75

Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med (2001) 27.70

Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA (2001) 10.03

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med (1997) 4.86

Acute renal failure in the ICU: risk factors and outcome evaluated by the SOFA score. Intensive Care Med (2000) 4.74

The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study. Working Group on Sepsis related Problems of the ESICM. Intensive Care Med (1999) 3.93

Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg (1996) 3.31

Has the mortality of septic shock changed with time. Crit Care Med (1998) 3.29

Erythropoietin response is blunted in critically ill patients. Intensive Care Med (1997) 3.20

Procalcitonin used as a marker of infection in the intensive care unit. Crit Care Med (1999) 2.93

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med (1993) 2.84

Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality. Chest (1993) 2.79

Sedative and analgesic practice in the intensive care unit: the results of a European survey. Br J Anaesth (2001) 2.75

A profile of European intensive care unit physiotherapists. European Society of Intensive Care Medicine. Intensive Care Med (2000) 2.72

Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study. Crit Care Med (2001) 2.56

Methylene blue administration in septic shock: a clinical trial. Crit Care Med (1995) 2.50

Predictive value of microalbuminuria in medical ICU patients: results of a pilot study. Chest (2001) 2.43

The hepatosplanchnic area is not a common source of lactate in patients with severe sepsis. Crit Care Med (2001) 2.34

An open-label dose escalation study of the nitric oxide synthase inhibitor, N(G)-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Glaxo Wellcome International Septic Shock Study Group. Crit Care Med (1999) 2.33

Relationship between plasma levels of lipopolysaccharide (LPS) and LPS-binding protein in patients with severe sepsis and septic shock. J Infect Dis (1999) 2.32

Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med (2008) 2.31

Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest (1991) 2.25

Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery. Anesth Analg (1993) 2.12

Interleukin-10 production during septicaemia. Lancet (1994) 2.05

How to use an article on therapy or prevention: pneumonia prevention using subglottic secretion drainage. Crit Care Med (1997) 2.03

Relationship between oxygen uptake and oxygen delivery in septic patients: effects of prostacyclin versus dobutamine. Crit Care Med (1993) 2.00

Effects of methylene blue on oxygen availability and regional blood flow during endotoxic shock. Crit Care Med (1995) 1.97

Serial lactate determinations during circulatory shock. Crit Care Med (1983) 1.93

European participation in major intensive care journals. Intensive Care Med (1995) 1.93

Strong vasopressor support may be futile in the intensive care unit patient with multiple organ failure. Crit Care Med (2000) 1.84

Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol (2005) 1.83

Effects of vasoactive drugs on gastric intramucosal pH. Crit Care Med (1998) 1.77

Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit Care Med (2000) 1.70

Application of SOFA score to trauma patients. Sequential Organ Failure Assessment. Intensive Care Med (1999) 1.66

Human cytokine responses to cardiac transplantation and coronary artery bypass grafting. J Thorac Cardiovasc Surg (1996) 1.63

The Brussels sedation scale: use of a simple clinical sedation scale can avoid excessive sedation in patients undergoing mechanical ventilation in the intensive care unit. Br J Anaesth (1999) 1.63

Hemodynamic responses to successful weaning from mechanical ventilation after cardiovascular surgery. Intensive Care Med (2000) 1.62

Estimating left ventricular filling pressure during positive end-expiratory pressure in humans. Am Rev Respir Dis (1991) 1.61

Effects of propofol on human microcirculation. Br J Anaesth (2008) 1.56

Correlation of serial blood lactate levels to organ failure and mortality after trauma. Am J Emerg Med (1995) 1.53

Do established prognostic factors explain the different mortality rates in ICU septic patients around the world? Minerva Anestesiol (2012) 1.53

Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance. J Clin Microbiol (1997) 1.51

Sepsis, severe sepsis or sepsis syndrome: need for clarification. Intensive Care Med (1992) 1.48

Coagulopathy induced by hydroxyethyl starch. Anesth Analg (1997) 1.47

Roundtable Conference on Clinical Trials for the Treatment of Sepsis. Brussels, March 12-14, 1994. Chest (1995) 1.47

Comparison of cellulose diacetate and polysulfone membranes in the outcome of acute renal failure. A prospective randomized study. Nephrol Dial Transplant (2000) 1.46

Hypertonic saline solution-hetastarch for fluid resuscitation in experimental septic shock. Anesth Analg (1989) 1.44

Doctors' perceptions of the effects of interventions tested in prospective, randomised, controlled, clinical trials: results of a survey of ICU physicians. Intensive Care Med (2001) 1.41

Bretylium tosylate versus lidocaine in experimental cardiac arrest. Am J Emerg Med (1990) 1.39

Atropine administration in experimental electromechanical dissociation. Am J Emerg Med (1992) 1.39

Thermodilution for measurement of cardiac output during artificial ventilation. Intensive Care Med (1988) 1.39

Cardiac tamponade due to spontaneous rupture of right coronary artery aneurysm. Ann Thorac Surg (1996) 1.37

Effects of nitric oxide in septic shock. Am J Respir Crit Care Med (2000) 1.27

Veno-arterial carbon dioxide gradient in human septic shock. Chest (1992) 1.26

Lactate production by the lungs in acute lung injury. Am J Respir Crit Care Med (1997) 1.25

Is outcome from ARDS related to the severity of respiratory failure? Eur Respir J (1997) 1.25

Myocardium is a major source of proinflammatory cytokines in patients undergoing cardiopulmonary bypass. J Thorac Cardiovasc Surg (1996) 1.14

A profile of European ICU nursing. Intensive Care Med (1998) 1.13

Leukocyte glycolysis and lactate output in animal sepsis and ex vivo human blood. Metabolism (1999) 1.10

Blood interleukin 10 levels parallel the severity of septic shock. J Crit Care (1997) 1.09

Combined measurements of blood lactate concentrations and gastric intramucosal pH in patients with severe sepsis. Crit Care Med (1995) 1.09

Arteriovenous differences in PCO2 and pH are good indicators of critical hypoperfusion. Am Rev Respir Dis (1993) 1.08

Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation. Ann Thorac Surg (1997) 1.07

Is ARDS usually associated with right ventricular dysfunction or failure? Intensive Care Med (1995) 1.07

Disseminated aspergillosis in intensive care unit patients: an autopsy study. J Chemother (2003) 1.07

Does N-acetyl-L-cysteine influence cytokine response during early human septic shock? Chest (1998) 1.07

Thermodilution measurement of right ventricular ejection fraction with a modified pulmonary artery catheter. Intensive Care Med (1986) 1.06

Effect of positive end-expiratory pressure on right ventricular function in humans. Am Rev Respir Dis (1992) 1.05

Oxygen free radicals in ARDS, septic shock and organ dysfunction. Intensive Care Med (2000) 1.04

Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock. Intensive Care Med (1996) 1.04

Oxygen supply dependency can characterize septic shock. Intensive Care Med (1998) 1.03

Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock. J Clin Immunol (1995) 1.02

Measurements of right ventricular volumes during fluid challenge. Chest (1990) 1.02

Management of nutrition in European intensive care units: results of a questionnaire. Working Group on Metabolism and Nutrition of the European Society of Intensive Care Medicine. Intensive Care Med (1999) 1.01

Monitoring gastric mucosal carbon dioxide pressure using gas tonometry: in vitro and in vivo validation studies. Anesthesiology (1997) 1.00

Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men. Surgery (1996) 1.00

The time course of blood C-reactive protein concentrations in relation to the response to initial antimicrobial therapy in patients with sepsis. Infection (2008) 1.00

Effect of empiric antibiotic treatment on plasma endotoxin activity in septic patients. Infection (2014) 0.98

Power spectral analysis of cardiovascular variability in critically ill neurosurgical patients. Crit Care Med (2000) 0.96

Protective effects of N-acetyl-L-cysteine in endotoxemia. Am J Physiol (1994) 0.96

Continuous venovenous hemofiltration improves cardiac performance by mechanisms other than tumor necrosis factor-alpha attenuation during endotoxic shock. Crit Care Med (1999) 0.96

Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock. Anaesth Intensive Care (2012) 0.95

Oxygen extraction is altered by endotoxin during tamponade-induced stagnant hypoxia in the dog. Circ Shock (1993) 0.94

Association of tumor necrosis factor-2 allele with plasma tumor necrosis factor-alpha levels and mortality from septic shock. Am J Med (2001) 0.94

Do we need intermediate care units? Intensive Care Med (1999) 0.94

Procalcitonin: THE marker of sepsis? Crit Care Med (2000) 0.93

Detection of tissue hypoxia by arteriovenous gradient for PCO2 and pH in anesthetized dogs during progressive hemorrhage. Anesth Analg (1995) 0.92

Evidence based critical care medicine; what is it and what can it do for us? Evidence Based Medicine in Critical Care Group. Crit Care Med (1996) 0.92

Interleukin-6 administration has no acute hemodynamic or hematologic effect in the dog. Cytokine (1991) 0.91

Enteral feeding with a solution enriched with antioxidant vitamins A, C, and E enhances the resistance to oxidative stress. Crit Care Med (2000) 0.91

CDP571, a humanized antibody to human tumor necrosis factor-alpha: safety, pharmacokinetics, immune response, and influence of the antibody on cytokine concentrations in patients with septic shock. CPD571 Sepsis Study Group. Crit Care Med (1995) 0.90

Dear Sirs, what is your PCT? Intensive Care Med (2000) 0.90

Reduction of stress/catecholamine-induced cardiac necrosis by beta 1-selective blockade. Lancet (1987) 0.90

Heparin-coated circuits reduce myocardial injury in heart or heart-lung transplantation: a prospective, randomized study. Ann Thorac Surg (1999) 0.90